当前位置： SCI文献检索 > DIABETOLOGIA期刊下所有文献 > Glycosylated haemoglobin and steady-state mean blood glucose concentration in Type 1 (insulin-dependent) diabetes.

Glycosylated haemoglobin and steady-state mean blood glucose concentration in Type 1 (insulin-dependent) diabetes.

Abstract：

:Since glucose control and glycosylated haemoglobin varies asyncroneously, we have studied the steady-state relationship between these two factors. In Type 1 (insulin-dependent) diabetic patients with a constant haemoglobin A1c during the preceding 2 years, 15 ambulatory blood glucose profiles during a 5-week period showed a constant glucose level and provided a precise estimate of the mean blood glucose concentration. In addition, we studied 15 non-diabetic subjects who provided three glucose profiles and had one haemoglobin A1c determination performed. A good correlation was found for a curvilinear relationship (haemoglobin A1c = 2.07 X mean blood glucose0.596, r = 0.98). This close relationship indicates that glycosylated haemoglobin is a valuable, but not very sensitive, index of glucose control.

journal_name

Diabetologia

journal_title

Diabetologia

authors

Svendsen PA,Lauritzen T,Søegaard U,Nerup J

doi

10.1007/BF00260951

subject

Has Abstract

pub_date

1982-11-01 00:00:00

pages

403-5

issue

5

eissn

0012-186X

issn

1432-0428

journal_volume

23

pub_type

杂志文章

相关文献

DIABETOLOGIA文献大全
  • Markers of renal tubular dysfunction measured annually do not predict risk of microalbuminuria in the first few years after diagnosis of Type I diabetes.

    abstract：AIMS/HYPOTHESIS:Early detection of risk of microalbuminuria could prevent early renal damage. We investigated whether urine retinol binding protein and N-acetyl-glucosaminidase could predict the risk of microalbuminuria in a large cohort of children followed from diagnosis of Type I (insulin-dependent) diabetes mellitu...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/s001250051603

    authors： Schultz CJ,Dalton RN,Neil HA,Konopelska-Bahu T,Dunger DB,Oxford Regional Prospective Study Group.

    更新日期：2001-02-01 00:00:00

  • Cardiovascular and alcohol-related deaths in abnormal glucose tolerant and diabetic subjects.

    abstract：:The aim of this study was to compare the causes of death and parameters related to alcohol consumption, between subjects diagnosed as diabetic, clinically by their general practitioner, or glucose intolerant and in particular as diabetic, using the epidemiological criteria of an abnormal glucose level following an ora...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/BF00400850

    authors： Balkau B,Eschwège E,Fontbonne A,Claude JR,Warnet JM

    更新日期：1992-01-01 00:00:00

  • The role of the p75 neurotrophin receptor in the morphology of dorsal root ganglion cells in streptozotocin diabetic mice: effects of sciatic nerve crush.

    abstract：AIMS/HYPOTHESIS:Neuronal dorsal root ganglion (DRG) cells seem to be vulnerable in diabetes. The aim of this study was to determine whether the p75 neurotrophin receptor stimulates perikaryal shrinkage and neuronal death, and further accelerates neuronal DRG cell loss after axotomy in a mouse model of diabetes. METHOD...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/s00125-004-1504-6

    authors： Jiang Y,Jakobsen J

    更新日期：2004-09-01 00:00:00

  • HGF/NK4 inhibited VEGF-induced angiogenesis in in vitro cultured endothelial cells and in vivo rabbit model.

    abstract：AIMS/HYPOTHESIS:As vascular endothelial growth factor (VEGF) plays a pivotal role in the development of diabetic retinopathy, inhibition of angiogenesis induced by VEGF is crucial to treat diabetic retinopathy. HGF (hepatocyte growth factor)/NK4, containing the N-terminal hairpin domain and the four subsequent kringle ...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/s00125-002-0954-y

    authors： Nakabayashi M,Morishita R,Nakagami H,Kuba K,Matsumoto K,Nakamura T,Tano Y,Kaneda Y

    更新日期：2003-01-01 00:00:00

  • Orosomucoid in urine predicts cardiovascular and over-all mortality in patients with Type II diabetes.

