Abstract:
:To learn more about the preclinical phase of IDDM we observed for a median period of 46.5 months (range 0.5-69 months) a group of 57 siblings positive for ICA and/or IAA when first screened within 6 months of the diagnosis of the proband. Sequential blood samples and IVGTTs were obtained at intervals of 6-12 months. Seventeen siblings (29.8%) presented with IDDM during the observation period. The duration of the known preclinical period ranged from 0.5 to 51 months (median 29 months). The converters were younger than the other siblings (P < 0.05) and had higher initial ICA levels (P < 0.01). In addition they had a lower FPIR in the first IVGTT (P < 0.001). On all subsequent tests the converters had higher ICA levels and a lower FPIR (P < 0.05 or less), a lower glucose elimination rate from the third test onwards (P < 0.01 or less) and higher IAA levels at 3 years (P < 0.05). Some variation could be observed in the FPIR in the converters with an initial increase and subsequent decrease (P < 0.05 for both). Their levels of complement-fixing ICA increased up to 18 months (P < 0.05) and IAA levels up to 3 years (P < 0.01). Those high risk siblings who progress to clinical IDDM are characterized by young age, strong and increasing signs of islet-cell specific autoimmunity, reduced insulin secreting capacity and emerging glucose intolerance. The present observations seem to be incompatible with the hypothesis of beta-cell destruction occurring at a constant, predictable rate.
journal_name
Diabetologiajournal_title
Diabetologiaauthors
Knip M,Vähäsalo P,Karjalainen J,Lounamaa R,Akerblom HKdoi
10.1007/s001250050122subject
Has Abstractpub_date
1994-04-01 00:00:00pages
388-93issue
4eissn
0012-186Xissn
1432-0428journal_volume
37pub_type
杂志文章相关文献
DIABETOLOGIA文献大全abstract::The binding of 125I-labelled insulin to human adipocytes was studied at 37 degrees C. The precipitability of the 125I-labelled insulin preparation (0.03 nmol/l) in trichloroacetic acid and the concentration of biologically active insulin (7.5 nmol/l) remained constant in buffer incubated with human adipocytes (100 mic...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF01236312
更新日期:1977-12-01 00:00:00
abstract::Cases of malnutrition-related diabetes mellitus conforming to the description of the protein deficient pancreatic diabetes type in Ethiopian patients were compared with Type 1 (insulin-dependent) and Type 2 (non-insulin-dependent) diabetic. Fourteen of 39 malnutrition-related diabetes mellitus patients had fat malabso...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF00404800
更新日期:1990-04-01 00:00:00
abstract:AIMS/HYPOTHESIS:Diabetes increases the risk of premature death and reduces work productivity. We estimated the impact of diabetes in China in terms of mortality, years of life lost, and productivity-adjusted life years (PALYs) lost in the Chinese population. METHODS:Life table modelling was used with simulated follow-...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-019-4875-4
更新日期:2019-07-01 00:00:00
abstract::The art of obstetrics is not a subject which is often discussed in the pages of Diabetologia. However, as the care of the diabetic mother and her offspring is rightly an interdisciplinary responsibility between obstetrician, diabetologist and neonatologist, it is important that each has a close understanding of the va...
journal_title:Diabetologia
pub_type: 杂志文章,评审
doi:10.1007/BF02427272
更新日期:1986-01-01 00:00:00
abstract::The plasma concentration of 1,5-anhydro-D-glucitol(AG)(1-deoxyglucose) is known to decrease in diabetic patients. In order to evaluate the usefulness of this polyol as a diabetic marker, we examined the specificity of the plasma AG reduction in various diseases: the plasma AG level was determined in 108 newly diagnose...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF00279131
更新日期:1988-01-01 00:00:00
abstract::A prominent feature of Type 2 (non-insulin-dependent) diabetes mellitus is the inability of insulin to appropriately increase the transport of glucose into target tissue. In adipocytes from individuals with Type 2 diabetes, insulin resistance has been shown to be associated with a depletion of glucose transporters. Si...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF00400207
更新日期:1990-10-01 00:00:00
abstract::The effect of early antihypertensive treatment on survival of patients with diabetic nephropathy was evaluated by studying two cohorts of Type 1 (insulin-dependent) diabetic patients developing persistent proteinuria in I: 1957-1973 (late treatment group n = 49) and II: 1979-1983 (early treatment group n = 71). At ons...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF00297455
更新日期:1989-12-01 00:00:00
abstract:AIMS/HYPOTHESIS:Glucagon-like peptide-2 (GLP-2) is a gut hormone regulating intestinal growth and nutrient absorption. Recently, GLP-2 has been reported to stimulate glucagon secretion in healthy humans. We sought to clarify the mechanism and physiological significance of this endocrine effect. MATERIALS AND METHODS:T...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-007-0761-6
更新日期:2007-10-01 00:00:00
abstract:AIMS/HYPOTHESIS:Type 2 diabetes is an established risk factor for cardiovascular disease (CVD). This increased risk may be due in part to the increased levels of inflammatory factors associated with diabetes. Lipoprotein-associated phospholipase A(2) (Lp-PLA(2)) is a risk marker for CVD and has pro-inflammatory effects...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-010-1969-4
更新日期:2011-02-01 00:00:00
abstract:AIMS/HYPOTHESIS:Glucagon-like peptide-1 (GLP-1) lowers glucose levels by potentiating glucose-induced insulin secretion and inhibiting glucagon release. The question of whether GLP-1 exerts direct effects on the liver, independently of the hormonal changes, is controversial. We tested whether an exogenous GLP-1 infusio...
