Persistent reduction of pancreatic beta-cell mass after a limited period of protein-energy malnutrition in the young rat.

abstract：AIMS/HYPOTHESIS:Monogenic diabetes (MD) might be misdiagnosed as type 1 diabetes. The prevalence of MD among children with apparent type 1 diabetes has not been established. Our aim was to estimate the prevalence of common forms of MD in childhood diabetes. METHODS:We investigated 2,756 children aged 0-14 years with n...

journal_title：Diabetologia

authors： Irgens HU,Molnes J,Johansson BB,Ringdal M,Skrivarhaug T,Undlien DE,Søvik O,Joner G,Molven A,Njølstad PR

更新日期：2013-07-01 00:00:00

abstract：AIM/HYPOTHESIS:Mitochondria and the endoplasmic reticulum (ER) physically interact by close structural juxtaposition, via the mitochondria-associated ER membrane. Inter-organelle communication between the ER and mitochondria has been shown to regulate energy metabolism and to be central to the modulation of various key...

journal_title：Diabetologia

authors： Wang L,Ishihara T,Ibayashi Y,Tatsushima K,Setoyama D,Hanada Y,Takeichi Y,Sakamoto S,Yokota S,Mihara K,Kang D,Ishihara N,Takayanagi R,Nomura M

更新日期：2015-10-01 00:00:00

abstract：AIMS/HYPOTHESIS:Insulin enhances coronary vasodilation in healthy subjects. We tested whether insulin is able to induce coronary vasodilation in Type I (insulin-dependent) diabetic mellitus patients. Additionally, the effect of short-term hyperglycaemia on myocardial perfusion was studied. METHODS:Myocardial blood flo...

journal_title：Diabetologia

authors： Sundell J,Laine H,Nuutila P,Rönnemaa T,Luotolahti M,Raitakari O,Knuuti J

更新日期：2002-06-01 00:00:00

abstract：:It is increasingly appreciated that the pathogenic mechanisms of type 1 diabetes involve both the autoimmune aggressors and their beta cell targets, which engage in a conflicting dialogue within and possibly outside the pancreas. Indeed, autoimmune CD8+ T cells, which are the final mediators of beta cell destruction, ...

journal_title：Diabetologia

authors： Mallone R,Eizirik DL

更新日期：2020-10-01 00:00:00

abstract：AIMS/HYPOTHESIS:The aim of this study was to examine human enteroviruses (HEVs) and other intestinal viruses derived from children who participated in the Babydiet intervention study and to analyse the findings according to the appearance of islet autoantibodies, dietary intervention, maternal type 1 diabetes and clini...

journal_title：Diabetologia

authors： Simonen-Tikka ML,Pflueger M,Klemola P,Savolainen-Kopra C,Smura T,Hummel S,Kaijalainen S,Nuutila K,Natri O,Roivainen M,Ziegler AG

更新日期：2011-12-01 00:00:00

abstract：AIMS/HYPOTHESIS:It is difficult to use HbA(1c) as an indicator of glycaemic control in patients with neonatal diabetes mellitus (NDM) because of high levels of fetal haemoglobin (HbF) remaining in the blood. In this study, glycated albumin (GA), which is not affected by HbF, and HbA(1c) were compared to evaluate whethe...

journal_title：Diabetologia

authors： Suzuki S,Koga M,Amamiya S,Nakao A,Wada K,Okuhara K,Hayano S,Sarhat AR,Takahashi H,Matsuo K,Tanahashi Y,Fujieda K

更新日期：2011-09-01 00:00:00

abstract：AIMS/HYPOTHESIS:The aim of this study was to assess whether the diabetogenicity of areca nut (Areca catechu or 'betel-nut'), which has previously been demonstrated experimentally in mice, independently contributes to the risk of hyperglycaemia or type 2 diabetes in men in Taiwan, where the habit has become established ...

journal_title：Diabetologia

authors： Tung TH,Chiu YH,Chen LS,Wu HM,Boucher BJ,Chen TH,Keelung Community-based Integrated Screening programme No. 2.

