A radioreceptor-assay for glucagon: binding of enteroglucagon to liver plasma membranes.

abstract：:Kwashiorkor, the human disease of protein-energy malnutrition, has been implicated in the aetiology of malnutrition-related diabetes mellitus, a form of diabetes not uncommon in developing countries. We have previously demonstrated that temporary protein-energy malnutrition in young rats causes a persisting impairment...

journal_title：Diabetologia

authors： Swenne I,Borg LA,Crace CJ,Schnell Landström A

更新日期：1992-10-01 00:00:00

abstract：:The impact of improved glycaemic control on renal function in newly-presenting Type 2 (non-insulin-dependent) diabetic patients has not been adequately researched. Consequently, glomerular filtration rate and effective renal plasma flow and urinary albumin excretion rates were determined in 76 subjects (age (mean (SD)...

journal_title：Diabetologia

authors： Vora JP,Dolben J,Williams JD,Peters JR,Owens DR

更新日期：1993-08-01 00:00:00

abstract：:Barium x-ray patterns of ketonuric diabetic Chinese hamsters displayed marked dilatation of the stomach, small and large intestine. Hypomotility was manifested by flocculation of barium in the small and large bowel. Impaired transit time was further characterized by prolonged emptying of the stomach (mean 570 min diab...

journal_title：Diabetologia

authors： Diani AR,Grogan DM,Yates ME,Risinger DL,Gerritsen GC

更新日期：1979-07-01 00:00:00

abstract：:Employing saline-impregnated cotton threads, an implanted-wick technique was adopted in dogs to obtain specimen from the subcutaneous interstitial compartment in order to estimate its glucose concentration. By measuring the protein, potassium and haemoglobin contents, the centrifuged wick fluid was shown to contain th...

journal_title：Diabetologia

authors： Fischer U,Ertle R,Abel P,Rebrin K,Brunstein E,Hahn von Dorsche H,Freyse EJ

更新日期：1987-12-01 00:00:00

abstract：:Endothelium-derived nitric oxide plays a major role in the regulation of vascular tone and in the maintenance of vascular homeostasis. Endothelial dysfunction with impaired nitric oxide biosynthesis and decreased bioavailability has been implicated in insulin resistance syndrome and Type II (non-insulin-dependent) dia...

journal_title：Diabetologia

authors： Chan NN,Chan JC

更新日期：2002-12-01 00:00:00

abstract：AIMS/HYPOTHESIS:The cardiometabolic risk associated with metabolically healthy obesity (MHO) remains the subject of debate. It is unclear whether MHO is a transient condition that affects subclinical atherosclerosis risk. In this study, we aimed to investigate the association of MHO and its transition over time with in...

journal_title：Diabetologia

authors： Lin L,Zhang J,Jiang L,Du R,Hu C,Lu J,Wang T,Li M,Zhao Z,Xu Y,Xu M,Bi Y,Ning G,Wang W,Chen Y

更新日期：2020-07-01 00:00:00

abstract：:Since glucose control and glycosylated haemoglobin varies asyncroneously, we have studied the steady-state relationship between these two factors. In Type 1 (insulin-dependent) diabetic patients with a constant haemoglobin A1c during the preceding 2 years, 15 ambulatory blood glucose profiles during a 5-week period sh...

journal_title：Diabetologia

authors： Svendsen PA,Lauritzen T,Søegaard U,Nerup J

更新日期：1982-11-01 00:00:00

abstract：AIMS/HYPOTHESIS:The aim of this study was to test the hypothesis that intensive glycaemic control (INT) and higher plasma C-peptide levels in patients with poorly controlled diabetes would be associated with better eye outcomes. METHODS:The incidence and progression of diabetic retinopathy (DR) was assessed by grading...

journal_title：Diabetologia

authors： Azad N,Agrawal L,Emanuele NV,Klein R,Bahn GD,Reaven P,VADT Study Group.

更新日期：2014-06-01 00:00:00

abstract：AIMS/HYPOTHESIS:Contemporary data on diabetic foot ulcer prevalence are scarce. Most studies were conducted in the 1990s, reporting incidence rates of 1.9-2.6%. Since then the prevalence of diabetes has doubled and the organisation of diabetes care has undergone major changes. Up-to-date data that quantify the occurren...

journal_title：Diabetologia

authors： Stoekenbroek RM,Lokin JLC,Nielen MM,Stroes ESG,Koelemay MJW

更新日期：2017-07-01 00:00:00

abstract：AIMS/HYPOTHESIS:Activation of the G protein-coupled receptor (GPR)40 by long-chain fatty acids potentiates glucose-stimulated insulin secretion (GSIS) from pancreatic beta cells, and GPR40 agonists are in clinical development for type 2 diabetes therapy. GPR40 couples to the G protein subunit Gα(q/11) but the signallin...

journal_title：Diabetologia

authors： Ferdaoussi M,Bergeron V,Zarrouki B,Kolic J,Cantley J,Fielitz J,Olson EN,Prentki M,Biden T,MacDonald PE,Poitout V

