Cardiovascular and alcohol-related deaths in abnormal glucose tolerant and diabetic subjects.

abstract：AIMS/HYPOTHESIS:In type 2 diabetic patients we compared 9 months of combination therapy with insulin glargine and metformin with 9 months of NPH insulin combined with metformin. The primary focus was changes in HbA(1c); secondary focus was diurnal glucose profiles and symptomatic hypoglycaemia. METHODS:In this investi...

journal_title：Diabetologia

authors： Yki-Järvinen H,Kauppinen-Mäkelin R,Tiikkainen M,Vähätalo M,Virtamo H,Nikkilä K,Tulokas T,Hulme S,Hardy K,McNulty S,Hänninen J,Levänen H,Lahdenperä S,Lehtonen R,Ryysy L

更新日期：2006-03-01 00:00:00

abstract：AIMS/HYPOTHESIS:Fetal growth is influenced by genetic factors as well as the intra-uterine environment. We hypothesised that some genetic factors may alter fetal insulin secretion and insulin action. SUBJECTS, MATERIALS AND METHODS:To assess this, we analysed plasma insulin concentration in umbilical cord blood from 6...

journal_title：Diabetologia

authors： Shields BM,Knight B,Turner M,Wilkins-Wall B,Shakespeare L,Powell RJ,Hannemann M,Clark PM,Yajnik CS,Hattersley AT

更新日期：2006-11-01 00:00:00

abstract：:The insulin storage granule of the pancreatic beta cell is assembled within the trans Golgi network from around 50 or so gene products many of which are synthesized coordinately with the major component, proinsulin. An important contribution to our understanding of the regulation of this process has come from studies ...

journal_title：Diabetologia

authors： Hutton JC

更新日期：1994-09-01 00:00:00

abstract：:Three members of the angiopoietin-like (ANGPTL) family of proteins, ANGPTL3, ANGPTL4 and ANGPTL8, are known regulators of plasma triacylglycerol levels. Recently, these three proteins have garnered considerable interest as potential targets for therapeutically reducing plasma triacylglycerol levels and improving cardi...

journal_title：Diabetologia

authors： Davies BSJ

更新日期：2018-06-01 00:00:00

abstract：:Pancreatic beta cells differ in terms of glucose responsiveness, insulin secretion and proliferative capacity; however, the molecular pathways that regulate this cellular heterogeneity are unknown. We have identified the Wnt-planar cell polarity (PCP) effector Flattop (FLTP) as a biomarker that identifies mature beta ...

journal_title：Diabetologia

authors： Migliorini A,Roscioni SS,Lickert H

更新日期：2016-09-01 00:00:00

abstract：:The development of proteinuria and its response to insulin therapy in acute experimental diabetes was examined in 11 female rats by sequentially measuring 24 h excretion of glucose and total protein before diabetes, during 5-37 days of acute streptozotocin diabetes, during and after 7-14 days of continuous subcutaneou...

journal_title：Diabetologia

authors： Pennell JP,Millard MM,Ashby MH

更新日期：1981-07-01 00:00:00

abstract：:The response of Gastric Inhibitory Polypeptide (GIP) and insulin to a 50 g oral glucose tolerance test (OGTT) and an intravenous glucose infusion (IVGI), which copied the changes in plasma glucose concentrations during the OGTT, were measured in 10 patients with duodenal ulcer and in 10 healthy control subjects. The m...

journal_title：Diabetologia

authors： Lauritsen KB,Moody AJ

更新日期：1978-03-01 00:00:00

abstract：:A diabetes prevalence study on an isolated urbanized Central Pacific Island has established a prevalence rate of 34.4% in individuals aged 15 years and over. Of these, 10.4% had previously known diabetes; in the others the diagnosis was made on the basis of a plasma glucose level of at least 160 mg/100 ml 2h after a 7...

journal_title：Diabetologia

authors： Zimmet P,Taft P,Guinea A,Guthrie W,Thoma K

更新日期：1977-04-01 00:00:00

abstract：:The obese Zucker rat represents a model of obesity combined with insulin resistance and hyperlipidaemia, which over a period of several months develops spontaneous glomerulosclerosis. The present study addressed the question as to whether glomerular sclerosis was associated with alterations in the degradation of matri...

journal_title：Diabetologia

authors： Schaefer L,Han X,August C,Matzkies F,Lorenz T,Schaefer RM

更新日期：1997-09-01 00:00:00

abstract：:The accumulation of noradrenaline in constricted sciatic nerves was measured in 6 month diabetic rats (streptozotocin 35 mg/kg) and 4 day diabetic rats (streptozotocin 70 mg/kg) together with two groups of age-matched control animals. There was no alteration in the amount of noradrenaline accumulated in the nerves of ...