更新日期：2004-10-01 00:00:00

abstract：AIMS/HYPOTHESIS:The paucity of information on the epigenetic barriers that are blocking reprogramming protocols, and on what makes a beta cell unique, has hampered efforts to develop novel beta cell sources. Here, we aimed to identify enhancers in pancreatic islets, to understand their developmental ontologies, and to ...

journal_title：Diabetologia

authors： Tennant BR,Robertson AG,Kramer M,Li L,Zhang X,Beach M,Thiessen N,Chiu R,Mungall K,Whiting CJ,Sabatini PV,Kim A,Gottardo R,Marra MA,Lynn FC,Jones SJ,Hoodless PA,Hoffman BG

更新日期：2013-03-01 00:00:00

abstract：:In vitro and in vivo studies have suggested that metabolic deterioration can be induced by hyperglycaemia per se. The effect of 53 h of 2.2 mg glucose.kg ideal body weight-1.min-1 was examined in four normal male subjects. This produced overnight hyperglycaemia of 6.0 mmol/l on the two nights of the study compared wit...

journal_title：Diabetologia

authors： Flax H,Matthews DR,Levy JC,Coppack SW,Turner RC

更新日期：1991-08-01 00:00:00

abstract：:Patients with Type II (non-insulin-dependent) diabetes mellitus manifest abnormalities in insulin action and insulin secretion. It is widely accepted that insulin resistance is an early finding, evident before the onset of hyperglycaemia and predictive of the subsequent development of diabetes. Whether abnormalities i...

journal_title：Diabetologia

authors： Pratley RE,Weyer C

更新日期：2001-08-01 00:00:00

abstract：AIMS/HYPOTHESIS:Insulin resistance is recognised as the core factor in the pathogenesis of Type II (non-insulin-dependent) diabetes mellitus, hypertension and atherosclerosis. Several studies indicate the possible role of mutations of the insulin receptor substrate-1 (IRS-1) gene in the pathogenesis of insulin-resistan...

journal_title：Diabetologia

authors： Baroni MG,Arca M,Sentinelli F,Buzzetti R,Capici F,Lovari S,Vitale M,Romeo S,Di Mario U

更新日期：2001-03-01 00:00:00

abstract：AIMS/HYPOTHESIS:The study aimed to assess the incidence, age of onset, survival and relative hazard of dementia in well-categorised community-based patients with type 2 diabetes compared with a matched cohort of individuals without diabetes. METHODS:A longitudinal observational study was undertaken involving 1291 part...

journal_title：Diabetologia

authors： Davis WA,Zilkens RR,Starkstein SE,Davis TM,Bruce DG

更新日期：2017-01-01 00:00:00

abstract：AIMS/HYPOTHESIS:Type 2 diabetes is an established risk factor for cardiovascular disease (CVD). This increased risk may be due in part to the increased levels of inflammatory factors associated with diabetes. Lipoprotein-associated phospholipase A(2) (Lp-PLA(2)) is a risk marker for CVD and has pro-inflammatory effects...

journal_title：Diabetologia

authors： Nelson TL,Kamineni A,Psaty B,Cushman M,Jenny NS,Hokanson J,Furberg C,Mukamal KJ

更新日期：2011-02-01 00:00:00

abstract：:Three members of the angiopoietin-like (ANGPTL) family of proteins, ANGPTL3, ANGPTL4 and ANGPTL8, are known regulators of plasma triacylglycerol levels. Recently, these three proteins have garnered considerable interest as potential targets for therapeutically reducing plasma triacylglycerol levels and improving cardi...

journal_title：Diabetologia

authors： Davies BSJ

更新日期：2018-06-01 00:00:00

abstract：AIMS/HYPOTHESIS:We aimed to examine risk factors for, and differences in, renal failure in diabetic patients from 10 centres. METHODS:Risk factors for renal failure were examined in 3,558 diabetic patients who did not have renal disease at baseline in the WHO Multinational Study of Vascular Disease in Diabetes (WHO MS...

