Abstract:
:Rheological studies were made on the blood of 12 diabetic patients after a period of poor diabetic control (HbA1 12.6 +/- 0.7% (mean +/- SD); mean home capillary blood glucose level 11.7 +/- 1.2 mmol/l), and after at least three months of improved control (HbA1 9.1 +/- 0.4%, p < 0.01; mean home capillary blood glucose level 9.2 +/- 0.6 mmol/l). There were significant decreases in plasma fibrinogen levels (4.1 +/- 0.6 to 3.7 +/- 0.6 g/l, p < 0.01), plasma viscosity (1.31 +/- 0.1 to 1.25 +/- 0.04, p < 0.001), and whole blood viscosity at low (22.8 +/- 2.7 to 20.2 +/- 2.9, p < 0.01) and high shear rates (3.4 +/- 0.2 to 3.1 +/- 0.2, p < 0.01). Ten diabetics with clinically evident complications were matched with diabetics of similar age, sex, duration and current control of diabetes. There were no significant differences in plasma or whole blood viscosities between the two groups. Hyperviscosity in diabetes seems strongly related to hyperglycaemia and to be influenced by the quality of diabetic control.
journal_name
Diabetologiajournal_title
Diabetologiaauthors
Paisey RB,Harkness J,Hartog M,Chadwick Tdoi
10.1007/BF00280518subject
Has Abstractpub_date
1980-10-01 00:00:00pages
345-9issue
4eissn
0012-186Xissn
1432-0428journal_volume
19pub_type
杂志文章相关文献
DIABETOLOGIA文献大全abstract:AIMS/HYPOTHESIS:The aim of this study was to provide evidence that the anterior chamber of the eye serves as a novel clinical islet implantation site. METHODS:In a preclinical model, allogeneic pancreatic islets were transplanted into the anterior chamber of the eye of a baboon model for diabetes, and metabolic and op...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-011-2091-y
更新日期:2011-05-01 00:00:00
abstract::The effect of acute lowering of arterial blood pressure upon kidney function in nephropathy was studied in 13 patients with long-term Type 1 (insulin-dependent) diabetes. Ten normal subjects (six normotensive and four hypertensive) and five short-term Type 1 diabetic patients without nephropathy served as controls. Re...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF00276965
更新日期:1984-12-01 00:00:00
abstract:AIMS/HYPOTHESIS:Glucose-dependent insulinotropic polypeptide (GIP) is a peptide hormone released from gut K cells. While the predominant form is GIP(1-42), a shorter form, GIP(1-30), is produced by pancreatic alpha cells and promotes insulin secretion in a paracrine manner. Here, we elucidated whether GIP(1-30) express...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-015-3842-y
更新日期:2016-03-01 00:00:00
abstract:AIMS/HYPOTHESIS:Hyperlipidaemia is an independent risk factor for the progression of diabetic nephropathy, but its molecular mechanism remains elusive. We investigated in mice how diabetes and hyperlipidaemia cause renal lesions separately and in combination, and the involvement of Toll-like receptor 4 (TLR4) in the pr...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-012-2578-1
更新日期:2012-08-01 00:00:00
abstract::Significant progress has been made in recent years in the characterisation of the signal pathways of beta cell dysfunction and death in the pathogenesis of type 2 diabetes. Glucolipotoxicity acts as an exogenous factor whereas oxidative stress and endoplasmic reticulum stress may result from the processes of signal re...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-010-1839-0
更新日期:2010-10-01 00:00:00
abstract:AIMS/HYPOTHESIS:Currently, three categories of measures are used to assess cardiovascular autonomic dysfunction: measures of the Ewing-test, measures of heart-rate variability, and measures of baroreflex sensitivity. We studied the determinants of these measures obtained from cardiovascular autonomic function tests in ...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s001250051344
更新日期:2000-05-01 00:00:00
abstract::Glucagon-like peptide-1 and glucagon-like peptide-2 are encoded by the m-RNA of pancreatic preproglucagon. They show high conservation in different species and substantial sequence homology to glucagon. Because no definite biological activity of these peptides has been reported, we investigated the effect of synthetic...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF00291980
更新日期:1985-09-01 00:00:00
abstract::The liver has a central role in the regulation of systemic glucose and lipid fluxes during feeding and fasting and also relies on these substrates for its own energy needs. These parallel requirements are met by coordinated control of carbohydrate and lipid fluxes into and out of the Krebs cycle, which is highly tuned...