journal_title:Diabetologia
pub_type: 临床试验,杂志文章
doi:10.1007/s00125-012-2738-3
更新日期:2013-01-01 00:00:00
abstract:AIMS/HYPOTHESIS:An increased risk of type 2 diabetes mellitus is associated with low birthweight after full-term gestation, including amplification of this risk by weight gain during infancy and adult body composition. Premature birth is also associated with insulin resistance, but studies conducted so far have not pro...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-005-0118-y
更新日期:2006-03-01 00:00:00
abstract::Plasma corticosterone concentrations in diabetic (db) mice maintained on two different inbred backgrounds were found to be elevated significantly when compared to normal controls. These data are similar to that reported with the phenotypically similar obese (ob) mouse. These results suggest that the hyperadrenolcortic...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF00996323
更新日期:1977-01-01 00:00:00
abstract::Recently, we demonstrated that approximately 60% of GLUT 1 in a crude membrane fraction of rat skeletal muscle originates from perineurial sheaths. To study the in vivo regulation of GLUT 1 expression in different tissues in muscles, we measured the level of GLUT 1 in crude muscle membranes and in perineurial sheaths ...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s001250050130
更新日期:1994-05-01 00:00:00
abstract::The effect of a five day pretreatment with phenformin (3 X 50 mg daily) on hepatic metabolism was studied in six healthy volunteers. Arterial and hepatic venous concentrations of substrates and hepatic blood flow were estimated during a basal period and during a low-dose lactate infusion (0,03 mmol . kg-1 . min-1). Th...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF01219423
更新日期:1978-04-01 00:00:00
abstract::We examined glomerular basement membrane anionic site distribution identified by cationic gold in seven patients with insulin-dependent and four patients with non-insulin-dependent diabetes mellitus, presenting a spectrum of clinical and glomerular changes. Anionic sites were investigated by pretreatment of tissue wit...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF00400607
更新日期:1995-12-01 00:00:00
abstract:AIMS:We compared the effects of continuous subcutaneous insulin infusion (CSII) with those of multiple daily insulin (MDI) injections on glycaemic control, risk of hypoglycaemic episodes, insulin requirements and adverse events in type 1 and type 2 diabetes mellitus. METHODS:The electronic databases MEDLINE, EMBASE an...
journal_title:Diabetologia
pub_type: 杂志文章,meta分析,评审
doi:10.1007/s00125-008-0974-3
更新日期:2008-06-01 00:00:00
abstract::We have studied the temporal relationship of plasma von Willebrand Factor (vWF), a marker of endothelial damage, with the development of complications in 63 young diabetic patients (56 of whom were insulin-dependent) who took part in a prospective study. Results are presented from baseline to follow-up. In the group a...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF00418350
更新日期:1996-03-01 00:00:00
abstract:AIMS/HYPOTHESIS:This 52-week multinational, randomised, open-label, parallel-group, non-inferiority trial compared clinical outcomes following supplementation of oral glucose-lowering drugs with basal insulin analogues detemir and glargine in type 2 diabetic patients. METHODS:Insulin-naive adults (n=582, HbA(1c) 7.5-1...
