Influence of a transplantable insulinoma on the pancreatic status of insulin and pancreatic polypeptide in the rat.

abstract：:Non-diabetic first degree relatives of non-insulin-dependent diabetic (NIDDM) families are at increased risk of developing diabetes mellitus, and have been studied to identify early metabolic abnormalities. Hormone concentrations measured by specific enzyme immunoassays were assessed in non-diabetic relatives of North...

journal_title：Diabetologia

authors： Humphriss DB,Stewart MW,Berrish TS,Barriocanal LA,Trajano LR,Ashworth LA,Brown MD,Miller M,Avery PJ,Alberti KG,Walker M

更新日期：1997-10-01 00:00:00

abstract：:Using an antiserum raised to a recombinant coxsackie virus B 3 capsid protein, VP1, an immunocytochemical technique was developed which was capable of detecting the presence of all coxsackie B viruses in formalin fixed paraffin embedded infected tissue culture cells. This technique was tested on autopsy heart and panc...

journal_title：Diabetologia

authors： Foulis AK,Farquharson MA,Cameron SO,McGill M,Schönke H,Kandolf R

更新日期：1990-05-01 00:00:00

abstract：:The metabolic and hormonal effects of stable hyperglycaemia (10-12 mmol/l) have been examined in five insulin-dependent diabetics and compared with the results of 8 h (1200 to 2000 h) normoglycaemic (5-6 mmol/l) clamping. Glucose levels were maintained using a glucose controlled insulin infusion system. Mean blood lac...

journal_title：Diabetologia

authors： Nosadini R,Noy GA,Alberti KG,Hodson A,Orskoy H

更新日期：1981-02-01 00:00:00

abstract：AIMS/HYPOTHESIS:We analysed the cost-effectiveness of intensified prevention in diabetic patients with different risks for foot ulcers and lower extremity amputations. Specifically, we examined whether the additional prevention costs associated with present recommendations would be offset by reduced costs of future foo...

journal_title：Diabetologia

authors： Ragnarson Tennvall G,Apelqvist J

更新日期：2001-11-01 00:00:00

abstract：:We have recently shown that leptin mimicks insulin effects on glucose transport and glycogen synthesis through a phosphatidylinositol-3 (PI) kinase dependent pathway in C2C12 myotubes. The aim of the present study was to identify the signalling path from the leptin receptor to the PI-3 kinase. We stimulated C2C12 myot...

journal_title：Diabetologia

authors： Kellerer M,Koch M,Metzinger E,Mushack J,Capp E,Häring HU

更新日期：1997-11-01 00:00:00

abstract：:Ciglitazone is orally active in preventing and reversing the hyperglycaemic syndrome in C57BL/6J-ob/ob mice and it is only mildly and transiently hypoglycaemic in lean littermates (C57BL/6J-+/?). Its effect on glucose disposal in vivo was estimated by injecting glucose-6-3H/14C and following the specific activity of r...

journal_title：Diabetologia

authors： Chang AY,Gilchrist BJ,Wyse BM

更新日期：1983-12-01 00:00:00

abstract：AIMS/HYPOTHESIS:To determine the effects of marine-derived n-3 polyunsaturated fatty acids (PUFA) on established and emerging lipid and lipoprotein cardiovascular risk markers in patients with type 2 diabetes. MATERIALS AND METHODS:We performed a systematic review and meta-analysis of randomised controlled trials comp...

journal_title：Diabetologia

authors： Hartweg J,Farmer AJ,Perera R,Holman RR,Neil HA

更新日期：2007-08-01 00:00:00

abstract：AIMS/HYPOTHESIS:Genetic studies show coupling of genes affecting beta cell function to type 1 diabetes, but hitherto no studies on whether beta cell dysfunction could precede insulitis and clinical onset of type 1 diabetes are available. METHODS:We used 40-day-old BioBreeding (BB) DRLyp/Lyp rats (a model of spontaneou...