journal_title:Diabetologia
pub_type: 杂志文章,评审
doi:10.1007/s00125-016-3940-5
更新日期:2016-06-01 00:00:00
abstract:AIMS/HYPOTHESIS:The aim of this study was to assess the predictive role of autonomic reactivity in body weight loss induced by gastric bypass. METHODS:A group of 22 morbidly obese subjects, who were due to undergo a gastric bypass, were submitted, before surgery, to a euglycaemic-hyperinsulinaemic clamp, during which ...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-005-1792-5
更新日期:2005-07-01 00:00:00
abstract::Isolated pancreatic islets of normoglycemic sand rats do not respond to 2.5 mM glucose with an enhanced glucagon secretion, which could be observed in normal Wistar rats. Arginine stimulates glucagon release in the presence of 2.5 mM glucose in Wistar rats as well as in sand rats. The secretion pattern is not caused b...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF00422820
更新日期:1975-02-01 00:00:00
abstract:AIMS/HYPOTHESIS:In order to identify type 2 diabetes disease susceptibility gene(s) in a Japanese population, we applied a region-wide case-control association test to the 20.4 Mb region between D3S1293 and D3S2319 on chromosome 3p24.3-22.1, supported by linkage to type 2 diabetes and its related traits in Japanese and...
journal_title:Diabetologia
pub_type: 杂志文章,多中心研究
doi:10.1007/s00125-007-0631-2
更新日期:2007-06-01 00:00:00
abstract::AbstractIn Table 1 the data for age group, sex and Townsend index were incorrectly identified as mean ± SD instead of n (%). The table is corrected here. ...
journal_title:Diabetologia
pub_type: 杂志文章,已发布勘误
doi:10.1007/s00125-018-4620-4
更新日期:2018-07-01 00:00:00
abstract::Decreased release of nitric oxide from damaged endothelium is responsible for the impaired endothelium-dependent vasodilator responses found in animal models of vascular disease. Dietary supplementation with fish oils has been shown to augment endothelium-dependent relaxations, principally by improving the release of ...
journal_title:Diabetologia
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/BF00399090
更新日期:1993-01-01 00:00:00
abstract::Of 89 pancreas transplants performed in 77 diabetic patients (43 with and 34 without previous kidney transplants), 53 were from cadaver and 36 from related donors. To date, 64 patients (83%) are alive and 27 (35%) have functioning grafts (14 greater than 1 year), including 0 out of 3 duct-ligated, 3 out of 15 open-duc...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF00275675
更新日期:1984-07-01 00:00:00
abstract::The involvement of nitric oxide as an intracellular messenger in the control of insulin secretion from pancreatic Beta cells was studied in rat islets of Langerhans by measuring: (i) nitric oxide generation in response to physiological insulin secretagogues; (ii) the effects of inhibitors of nitric oxide synthesis on ...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF02221676
更新日期:1992-11-01 00:00:00
abstract:AIMS/HYPOTHESIS:We aimed to assess the risk factors for diabetes mellitus, by age and sex in Canada and to recommend prevention and control strategies. METHODS:This study was based on the Canadian 1996-1997 National Population Health Survey which comprised 69 494 participants aged 12 years and over. The prevalence of ...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s001250100648
更新日期:2001-10-01 00:00:00
abstract::The effect of endogenous hyperinsulinaemia, produced by syngeneic transplantation of rat insulinoma at an extrapancreatic site, on pancreatic insulin and pancreatic polypeptide has been examined by radioimmunoassay and immunohistochemistry. Twenty days after subcutaneous transplantation, tumour-bearing rats exhibited ...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF00273864
更新日期:1985-03-01 00:00:00
abstract:AIMS/HYPOTHESIS:The humoral part of the immune system, including autoantibodies, is known to predict manifest Type I (insulin-dependent) diabetes mellitus in first-degree relatives but the cell-mediated immune process preceding the manifest disease still is not known. The aim of this investigation was to estimate the i...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s001250051372
更新日期:2000-06-01 00:00:00
abstract:AIMS/HYPOTHESIS:The thiazolidinedione (TZD) rosiglitazone is a peroxisome proliferator-activated receptor-gamma agonist that induces adipocyte differentiation and, hence, lipid accumulation. This is in apparent contrast to the long-term glucose-lowering, insulin-sensitising effect of rosiglitazone. We tested whether th...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-006-0565-0
更新日期:2007-03-01 00:00:00