    abstract：AIMS/HYPOTHESIS:Urinary orosomucoid excretion rate is increased in a substantial proportion of patients with Type II (non-insulin-dependent) diabetes mellitus and normal urinary albumin excretion rate. The aim of this study was to determine whether increased urinary orosomucoid excretion rate is predictive of increased...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/s125-002-8251-3

    authors： Christiansen MS,Hommel E,Magid E,Feldt-Rasmussen B

    更新日期：2002-01-01 00:00:00

  • Epidemiology and genetic determinants of progressive deterioration of glycaemia in American Indians: the Strong Heart Family Study.

    abstract：AIMS/HYPOTHESIS:Type 2 diabetes is a chronic, heterogeneous disease and a major risk factor for cardiovascular diseases. The underlying mechanisms leading to progression to type 2 diabetes are not fully understood and genetic tools may help to identify important pathways of glycaemic deterioration. METHODS:Using prosp...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/s00125-013-2988-8

    authors： Franceschini N,Haack K,Göring HH,Voruganti VS,Laston S,Almasy L,Lee ET,Best LG,Fabsitz RR,North KE,Maccluer JW,Meigs JB,Pankow JS,Cole SA

    更新日期：2013-10-01 00:00:00

  • Pre-diabetes in the spontaneously diabetic BB/E rat: lymphocyte subpopulations in the pancreatic infiltrate and expression of rat MHC class II molecules in endocrine cells.

    abstract：:Use of monoclonal antibodies specific for rat lymphocyte subsets and an anti-insulin marker has allowed us to document the following sequence of events leading to the development of clinical diabetes in this animal model. The first change observed in the pancreas is increased expression of MHC class II molecules on va...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/BF00280892

    authors： Dean BM,Walker R,Bone AJ,Baird JD,Cooke A

    更新日期：1985-07-01 00:00:00

  • Silencing Jnk1 and Jnk2 accelerates basal lipolysis and promotes fatty acid re-esterification in mouse adipocytes.

    abstract：AIMS/HYPOTHESIS:Elevated plasma levels of NEFA impair insulin action. Given the positive linear correlation between NEFA released by adipocytes and plasma NEFA levels, identification of mechanisms controlling adipocyte lipolysis and NEFA release could provide a guide to new therapies for insulin resistance and type 2 d...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/s00125-008-1036-6

    authors： Rozo AV,Vijayvargia R,Weiss HR,Ruan H

    更新日期：2008-08-01 00:00:00

  • C-reactive protein and the development of the metabolic syndrome and diabetes in middle-aged men.

    abstract：AIMS/HYPOTHESIS:Low-grade inflammation has been implicated in the development of Type 2 diabetes and cardiovascular disease, but its role in the pathogenesis of the metabolic syndrome is unclear. We investigated the association between C-reactive protein (CRP) levels and the development of the metabolic syndrome and di...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/s00125-004-1472-x

    authors： Laaksonen DE,Niskanen L,Nyyssönen K,Punnonen K,Tuomainen TP,Valkonen VP,Salonen R,Salonen JT

    更新日期：2004-08-01 00:00:00

  • Collagen I induction by high glucose levels is mediated by epidermal growth factor receptor and phosphoinositide 3-kinase/Akt signalling in mesangial cells.

    abstract：AIMS/HYPOTHESIS:Glomerular matrix accumulation is a hallmark of diabetic nephropathy. Recent data have linked the serine/threonine kinase protein kinase B (Akt) to matrix modulation. Here, we studied its role in high glucose-induced collagen elaboration by mesangial cells. METHODS:Primary rat mesangial cells were trea...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/s00125-007-0721-1

    authors： Wu D,Peng F,Zhang B,Ingram AJ,Gao B,Krepinsky JC

    更新日期：2007-09-01 00:00:00

  • In the lipodystrophy associated with highly active antiretroviral therapy, pseudo-Cushing's syndrome is associated with increased regeneration of cortisol by 11beta-hydroxysteroid dehydrogenase type 1 in adipose tissue.

    abstract：AIMS/HYPOTHESIS:Highly active antiretroviral therapy (HAART) in patients infected with human immunodeficiency virus (HIV) is associated with a poorly understood lipodystrophic and hypertriglyceridaemic syndrome, which resembles Cushing's syndrome, but in which plasma cortisol is not elevated. We tested the hypothesis t...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/s00125-004-1508-2

    authors： Sutinen J,Kannisto K,Korsheninnikova E,Nyman T,Ehrenborg E,Andrew R,Wake DJ,Hamsten A,Walker BR,Yki-Järvinen H

