Genetic variants of the renin-angiotensin system, diabetic nephropathy and hypertension.

abstract：:The nerve fibre loss, atrophy and injury of diabetic peripheral polyneuropathy and their responses to metabolic intervention have been studied by morphometric analysis of sural nerve biopsies. The magnitudes and sources of intra- and inter-individual variation in these morphometric measures have not been investigated ...

journal_title：Diabetologia

authors： Sima AA,Brown MB,Prashar A,Chakrabarti S,Laudadio C,Greene DA

更新日期：1992-06-01 00:00:00

abstract：AIMS/HYPOTHESIS:Mesenchymal stem cells (MSCs) can exert an immunosuppressive effect on any component of the immune system, including dendritic cells (DCs), by direct contact, the release of soluble markers and extracellular vesicles (EVs). We evaluated whether MSCs and MSC-derived EVs have an immunomodulatory effect on...

journal_title：Diabetologia

authors： Favaro E,Carpanetto A,Caorsi C,Giovarelli M,Angelini C,Cavallo-Perin P,Tetta C,Camussi G,Zanone MM

更新日期：2016-02-01 00:00:00

abstract：AIMS/HYPOTHESIS:The aim of this study was to examine the effects of childhood BMI growth dynamics on the risk of developing young adult-onset type 1 and type 2 diabetes. METHODS:Finnish national healthcare registers were used to identify individuals with diabetes diagnosed between 1992 and 1996 at 15-39 years of age. ...

journal_title：Diabetologia

authors： Lammi N,Moltchanova E,Blomstedt PA,Tuomilehto J,Eriksson JG,Karvonen M

更新日期：2009-03-01 00:00:00

abstract：AIMS/HYPOTHESIS:Abnormal serum IGF-1 levels are associated with an increased risk of type 2 diabetes and cardiovascular disease. However, the causal role of IGF-1 levels within the normal range in cardiometabolic disease remains unclear. We employed Mendelian randomisation to explore the associations between geneticall...

journal_title：Diabetologia

authors： Larsson SC,Michaëlsson K,Burgess S

更新日期：2020-09-01 00:00:00

abstract：AIMS/HYPOTHESIS:The primary aim of the study was to investigate the risk of developing gestational diabetes in women who were exposed to tobacco smoke in utero. Secondary aims were to assess the risk of obesity and non-gestational diabetes. METHODS:Data were retrieved from the Medical Birth Register of Sweden for wome...

journal_title：Diabetologia

authors： Mattsson K,Källén K,Longnecker MP,Rignell-Hydbom A,Rylander L

更新日期：2013-08-01 00:00:00

abstract：:A follow-up study was carried out to determine whether reduced fetal growth is associated with the development of impaired glucose tolerance in men and women aged 50 years. Standard oral glucose tolerance tests were carried out on 140 men and 126 women born in Preston (Lancashire, UK) between 1935 and 1943, whose size...

journal_title：Diabetologia

authors： Phipps K,Barker DJ,Hales CN,Fall CH,Osmond C,Clark PM

更新日期：1993-03-01 00:00:00

abstract：:The glucose phosphorylating enzyme glucokinase plays an important role in the regulation of glucose homeostasis. Studies in rodents indicate that pancreatic Beta cells and hepatocytes express different isoforms of this protein as a consequence of the presence of tissue-specific promoters and exon 1 sequences which are...

journal_title：Diabetologia

authors： Nishi S,Stoffel M,Xiang K,Shows TB,Bell GI,Takeda J

更新日期：1992-08-01 00:00:00

abstract：:The presence of HLA-DR 3 was analysed in 745 patients with Type 1 (insulin-dependent) diabetes with age at diagnosis between 1-19 years. HLA-DR 3 and/or 4 was found in 678/745 (91%) of the patients. Presence of DR2 with neither DR 3 nor 4 was demonstrated in 15 patients. Patients with HLA-DR 3 without DR 4 presented w...

journal_title：Diabetologia

authors： Ludvigsson J,Samuelsson U,Beauforts C,Deschamps I,Dorchy H,Drash A,Francois R,Herz G,New M,Schober E

更新日期：1986-04-01 00:00:00

abstract：:The physiologically predominant signal for pancreatic beta cells to secrete insulin is glucose. While circulating glucose levels and beta cell glucose metabolism regulate the amount of released insulin, additional signals emanating from other tissues and from neighbouring islet endocrine cells modulate beta cell funct...

journal_title：Diabetologia

authors： Hussain MA,Akalestou E,Song WJ

更新日期：2016-04-01 00:00:00

abstract：AIMS/HYPOTHESIS:The role of infections in the aetiology of Type I diabetes is controversial. Certain enteroviral infections might be involved in triggering the beta-cell destruction but insufficient exposure to early infections might increase the risk. We studied how the number of infections experienced during several ...

journal_title：Diabetologia

authors： Pundziute-Lyckå A,Urbonaite B,Dahlquist G

更新日期：2000-10-01 00:00:00

abstract：AIMS/HYPOTHESIS:Thus far, it is unclear whether lifestyle recommendations for people with diabetes should be different from those for the general public. We investigated whether the associations between lifestyle factors and mortality risk differ between individuals with and without diabetes. METHODS:Within the Europe...

