Human enterovirus infections in children at increased risk for type 1 diabetes: the Babydiet study.

abstract：:Hepatic microsomal glucose-6-phosphatase activity levels and the hepatic output of glucose are increased in diabetes. We have used protein chemistry and immunological techniques to determine the mechanism by which the activity levels of the glucose-6-phosphatase system are increased in streptozotocin-induced diabetic ...

journal_title：Diabetologia

authors： Burchell A,Cain DI

更新日期：1985-11-01 00:00:00

abstract：:The appropriate utilisation, storage and conversion of nutrients in peripheral tissues, referred to as nutrient partitioning, is a fundamental process to adapt to nutritional and metabolic challenges and is thus critical for the maintenance of a healthy energy balance. Alterations in this process during nutrient exces...

journal_title：Diabetologia

authors： Manceau R,Majeur D,Alquier T

更新日期：2020-04-01 00:00:00

abstract：:Muscle glycogen synthase (GYS1) is a key enzyme of non-oxidative pathway of glucose metabolism that has been reported to be related to insulin resistance in non-insulin-dependent diabetic (NIDDM) patients. We scanned the GYS1 gene for mutation by single strand conformational polymorphism in 244 non-obese Japanese NIDD...

journal_title：Diabetologia

authors： Shimomura H,Sanke T,Ueda K,Hanabusa T,Sakagashira S,Nanjo K

更新日期：1997-08-01 00:00:00

abstract：:The importance of both insulin resistance and beta cell dysfunction in the pathogenesis of glucose intolerance is widely recognised. Also popular is the concept that beta cell secretory function must be viewed in the context of extant insulin resistance. This For Debate moves from the premise that, whilst insulin acti...

journal_title：Diabetologia

authors： Ferrannini E,Mari A

更新日期：2004-05-01 00:00:00

abstract：AIMS/HYPOTHESIS:The purpose of this study was to assess the therapeutic implication of leptin in insulin-deficient diabetes. METHODS:Insulin-deficient diabetes was induced by streptozotocin (STZ) in transgenic skinny mice overexpressing leptin. Plasma concentrations of glucose, insulin, and leptin were measured. The e...

journal_title：Diabetologia

authors： Miyanaga F,Ogawa Y,Ebihara K,Hidaka S,Tanaka T,Hayashi S,Masuzaki H,Nakao K

更新日期：2003-10-01 00:00:00

abstract：AIMS/HYPOTHESIS:We analysed whether the prognosis of a first acute coronary syndrome (ACS) in patients treated for type 2 diabetes has improved. We also compared the trends in patients with and without diabetes. METHODS:We used national registers to identify all patients with clinically known type 2 diabetes in Finlan...

journal_title：Diabetologia

authors： Winell KM,Pääkkönen R,Pietilä A,Niemi MK,Reunanen AR,Salomaa VV

更新日期：2010-03-01 00:00:00

abstract：AIMS/HYPOTHESIS:The aim of this study was to investigate the action of the glucose-lowering compound sodium tungstate on glucose transport in muscle myotubes and to unravel the molecular events underlying the effects observed. METHODS:We studied the effects of tungstate on 2-deoxy-D: -glucose uptake, levels and transl...

journal_title：Diabetologia

authors： Girón MD,Sevillano N,Vargas AM,Domínguez J,Guinovart JJ,Salto R

更新日期：2008-07-01 00:00:00

abstract：AIMS/HYPOTHESIS:Type 2 diabetes is an established risk factor for cardiovascular disease (CVD). This increased risk may be due in part to the increased levels of inflammatory factors associated with diabetes. Lipoprotein-associated phospholipase A(2) (Lp-PLA(2)) is a risk marker for CVD and has pro-inflammatory effects...

journal_title：Diabetologia

authors： Nelson TL,Kamineni A,Psaty B,Cushman M,Jenny NS,Hokanson J,Furberg C,Mukamal KJ

