Impaired autoregulation of glomerular filtration rate in type 1 (insulin-dependent) diabetic patients with nephropathy.

abstract：UNLABELLED:AIMS/HYPOTHESIS. We investigated whether the reported HLA-DQ/DR restricted male-to-female (M:F) excess in Type I (insulin-dependent) diabetes mellitus also exists in Belgian patients, is specific for immune-mediated diabetes, remains genotype-restricted after adjustment for age at diagnosis, and is associate...

journal_title：Diabetologia

authors： Weets I,Van Autreve J,Van der Auwera BJ,Schuit FC,Du Caju MV,Decochez K,De Leeuw IH,Keymeulen B,Mathieu C,Rottiers R,Dorchy H,Quartier E,Gorus FK,Belgian Diabetes Registry.

更新日期：2001-01-01 00:00:00

abstract：:The incidence, sex, seasonal and geographical patterns of juvenile-onset insulin-dependent diabetes mellitus (j.i.d.m.) were studied retrospectively on one third of the Danish population 1970-1974. The j.i.d.m. incidence remained fairly constant during the study period, the average being 13.2 per 100000 per year. The ...

journal_title：Diabetologia

authors： Christau B,Kromann H,Andersen OO,Christy M,Buschard K,Arnung K,Kristensen IH,Peitersen B,Steinrud J,Nerup J

更新日期：1977-08-01 00:00:00

abstract：AIMS/HYPOTHESIS:Changes in kidney function in diabetes could be due to changes in the kidney basement membranes. Proteoglycans are important constituents of this kidney extracellular matrix. This study explored the possibility that advanced glycation end products affect proteoglycan synthesis in cultured kidney epithel...

journal_title：Diabetologia

authors： Borrebaek J,Prydz K,Fjeldstad K,Vuong TT,Berg TJ,Holkov C,Kolset SO

更新日期：2001-04-01 00:00:00

abstract：AIMS/HYPOTHESIS:The aim of this study was to study differences in the prevalence of the metabolic syndrome and its associations with prevalent CHD according to ethnicity and sex. METHODS:We performed a combined analysis of two population-based cross-sectional studies conducted between 1988 and 1991 that followed ident...

journal_title：Diabetologia

authors： Tillin T,Forouhi N,Johnston DG,McKeigue PM,Chaturvedi N,Godsland IF

更新日期：2005-04-01 00:00:00

abstract：AIMS/HYPOTHESIS:The aim of this study was to examine the effects of childhood BMI growth dynamics on the risk of developing young adult-onset type 1 and type 2 diabetes. METHODS:Finnish national healthcare registers were used to identify individuals with diabetes diagnosed between 1992 and 1996 at 15-39 years of age. ...

journal_title：Diabetologia

authors： Lammi N,Moltchanova E,Blomstedt PA,Tuomilehto J,Eriksson JG,Karvonen M

更新日期：2009-03-01 00:00:00

abstract：:The role of syntaxin 1, a protein involved in the docking of synaptic vesicles at presynaptic active zones, has been investigated in pancreatic islet cells. Using two different monoclonal antibodies we have shown that syntaxin 1 is present in the pancreatic islet cell microsomal fraction. Furthermore, functional exper...

journal_title：Diabetologia

authors： Martín F,Moya F,Gutierrez LM,Reig JA,Soria B

更新日期：1995-07-01 00:00:00

abstract：:The NOD mouse, which shows many features of human IDDM, is extensively used to evaluate the role of T lymphocytes in the pathogenesis of autoimmune diabetes. The development of diabetes in this model appears to be controlled by a finely tuned immunoregulatory balance between autoaggressive T cells and regulatory immun...

journal_title：Diabetologia

authors： Sempé P,Richard MF,Bach JF,Boitard C

更新日期：1994-04-01 00:00:00

abstract：AIMS/HYPOTHESIS:Young children who develop multiple autoantibodies (mAbs) are at very high risk for type 1 diabetes. We assessed whether a population with mAbs detected by screening is also at very high risk, and how risk varies according to age, type of autoantibodies and metabolic status. METHODS:Type 1 Diabetes Tri...

journal_title：Diabetologia

authors： Jacobsen LM,Bocchino L,Evans-Molina C,DiMeglio L,Goland R,Wilson DM,Atkinson MA,Aye T,Russell WE,Wentworth JM,Boulware D,Geyer S,Sosenko JM

更新日期：2020-03-01 00:00:00

abstract：:It is hoped that information garnered from studies on population genetics will one day be translated into a form in which it meaningfully improves the prediction, prevention or treatment of type 2 diabetes. Type 2 diabetes genetics researchers have made extraordinary progress in identifying common genetic variants tha...

journal_title：Diabetologia

authors： Franks PW

更新日期：2012-10-01 00:00:00

abstract：:Insulin and somatostatin reportedly affect pancreatic acinar cell function via specific receptor binding. Theoretically peri-insular levels depend on the islet-acinar portal system, but the actual hormone levels have never been demonstrated. Rat pancreata were perfused anterogradely or retrogradely with 125I-insulin, ...