journal_title：Diabetologia

authors： Sluik D,Boeing H,Li K,Kaaks R,Johnsen NF,Tjønneland A,Arriola L,Barricarte A,Masala G,Grioni S,Tumino R,Ricceri F,Mattiello A,Spijkerman AM,van der A DL,Sluijs I,Franks PW,Nilsson PM,Orho-Melander M,Fhärm E,Roland

更新日期：2014-01-01 00:00:00

abstract：:Short- and long-term regulation of hepatic carbohydrate metabolism by insulin-like growth factor II was studied in primary cultures of adult rat hepatocytes and compared to the metabolic potency of insulin. Insulin-like growth factor II stimulated glycogen synthesis from [14C]glucose, uptake of [3H]aminoisobutyric aci...

journal_title：Diabetologia

authors： Hartmann H,Meyer-Alber A,Braulke T

更新日期：1992-03-01 00:00:00

abstract：AIMS/HYPOTHESIS:Activation of the G protein-coupled receptor (GPR)40 by long-chain fatty acids potentiates glucose-stimulated insulin secretion (GSIS) from pancreatic beta cells, and GPR40 agonists are in clinical development for type 2 diabetes therapy. GPR40 couples to the G protein subunit Gα(q/11) but the signallin...

journal_title：Diabetologia

authors： Ferdaoussi M,Bergeron V,Zarrouki B,Kolic J,Cantley J,Fielitz J,Olson EN,Prentki M,Biden T,MacDonald PE,Poitout V

更新日期：2012-10-01 00:00:00

abstract：AIMS/HYPOTHESIS:Interleukin-1beta is a putative mediator of pancreatic beta-cell dysfunction and damage in Type I (insulin-dependent) diabetes mellitus. To better understand the molecular mechanisms involved in IL-1beta effects, we carried out a differential display of mRNA by RT-PCR to identify novel cytokine-regulate...

journal_title：Diabetologia

authors： Chen MC,Schuit F,Eizirik DL

更新日期：1999-10-01 00:00:00

abstract：:The damaging effects of glucose on the cells which contribute to the development of diabetic complications are ill-understood. There are three major hypotheses - the sorbitol pathway, non-enzymatic glycation of proteins and increased oxidative stress - and many examples illustrate inter-connections between the three. ...

journal_title：Diabetologia

authors： Tomlinson DR

更新日期：1999-11-01 00:00:00

abstract：AIMS/HYPOTHESIS:Pregnancies complicated by diabetes have a higher risk of adverse outcomes for mothers and children, including predisposition to disease later in life, e.g. metabolic syndrome and hypertension. We hypothesised that adverse outcomes from diabetic pregnancies may be linked to compromised placental functio...

journal_title：Diabetologia

authors： Salbaum JM,Kruger C,Zhang X,Delahaye NA,Pavlinkova G,Burk DH,Kappen C

更新日期：2011-07-01 00:00:00

abstract：:Recently, we demonstrated that approximately 60% of GLUT 1 in a crude membrane fraction of rat skeletal muscle originates from perineurial sheaths. To study the in vivo regulation of GLUT 1 expression in different tissues in muscles, we measured the level of GLUT 1 in crude muscle membranes and in perineurial sheaths ...

journal_title：Diabetologia

authors： Handberg A,Kayser L,Høyer PE,Micheelsen J,Vinten J

更新日期：1994-05-01 00:00:00

abstract：:The aims of this survey were (1) to estimate the prevalence of known diabetes mellitus in 1988 in Casale Monferrato (Northern Italy); (2) to validate different data sources available in Italy; (3) to identify a population-based cohort of diabetic patients. Multiple independent data sources were used and the capture-re...

journal_title：Diabetologia

authors： Bruno G,Bargero G,Vuolo A,Pisu E,Pagano G

更新日期：1992-09-01 00:00:00

abstract：AIMS/HYPOTHESIS:Augmented oxidative stress induced by hyperglycaemia possibly contributes to the pathogenesis of diabetic complications. Oxidative stress is known to increase the conversion of deoxyguanosine to 8-oxo, 2'-deoxyguanosine in DNA. To investigate the possible contribution of oxidative DNA damage to the path...

journal_title：Diabetologia

authors： Hinokio Y,Suzuki S,Hirai M,Chiba M,Hirai A,Toyota T

更新日期：1999-08-01 00:00:00

abstract：:A nationwide mumps-measles-rubella vaccination was introduced in 1982 in Finland to children aged 1.5 to 6 years and since then mumps has virtually disappeared in the country. We investigated whether this rapid epidemiological change had any impact on antibody activity against mumps virus in Type 1 (insulin-dependent)...

journal_title：Diabetologia

authors： Hyöty H,Hiltunen M,Reunanen A,Leinikki P,Vesikari T,Lounamaa R,Tuomilehto J,Akerblom HK