abstract:AIMS/HYPOTHESIS:The molecular factors that cause an acute wound in diabetic patients to become chronic have not yet been established. Wound healing is known to require a balance between the accumulation of collagenous and non-collagenous extracellular matrix components and their remodelling by matrix metalloproteinases...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-002-0868-8
更新日期:2002-07-01 00:00:00
abstract:AIMS/HYPOTHESIS:The gene encoding the beta(3)-subunit (GPIIIa) of the platelet alpha(2)beta(3)-integrin (fibrinogen receptor) shows a polymorphism PlA1/A2 with the A2 allele putatively associated with an increased risk of acute ischaemic events. This study investigated whether Type 2 diabetes as a particular macrovascu...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-003-1132-6
更新日期:2003-07-01 00:00:00
abstract::This paper presents a survey of the biological potencies of a variety of naturally-occurring and semi-synthetic insulin analogues and a study of the joint biological action of some of these materials with native insulin. Biological activity was tested on isolated rat fat cells using lipogenesis from glucose as the met...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF01219650
更新日期:1978-11-01 00:00:00
abstract:AIMS/HYPOTHESIS:Acute insulinaemia activates the sympathetic drive in a nonuniform manner. The extent and nature of such activation in type 2 diabetic patients who do not have neuropathy have not yet been addressed despite evidence relating sympathetic activation to cardiovascular risk. We planned to determine the magn...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-004-1601-6
更新日期:2005-01-01 00:00:00
abstract:AIMS/HYPOTHESIS:The workplace is a potentially important arena for prevention of type 2 diabetes and the first step is to identify occupations where the disease is common and/or risk is high. Therefore, our aim was to analyse incidence and prevalence of type 2 diabetes across all occupational groups in Sweden. METHODS...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-019-04997-5
更新日期:2020-01-01 00:00:00
abstract:AIMS/HYPOTHESIS:Platelet activation, endothelial dysfunction and inflammation may be involved in early stages of diabetic microangiopathy. We therefore investigated patients with Type 1 diabetes mellitus, without ( n=19) and with ( n=20) microangiopathy, matched for glycaemic control and duration of disease, and matche...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-004-1352-4
更新日期:2004-03-01 00:00:00
abstract:AIMS/HYPOTHESIS:Depression and glucose intolerance commonly co-occur among non-pregnant individuals; however, the temporal relationship between gestational diabetes (GDM) and depression during pregnancy and the postpartum period is less understood. Our objective was to assess longitudinal associations between depressio...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-016-4086-1
更新日期:2016-12-01 00:00:00
abstract:AIMS/HYPOTHESIS:Levels of ideal cardiovascular health (ICH) and incident type 2 diabetes mellitus have not been examined in a multiethnic population. We assessed the total and race/ethnicity-specific incidence of diabetes based on American Heart Association (AHA) ICH components. METHODS:Incident diabetes was assessed ...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-016-4003-7
更新日期:2016-09-01 00:00:00
abstract:AIMS/HYPOTHESIS:Increased NEFA levels, characteristic of type 2 diabetes mellitus, contribute to skeletal muscle insulin resistance. While NEFA-induced insulin resistance was formerly attributed to decreased glycolysis, it is likely that glucose transport is the rate-limiting defect. Recently, the plant-derived sugar a...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-012-2527-z
更新日期:2012-06-01 00:00:00
abstract:AIMS/HYPOTHESIS:The study aimed to assess the incidence, age of onset, survival and relative hazard of dementia in well-categorised community-based patients with type 2 diabetes compared with a matched cohort of individuals without diabetes. METHODS:A longitudinal observational study was undertaken involving 1291 part...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-016-4127-9
更新日期:2017-01-01 00:00:00
abstract::Polycystic ovary syndrome (PCOS), the most common hormonal disorder among women of reproductive age, has various metabolic and reproductive consequences. Metformin was originally shown to lower testosterone levels in women with PCOS in the 1990s, an effect presumably related to its insulin sensitising actions. However...
journal_title:Diabetologia
pub_type: 社论
doi:10.1007/s00125-017-4306-3
更新日期:2017-09-01 00:00:00