当前位置： SCI文献检索 > DIABETOLOGIA期刊下所有文献 > A population-based prevalence survey of known diabetes mellitus in northern Italy based upon multiple independent sources of ascertainment.

A population-based prevalence survey of known diabetes mellitus in northern Italy based upon multiple independent sources of ascertainment.

Abstract：

:The aims of this survey were (1) to estimate the prevalence of known diabetes mellitus in 1988 in Casale Monferrato (Northern Italy); (2) to validate different data sources available in Italy; (3) to identify a population-based cohort of diabetic patients. Multiple independent data sources were used and the capture-recapture method was applied to estimate the completeness of ascertainment of the survey. The primary data source was the list of all patients attending the diabetic clinic or those referred by family physicians and paediatricians of the area. The secondary data sources were the list of hospital discharges, the prescriptions data source and the list of all people using reagent strips and insulin syringes. On 1 October 1988 (the cut-off date) 2,069 cases of known diabetes were identified. The estimated completeness of ascertainment of the survey was 91%. Prevalence of known diabetes, Type 1 (insulin-dependent), Type 2 (non-insulin-dependent) and insulin-treated diabetes were, respectively, 2.21% (95% CI 2.13-2.29), 0.80/1,000 (0.62-0.98) and 2.10% (2.01-2.19), 2.92/1,000 (2.57-3.27). A higher prevalence of Type 2 diabetes was observed in women (2.30%, 2.18-2.42) than in men (1.88%, 1.76-2.00). Age-specific prevalence of Type 2 diabetes increased with age. Computerized data sources routinely available in the Piedmont Region (hospital discharges and prescriptions data sources) showed a low completeness of ascertainment when considered together (65%, 1,338 of 2,069), indicating the need to involve the diabetic clinic and family physicians in the ascertainment of known diabetes. In conclusion, the prevalence of known diabetes in Italy was lower than in Northern Europe and the United States.

journal_name

Diabetologia

journal_title

Diabetologia

authors

Bruno G,Bargero G,Vuolo A,Pisu E,Pagano G

doi

10.1007/BF00399931

subject

Has Abstract

pub_date

1992-09-01 00:00:00

pages

851-6

issue

9

eissn

0012-186X

issn

1432-0428

journal_volume

35

pub_type

杂志文章

相关文献

DIABETOLOGIA文献大全
  • Association between diabetes and haematological malignancies: a population-based study.

    abstract：AIMS/HYPOTHESIS:Contemporary data for the association of diabetes with haematological malignancies are lacking. We evaluated the risk of developing haematological malignancies and subsequent mortality in individuals with diabetes compared with those without diabetes. METHODS:We conducted a population-based observation...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/s00125-020-05338-7

    authors： Gong IY,Cheung MC,Read S,Na Y,Lega IC,Lipscombe LL

    更新日期：2021-01-06 00:00:00

  • Impaired estrogen-induced uterine insulin-like growth factor-I gene expression in the streptozotocin diabetic rat.

    abstract：:Circulating somatomedin-C/insulin-like growth factor-I levels are low in the diabetic rat and unresponsive to exogenous growth hormone. However, the nature of this defect in growth hormone action remains unclear and there is little data on insulin-like growth factor-I gene expression in response to other stimuli and i...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/BF00277488

    authors： Murphy LJ

    更新日期：1988-11-01 00:00:00

  • The Gly482Ser polymorphism in the peroxisome proliferator-activated receptor-gamma coactivator-1 gene is associated with hypertension in type 2 diabetic men.

    abstract：AIMS/HYPOTHESIS:Peroxisome proliferator-activated receptor-gamma coactivator-1 (PPARGC1) acts as a cofactor for several nuclear hormone receptors in many tissues and organs implicated in blood pressure regulation. Here, we assessed the association between the Gly482Ser variant of PPARGC1 and the arterial hypertension f...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/s00125-004-1567-4

    authors： Cheurfa N,Reis AF,Dubois-Laforgue D,Bellanné-Chantelot C,Timsit J,Velho G

    更新日期：2004-11-01 00:00:00

  • Stimulation of adipose tissue lipolysis following insulin-induced hypoglycaemia: evidence of increased beta-adrenoceptor-mediated lipolytic response in IDDM.