journal_title：Diabetologia

authors： Nakagawa A,Stagner JI,Samols E

更新日期：1995-03-01 00:00:00

abstract：AIMS/HYPOTHESIS:Type I (insulin-dependent) diabetes mellitus is characterised by leucocyte infiltration of pancreatic islets and a progressive destruction of insulin-producing beta cells. As endothelial nitric oxide production is known to regulate adhesion molecule expression and leucocyte permeation, we examined the a...

journal_title：Diabetologia

authors： Suschek CV,Bonmann E,Kolb-Bachofen V

更新日期：1999-04-01 00:00:00

abstract：AIMS/HYPOTHESIS:Circulating levels of adiponectin are negatively associated with multiple indices of insulin resistance, and the concentration is reduced in humans with insulin resistance and type 2 diabetes. However, the mechanisms by which adiponectin improves insulin sensitivity remain unclear. SUBJECTS AND METHODS...

journal_title：Diabetologia

authors： Højlund K,Frystyk J,Levin K,Flyvbjerg A,Wojtaszewski JF,Beck-Nielsen H

更新日期：2006-06-01 00:00:00

abstract：:The polymerization and precipitation of highly purified insulins which causes major problems in portable infusion systems does not occur with sulphated insulin. To compare the biological behaviour of sulphated insulin with that of a neutral highly purified monocomponent insulin, insulin receptor studies were performed...

journal_title：Diabetologia

authors： Zeuzem S,Taylor R,Agius L,Albisser AM,Alberti KG

更新日期：1984-08-01 00:00:00

abstract：:In healthy subjects hypoglycaemia causes a fall in body temperature through increased sweating and limb blood flow, and despite increased metabolic heat production. We studied thermoregulatory responses to hyperinsulinaemic (100 mU.m-2.min-1) (a) hypoglycaemia (2.5 mmol/l) and (b) euglycaemia (4.5 mmol/l) in insulin-d...

journal_title：Diabetologia

authors： Maggs DG,Macdonald IA,Tattersall RB

更新日期：1994-07-01 00:00:00

abstract：:Renal tubular lesions have been studied in streptozotocin-diabetic rats after 50 days of diabetes and compared with age-matched controls. The kidney weight increased by 67% in the diabetic animals and the length of the proximal tubules increased by 22%, but no abnormalities were found. The length of the distal tubules...

journal_title：Diabetologia

authors： Rasch R

更新日期：1984-07-01 00:00:00

abstract：AIM/HYPOTHESIS:A strong association between susceptibility to type 2 diabetes and common variants of transcription factor 7-like 2 (TCF7L2), encoding an enteroendocrine transcription factor involved in glucose homeostasis, has been reported in three different populations (Iceland, Denmark and USA) by Grant et al. We ai...

journal_title：Diabetologia

authors： van Vliet-Ostaptchouk JV,Shiri-Sverdlov R,Zhernakova A,Strengman E,van Haeften TW,Hofker MH,Wijmenga C

更新日期：2007-01-01 00:00:00

abstract：:Severe microvascular disease exists at the stage of clinical diabetic neuropathy. A non-invasive test that will identify those diabetic subjects who will eventually develop neuropathy is essential for early intervention. Sural sensory conduction velocity was recorded (x3) in 12 non-neuropathic diabetic subjects, 15 di...

journal_title：Diabetologia

authors： Tesfaye S,Harris ND,Wilson RM,Ward JD

更新日期：1992-02-01 00:00:00

abstract：AIMS/HYPOTHESIS:Although obesity is a major risk factor for diabetes, little is known about weight gain trajectories across adulthood, and whether they are differentially associated with metabolic markers of diabetes. METHODS:We used fasting blood samples and longitudinal weight data for 5,436 adults (5,734 observatio...

journal_title：Diabetologia

authors： Gordon-Larsen P,Koehler E,Howard AG,Paynter L,Thompson AL,Adair LS,Mayer-Davis EJ,Zhang B,Popkin BM,Herring AH

更新日期：2014-09-01 00:00:00

abstract：AIMS/HYPOTHESIS:In patients with type 1 diabetes, there has been concern about the effects of recurrent hypoglycaemia and chronic hyperglycaemia on cognitive function. Because other biomedical factors may also increase the risk of cognitive decline, this study examined whether macrovascular risk factors (hypertension, ...

journal_title：Diabetologia

authors： Jacobson AM,Ryan CM,Cleary PA,Waberski BH,Weinger K,Musen G,Dahms W,Diabetes Control and Complications Trial\/EDIC Research Group.

