Abstract:
:Stroke incidence, case fatality and mortality in diabetic patients were compared to non-diabetic subjects in a 35-74-year-old population in northern Sweden (target population 241,000). During an 8-year period, 1,544 stroke events in diabetic patients and 4,826 events in non-diabetic subjects were recorded. The crude incidence of stroke was 1,000 per 100,000 in the diabetic men vs 247 in the non-diabetic men (relative risk 4.1; 95% confidence interval 3.2-5.2). Among diabetic women, the crude incidence was 757 per 100,000 and 152 in non-diabetic women (relative risk 5.8; 95% confidence interval 3.7-6.9). The 28-day case fatality among men was similar in the diabetic and non-diabetic stroke patients (18.6 vs 17.1%; p = 0.311), but significantly higher in diabetic women compared with non-diabetic women (22.2 vs 17.9%; p = 0.02). When compared with the non-diabetic population, the overall mortality from stroke in the diabetic population (first and recurrent) was 4.4-times higher in male and 5.1-times higher in the female patients. Hypertension, atrial fibrillation, heart failure or myocardial infarction were all significantly more common in diabetic than in non-diabetic stroke patients. The population attributable risk, a crude estimate of all strokes ascribed to diabetes mellitus, was 18% in men and 22% in women. In Sweden, about 50 strokes are annually directly attributed to diabetes in a population of 100,000 in this age group.
journal_name
Diabetologiajournal_title
Diabetologiaauthors
Stegmayr B,Asplund Kdoi
10.1007/BF00402176subject
Has Abstractpub_date
1995-09-01 00:00:00pages
1061-8issue
9eissn
0012-186Xissn
1432-0428journal_volume
38pub_type
杂志文章相关文献
DIABETOLOGIA文献大全abstract:AIMS/HYPOTHESIS:We evaluated the secular trend of glycaemic control in individuals with type 2 diabetes in developing countries, where data are limited. METHODS:The International Diabetes Management Practices Study provides real-world evidence of patient profiles and diabetes care practices in developing countries in ...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-019-05078-3
更新日期:2020-04-01 00:00:00
abstract:AIMS/HYPOTHESIS:Although the variable number tandem repeat (VNTR) minisatellite 5' to the insulin gene is among the most studied polymorphisms in diabetes, the relationships between VNTR variation, diabetes-related traits and predisposition to type 2 diabetes remain unclear. Since inadequate sample size is likely to ha...
journal_title:Diabetologia
pub_type: 杂志文章,多中心研究
doi:10.1007/s00125-005-1737-z
更新日期:2005-05-01 00:00:00
abstract:AIMS/HYPOTHESIS:Sphingolipids play important roles in beta cell physiology, by regulating proinsulin folding and insulin secretion and in controlling apoptosis, as studied in animal models and cell cultures. Here we investigate whether sphingolipid metabolism may contribute to the pathogenesis of human type 1 diabetes ...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-018-4614-2
更新日期:2018-07-01 00:00:00
abstract::We have developed a mouse monoclonal antibody against rat/mouse islet amyloid polypeptide (IAPP). The antibody recognises an epitope in the N-terminal part of the molecule, which is conserved between different species. The antibody immunohistochemically labelled beta cells in normal islets of most different mammalian ...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s001250050751
更新日期:1997-07-01 00:00:00
abstract:AIMS/HYPOTHESIS:Intensive glucose control reduces the risk of vascular complications while increasing the risk of severe hypoglycaemia at a group level. We sought to estimate individual beneficial and adverse effects of intensive glucose control in patients with type 2 diabetes. METHODS:We performed a post hoc analysi...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-016-4082-5
更新日期:2016-12-01 00:00:00
abstract:AIMS/HYPOTHESIS:The aim of this study was to provide evidence that the anterior chamber of the eye serves as a novel clinical islet implantation site. METHODS:In a preclinical model, allogeneic pancreatic islets were transplanted into the anterior chamber of the eye of a baboon model for diabetes, and metabolic and op...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-011-2091-y
更新日期:2011-05-01 00:00:00
abstract:AIMS/HYPOTHESIS:Brain natriuretic peptide (BNP) is a potent vasorelaxing and natriuretic peptide that is secreted from the heart and has cardioprotective properties. We have previously generated hypotensive transgenic mice (BNP-Tg mice) that overproduce BNP in the liver, which is released into the circulation. Using th...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-006-0352-y
更新日期:2006-10-01 00:00:00