    abstract：:The adrenergic regulation of adipose tissue lipolysis in response to insulin-induced hypoglycaemia (intravenous infusion of soluble insulin 0.10 IU.kg body weight-1.h-1 until the arterial plasma glucose fell below 2.8 mmol/l) was investigated directly in vivo in 11 insulin-dependent diabetic (IDDM) patients and 12 con...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/s001250050519

    authors： Bolinder J,Sjöberg S,Arner P

    更新日期：1996-07-01 00:00:00

  • Glucose-induced changes of multiple mouse islet proteins analysed by two-dimensional gel electrophoresis and mass spectrometry.

    abstract：AIMS/HYPOTHESIS:The aim of this study was to investigate molecular mechanisms of glucose-induced changes in islets of Langerhans by analysing global changes in protein patterns of islets exposed to elevated glucose concentrations. METHODS:Islets were isolated from C57BL/6J mice and used either directly or after exposu...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/s00125-004-1661-7

    authors： Ahmed M,Bergsten P

    更新日期：2005-03-01 00:00:00

  • Case fatality rates after first acute coronary syndrome in persons treated for type 2 diabetes show an improving trend.

    abstract：AIMS/HYPOTHESIS:We analysed whether the prognosis of a first acute coronary syndrome (ACS) in patients treated for type 2 diabetes has improved. We also compared the trends in patients with and without diabetes. METHODS:We used national registers to identify all patients with clinically known type 2 diabetes in Finlan...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/s00125-009-1606-2

    authors： Winell KM,Pääkkönen R,Pietilä A,Niemi MK,Reunanen AR,Salomaa VV

    更新日期：2010-03-01 00:00:00

  • Immunoisolation of pancreatic B cells by microencapsulation. An in vitro study.

    abstract：:The selective permeability of alginate microcapsules, containing isolated rat islets of Langerhans or insulin secreting RINm5F cells, was investigated in vitro. An increase in insulin release was observed when microencapsulated islets were stimulated by glucose+theophylline, and when microencapsulated RINm5F cells wer...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/BF00265027

    authors： Darquy S,Reach G

    更新日期：1985-10-01 00:00:00

  • The linkage and association of the gene encoding upstream stimulatory factor 1 with type 2 diabetes and metabolic syndrome in the Chinese population.

    abstract：AIMS/HYPOTHESIS:The transcription factor upstream stimulatory factor 1 (USF1) regulates the expression of genes involved in glucose and lipid metabolism and has been associated with familial combined hyperlipidaemia. USF1 is located on chromosome 1q22-23, a region with evidence for linkage to type 2 diabetes and variou...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/s00125-005-1914-0

    authors： Ng MC,Miyake K,So WY,Poon EW,Lam VK,Li JK,Cox NJ,Bell GI,Chan JC

    更新日期：2005-10-01 00:00:00

  • Independent associations of physical activity and cardiorespiratory fitness with metabolic risk factors in children: the European youth heart study.

    abstract：AIMS/HYPOTHESIS:High levels of cardiorespiratory fitness (CRF) and physical activity (PA) are associated with a favourable metabolic risk profile. However, there has been no thorough exploration of the independent contributions of cardiorespiratory fitness and subcomponents of activity (total PA, time spent sedentary, ...

    journal_title：Diabetologia

    pub_type： 杂志文章,多中心研究

    doi：10.1007/s00125-007-0762-5

    authors： Ekelund U,Anderssen SA,Froberg K,Sardinha LB,Andersen LB,Brage S,European Youth Heart Study Group.

    更新日期：2007-09-01 00:00:00

  • The potential contribution of endothelin-1 to neurovascular abnormalities in streptozotocin-diabetic rats.

    abstract：:Abnormal vascular endothelium function may contribute to the reduced nerve perfusion implicated in the aetiology of neuropathy in diabetes mellitus. The aim was to test the hypothesis that a powerful vasoconstrictor, endothelin-1, could be involved in nerve dysfunction in streptozotocin-diabetic rats. After 6 weeks of...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/BF00399794

    authors： Cameron NE,Dines KC,Cotter MA

    更新日期：1994-12-01 00:00:00

  • The role of arginase I in diabetes-induced retinal vascular dysfunction in mouse and rat models of diabetes.