journal_title：Diabetologia

authors： Medina A,Parween S,Ullsten S,Vishnu N,Siu YT,Quach M,Bennet H,Balhuizen A,Åkesson L,Wierup N,Carlsson PO,Ahlgren U,Lernmark Å,Fex M

更新日期：2018-04-01 00:00:00

abstract：AIMS/HYPOTHESIS:The newly identified liver- and fat-derived hormone, betatrophin, has recently been linked to insulin resistance and pancreatic beta cell growth in mice. These preclinical findings have suggested betatrophin as a potential candidate for novel glucose-lowering treatment concepts involving beta cell regen...

journal_title：Diabetologia

authors： Fenzl A,Itariu BK,Kosi L,Fritzer-Szekeres M,Kautzky-Willer A,Stulnig TM,Kiefer FW

更新日期：2014-06-01 00:00:00

abstract：AIMS/HYPOTHESIS:Inflammation is associated with obesity and has been implicated in the development of diabetes and atherosclerosis. During gram-negative bacterial infection, lipopolysaccharide causes an inflammatory reaction via toll-like receptor 4 (TLR4), which has an essential function in the induction of innate and...

journal_title：Diabetologia

authors： Poggi M,Bastelica D,Gual P,Iglesias MA,Gremeaux T,Knauf C,Peiretti F,Verdier M,Juhan-Vague I,Tanti JF,Burcelin R,Alessi MC

更新日期：2007-06-01 00:00:00

abstract：:Previous studies have suggested that nerve regeneration may be defective in patients with diabetic polyneuropathy. Since insulin-like growth factor I (IGF-I) has been shown to stimulate nerve regeneration, and IGF binding protein-1 is acutely regulated by plasma insulin we have investigated the relationships between p...

journal_title：Diabetologia

authors： Crosby SR,Tsigos C,Anderton CD,Gordon C,Young RJ,White A

更新日期：1992-09-01 00:00:00

abstract：AIMS/HYPOTHESIS:To document the prevalence of typical diabetic symptoms, signs and complications in the diagnosis of type 2 diabetes mellitus, examine their pre-diagnostic duration, and analyse associations with glycaemic level, blood pressure (BP), and weight. METHODS:An epidemiological population-based study of 1137...

journal_title：Diabetologia

authors： Drivsholm T,de Fine Olivarius N,Nielsen AB,Siersma V

更新日期：2005-02-01 00:00:00

abstract：:Obesity, which has long since reached epidemic proportions worldwide, is associated with long-term stress to a variety of organs and results in diseases including type 2 diabetes. In the brain, overnutrition induces hypothalamic stress associated with the activation of several signalling pathways, together with centra...

journal_title：Diabetologia

authors： Nogueiras R,Sabio G

更新日期：2021-02-01 00:00:00

abstract：:The antiprotozoal drug pentamidine can be toxic to islet cells in vivo and in vitro. Rat islets were exposed to pentamidine (mesylate and isethionate salts) and six other structurally related diamidines. The beta-cell response to arginine + theophylline was suppressed by pentamidine (10(-2) mmol/l) while the glucagon ...

journal_title：Diabetologia

authors： Boillot D,in't Veld P,Sai P,Feutren G,Gepts W,Assan R

更新日期：1985-06-01 00:00:00

abstract：AIMS/HYPOTHESIS:We have examined the effects of streptozotocin-induced type 1 diabetes on the expression and subcellular distribution of the classic sugar transporters (GLUT-1 to 5 and sodium-dependent glucose transporter-1 [SGLT-1]) in the endothelial cells of an en face preparation of septal coronary artery from Wist...

journal_title：Diabetologia

authors： Gaudreault N,Scriven DR,Moore ED

更新日期：2004-12-01 00:00:00

abstract：:It is increasingly appreciated that the pathogenic mechanisms of type 1 diabetes involve both the autoimmune aggressors and their beta cell targets, which engage in a conflicting dialogue within and possibly outside the pancreas. Indeed, autoimmune CD8+ T cells, which are the final mediators of beta cell destruction, ...