更新日期：2011-02-01 00:00:00

abstract：:498 diabetics were discovered in a survey of ischaemic heart disease in 10,059 men aged 40 years and over in Israel. -The diabetics were divided into previously known and newly diagnosed. -During a 5 year follow-up period, the incidence rates of fatal and non-fatal myocardial infarction and the incidence of intermitte...

journal_title：Diabetologia

authors： Herman JB,Medalie JH,Goldbourt U

更新日期：1977-05-01 00:00:00

abstract：AIMS/HYPOTHESIS:We hypothesised that non-obese diabetic mice (NOD) mice have an autoimmune-mediated loss of islet sympathetic nerves and an impairment of sympathetically mediated glucagon responses. We aimed: (1) to determine whether diabetic NOD mice have an early impairment of the glucagon response to insulin-induced...

journal_title：Diabetologia

authors： Taborsky GJ Jr,Mei Q,Hackney DJ,Figlewicz DP,LeBoeuf R,Mundinger TO

更新日期：2009-12-01 00:00:00

abstract：:Recent studies have suggested an association between a deletion (D) variant of the angiotensin-converting-enzyme (ACE) gene and diabetic nephropathy. However, this finding has not been confirmed by all investigators. Furthermore, an M235T variant of the angiotensinogen (AGT) gene has been associated with hypertension,...

journal_title：Diabetologia

authors： Ringel J,Beige J,Kunz R,Distler A,Sharma AM

更新日期：1997-02-01 00:00:00

abstract：:Factor VIII-related antigen and von Willebrand factor are synthesised by and released from vascular endothelium. Acute increases in the plasma concentration of these proteins may reflect endothelial cell damage. We have thus measured the plasma concentration of factor VIII-related antigen and von Willebrand factor, to...

journal_title：Diabetologia

authors： Greaves M,Pickering C,Knight G,Boulton AJ,Ball J,Ward JD,Preston FE

更新日期：1987-03-01 00:00:00

abstract：:Stroke incidence, case fatality and mortality in diabetic patients were compared to non-diabetic subjects in a 35-74-year-old population in northern Sweden (target population 241,000). During an 8-year period, 1,544 stroke events in diabetic patients and 4,826 events in non-diabetic subjects were recorded. The crude i...

journal_title：Diabetologia

authors： Stegmayr B,Asplund K

更新日期：1995-09-01 00:00:00

abstract：AIMS/HYPOTHESIS:Oral administration of antigen can induce immunological tolerance. Insulin is a key autoantigen in childhood type 1 diabetes. Here, oral insulin was given as antigen-specific immunotherapy before the onset of autoimmunity in children from age 6 months to assess its safety and immune response actions on ...

journal_title：Diabetologia

authors： Assfalg R,Knoop J,Hoffman KL,Pfirrmann M,Zapardiel-Gonzalo JM,Hofelich A,Eugster A,Weigelt M,Matzke C,Reinhardt J,Fuchs Y,Bunk M,Weiss A,Hippich M,Halfter K,Hauck SM,Hasford J,Petrosino JF,Achenbach P,Bonifacio E,

更新日期：2021-01-30 00:00:00

abstract：AIMS/HYPOTHESIS:Abnormal gut microbiota and blood metabolome profiles have been reported both in children and adults with uncomplicated type 1 diabetes as well as in adults with type 1 diabetes and advanced stages of diabetic nephropathy. In this study we aimed to investigate the gut microbiota and a panel of targeted ...

journal_title：Diabetologia

authors： Winther SA,Henriksen P,Vogt JK,Hansen TH,Ahonen L,Suvitaival T,Hein Zobel E,Frimodt-Møller M,Hansen TW,Hansen T,Parving HH,Legido-Quigley C,Rossing P,Pedersen O