journal_title：Diabetologia

authors： Colhoun HM,Lee ET,Bennett PH,Lu M,Keen H,Wang SL,Stevens LK,Fuller JH

更新日期：2001-09-01 00:00:00

abstract：AIM/HYPOTHESIS:A strong association between susceptibility to type 2 diabetes and common variants of transcription factor 7-like 2 (TCF7L2), encoding an enteroendocrine transcription factor involved in glucose homeostasis, has been reported in three different populations (Iceland, Denmark and USA) by Grant et al. We ai...

journal_title：Diabetologia

authors： van Vliet-Ostaptchouk JV,Shiri-Sverdlov R,Zhernakova A,Strengman E,van Haeften TW,Hofker MH,Wijmenga C

更新日期：2007-01-01 00:00:00

abstract：AIMS/HYPOTHESIS:We examined whether diabetic background retinopathy is associated with reduced coronary vasoreactivity in people with Type 1 diabetes. METHODS:A total of 21 men with Type 1 diabetes were investigated, including 9 men with background retinopathy and 12 men without retinopathy. In addition, 12 non-diabet...

journal_title：Diabetologia

authors： Sundell J,Janatuinen T,Rönnemaa T,Raitakari OT,Toikka J,Nuutila P,Knuuti J

更新日期：2004-04-01 00:00:00

abstract：AIMS/HYPOTHESIS:Post-translational modifications, such as isomerisation of native proteins, may create new antigenic epitopes and play a role in the development of the autoimmune response. Protein-L-isoaspartate (D-aspartate) O-methyltransferase (PIMT), encoded by the gene PCMT1, is an enzyme that recognises and repair...

journal_title：Diabetologia

authors： Wägner AM,Cloos P,Bergholdt R,Boissy P,Andersen TL,Henriksen DB,Christiansen C,Christgau S,Pociot F,Nerup J

更新日期：2007-03-01 00:00:00

abstract：:Nicotinamide, the amide derivative of nicotinic acid, has over the past forty years been given at high doses for a variety of therapeutic applications. It is currently in trial as a potential means of preventing the onset of Type I (insulin-dependent) diabetes mellitus in high-risk, first-degree relatives. Nicotinamid...

journal_title：Diabetologia

authors： Knip M,Douek IF,Moore WP,Gillmor HA,McLean AE,Bingley PJ,Gale EA,European Nicotinamide Diabetes Intervention Trial Group.

更新日期：2000-11-01 00:00:00

abstract：:The present study examined the acute effects of co-ingestion of fat (37.5 g) on the post-prandial metabolic responses to 75 g of carbohydrate which was either slowly absorbed (lentils) or rapidly absorbed (potatoes). Co-ingestion of fat resulted in a significant flattening of the post-prandial glucose curves, the effe...

journal_title：Diabetologia

authors： Collier G,McLean A,O'Dea K

更新日期：1984-01-01 00:00:00

abstract：AIMS/HYPOTHESIS:Glucose and the peptide growth factors insulin, IGF-I and IGF-II strongly regulate beta cell mass. Furthermore, beta cell expression of IGF-I receptor (Igf1r) and insulin receptor (Insr) is mandatory for several steps of insulin secretion. MATERIALS AND METHODS:We hypothesised that glucose concentratio...

journal_title：Diabetologia

authors： Raile K,Klammt J,Laue S,Garten A,Blüher M,Kralisch S,Klöting N,Kiess W

更新日期：2005-09-01 00:00:00

abstract：:We studied the effect of chronic exposure to high glucose on the glucose transport regulation in hamster pancreatic Beta cells in permanent culture (HIT). Cells were exposed to either 5.5 mmol/l or 16.7 mmol/l glucose for 48 h and then glucose transport was studied by measuring the (3H)-2-deoxyglucose uptake for 5 and...

journal_title：Diabetologia

authors： Purrello F,Buscema M,Vetri M,Vinci C,Gatta C,Forte F,Rabuazzo AM,Vigneri R