更新日期：2012-10-01 00:00:00

abstract：:Type 1 (insulin-dependent) diabetes is less common in Asian Indians than in white Caucasoids. Forty-five Punjabi Asians with Type 1 diabetes and 96 racially matched control subjects were HLA-DR typed. DR3 was increased in diabetic patients vs control subjects (82% vs 38%, p less than 10(-5)) with relative risk 7.7 and...

journal_title：Diabetologia

authors： Odugbesan O,Fletcher J,Mijovic C,Mackay E,Bradwell AR,Barnett AH

更新日期：1987-08-01 00:00:00

abstract：AIMS/HYPOTHESIS:Levels of ideal cardiovascular health (ICH) and incident type 2 diabetes mellitus have not been examined in a multiethnic population. We assessed the total and race/ethnicity-specific incidence of diabetes based on American Heart Association (AHA) ICH components. METHODS:Incident diabetes was assessed ...

journal_title：Diabetologia

authors： Joseph JJ,Echouffo-Tcheugui JB,Carnethon MR,Bertoni AG,Shay CM,Ahmed HM,Blumenthal RS,Cushman M,Golden SH

更新日期：2016-09-01 00:00:00

abstract：AIMS/HYPOTHESIS:Soluble CD163 (sCD163) was recently identified as a strong risk marker for developing type 2 diabetes. We hypothesised that sCD163 independently associates with insulin resistance. METHODS:This cross-sectional study includes 234 participants: 96 with type 2 diabetes, 34 with impaired glucose tolerance ...

journal_title：Diabetologia

authors： Parkner T,Sørensen LP,Nielsen AR,Fischer CP,Bibby BM,Nielsen S,Pedersen BK,Møller HJ

更新日期：2012-06-01 00:00:00

abstract：AIMS/HYPOTHESIS:We aimed to describe the prevalence of retinopathy in an aged cohort of Icelanders with and without diabetes mellitus. METHODS:The study population consisted of 4,994 persons aged ≥ 67 years, who participated in the Age, Gene/Environment Susceptibility-Reykjavik Study (AGES-R). Type 2 diabetes mellitus...

journal_title：Diabetologia

authors： Gunnlaugsdottir E,Halldorsdottir S,Klein R,Eiriksdottir G,Klein BE,Benediktsson R,Harris TB,Launer LJ,Aspelund T,Gudnason V,Cotch MF,Jonasson F

更新日期：2012-03-01 00:00:00

abstract：AIMS/HYPOTHESIS:We have examined the effects of streptozotocin-induced type 1 diabetes on the expression and subcellular distribution of the classic sugar transporters (GLUT-1 to 5 and sodium-dependent glucose transporter-1 [SGLT-1]) in the endothelial cells of an en face preparation of septal coronary artery from Wist...

journal_title：Diabetologia

authors： Gaudreault N,Scriven DR,Moore ED

更新日期：2004-12-01 00:00:00

abstract：:In 1971, 107 newly diagnosed black diabetics admitted to Harare Central Hospital, Rhodesia, were studied. Nine died before discharge. In 1977, 93 of the 98 patients discharged alive were traced but of these 38 (41%) had since died. Of 18 autopsies performed the cause of death was hypoglycaemia in 8 patients and hyperg...

journal_title：Diabetologia

authors： Castle WM,Wicks AC

更新日期：1980-01-01 00:00:00

abstract：:The accumulation of noradrenaline in constricted sciatic nerves was measured in 6 month diabetic rats (streptozotocin 35 mg/kg) and 4 day diabetic rats (streptozotocin 70 mg/kg) together with two groups of age-matched control animals. There was no alteration in the amount of noradrenaline accumulated in the nerves of ...

journal_title：Diabetologia

authors： Tomlinson DR,Gillon KR,Smith MG

更新日期：1982-03-01 00:00:00

abstract：AIMS/HYPOTHESIS:Recruitment of the protein c-Cbl to the insulin receptor (IR) and its tyrosine phosphorylation via a pathway that is independent from phosphatidylinositol 3'-kinase is necessary for insulin-stimulated GLUT4 translocation in 3T3-L1 adipocytes. The activation of this pathway by insulin or exercise has yet...

journal_title：Diabetologia

authors： Wadley GD,Bruce CR,Konstantopoulos N,Macaulay SL,Howlett KF,Hawley JA,Cameron-Smith D

更新日期：2004-03-01 00:00:00

abstract：AIMS/HYPOTHESIS:Enterovirus (e.g. Coxsackie B virus serotypes [CVBs]) infections may be associated with development of type 1 diabetes. Studies conducted in several European countries have, however, shown an inverse correlation between the incidence of type 1 diabetes and the prevalence of enterovirus infections. These...

journal_title：Diabetologia

authors： Larsson PG,Lakshmikanth T,Svedin E,King C,Flodström-Tullberg M

更新日期：2013-04-01 00:00:00

abstract：:This review focuses on two paralogue Rab GTPase activating proteins known as TBC1D1 Tre-2/BUB2/cdc 1 domain family (TBC1D) 1 and TBC1D4 (also called Akt Substrate of 160 kDa, AS160) and their roles in controlling skeletal muscle glucose transport in response to the independent and combined effects of insulin and exerc...