更新日期：2020-12-01 00:00:00

abstract：:A potent high-titre glucagon antibody pool was used to induce a state of acute glucagon deficiency in order to investigate the importance of glucagon in maintaining euglycaemia in the fed and fasted anaesthetised rat. Binding characteristics of the antiserum and evidence of its neutralisation of the biological effects...

journal_title：Diabetologia

authors： Tan K,Tsiolakis D,Marks V

更新日期：1985-07-01 00:00:00

abstract：AIMS/HYPOTHESIS:The relevance of the OGTT in predicting type 2 diabetes is unclear. We assessed the performance of 14 OGTT glucose traits in type 2 diabetes prediction. METHODS:We studied 2,603 and 2,386 Europeans from the Botnia study and Malmö Prevention Project (MPP) cohorts with baseline OGTT data. Over a follow-u...

journal_title：Diabetologia

authors： Alyass A,Almgren P,Akerlund M,Dushoff J,Isomaa B,Nilsson P,Tuomi T,Lyssenko V,Groop L,Meyre D

更新日期：2015-01-01 00:00:00

abstract：:AMP-activated protein kinase (AMPK) serves as a major regulator of energy homeostasis and is activated by different glucose-lowering agents. Indeed, AMPK has been identified as an attractive target for the development of innovative molecules to treat type 2 diabetes. In this issue of Diabetologia (doi: ...

journal_title：Diabetologia

authors： Miele C,Beguinot F

更新日期：2012-05-01 00:00:00

abstract：:The nerve fibre loss, atrophy and injury of diabetic peripheral polyneuropathy and their responses to metabolic intervention have been studied by morphometric analysis of sural nerve biopsies. The magnitudes and sources of intra- and inter-individual variation in these morphometric measures have not been investigated ...

journal_title：Diabetologia

authors： Sima AA,Brown MB,Prashar A,Chakrabarti S,Laudadio C,Greene DA

更新日期：1992-06-01 00:00:00

abstract：:C-peptide was determined in 24-h urine collections and in fasting plasma of 27 Type 1 (insulin-dependent) diabetic children (duration of disease 0-6 years) and in 11 matched normal children. Grouping the patients according to duration of disease from onset to 6 years, it was found that in the first year of disease the...

journal_title：Diabetologia

authors： Aurbach-Klipper J,Sharph-Dor R,Heding LG,Karp M,Laron Z

更新日期：1983-02-01 00:00:00

abstract：:We have studied the presence of GAD65 autoantibodies in women with insulin-dependent diabetes mellitus (IDDM) (n = 28) or gestational diabetes (GDM) (n = 139) diagnosed during pregnancy and investigated the temporal relationship between these autoantibodies and the subsequent recurrence or development of IDDM. Among t...

journal_title：Diabetologia

authors： Petersen JS,Dyrberg T,Damm P,Kühl C,Mølsted-Pedersen L,Buschard K

更新日期：1996-11-01 00:00:00

abstract：AIMS/HYPOTHESIS:Increased oxidative-nitrosative stress, poly(ADP-ribose) polymerase (PARP) activation and subsequent cellular damage play important roles in the complications of both diabetes mellitus and pregnancy. Our aim was to investigate nitrative stress and PARP activity levels during normal and gestational diabe...

journal_title：Diabetologia

authors： Horváth EM,Magenheim R,Kugler E,Vácz G,Szigethy A,Lévárdi F,Kollai M,Szabo C,Lacza Z

更新日期：2009-09-01 00:00:00

abstract：AIMS/HYPOTHESIS:We investigated the potential effects of the Continuous Glucose Monitoring System (CGMS), as compared with self-monitoring of blood glucose, on glycaemic control in children with type 1 diabetes. METHODS:The following electronic databases were searched throughout June 2007: MEDLINE, EMBASE and The Coch...