更新日期：1991-05-01 00:00:00

abstract：AIMS/HYPOTHESIS:We evaluated and compared the effects on glycaemic control of two different exercise protocols in elderly men with type 2 diabetes mellitus. METHODS:Eighteen patients with type 2 diabetes mellitus carried out home-based bicycle training for 5 weeks. Patients were randomly assigned to one of two trainin...

journal_title：Diabetologia

authors： Eriksen L,Dahl-Petersen I,Haugaard SB,Dela F

更新日期：2007-11-01 00:00:00

abstract：:Demographic and biological data were collected from all Caucasian Type 1 diabetic patients (n = 279) who were recruited at clinical onset by the Belgian Diabetes Registry over 34 months. The male/female ratio was significantly higher for onset between age 20 and 40 years (2.4) than before age 20 years (1.0); no age-or...

journal_title：Diabetologia

authors： Vandewalle CL,Decraene T,Schuit FC,De Leeuw IH,Pipeleers DG,Gorus FK

更新日期：1993-11-01 00:00:00

abstract：:Glutathione-insulin transhydrogenase catalyzed the inactivation of insulin by splitting the hormone into A and B chains. We have localized this enzyme immunocytochemically by light microscopy in the pancreas, kidney and liver of both lean and obese (ob/ob) mice and similarly in normal and streptozotocin-diabetic rats....

journal_title：Diabetologia

authors： Taylor CA,Varandani PT

更新日期：1981-11-01 00:00:00

abstract：AIMS/HYPOTHESIS:Recent genome-wide association studies have suggested that a polymorphism in GCKR, the gene encoding the glucokinase regulatory protein, is involved in triacylglycerol regulation. Our aim was to examine in large-scale studies the common GCKR rs780094 polymorphism in relation to metabolic traits (mainly ...

journal_title：Diabetologia

authors： Sparsø T,Andersen G,Nielsen T,Burgdorf KS,Gjesing AP,Nielsen AL,Albrechtsen A,Rasmussen SS,Jørgensen T,Borch-Johnsen K,Sandbaek A,Lauritzen T,Madsbad S,Hansen T,Pedersen O

更新日期：2008-01-01 00:00:00

abstract：:Glycogen phosphorylase regulates the breakdown of glycogen into glucose, but as previous studies have demonstrated, the control of glycogen metabolism becomes deregulated in diabetes mellitus. Messenger RNA levels encoding several different proteins are altered in skeletal muscle biopsies of patients with insulin-depe...

journal_title：Diabetologia

authors： Reynet C,Kahn CR,Loeken MR

更新日期：1996-02-01 00:00:00

abstract：AIMS/HYPOTHESIS:Glutamic acid decarboxylase autoantibodies (GADA) are the most frequent beta-cell-specific autoantibodies in type 1 diabetes and in latent autoimmune diabetes in adults (LADA). The autoimmune attack on pancreatic islet cells is associated with a T helper 1 cell (T(h)1) response, mainly represented by Ig...

journal_title：Diabetologia

authors： Hillman M,Törn C,Thorgeirsson H,Landin-Olsson M

更新日期：2004-11-01 00:00:00

abstract：:The presence of HLA-DR 3 was analysed in 745 patients with Type 1 (insulin-dependent) diabetes with age at diagnosis between 1-19 years. HLA-DR 3 and/or 4 was found in 678/745 (91%) of the patients. Presence of DR2 with neither DR 3 nor 4 was demonstrated in 15 patients. Patients with HLA-DR 3 without DR 4 presented w...

journal_title：Diabetologia

authors： Ludvigsson J,Samuelsson U,Beauforts C,Deschamps I,Dorchy H,Drash A,Francois R,Herz G,New M,Schober E

更新日期：1986-04-01 00:00:00

abstract：AIMS/HYPOTHESIS:Studies have identified an association between diabetes and breast cancer in postmenopausal women in Western countries. Such an association needs to be confirmed in an Asian population. The aim of this study was to evaluate the secular trend for breast cancer mortality in Taiwanese women in the general ...

journal_title：Diabetologia

authors： Tseng CH,Chong CK,Tai TY

更新日期：2009-02-01 00:00:00