journal_title:Diabetologia
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1007/s00125-007-0911-x
更新日期:2008-03-01 00:00:00
abstract:AIM/HYPOTHESIS:Although mitochondrial oxidative phosphorylation (OxPhos) dysfunction is believed to be responsible for beta cell dysfunction in insulin resistance and mitochondrial diabetes, the mechanisms underlying progressive beta cell failure caused by defective mitochondrial OxPhos are largely unknown. METHODS:We...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-015-3506-y
更新日期:2015-04-01 00:00:00
abstract::The glycaemic control of infants and of their mothers was studied at delivery and on day 7 after birth in 11 control and 20 insulin-dependent diabetic women. At delivery, venous blood glucose was lower in infants of diabetic mothers compared with control infants (p less than 0.02). Seven days after birth, no significa...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF00276966
更新日期:1984-12-01 00:00:00
abstract::Renal injury in diabetes mellitus is associated with progressive interstitial fibrosis and extracellular matrix accumulation. However, the phenotypes of cells forming the interstitial infiltrate in diabetic nephropathy have not been precisely defined. There is increasing evidence for the association of mast cells with...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF02658509
更新日期:1996-10-01 00:00:00
abstract:AIMS/HYPOTHESIS:Levels of ideal cardiovascular health (ICH) and incident type 2 diabetes mellitus have not been examined in a multiethnic population. We assessed the total and race/ethnicity-specific incidence of diabetes based on American Heart Association (AHA) ICH components. METHODS:Incident diabetes was assessed ...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-016-4003-7
更新日期:2016-09-01 00:00:00
abstract::Islet amyloid polypeptide (IAPP) is overexpressed relative to insulin under several experimental conditions relevant to diabetes mellitus, including the immediate phase (7 days) following induction of streptozotocin diabetes. In the present study, IAPP and insulin gene expression were examined in chronic streptozotoci...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF00418536
更新日期:1996-06-01 00:00:00
abstract:AIMS/HYPOTHESIS:We previously reported that exposure to antibodies neutralising serpin B13, a protease inhibitor expressed in exocrine pancreatic ducts, promotes beta cell proliferation, underscoring the importance of a functional relationship between exocrine and endocrine pancreas. The aim of the present study was to...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-019-4834-0
更新日期:2019-05-01 00:00:00
abstract::A geographically based sample of 1069 Hispanic and non-Hispanic white persons aged 20-74 years, living in southern Colorado and who tested normal on an oral glucose tolerance test (World Health Organization criteria) were evaluated to determine associations of dietary factors with fasting serum insulin concentrations....
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s001250050697
更新日期:1997-04-01 00:00:00
abstract::The aim of this study was to compare the causes of death and parameters related to alcohol consumption, between subjects diagnosed as diabetic, clinically by their general practitioner, or glucose intolerant and in particular as diabetic, using the epidemiological criteria of an abnormal glucose level following an ora...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF00400850
更新日期:1992-01-01 00:00:00
abstract::In order to establish a model for the in vivo assessment of islet function we have used the Rowett nude rat with transplantation of allogeneic and xenogeneic (mouse) islets into the renal subcapsular space following a minimal period of diabetic induction. Thirty-one nude rats were given streptozotocin and 30 became di...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF02341509
更新日期:1988-06-01 00:00:00
abstract::QT intervals were measured over RR intervals ranging from 500 ms to 1000 ms in 13 normal male subjects, 13 male diabetic subjects without and 13 with autonomic neuropathy. There was a close linear relationship between QT and RR in all subjects. The slope of the regression line was significantly greater in the autonomi...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF00418273
更新日期:1991-03-01 00:00:00
abstract:AIMS/HYPOTHESIS:High levels of cardiorespiratory fitness (CRF) and physical activity (PA) are associated with a favourable metabolic risk profile. However, there has been no thorough exploration of the independent contributions of cardiorespiratory fitness and subcomponents of activity (total PA, time spent sedentary, ...
journal_title:Diabetologia
pub_type: 杂志文章,多中心研究
doi:10.1007/s00125-007-0762-5
更新日期:2007-09-01 00:00:00
abstract:AIMS/HYPOTHESIS:Our aim was to examine the association between markers of insulin resistance and: (1) body fat and waist circumference, taking into account cardiorespiratory fitness in school-aged children; and (2) cardiorespiratory fitness at differing levels of body fat and waist circumference. SUBJECTS AND METHODS:...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-007-0678-0
更新日期:2007-07-01 00:00:00