journal_title：Diabetologia

authors： Golicki DT,Golicka D,Groele L,Pankowska E

更新日期：2008-02-01 00:00:00

abstract：AIMS/HYPOTHESIS:Satellite cells are responsible for postnatal skeletal muscle regeneration. It has been demonstrated that mouse satellite cells behave as multipotent stem cells. We studied the differentiation capacities of human satellite cells and evaluated the effect of the insulin sensitiser rosiglitazone, a well kn...

journal_title：Diabetologia

authors： De Coppi P,Milan G,Scarda A,Boldrin L,Centobene C,Piccoli M,Pozzobon M,Pilon C,Pagano C,Gamba P,Vettor R

更新日期：2006-08-01 00:00:00

abstract：AIMS/HYPOTHESIS:The thiazolidinedione (TZD) rosiglitazone is a peroxisome proliferator-activated receptor-gamma agonist that induces adipocyte differentiation and, hence, lipid accumulation. This is in apparent contrast to the long-term glucose-lowering, insulin-sensitising effect of rosiglitazone. We tested whether th...

journal_title：Diabetologia

authors： Wang P,Renes J,Bouwman F,Bunschoten A,Mariman E,Keijer J

更新日期：2007-03-01 00:00:00

abstract：AIMS/HYPOTHESIS:MicroRNAs are key regulators of gene expression involved in health and disease. The goal of our study was to investigate the global changes in beta cell microRNA expression occurring in two models of obesity-associated type 2 diabetes and to assess their potential contribution to the development of the ...

journal_title：Diabetologia

authors： Nesca V,Guay C,Jacovetti C,Menoud V,Peyot ML,Laybutt DR,Prentki M,Regazzi R

更新日期：2013-10-01 00:00:00

abstract：:The NOD mouse, which shows many features of human IDDM, is extensively used to evaluate the role of T lymphocytes in the pathogenesis of autoimmune diabetes. The development of diabetes in this model appears to be controlled by a finely tuned immunoregulatory balance between autoaggressive T cells and regulatory immun...

journal_title：Diabetologia

authors： Sempé P,Richard MF,Bach JF,Boitard C

更新日期：1994-04-01 00:00:00

abstract：AIMS/HYPOTHESIS:Exposure to sunlight has the potential to suppress metabolic dysfunction and obesity. We previously demonstrated that regular exposure to low-doses of ultraviolet radiation (UVR) reduced weight gain and signs of diabetes in male mice fed a high-fat diet, in part via release of nitric oxide from skin. He...

journal_title：Diabetologia

authors： Dhamrait GK,Panchal K,Fleury NJ,Abel TN,Ancliffe MK,Crew RC,Croft K,Fernandez BO,Minnion M,Hart PH,Lucas RM,Mark PJ,Feelisch M,Weller RB,Matthews V,Gorman S

更新日期：2020-01-01 00:00:00

abstract：AIMS/HYPOTHESIS:In type 2 diabetic patients we compared 9 months of combination therapy with insulin glargine and metformin with 9 months of NPH insulin combined with metformin. The primary focus was changes in HbA(1c); secondary focus was diurnal glucose profiles and symptomatic hypoglycaemia. METHODS:In this investi...

journal_title：Diabetologia

authors： Yki-Järvinen H,Kauppinen-Mäkelin R,Tiikkainen M,Vähätalo M,Virtamo H,Nikkilä K,Tulokas T,Hulme S,Hardy K,McNulty S,Hänninen J,Levänen H,Lahdenperä S,Lehtonen R,Ryysy L

更新日期：2006-03-01 00:00:00

abstract：:The concentrations of zinc, copper, and chromium in liver, kidney, muscle, bone and serum from control normoinsulinaemic and hyperinsulinaemic sand rats (Psammomys obesus) and from untreated spontaneously hyperinsulinaemic-hyperglycaemic sand rats were compared. A chronic hyperinsulinaemic-hyperglycaemic state was ass...

journal_title：Diabetologia

authors： Raz I,Adler JH,Havivi E

更新日期：1988-05-01 00:00:00