更新日期：1993-12-01 00:00:00

abstract：:Neurotrophin-3 (NT-3) acts as a target-derived neurotrophic factor for large calibre sensory neurones and plays a role in the maintenance of the adult phenotype of proprioceptive and mechanoreceptive fibres. Large fibre sensory neuropathy is common in diabetes mellitus and the aim of this study was to determine whethe...

journal_title：Diabetologia

authors： Fernyhough P,Diemel LT,Tomlinson DR

更新日期：1998-03-01 00:00:00

abstract：:Insulin action and insulin specific binding to erythrocytes were examined in ten recipients of a pancreatic segment and renal graft (Group 1), in nine non-diabetic kidney recipients (Group 2) and in ten age- and weight-matched healthy control subjects (Group 3). All transplant recipients were normoglycaemic without ne...

journal_title：Diabetologia

authors： Saudek F,Pelikánová T,Bartos V,Reneltová I,Kazdová L,Kovár J,Karasová L

更新日期：1991-08-01 00:00:00

abstract：AIMS/HYPOTHESIS:Monogenic diabetes (MD) might be misdiagnosed as type 1 diabetes. The prevalence of MD among children with apparent type 1 diabetes has not been established. Our aim was to estimate the prevalence of common forms of MD in childhood diabetes. METHODS:We investigated 2,756 children aged 0-14 years with n...

journal_title：Diabetologia

authors： Irgens HU,Molnes J,Johansson BB,Ringdal M,Skrivarhaug T,Undlien DE,Søvik O,Joner G,Molven A,Njølstad PR

更新日期：2013-07-01 00:00:00

abstract：AIMS/HYPOTHESIS:The aim of this study was to investigate whether the higher prevalence of insulin resistance and glucose intolerance in urban compared with rural Indian men is related to their higher adiposity (percentage body fat) and the associated inflammatory state. METHODS:We studied 149 rural, 142 urban slum and...

journal_title：Diabetologia

authors： Yajnik CS,Joglekar CV,Lubree HG,Rege SS,Naik SS,Bhat DS,Uradey B,Raut KN,Shetty P,Yudkin JS

更新日期：2008-01-01 00:00:00

abstract：AIMS/HYPOTHESIS:It has been proposed that muscle fibre type composition and perfusion are key determinants of insulin-stimulated muscle glucose uptake, and alterations in muscle fibre type composition and perfusion contribute to muscle, and consequently whole-body, insulin resistance in people with obesity. The goal of...

journal_title：Diabetologia

authors： Koh HE,van Vliet S,Meyer GA,Laforest R,Gropler RJ,Klein S,Mittendorfer B

更新日期：2021-01-29 00:00:00

abstract：AIMS/HYPOTHESIS:The abnormal intrauterine milieu of intrauterine growth retardation (IUGR) permanently alters gene expression and function of pancreatic beta cells leading to the development of diabetes in adulthood. Expression of the pancreatic homeobox transcription factor Pdx1 is permanently reduced in IUGR islets s...

journal_title：Diabetologia

authors： Pinney SE,Jaeckle Santos LJ,Han Y,Stoffers DA,Simmons RA

更新日期：2011-10-01 00:00:00

abstract：:Most polypeptides originally assigned to a specific organ and a specific effect seem to occur in many different parts of the body, in neurons as well as in endocrine cells. Thus gastrin and insulin, or very similar peptides can be demonstrated in extracts of the vagal nerves and of peripheral somatic nerves. Electrica...

journal_title：Diabetologia

authors： Uvnäs-Wallensten K

更新日期：1981-03-01 00:00:00

abstract：AIMS/HYPOTHESIS:Serum potassium has been found to be a significant predictor of diabetes risk, but the effect of dietary potassium on diabetes risk is not clear. We sought to determine if dietary potassium is associated with risk of incident type 2 diabetes in young adults. METHODS:We used data from the Coronary Arter...

journal_title：Diabetologia

authors： Chatterjee R,Colangelo LA,Yeh HC,Anderson CA,Daviglus ML,Liu K,Brancati FL

更新日期：2012-05-01 00:00:00

abstract：AIMS/HYPOTHESIS:This study sought to identify genes and regions in the human genome that are associated with the acute insulin response to glucose (AIRg), an important predictor of type 2 diabetes, in Hispanic-American participants from the Insulin Resistance Atherosclerosis Family Study (IRAS FS). METHODS:A two-stage...

journal_title：Diabetologia

authors： Rich SS,Goodarzi MO,Palmer ND,Langefeld CD,Ziegler J,Haffner SM,Bryer-Ash M,Norris JM,Taylor KD,Haritunians T,Rotter JI,Chen YD,Wagenknecht LE,Bowden DW,Bergman RN

更新日期：2009-07-01 00:00:00

abstract：AIMS/HYPOTHESIS:Differences in seasonality of birth patterns between the general population and the group who develop Type I (insulin-dependent) diabetes mellitus indicate that environmental factors operating around the antenatal and perinatal period could be important. We investigated whether the same unsual patterns ...

journal_title：Diabetologia

authors： McKinney PA,EURODIAB Seasonality Of Birth Group. Europe and Diabetes.

更新日期：2001-10-01 00:00:00