journal_title：Diabetologia

authors： Tomlinson DR,Gillon KR,Smith MG

更新日期：1982-03-01 00:00:00

abstract：:It has been suggested that bradykinin stimulates glucose uptake in experiments in vivo and in cultured cells. However, its mechanism has not yet been fully elucidated. In this study, the effects of bradykinin on the insulin signalling pathway were evaluated in isolated dog adipocytes. The bradykinin receptor binding s...

journal_title：Diabetologia

authors： Isami S,Kishikawa H,Araki E,Uehara M,Kaneko K,Shirotani T,Todaka M,Ura S,Motoyoshi S,Matsumoto K,Miyamura N,Shichiri M

更新日期：1996-04-01 00:00:00

abstract：:The involvement of nitric oxide as an intracellular messenger in the control of insulin secretion from pancreatic Beta cells was studied in rat islets of Langerhans by measuring: (i) nitric oxide generation in response to physiological insulin secretagogues; (ii) the effects of inhibitors of nitric oxide synthesis on ...

journal_title：Diabetologia

authors： Jones PM,Persaud SJ,Bjaaland T,Pearson JD,Howell SL

更新日期：1992-11-01 00:00:00

abstract：:Weaning onto chow diets causes the highest incidence of diabetes in the BB rat. Changes in gut development and absorption of nutrients in the diabetes prone rat and the subsequent effect on pancreatic function may play a role in the ultimate development of the disease. BB diabetes prone (dp) and BB normal (n) dams wer...

journal_title：Diabetologia

authors： Reimer RA,Field CJ,McBurney MI

更新日期：1997-08-01 00:00:00

abstract：:Plasma insulin and growth hormone levels were measured during morning and afternoon oral glucose tolerance tests performed on 12 young men at three monthly intervals in the Antarctic. No diurnal or seasonal differences in growth hormone levels were found. However there were diurnal and seasonal variations in the blood...

journal_title：Diabetologia

authors： Campbell IT,Jarrett RJ,Rutland P,Stimmler L

更新日期：1975-04-01 00:00:00

abstract：AIMS/HYPOTHESIS:The relationship of androgens to the metabolic syndrome has not been resolved. The polymorphic number of CAG repeats within the androgen receptor gene is inversely associated with the transcriptional activity of target genes. This polymorphism might thus influence testosterone effects on body fat conten...

journal_title：Diabetologia

authors： Zitzmann M,Gromoll J,von Eckardstein A,Nieschlag E

更新日期：2003-01-01 00:00:00

abstract：AIMS/HYPOTHESIS:We investigated the potential effects of the Continuous Glucose Monitoring System (CGMS), as compared with self-monitoring of blood glucose, on glycaemic control in children with type 1 diabetes. METHODS:The following electronic databases were searched throughout June 2007: MEDLINE, EMBASE and The Coch...

journal_title：Diabetologia

authors： Golicki DT,Golicka D,Groele L,Pankowska E

更新日期：2008-02-01 00:00:00

abstract：:Diabetes is an important risk factor for atherosclerosis but the mechanism of the risk is unknown. As endothelial injury is considered to be an early event in the development of atherosclerosis, the effect of glucose on endothelial cell replication was studied. Concentrations of glucose of 11.2, 16.8 and 22.4 mmol/l i...

journal_title：Diabetologia

authors： Stout RW

更新日期：1982-11-01 00:00:00

abstract：:Glycerol release from epididymal fat fragments of young adult (3-month old) ob/ob mice was three times lower than normal, on a tissue weight basis. Dose-response curves in response to isoproterenol and ACTH-(1--24) indicated that the capacity of the lipolytic process was reduced. However, the sensitivity to both hormo...

journal_title：Diabetologia

authors： Dehaye JP,Winand J,Christophe J

更新日期：1977-12-01 00:00:00

abstract：AIMS/HYPOTHESIS:Recent genome-wide association studies in East Asian populations reported that single nucleotide polymorphisms (SNPs) in KCNQ1 are associated with type 2 diabetes. The aim of this study was to validate this finding in a Chinese population. METHODS:We genotyped four SNPs, rs2074196, rs2237892, rs2237895...

journal_title：Diabetologia

authors： Hu C,Wang C,Zhang R,Ma X,Wang J,Lu J,Qin W,Bao Y,Xiang K,Jia W

更新日期：2009-07-01 00:00:00

abstract：:The relation between urinary albumin excretion rate (UAE), transcapillary escape rate of albumin (TERalb), haemostatic factors, ambulatory blood pressure, and metabolic variables was investigated in 45 Type II (non-insulin-dependent) diabetic patients without overt nephropathy or uncontrolled blood pressure. We enroll...

journal_title：Diabetologia

authors： Nielsen S,Schmitz A,Bacher T,Rehling M,Ingerslev J,Mogensen CE

更新日期：1999-01-01 00:00:00

abstract：:The Neurometer is a variable constant current sine wave stimulator, and has recently been proposed as a simple non-invasive and quantitative measure of peripheral nerve function. The device is portable and battery operated; assessment of upper and lower extremities takes only a few min, in contrast to conventional ass...