abstract:AIM/HYPOTHESIS:Although mitochondrial oxidative phosphorylation (OxPhos) dysfunction is believed to be responsible for beta cell dysfunction in insulin resistance and mitochondrial diabetes, the mechanisms underlying progressive beta cell failure caused by defective mitochondrial OxPhos are largely unknown. METHODS:We...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-015-3506-y
更新日期:2015-04-01 00:00:00
abstract:AIMS/HYPOTHESIS:Bariatric surgery consistently induces remission of type 2 diabetes. We tested whether there are diabetes-specific mechanisms in addition to weight loss. METHODS:We studied 25 morbidly obese patients (BMI 51.7 ± 1.5 kg/m(2) [mean ± SEM]), 13 with non-insulin-treated type 2 diabetes (HbA(1c) 7.1 ± 0.5% ...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-011-2193-6
更新日期:2011-08-01 00:00:00
abstract::Free-radical scavengers and inhibitors of tumour necrosis factor-alpha (TNF-alpha) such as N-acetylcysteine and pentoxifylline have been shown to inhibit the development of peripheral neuropathy in streptozotocin(STZ)-induced diabetic rats. In this study we examined the effect of troglitazone, an anti-diabetic thiazol...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s001250051072
更新日期:1998-11-01 00:00:00
abstract::Insulin secretion was stimulated and cyclic adenosine 3', 5'-monophosphate (cAMP) levels were elevated in isolated rat islets by 27.5 mmol/l glucose. Alloxan caused a dose-dependent decrease in both variables with complete obliteration of insulin release at a concentration of 1.25 mmol/l. D-glucose, in the presence or...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF01225460
更新日期:1979-02-01 00:00:00
abstract:AIMS/HYPOTHESIS:Carbohydrate-free diet prevents hyperglycaemia and beta cell destruction in the New Zealand Obese (NZO) mouse model. Here we have used a sequential dietary regimen to dissociate the effects of obesity and hyperglycaemia on beta cell function and integrity, and to study glucose-induced alterations of key...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-010-1973-8
更新日期:2011-03-01 00:00:00
abstract::The purpose of this study was to investigate whether young insulin-dependent diabetic patients still develop peripheral nerve dysfunction when using modern multiple insulin injection therapy and to elucidate if this correlated with various disease parameters. Seventy-five patients, 7 to 20 years old with a duration of...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF00401840
更新日期:1995-06-01 00:00:00
abstract:AIMS/HYPOTHESIS:Several investigations have shown that the renal medulla has a greater capacity to generate nitric oxide than the renal cortex. To further evaluate the changes of nitric oxide synthesis in the kidney, particularly in the outer medulla, in disorders involving fluid and electrolyte imbalances, we sought t...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s001250051354
更新日期:2000-05-01 00:00:00
abstract::The antiprotozoal drug pentamidine can be toxic to islet cells in vivo and in vitro. Rat islets were exposed to pentamidine (mesylate and isethionate salts) and six other structurally related diamidines. The beta-cell response to arginine + theophylline was suppressed by pentamidine (10(-2) mmol/l) while the glucagon ...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF00283144
更新日期:1985-06-01 00:00:00
abstract::To learn more about the preclinical phase of IDDM we observed for a median period of 46.5 months (range 0.5-69 months) a group of 57 siblings positive for ICA and/or IAA when first screened within 6 months of the diagnosis of the proband. Sequential blood samples and IVGTTs were obtained at intervals of 6-12 months. S...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s001250050122
更新日期:1994-04-01 00:00:00
abstract::In diabetic nephropathy, expression of glycosaminoglycan side chains of heparan sulphate proteoglycan in the glomerular basement membrane is reduced proportionally to the degree of proteinuria. We performed a cross-sectional study to evaluate whether non-vascular basement membranes also show a decrease in heparan sulp...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s001250050989
更新日期:1998-07-01 00:00:00
abstract::Multiple epidemiological studies have documented an association between metformin, used for treatment of type 2 diabetes, and reduced cancer incidence and mortality. Cell line models may not accurately reflect the effects of metformin in the clinical setting. Moreover, findings from animal model studies have been inco...
journal_title:Diabetologia
pub_type: 杂志文章,评审
doi:10.1007/s00125-017-4372-6
更新日期:2017-09-01 00:00:00
abstract:AIMS/HYPOTHESIS:Type I (insulin-dependent) diabetes mellitus is associated with an increased extracellular volume. Sodium restriction might seem a logical form of treatment but data on its renal effects is conflicting. We therefore studied the effects of sodium restriction on renal haemodynamics in uncomplicated Type I...