journal_title：Diabetologia

authors： Cartee GD

更新日期：2015-01-01 00:00:00

abstract：:Urinary albumin excretion has been assessed in 585 newly-presenting Type 2 (non-insulin-dependent) diabetic patients (aged 53 (8) years, 67% male) at diagnosis with fasting plasma glucose 10.3 (3.2) mmol/l and over 3 years of dietary treatment. Urinary albumin at diagnosis, geometric mean (1 SD interval) corrected for...

journal_title：Diabetologia

authors：

更新日期：1993-10-01 00:00:00

abstract：:Abnormal vascular endothelium function may contribute to the reduced nerve perfusion implicated in the aetiology of neuropathy in diabetes mellitus. The aim was to test the hypothesis that a powerful vasoconstrictor, endothelin-1, could be involved in nerve dysfunction in streptozotocin-diabetic rats. After 6 weeks of...

journal_title：Diabetologia

authors： Cameron NE,Dines KC,Cotter MA

更新日期：1994-12-01 00:00:00

abstract：:Non-insulin-dependent diabetes mellitus (NIDDM) is commonly associated with hypertriglyceridaemia, low serum HDL-cholesterol concentrations, hypertension, obesity and accelerated atherosclerosis (metabolic syndrome X). Since a similar dyslipidaemia occurs with the acute-phase response, we investigated whether elevated...

journal_title：Diabetologia

authors： Pickup JC,Mattock MB,Chusney GD,Burt D

更新日期：1997-11-01 00:00:00

abstract：AIMS/HYPOTHESIS:Vitamin D, a molecule with antiproliferative, antiangiogenic, antioxidant and immunosuppressive effects, could play a role in the pathogenesis of severe diabetic retinopathy. We examined whether Taq I polymorphism of the vitamin D receptor is involved in the development of severe diabetic retinopathy. ...

journal_title：Diabetologia

authors： Taverna MJ,Sola A,Guyot-Argenton C,Pacher N,Bruzzo F,Slama G,Reach G,Selam JL

更新日期：2002-03-01 00:00:00

abstract：AIMS/HYPOTHESIS:Sulphonylureas stimulate insulin secretion by closing ATP-sensitive potassium (KATP) channels in the pancreatic beta-cell membrane. KATP channels are also found in other tissues, including heart and smooth muscle, where they link cellular metabolism to electrical activity. The sulphonylurea gliclazide b...

journal_title：Diabetologia

authors： Lawrence CL,Proks P,Rodrigo GC,Jones P,Hayabuchi Y,Standen NB,Ashcroft FM

更新日期：2001-08-01 00:00:00

abstract：:The validity of the new diagnostic criteria for diabetes mellitus for Japanese subjects was assessed by the long-term prognosis of 501 patients, found in an epidemiological survey of 6,681 people in a Japanese town. Ten-year relative survival rates were examined in relation to the 50 g oral glucose tolerance test (ser...

journal_title：Diabetologia

authors： Sasaki A

更新日期：1981-03-01 00:00:00

abstract：:Insulin dependent (IDD) and non-insulin dependent diabetes (NIDD) are separate disorders. Twin studies show that IDD cannot be entirely due to genetic causes as concordance is no more than about 50%, but there is some inherited predisposition to it as shown by HLA patterns. NIDD, on the other hand, is predominantly du...

journal_title：Diabetologia

authors： Pyke DA

更新日期：1979-12-01 00:00:00

abstract：:Patients with Type II (non-insulin-dependent) diabetes mellitus manifest abnormalities in insulin action and insulin secretion. It is widely accepted that insulin resistance is an early finding, evident before the onset of hyperglycaemia and predictive of the subsequent development of diabetes. Whether abnormalities i...

journal_title：Diabetologia

authors： Pratley RE,Weyer C

更新日期：2001-08-01 00:00:00

abstract：AIMS/HYPOTHESIS:Berardinelli-Seip congenital lipodystrophy type 2 (BSCL2) is an autosomal recessive disorder characterised by lipodystrophy and insulin resistance. BSCL2 is caused by loss-of-function mutations in the Seipin gene (also known as Bscl2). Deletion of this gene in mice induces insulin resistance, glucose in...

journal_title：Diabetologia

authors： Xiong J,Sun P,Wang Y,Hua X,Song W,Wang Y,Wu J,Yu W,Liu G,Chen L

更新日期：2020-02-01 00:00:00

abstract：:The aim of the present study was to determine whether short-term appropriate insulinization of Type 1 (insulin-dependent) diabetic patients in long-term poor glycaemic control (HbA1C > 9.5%) was associated with an adaptive regulation of the activity and gene expression of key proteins in muscle glycogen storage and gl...

journal_title：Diabetologia

authors： Vestergaard H,Andersen PH,Lund S,Vedel P,Pedersen O

更新日期：1994-01-01 00:00:00