journal_title：Diabetologia

authors： Masson EA,Veves A,Fernando D,Boulton AJ

更新日期：1989-10-01 00:00:00

abstract：:The migration of Tokelauans from a traditional atoll in the Pacific to urban New Zealand is associated with an increased prevalence and incidence of Type 2 (non-insulin-dependent) diabetes mellitus over the period 1968-1982. During the same period, a lesser but definite increase is seen among non-migrants in Tokelau. ...

journal_title：Diabetologia

authors： Ostbye T,Welby TJ,Prior IA,Salmond CE,Stokes YM

更新日期：1989-08-01 00:00:00

abstract：AIMS/HYPOTHESIS:The aim of this study was to assess whether the diabetogenicity of areca nut (Areca catechu or 'betel-nut'), which has previously been demonstrated experimentally in mice, independently contributes to the risk of hyperglycaemia or type 2 diabetes in men in Taiwan, where the habit has become established ...

journal_title：Diabetologia

authors： Tung TH,Chiu YH,Chen LS,Wu HM,Boucher BJ,Chen TH,Keelung Community-based Integrated Screening programme No. 2.

更新日期：2004-10-01 00:00:00

abstract：AIMS/HYPOTHESIS:Pancreatic beta cells play a central role in the control of glucose homeostasis by secreting insulin to stimulate glucose uptake by peripheral tissues. Understanding the molecular mechanisms that control beta cell function and plasticity has critical implications for the pathophysiology and therapy of m...

journal_title：Diabetologia

authors： Thorens B,Tarussio D,Maestro MA,Rovira M,Heikkilä E,Ferrer J

更新日期：2015-03-01 00:00:00

abstract：AIMS/HYPOTHESIS:IRS2 is an important molecular switch that mediates insulin signalling in the liver. IRS2 dysregulation is responsible for the phenomenon of selective insulin resistance that is observed in type 2 diabetes. We hypothesise that epigenetic mechanisms are involved in the regulation of IRS2 in the liver of ...

journal_title：Diabetologia

authors： Krause C,Geißler C,Tackenberg H,El Gammal AT,Wolter S,Spranger J,Mann O,Lehnert H,Kirchner H

更新日期：2020-10-01 00:00:00

abstract：:In order to assess the possible progression of neurological abnormalities over time and the value of visual evoked potential alterations in predicting stability and severity of diabetes-related optic pathway disease, a longitudinal study in non-insulin-dependent diabetic patients was performed. Neurological examinatio...

journal_title：Diabetologia

authors： Moreo G,Mariani E,Pizzamiglio G,Colucci GB

更新日期：1995-05-01 00:00:00

abstract：AIMS/HYPOTHESIS:Intraportal human islet cell grafts do not consistently and sustainably induce insulin-independency in type 1 diabetic patients. The reasons for losses in donor cells are difficult to assess in patients. This study in streptozotocin-diabetic nude rats examines whether outcome is better in an extra-hepat...

journal_title：Diabetologia

authors： Jacobs-Tulleneers-Thevissen D,Bartholomeus K,Suenens K,Vermeulen I,Ling Z,Hellemans KH,In't Veld P,Pipeleers-Marichal M,Pipeleers D

更新日期：2010-08-01 00:00:00

abstract：AIMS/HYPOTHESIS:Early detection of risk of microalbuminuria could prevent early renal damage. We investigated whether urine retinol binding protein and N-acetyl-glucosaminidase could predict the risk of microalbuminuria in a large cohort of children followed from diagnosis of Type I (insulin-dependent) diabetes mellitu...

journal_title：Diabetologia

authors： Schultz CJ,Dalton RN,Neil HA,Konopelska-Bahu T,Dunger DB,Oxford Regional Prospective Study Group.

更新日期：2001-02-01 00:00:00

abstract：:It is increasingly appreciated that the pathogenic mechanisms of type 1 diabetes involve both the autoimmune aggressors and their beta cell targets, which engage in a conflicting dialogue within and possibly outside the pancreas. Indeed, autoimmune CD8+ T cells, which are the final mediators of beta cell destruction, ...

journal_title：Diabetologia

authors： Mallone R,Eizirik DL

更新日期：2020-10-01 00:00:00

abstract：:Glucagon-like peptide-1 and glucagon-like peptide-2 are encoded by the m-RNA of pancreatic preproglucagon. They show high conservation in different species and substantial sequence homology to glucagon. Because no definite biological activity of these peptides has been reported, we investigated the effect of synthetic...

journal_title：Diabetologia

authors： Schmidt WE,Siegel EG,Creutzfeldt W

更新日期：1985-09-01 00:00:00