journal_title:Diabetologia
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/s00125-001-0763-8
更新日期:2002-04-01 00:00:00
abstract:AIMS/HYPOTHESIS:We sought to assess the role of coronary artery calcification (CAC) and its progression in predicting incident coronary artery disease (CAD) in individuals with type 1 diabetes using data from the Pittsburgh Epidemiology of Diabetes Complications (EDC) Study. METHODS:The present study examined 292 part...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-018-4764-2
更新日期:2019-02-01 00:00:00
abstract::MODY is an early-onset monogenic form of diabetes. Correctly identifying MODY is of considerable importance as diagnosing the specific genetic subtype can inform the optimal treatment, with many patients being able to discontinue unnecessary insulin treatment. Diagnostic molecular genetic testing to confirm MODY is ex...
journal_title:Diabetologia
pub_type: 评论,社论
doi:10.1007/s00125-017-4213-7
更新日期:2017-04-01 00:00:00
abstract::Lack of insulin receptors in mice is associated with near-normal intrauterine growth, unlike patients with leprechaunism, in whom growth deficiency is a prominent clinical feature. Genetic crosses of insulin receptor- and insulin-like growth-factor-1 (IGF-1) receptor-deficient mice indicate, however, that insulin rece...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s001250050886
更新日期:1998-02-01 00:00:00
abstract::Ciglitazone is orally active in preventing and reversing the hyperglycaemic syndrome in C57BL/6J-ob/ob mice and it is only mildly and transiently hypoglycaemic in lean littermates (C57BL/6J-+/?). Its effect on glucose disposal in vivo was estimated by injecting glucose-6-3H/14C and following the specific activity of r...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF00284462
更新日期:1983-12-01 00:00:00
abstract:AIMS/HYPOTHESIS:Fulminant type 1 diabetes, which is characterised by a markedly acute onset of diabetes and an absence of islet-related autoantibodies, accounts for 20% of type 1 diabetes in Japan. We aimed to clarify the contribution of the HLA subtype to fulminant type 1 diabetes in Japanese. METHODS:We determined t...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-004-1626-x
更新日期:2005-02-01 00:00:00
abstract:AIMS/HYPOTHESIS:Diabetes increases the risk of premature death and reduces work productivity. We estimated the impact of diabetes in China in terms of mortality, years of life lost, and productivity-adjusted life years (PALYs) lost in the Chinese population. METHODS:Life table modelling was used with simulated follow-...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-019-4875-4
更新日期:2019-07-01 00:00:00
abstract::In the present study, human islets were isolated by collagenase digestion from the pancreases of three kidney donors. Maintainance of the islets in tissue culture enabled insulin release, glucose oxidation and Ca2+ -calmodulin-dependent protein phosphorylation to be determined using the same islets. Increasing glucose...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF00279924
更新日期:1985-02-01 00:00:00
abstract::Efforts to phenotype pancreatic islets have contributed tremendously to our present understanding of endocrine function and diabetes. A continued evolution in approaches to study islet physiology is important given the need to establish reference points for mature islet functionality, understanding biological variatio...
journal_title:Diabetologia
pub_type: 杂志文章,评审
doi:10.1007/s00125-020-05159-8
更新日期:2020-10-01 00:00:00
abstract::It has been shown that, in streptozotocin diabetic rats, protamine-retarded insulin administered in vivo stimulates intimal hyperplasia in balloon-injured carotid artery. The aim of this study was to evaluate the influence of protamine on cultured human vascular smooth muscle cells (h VSMC), by observing its effects o...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s001250050644
更新日期:1997-01-01 00:00:00
abstract::The spontaneous hypertensive rat is an animal model characterized by a syndrome of hypertension, insulin resistance and hyperinsulinaemia. To elucidate whether in analogy to other insulin resistant animal models an inactivity of the insulin receptor kinase or an alteration of the glucose transporter (GLUT 4) level in ...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF00429089
更新日期:1992-08-01 00:00:00
abstract:AIMS/HYPOTHESIS:We aimed to examine risk factors for, and differences in, renal failure in diabetic patients from 10 centres. METHODS:Risk factors for renal failure were examined in 3,558 diabetic patients who did not have renal disease at baseline in the WHO Multinational Study of Vascular Disease in Diabetes (WHO MS...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/pl00002939
更新日期:2001-09-01 00:00:00