    abstract：AIMS/HYPOTHESIS:A reduction in retinal blood flow occurs early in diabetes and is likely to be involved in the development of diabetic retinopathy. We hypothesise that activation of the arginase pathway could have a role in the vascular dysfunction of diabetic retinopathy. METHODS:Experiments were performed using a mo...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/s00125-012-2789-5

    authors： Elms SC,Toque HA,Rojas M,Xu Z,Caldwell RW,Caldwell RB

    更新日期：2013-03-01 00:00:00

  • Perinatal assessment of glycaemic control in newborn infants of diabetic mothers.

    abstract：:The glycaemic control of infants and of their mothers was studied at delivery and on day 7 after birth in 11 control and 20 insulin-dependent diabetic women. At delivery, venous blood glucose was lower in infants of diabetic mothers compared with control infants (p less than 0.02). Seven days after birth, no significa...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/BF00276966

    authors： Gouédard HA,Ménez JF,Meskar A,Caroff J,Lucas D,Legendre JM

    更新日期：1984-12-01 00:00:00

  • Surface binding, internalization and degradation by cultured human fibroblasts of low density lipoproteins isolated from type 1 (insulin-dependent) diabetic patients: changes with metabolic control.

    abstract：:A previous study of low density lipoprotein metabolism by cultured cells focused on the metabolism of normal lipoproteins in vitro by fibroblasts isolated from diabetic patients. No abnormalities were found. We have followed the opposite approach. Using normal human fibroblasts as test cells we compared the metabolism...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/BF00282585

    authors： Lopes-Virella MF,Sherer GK,Lees AM,Wohltmann H,Mayfield R,Sagel J,LeRoy EC,Colwell JA

    更新日期：1982-06-01 00:00:00

  • Differential binding of sulphated insulin to adipocytes and hepatocytes.

    abstract：:The polymerization and precipitation of highly purified insulins which causes major problems in portable infusion systems does not occur with sulphated insulin. To compare the biological behaviour of sulphated insulin with that of a neutral highly purified monocomponent insulin, insulin receptor studies were performed...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/BF00273803

    authors： Zeuzem S,Taylor R,Agius L,Albisser AM,Alberti KG

    更新日期：1984-08-01 00:00:00

  • Hyperinsulinaemia and hyperglycaemia: possible risk factors of colorectal cancer among diabetic patients.

    abstract：:Hyperinsulinaemia and hyperglycaemia are two possible risk factors for colorectal cancer, which constitutes the third leading cause of cancer death in Western countries. Molecular evidence as well as animal models provide support for these associations: Insulin has been shown to be an important growth factor for colon...

    journal_title：Diabetologia

    pub_type： 杂志文章,评审

    doi：10.1007/s00125-003-1109-5

    authors： Chang CK,Ulrich CM

    更新日期：2003-05-01 00:00:00

  • Determination of peritoneal glucose kinetics in rats: implications for the peritoneal implantation of closed-loop insulin delivery systems.

    abstract：:Peritoneal glucose kinetics were evaluated in the anaesthetized rat, to assess whether the peritoneal cavity would be a suitable site for the implantation of membrane-protected islets of Langerhans (bioartificial pancreas) or the glucose sensor of an artificial B cell. Glucose was measured in peritoneal fluid samples ...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/BF00277254

    authors： Velho G,Froguel P,Reach G

    更新日期：1989-06-01 00:00:00

  • Diurnal rhythms in the white adipose tissue transcriptome are disturbed in obese individuals with type 2 diabetes compared with lean control individuals.

    abstract：AIMS/HYPOTHESIS:Animal studies have indicated that disturbed diurnal rhythms of clock gene expression in adipose tissue can induce obesity and type 2 diabetes. The importance of the circadian timing system for energy metabolism is well established, but little is known about the diurnal regulation of (clock) gene expres...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/s00125-019-4813-5

    authors： Stenvers DJ,Jongejan A,Atiqi S,Vreijling JP,Limonard EJ,Endert E,Baas F,Moerland PD,Fliers E,Kalsbeek A,Bisschop PH

    更新日期：2019-04-01 00:00:00

  • Elevated von Willebrand factor antigen predicts deterioration in diabetic peripheral nerve function.