    更新日期：2004-10-01 00:00:00

  • Diabetic background retinopathy is associated with impaired coronary vasoreactivity in people with Type 1 diabetes.

    abstract：AIMS/HYPOTHESIS:We examined whether diabetic background retinopathy is associated with reduced coronary vasoreactivity in people with Type 1 diabetes. METHODS:A total of 21 men with Type 1 diabetes were investigated, including 9 men with background retinopathy and 12 men without retinopathy. In addition, 12 non-diabet...

    journal_title：Diabetologia

    pub_type： 临床试验,杂志文章

    doi：10.1007/s00125-004-1340-8

    authors： Sundell J,Janatuinen T,Rönnemaa T,Raitakari OT,Toikka J,Nuutila P,Knuuti J

    更新日期：2004-04-01 00:00:00

  • Characterisation of insulin-like growth factor I receptor in skeletal muscles of normal and insulin resistant subjects.

    abstract：:The insulin-like growth factor I receptor and the activity of its associated tyrosine kinase activity were characterised in wheat germ agglutinin extracts from skeletal muscle biopsies from nine control and ten obese Type 2 (non-insulin-dependent) diabetic subjects, who had marked peripheral in vivo insulin resistance...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/BF00265369

    authors： Livingston N,Pollare T,Lithell H,Arner P

    更新日期：1988-12-01 00:00:00

  • Glycosylation of glomerular basement membrane in Type 1 (insulin-dependent) diabetic children.

    abstract：:Immunoelectrophoresis of glomerular basement membrane antigens in the urine of 20 Type 1 (insulin-dependent) diabetic and 10 healthy children was performed. In 10 of the diabetic children, there was altered alpha-1-mobility, while the other diabetic and normal children showed alpha-2-mobility. After incubation with gl...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/BF00254295

    authors： Schober E,Pollak A,Coradello H,Lubec G

    更新日期：1982-12-01 00:00:00

  • Reduced size at birth and persisting reductions in adiposity in recent, compared with earlier, cohorts of infants born to mothers with gestational diabetes mellitus.

    abstract：AIMS/HYPOTHESIS:This study aimed to explore the infancy growth trajectories of 'recent' and 'earlier' offspring of mothers with gestational diabetes mellitus (OGDM), each compared with the same control infants, and investigate whether 'recent' OGDM still exhibit a classical phenotype, with macrosomia and increased adip...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/s00125-019-4970-6

    authors： Prentice PM,Olga L,Petry CJ,Simmons D,Murphy HR,Hughes IA,Acerini CL,Ong KK,Dunger DB

    更新日期：2019-11-01 00:00:00

  • Pancreatic biopsies in type 1 diabetes: revisiting the myth of Pandora's box.

    abstract：:Over a century ago, inquisitive physicians made remarkable discoveries regarding pancreatic pathology in individuals with diabetes, including those who were likely afflicted with the type 1 (autoimmune) form of the disease. Those studies of post-mortem tissues noted unique anatomical changes in islet architecture as w...

    journal_title：Diabetologia

    pub_type： 评论,杂志文章

    doi：10.1007/s00125-013-3159-7

    authors： Atkinson MA

    更新日期：2014-04-01 00:00:00

  • Fatty liver and obesity: phenotypically correlated but genetically distinct traits in a mouse model of type 2 diabetes.

    abstract：AIMS/HYPOTHESIS:Obesity and fatty liver are commonly associated with type 2 diabetes, but the genetic and functional bases linking fatty liver with obesity and diabetes are largely unknown. Our aim was to investigate the association of fatty liver with obesity and other diabetes-related phenotypes and to define the gen...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/s00125-007-0700-6

    authors： Itoi-Babaya M,Ikegami H,Fujisawa T,Ueda H,Nojima K,Babaya N,Kobayashi M,Noso S,Kawaguchi Y,Yamaji K,Shibata M,Ogihara T

    更新日期：2007-08-01 00:00:00

  • Macrosomia despite good glycaemic control in Type I diabetic pregnancy; results of a nationwide study in The Netherlands.