journal_title：Diabetologia

authors： Mallone R,Eizirik DL

更新日期：2020-10-01 00:00:00

abstract：:Phosphoinositide 3-kinase (PI3-kinase) plays a crucial role in insulin signal transduction. We studied the molecular mechanism of the insulin-induced activation of PI3-kinase in rat hepatoma Fao cells using an antibody against the 110-kDa catalytic subunit (p110) and two against the 85-kDa regulatory subunit (p85 alph...

journal_title：Diabetologia

authors： Hayashi T,Okamoto M,Yoshimasa Y,Inoue G,Yamada K,Kono S,Shigemoto M,Suga J,Kuzuya H,Nakao K

更新日期：1996-05-01 00:00:00

abstract：AIMS/HYPOTHESIS:Glucose-dependent insulinotropic polypeptide (GIP) is a peptide hormone released from gut K cells. While the predominant form is GIP(1-42), a shorter form, GIP(1-30), is produced by pancreatic alpha cells and promotes insulin secretion in a paracrine manner. Here, we elucidated whether GIP(1-30) express...

journal_title：Diabetologia

authors： Yanagimachi T,Fujita Y,Takeda Y,Honjo J,Atageldiyeva KK,Takiyama Y,Abiko A,Makino Y,Kieffer TJ,Haneda M

更新日期：2016-03-01 00:00:00

abstract：AIMS/HYPOTHESIS:Depression and glucose intolerance commonly co-occur among non-pregnant individuals; however, the temporal relationship between gestational diabetes (GDM) and depression during pregnancy and the postpartum period is less understood. Our objective was to assess longitudinal associations between depressio...

journal_title：Diabetologia

authors： Hinkle SN,Buck Louis GM,Rawal S,Zhu Y,Albert PS,Zhang C

更新日期：2016-12-01 00:00:00

abstract：AIMS/HYPOTHESIS:One major objective of the St Vincent Declaration was to reduce the excess risk of myocardial infarction in patients with diabetes mellitus. We estimated the trend of the incidence and relative risk of myocardial infarction in the diabetic and non-diabetic populations in southern Germany from 1985 to 20...

journal_title：Diabetologia

authors： Icks A,Dickhaus T,Hörmann A,Heier M,Giani G,Kuch B,Meisinger C

更新日期：2009-09-01 00:00:00

abstract：AIMS/HYPOTHESIS:Insulin resistance is frequently associated with hypertension and type 2 diabetes. The cytochrome P450 (CYP) arachidonic acid epoxygenases (CYP2C, CYP2J) and their epoxyeicosatrienoic acid (EET) products lower blood pressure and may also improve glucose homeostasis. However, the direct contribution of e...

journal_title：Diabetologia

authors： Gangadhariah MH,Dieckmann BW,Lantier L,Kang L,Wasserman DH,Chiusa M,Caskey CF,Dickerson J,Luo P,Gamboa JL,Capdevila JH,Imig JD,Yu C,Pozzi A,Luther JM

更新日期：2017-06-01 00:00:00

abstract：:The role of islet amyloidosis in the onset and progression of Type 2 diabetes remains obscure. Islet amyloid polypeptide is a 37 amino-acid, beta-cell peptide which is co-stored and co-released with insulin. Human islet amyloid polypeptide refolds to a beta-conformation and oligomerises to form insoluble fibrils; prol...

journal_title：Diabetologia

authors： Clark A,Nilsson MR

更新日期：2004-02-01 00:00:00

abstract：AIMS/HYPOTHESIS:Potential differences in cardiovascular risk by ethnicity remain uncertain. We evaluated the association of ethnicity with cardiovascular disease (CVD) incidence in a large cohort of people with type 2 diabetes living in Scotland. METHODS:Data from Scottish Care Information-Diabetes (SCI-Diabetes) were...

journal_title：Diabetologia

authors： Malik MO,Govan L,Petrie JR,Ghouri N,Leese G,Fischbacher C,Colhoun H,Philip S,Wild S,McCrimmon R,Sattar N,Lindsay RS,Scottish Diabetes Research Network Epidemiology Group.