    abstract：:We have studied the temporal relationship of plasma von Willebrand Factor (vWF), a marker of endothelial damage, with the development of complications in 63 young diabetic patients (56 of whom were insulin-dependent) who took part in a prospective study. Results are presented from baseline to follow-up. In the group a...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/BF00418350

    authors： Plater ME,Ford I,Dent MT,Preston FE,Ward JD

    更新日期：1996-03-01 00:00:00

  • The effects of ezetimibe on non-alcoholic fatty liver disease and glucose metabolism: a randomised controlled trial.

    abstract：AIMS/HYPOTHESIS:The cholesterol absorption inhibitor ezetimibe has been shown to ameliorate non-alcoholic fatty liver disease (NAFLD) pathology in a single-armed clinical study and in experimental animal models. In this study, we investigated the efficacy of ezetimibe on NAFLD pathology in an open-label randomised cont...

    journal_title：Diabetologia

    pub_type： 杂志文章,随机对照试验

    doi：10.1007/s00125-013-3149-9

    authors： Takeshita Y,Takamura T,Honda M,Kita Y,Zen Y,Kato K,Misu H,Ota T,Nakamura M,Yamada K,Sunagozaka H,Arai K,Yamashita T,Mizukoshi E,Kaneko S

    更新日期：2014-05-01 00:00:00

  • Beta-cell hypersensitivity for glucose precedes loss of glucose-induced insulin secretion in 90% pancreatectomized rats.

    abstract：:Glucose-induced insulin secretion is impaired in the presence of chronic hyperglycaemia. Insulin secretion was studied in a diabetic rat model prior to the beta cells becoming non-responsive to glucose in order to map out the sequence of changes that accompany chronic hyperglycaemia. In vitro pancreas perfusions were ...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/BF00400800

    authors： Leahy JL,Bumbalo LM,Chen C

    更新日期：1993-12-01 00:00:00

  • Release of the angiogenesis inhibitor angiostatin in patients with proliferative diabetic retinopathy: association with retinal photocoagulation.

    abstract：AIMS/HYPOTHESIS:Proliferative diabetic retinopathy is a major debilitating disease causing most cases of blindness in humans in the Western world. Photocoagulation is the established therapy of proliferative diabetic retinopathy, although the molecular mechanisms of its effects are still not known. Recently angiostatin...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/s001250051546

    authors： Spranger J,Hammes HP,Preissner KT,Schatz H,Pfeiffer AF

    更新日期：2000-11-01 00:00:00

  • Human mesenchymal stem cells and derived extracellular vesicles induce regulatory dendritic cells in type 1 diabetic patients.

    abstract：AIMS/HYPOTHESIS:Mesenchymal stem cells (MSCs) can exert an immunosuppressive effect on any component of the immune system, including dendritic cells (DCs), by direct contact, the release of soluble markers and extracellular vesicles (EVs). We evaluated whether MSCs and MSC-derived EVs have an immunomodulatory effect on...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/s00125-015-3808-0

    authors： Favaro E,Carpanetto A,Caorsi C,Giovarelli M,Angelini C,Cavallo-Perin P,Tetta C,Camussi G,Zanone MM

    更新日期：2016-02-01 00:00:00

  • Post-translational protein modifications in type 1 diabetes: a role for the repair enzyme protein-L-isoaspartate (D-aspartate) O-methyltransferase?

    abstract：AIMS/HYPOTHESIS:Post-translational modifications, such as isomerisation of native proteins, may create new antigenic epitopes and play a role in the development of the autoimmune response. Protein-L-isoaspartate (D-aspartate) O-methyltransferase (PIMT), encoded by the gene PCMT1, is an enzyme that recognises and repair...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/s00125-006-0556-1

    authors： Wägner AM,Cloos P,Bergholdt R,Boissy P,Andersen TL,Henriksen DB,Christiansen C,Christgau S,Pociot F,Nerup J

    更新日期：2007-03-01 00:00:00

  • Metabolic actions of insulin-like growth factor II in cultured adult rat hepatocytes are not mediated through the insulin-like growth factor II receptor.

    abstract：:Short- and long-term regulation of hepatic carbohydrate metabolism by insulin-like growth factor II was studied in primary cultures of adult rat hepatocytes and compared to the metabolic potency of insulin. Insulin-like growth factor II stimulated glycogen synthesis from [14C]glucose, uptake of [3H]aminoisobutyric aci...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/BF00400920

    authors： Hartmann H,Meyer-Alber A,Braulke T

    更新日期：1992-03-01 00:00:00

  • Age influences DNA methylation and gene expression of COX7A1 in human skeletal muscle.