    abstract：AIMS/HYPOTHESIS:To investigate the incidence of foetal macrosomia (i.e. birth weight >90th percentile) in a non-selected nationwide cohort of women with Type I (insulin-dependent) diabetes mellitus in The Netherlands and to identify risk indicators predictive for macrosomia. METHODS:We conducted a prospective nationwi...

    journal_title：Diabetologia

    pub_type： 杂志文章,多中心研究

    doi：10.1007/s00125-002-0958-7

    authors： Evers IM,de Valk HW,Mol BW,ter Braak EW,Visser GH

    更新日期：2002-11-01 00:00:00

  • Down regulation of peroxisome proliferator-activated receptorgamma expression by inflammatory cytokines and its reversal by thiazolidinediones.

    abstract：AIMS/HYPOTHESIS:Previous studies show that inflammatory cytokines play a part in the development of insulin resistance. Thiazolidinediones were developed as insulin-sensitizing drugs and are ligands for the peroxisome proliferator-activated receptory (PPARgamma). We hypothesized that the anti-diabetic mechanism of thia...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/s001250051218

    authors： Tanaka T,Itoh H,Doi K,Fukunaga Y,Hosoda K,Shintani M,Yamashita J,Chun TH,Inoue M,Masatsugu K,Sawada N,Saito T,Inoue G,Nishimura H,Yoshimasa Y,Nakao K

    更新日期：1999-06-01 00:00:00

  • Elevated plasma insulin-like growth factor binding protein-1 levels in type 1 (insulin-dependent) diabetic patients with peripheral neuropathy.

    abstract：:Previous studies have suggested that nerve regeneration may be defective in patients with diabetic polyneuropathy. Since insulin-like growth factor I (IGF-I) has been shown to stimulate nerve regeneration, and IGF binding protein-1 is acutely regulated by plasma insulin we have investigated the relationships between p...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/BF00399934

    authors： Crosby SR,Tsigos C,Anderton CD,Gordon C,Young RJ,White A

    更新日期：1992-09-01 00:00:00

  • Altered amyloid precursor protein processing regulates glucose uptake and oxidation in cultured rodent myotubes.

    abstract：AIMS/HYPOTHESIS:Impaired glucose uptake in skeletal muscle is an important contributor to glucose intolerance in type 2 diabetes. The aspartate protease, beta-site APP-cleaving enzyme 1 (BACE1), a critical regulator of amyloid precursor protein (APP) processing, modulates in vivo glucose disposal and insulin sensitivit...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/s00125-014-3269-x

    authors： Hamilton DL,Findlay JA,Montagut G,Meakin PJ,Bestow D,Jalicy SM,Ashford ML

    更新日期：2014-08-01 00:00:00

  • Effects of L-leucine on the insulin production, oxidative metabolism and mitochondrial ultrastructure of isolated mouse pancreatic islets in tissue culture.

    abstract：:This study was performed to evaluate whether L-leucine is able to relieve the structural and functional alterations previously described in pancreatic islets exposed in vitro for a prolonged time to a subnormal glucose concentration (3.3 mM). It was found that both the impairment of secretion and the decreased rate of...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/BF00996329

    authors： Andersson A,Höiriis-Nielsen J,Borg LA

    更新日期：1977-01-01 00:00:00

  • Differential regulation of glomerular gelatinase B (MMP-9) and tissue inhibitor of metalloproteinase-1 (TIMP-1) in obese Zucker rats.

    abstract：:The obese Zucker rat represents a model of obesity combined with insulin resistance and hyperlipidaemia, which over a period of several months develops spontaneous glomerulosclerosis. The present study addressed the question as to whether glomerular sclerosis was associated with alterations in the degradation of matri...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/s001250050785

    authors： Schaefer L,Han X,August C,Matzkies F,Lorenz T,Schaefer RM

    更新日期：1997-09-01 00:00:00

  • Critical role of c-Kit in beta cell function: increased insulin secretion and protection against diabetes in a mouse model.