更新日期：2015-04-01 00:00:00

abstract：AIMS/HYPOTHESIS:To determine whether the clinical heterogeneity observed in the development of Type I (insulin-dependent) diabetes mellitus correlates with immunohistochemical differences observed at diagnosis. METHODS:Patients (n = 17) with recent-onset diabetes clinically considered to be insulin dependent (Type I),...

journal_title：Diabetologia

authors： Imagawa A,Hanafusa T,Itoh N,Waguri M,Yamamoto K,Miyagawa J,Moriwaki M,Yamagata K,Iwahashi H,Sada M,Tsuji T,Tamura S,Kawata S,Kuwajima M,Nakajima H,Namba M,Matsuzawa Y

更新日期：1999-05-01 00:00:00

abstract：AIMS/HYPOTHESIS:We tested the hypothesis that silent coeliac disease is more frequent than expected in both patients with Type I (insulin-dependent) diabetes mellitus and their first-degree relatives. We evaluated how the presence of other autoimmune disorders in diabetic patients and their first-degree relatives is re...

journal_title：Diabetologia

authors： Not T,Tommasini A,Tonini G,Buratti E,Pocecco M,Tortul C,Valussi M,Crichiutti G,Berti I,Trevisiol C,Azzoni E,Neri E,Torre G,Martelossi S,Soban M,Lenhardt A,Cattin L,Ventura A

更新日期：2001-02-01 00:00:00

abstract：:Liver protein kinase was determined in the absence and presence of cAMP4. Experimental alloxan diabetes resulted in a decrease in total protein kinase (+cAMP) and an increase in the activity ratio (-cAMP) divided by (+cAMP) in liver. Insulin treatment of diabetic rats reversed the observed changes in protein kinase in...

journal_title：Diabetologia

authors： Weber HE,Menahan LA,Chaudhuri SN,Shipp JC

更新日期：1977-04-01 00:00:00

abstract：AIMS/HYPOTHESIS:Monogenic diabetes (MD) might be misdiagnosed as type 1 diabetes. The prevalence of MD among children with apparent type 1 diabetes has not been established. Our aim was to estimate the prevalence of common forms of MD in childhood diabetes. METHODS:We investigated 2,756 children aged 0-14 years with n...

journal_title：Diabetologia

authors： Irgens HU,Molnes J,Johansson BB,Ringdal M,Skrivarhaug T,Undlien DE,Søvik O,Joner G,Molven A,Njølstad PR

更新日期：2013-07-01 00:00:00

abstract：AIMS/HYPOTHESIS:This study compared the incidence rate of type 1 diabetes in children diagnosed with enterovirus (EV) infections with that in age- and sex-matched children without EV infection in a population-based cohort. In addition, we examined whether the direction or magnitude of the association between EV infecti...

journal_title：Diabetologia

authors： Lin HC,Wang CH,Tsai FJ,Hwang KP,Chen W,Lin CC,Li TC

更新日期：2015-01-01 00:00:00

abstract：AIMS/HYPOTHESIS:Non-invasive imaging of the pancreatic beta cell mass (BCM) requires the identification of novel and specific beta cell biomarkers. We have developed a systems biology approach to the identification of promising beta cell markers. METHODS:We followed a functional genomics strategy based on massive para...

journal_title：Diabetologia

authors： Flamez D,Roland I,Berton A,Kutlu B,Dufrane D,Beckers MC,De Waele E,Rooman I,Bouwens L,Clark A,Lonneux M,Jamar JF,Goldman S,Maréchal D,Goodman N,Gianello P,Van Huffel C,Salmon I,Eizirik DL

更新日期：2010-07-01 00:00:00

abstract：:We have previously reported that oxygen free radical scavengers protect rat islet cells from damage by cytokines and we interpreted these findings as suggesting the involvement of oxygen free radicals but did not directly measure indices of free radical activity. In this study, we report on malondialdehyde, an end pro...

journal_title：Diabetologia

authors： Rabinovitch A,Suarez WL,Thomas PD,Strynadka K,Simpson I

更新日期：1992-05-01 00:00:00