更新日期：2011-02-01 00:00:00

abstract：:Immunoelectrophoresis of glomerular basement membrane antigens in the urine of 20 Type 1 (insulin-dependent) diabetic and 10 healthy children was performed. In 10 of the diabetic children, there was altered alpha-1-mobility, while the other diabetic and normal children showed alpha-2-mobility. After incubation with gl...

journal_title：Diabetologia

authors： Schober E,Pollak A,Coradello H,Lubec G

更新日期：1982-12-01 00:00:00

abstract：AIMS/HYPOTHESIS:Semaglutide is a glucagon-like peptide-1 analogue in development for the treatment of type 2 diabetes. Its effects on first- and second-phase insulin secretion and other measures of beta cell function and glycaemic control were assessed. METHODS:In this single-centre, double-blind, placebo-controlled, ...

journal_title：Diabetologia

authors： Kapitza C,Dahl K,Jacobsen JB,Axelsen MB,Flint A

更新日期：2017-08-01 00:00:00

abstract：:A representative sample (n = 2140) of the Israeli Jewish population aged 40-70 (excluding known diabetic patients), whose body mass index had been measured 10 years earlier, underwent an oral glucose tolerance test and redetermination of body mass index. Irrespective of weight changes, high concurrent and high past bo...

journal_title：Diabetologia

authors： Modan M,Karasik A,Halkin H,Fuchs Z,Lusky A,Shitrit A,Modan B

更新日期：1986-02-01 00:00:00

abstract：:Large-scale, centrally-coordinated screening for undiagnosed type 2 diabetes is an attractive option to reduce the mortality and morbidity resulting from inadequately controlled diabetes. However, there is limited research examining the direct consequences of such screening programmes on outcomes such as cardiovascula...

journal_title：Diabetologia

authors： Shaw JE

更新日期：2017-11-01 00:00:00

abstract：AIMS/HYPOTHESIS:High levels of cardiorespiratory fitness (CRF) and physical activity (PA) are associated with a favourable metabolic risk profile. However, there has been no thorough exploration of the independent contributions of cardiorespiratory fitness and subcomponents of activity (total PA, time spent sedentary, ...

journal_title：Diabetologia

authors： Ekelund U,Anderssen SA,Froberg K,Sardinha LB,Andersen LB,Brage S,European Youth Heart Study Group.

更新日期：2007-09-01 00:00:00

abstract：AIMS/HYPOTHESIS:Thickening of the basement membrane and selective loss of pericytes occur early in diabetic retinopathy. As we showed previously that pericyte adhesion is impaired on extracellular matrix produced by endothelial cells in high hexose concentrations, we aimed to verify if altered adhesion could influence ...

journal_title：Diabetologia

authors： Beltramo E,Buttiglieri S,Pomero F,Allione A,D'Alù F,Ponte E,Porta M

更新日期：2003-03-01 00:00:00

abstract：AIMS/HYPOTHESIS:The role of infections in the aetiology of Type I diabetes is controversial. Certain enteroviral infections might be involved in triggering the beta-cell destruction but insufficient exposure to early infections might increase the risk. We studied how the number of infections experienced during several ...

journal_title：Diabetologia

authors： Pundziute-Lyckå A,Urbonaite B,Dahlquist G

更新日期：2000-10-01 00:00:00

abstract：:Islet allografts in insulin-dependent diabetic (IDDM) patients exhibit variable survival lengths and low rates of insulin-independence despite treatment with anti-T-cell antibodies and maintenance immunosuppression. Use of poorly characterized freshly isolated preparations makes it difficult to determine whether failu...

journal_title：Diabetologia

authors： Keymeulen B,Ling Z,Gorus FK,Delvaux G,Bouwens L,Grupping A,Hendrieckx C,Pipeleers-Marichal M,Van Schravendijk C,Salmela K,Pipeleers DG

更新日期：1998-04-01 00:00:00

abstract：AIMS/HYPOTHESIS:Decreased sensing of the innate immune system may lead to chronic activation of the inflammatory cascade. We hypothesised that mannan-binding lectin (MBL) deficiency may confer risk of obesity and insulin resistance. MATERIALS AND METHODS:We performed a cross-sectional study of MBL protein concentratio...

journal_title：Diabetologia

authors： Fernández-Real JM,Straczkowski M,Vendrell J,Soriguer F,Pérez Del Pulgar S,Gallart L,López-Bermejo A,Kowalska I,Manco M,Cardona F,García-Gil MM,Mingrone G,Richart C,Ricart W,Zorzano A

更新日期：2006-10-01 00:00:00

abstract：:Structural alterations in arterial extracellular matrix components have been suggested to play a role in the development of arterial disease among patients with diabetes mellitus. This study examines the quantity and quality of collagenous components in aortas from diabetic patients. In order to obtain data about the ...

journal_title：Diabetologia

authors： Rasmussen LM,Ledet T

更新日期：1993-05-01 00:00:00

abstract：:AbstractIn Table 1 the data for age group, sex and Townsend index were incorrectly identified as mean ± SD instead of n (%). The table is corrected here. ...

journal_title：Diabetologia

authors： Nirantharakumar K,Mohammed N,Toulis KA,Thomas GN,Narendran P

更新日期：2018-07-01 00:00:00