    abstract：AIMS/HYPOTHESIS:The receptor tyrosine kinase, c-Kit, and its ligand, stem cell factor, control a variety of cellular processes, including pancreatic beta cell survival and differentiation as revealed in c-Kit ( Wv ) mice, which have a p...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/s00125-012-2566-5

    authors： Feng ZC,Li J,Turco BA,Riopel M,Yee SP,Wang R

    更新日期：2012-08-01 00:00:00

  • Early deficits in insulin secretion, beta cell mass and islet blood perfusion precede onset of autoimmune type 1 diabetes in BioBreeding rats.

    abstract：AIMS/HYPOTHESIS:Genetic studies show coupling of genes affecting beta cell function to type 1 diabetes, but hitherto no studies on whether beta cell dysfunction could precede insulitis and clinical onset of type 1 diabetes are available. METHODS:We used 40-day-old BioBreeding (BB) DRLyp/Lyp rats (a model of spontaneou...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/s00125-017-4512-z

    authors： Medina A,Parween S,Ullsten S,Vishnu N,Siu YT,Quach M,Bennet H,Balhuizen A,Åkesson L,Wierup N,Carlsson PO,Ahlgren U,Lernmark Å,Fex M

    更新日期：2018-04-01 00:00:00

  • Increased expression of cyclooxygenase-2 in human pancreatic islets treated with high glucose or ligands of the advanced glycation endproduct-specific receptor (AGER), and in islets from diabetic mice.

    abstract：AIMS/HYPOTHESIS:The cyclooxygenase-2 (PTGS2, previously known as COX2) enzyme and its products, such as prostaglandin E(2) (PGE(2)), have been implicated in the pathogenesis of several inflammatory diseases including islet dysfunction under diabetic conditions. In this study we evaluated whether diabetic conditions in ...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/s00125-005-0065-7

    authors： Shanmugam N,Todorov IT,Nair I,Omori K,Reddy MA,Natarajan R

    更新日期：2006-01-01 00:00:00

  • Obesity and insulin secretion in fasting high school students.

    abstract：:The relationship between plasma glucose, serum insulin, serum C-peptide and obesity was studied in 320 fasting high school students (13-18 years old), as part of a Busselton population study. For males and females respectively plasma glucose was 4.5 +/- 0.4 and 4.4 +/- 0.5 mmol/l (mean +/- SD), serum insulin 0.51 +/- ...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/BF00275268

    authors： Garcia-Webb P,Bonser A,Wearne KL,Gracey M

    更新日期：1980-09-01 00:00:00

  • Dynorphin A, kappa opioid receptors and the antinociceptive efficacy of asimadoline in streptozotocin-induced diabetic rats.

    abstract：AIMS/HYPOTHESIS:We investigated spinal and peripheral kappa opioid systems in diabetic rats. MATERIALS AND METHODS:Dynorphin A, N-methyl-D-aspartate (NMDA) and kappa opioid receptor (KOR) were measured in spinal cord, dorsal root ganglia, peripheral nerves and foot skin of control and streptozotocin-induced diabetic r...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/s00125-006-0397-y

    authors： Jolivalt CG,Jiang Y,Freshwater JD,Bartoszyk GD,Calcutt NA

    更新日期：2006-11-01 00:00:00

  • Visceral fat and beta cell function in non-diabetic humans.

    abstract：AIMS/HYPOTHESIS:Preferential visceral adipose tissue (VAT) accumulation has been clearly associated with insulin resistance. In contrast, the impact of visceral obesity on beta cell function is controversial. METHODS:In 62 non-diabetic women and men (age 24-69 years, BMI 21-39 kg/m2), we measured VAT and subcutaneous ...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/s00125-005-1891-3

    authors： Gastaldelli A,Sironi AM,Ciociaro D,Positano V,Buzzigoli E,Giannessi D,Lombardi M,Mari A,Ferrannini E

    更新日期：2005-10-01 00:00:00

  • The SstI polymorphism of the apo C-III gene is associated with insulin sensitivity in young men.

    abstract：AIMS/HYPOTHESIS:Insulin resistance is considered to be a risk factor for diabetes and coronary heart disease and is determined by the interaction between genetic and environmental factors. The SstI polymorphism in the apolipoprotein C-III gene has been related to the presence of different features of the insulin resist...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/s00125-002-0884-8

    authors： Pérez-Jiménez F,López-Miranda J,Gómez P,Velasco MJ,Marín C,Pérez-Martínez P,Moreno JA,Paniagua JA

    更新日期：2002-08-01 00:00:00