    abstract：AIMS/HYPOTHESIS:Reduced oxidative capacity of the mitochondria in skeletal muscle has been suggested to contribute to insulin resistance and type 2 diabetes. Moreover, a set of genes influencing oxidative phosphorylation (OXPHOS) is downregulated in diabetic muscle. Here we studied whether genetic, epigenetic and non-g...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/s00125-008-1018-8

    authors： Rönn T,Poulsen P,Hansson O,Holmkvist J,Almgren P,Nilsson P,Tuomi T,Isomaa B,Groop L,Vaag A,Ling C

    更新日期：2008-07-01 00:00:00

  • Association analysis of the IGF1 gene with childhood growth, IGF-1 concentrations and type 1 diabetes.

    abstract：AIMS/HYPOTHESIS:Insulin-like growth factor-1 is a major childhood growth factor and promotes pancreatic islet cell survival and growth in vitro. We hypothesised that genetic variation in IGF1 might be associated with childhood growth, glucose metabolism and type 1 diabetes risk. We therefore examined the association be...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/s00125-008-0970-7

    authors： Vella A,Bouatia-Naji N,Heude B,Cooper JD,Lowe CE,Petry C,Ring SM,Dunger DB,Todd JA,Ong KK

    更新日期：2008-05-01 00:00:00

  • Reduced plasma adiponectin concentrations may contribute to impaired insulin activation of glycogen synthase in skeletal muscle of patients with type 2 diabetes.

    abstract：AIMS/HYPOTHESIS:Circulating levels of adiponectin are negatively associated with multiple indices of insulin resistance, and the concentration is reduced in humans with insulin resistance and type 2 diabetes. However, the mechanisms by which adiponectin improves insulin sensitivity remain unclear. SUBJECTS AND METHODS...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/s00125-006-0240-5

    authors： Højlund K,Frystyk J,Levin K,Flyvbjerg A,Wojtaszewski JF,Beck-Nielsen H

    更新日期：2006-06-01 00:00:00

  • Multiple defects of both hepatic and peripheral intracellular glucose processing contribute to the hyperglycaemia of NIDDM.

    abstract：:Non-insulin-dependent diabetic (NIDDM) patients were studied during a modified euglycaemic state when fasting hyperglycaemia was normalized by a prior (-210 to -150 min)--and later withdrawn (-150-0 min)--intravenous insulin infusion. Glucose metabolism was assessed in NIDDM patients (n = 10) and matched control subje...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/BF00400638

    authors： Vaag A,Alford F,Henriksen FL,Christopher M,Beck-Nielsen H

    更新日期：1995-03-01 00:00:00

  • Type 1 diabetic patients with peripheral neuropathy have pan-enteric prolongation of gastrointestinal transit times and an altered caecal pH profile.

    abstract：AIMS/HYPOTHESIS:We hypothesised that type 1 diabetic patients with established diabetic sensorimotor polyneuropathy (DSPN) would have segmental and/or pan-enteric dysmotility in comparison to healthy age-matched controls. We aimed to investigate the co-relationships between gastrointestinal function, degree of DSPN and...

    journal_title：Diabetologia

    pub_type： 杂志文章,随机对照试验

    doi：10.1007/s00125-016-4199-6

    authors： Farmer AD,Pedersen AG,Brock B,Jakobsen PE,Karmisholt J,Mohammed SD,Scott SM,Drewes AM,Brock C

    更新日期：2017-04-01 00:00:00

  • Heterogeneity in glutamic acid decarboxylase expression among single rat pancreatic beta cells.

    abstract：AIMS/HYPOTHESIS:An isoform of glutamic acid decarboxylase, (GAD)65 has been identified as a pancreatic beta-cell autoantigen in Type I (insulin dependent) diabetes mellitus. We investigated the expression of GAD isoforms among single rat beta cells in culture, under different conditions and the correlation between GAD6...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/s001250051275

    authors： Sánchez-Soto MC,Larrieta ME,Vidaltamayo R,Hiriart M

    更新日期：1999-09-01 00:00:00