Differential expression of fructosyllysine-specific receptors on monocytes and macrophages and possible pathophysiological significance.

abstract：AIMS/HYPOTHESIS:The aim of this study was to evaluate the effects of oxygen consumption-matched short-term interval walking training (IWT) vs continuous walking training (CWT) on glycaemic control, including glycaemic variability, in individuals with type 2 diabetes. We also assessed whether any training-induced improv...

journal_title：Diabetologia

authors： Karstoft K,Clark MA,Jakobsen I,Müller IA,Pedersen BK,Solomon TP,Ried-Larsen M

更新日期：2017-03-01 00:00:00

abstract：:In order to examine the permeability of microvessels in diabetic children, the glomerular filtration rate, urinary excretion rates of albumin and beta 2-microglobulin, intravascular mass of albumin, and transcapillary escape rate of albumin were studied in 26 diabetic children without clinical signs of microangiopathy...

journal_title：Diabetologia

authors： Brøchner-Mortensen J,Ditzel J,Mogensen CE,Rødbro P

更新日期：1979-05-01 00:00:00

abstract：:Hyperinsulinaemia is a reported feature of the inherited multisystem disorder myotonic dystrophy. This phenomenon has been attributed to a compensatory beta cell response to tissue insulin resistance. In this study, circulating concentrations of insulin, proinsulin, and split proinsulin molecules were determined after...

journal_title：Diabetologia

authors： Krentz AJ,Clark PM,Cox L,Williams AC,Nattrass M

更新日期：1992-12-01 00:00:00

abstract：AIMS/HYPOTHESIS:We analysed whether the prognosis of a first acute coronary syndrome (ACS) in patients treated for type 2 diabetes has improved. We also compared the trends in patients with and without diabetes. METHODS:We used national registers to identify all patients with clinically known type 2 diabetes in Finlan...

journal_title：Diabetologia

authors： Winell KM,Pääkkönen R,Pietilä A,Niemi MK,Reunanen AR,Salomaa VV

更新日期：2010-03-01 00:00:00

abstract：AIMS/HYPOTHESIS:The rs1990760 polymorphism (Ala946Thr) of interferon induced with helicase C domain 1 (IFIH1) has been proposed to associate with type 1 diabetes. In this study, association between IFIH1 Ala946Thr and type 1 diabetes was investigated in two distinct white populations, the Hungarians and Finns. METHODS...

journal_title：Diabetologia

authors： Jermendy A,Szatmári I,Laine AP,Lukács K,Horváth KH,Körner A,Madácsy L,Veijola R,Simell O,Knip M,Ilonen J,Hermann R,Finnish Paediatric Diabetes Registry.,HUNT1DGENES Programme.

更新日期：2010-01-01 00:00:00

abstract：:We report the clinical characteristics of all insulin-treated diabetic patients (783 males and 716 females) living on July 1 1973 in a Danish county. In 18 patients diabetes was believed to be secondary to another disease or condition. Of all patients, 43% of the males and 55% of the females were greater than age 50 y...

journal_title：Diabetologia

authors： Green A,Hougaard P

更新日期：1983-09-01 00:00:00

abstract：AIMS/HYPOTHESIS:A key morphological feature of diabetic nephropathy is the accumulation and deposition of glycogen in renal tubular cells, known as Armanni-Ebstein lesions. While this observation has been consistently reported for many years, the molecular basis of these lesions remains unclear. METHODS:Using biochemi...

journal_title：Diabetologia

authors： Lau X,Zhang Y,Kelly DJ,Stapleton DI

更新日期：2013-03-01 00:00:00

abstract：AIMS/HYPOTHESIS:In type 1 diabetes, selective beta cell loss occurs within the inflamed milieu of insulitic islets. This milieu is generated via the enhanced secretion of proinflammatory cytokines and by the loss of anti-inflammatory molecules such as IL-4 and IL-13. While the actions of proinflammatory cytokines have ...

journal_title：Diabetologia

authors： Leslie KA,Russell MA,Taniguchi K,Richardson SJ,Morgan NG

更新日期：2019-01-01 00:00:00

abstract：:The insulin-like growth factor I receptor and the activity of its associated tyrosine kinase activity were characterised in wheat germ agglutinin extracts from skeletal muscle biopsies from nine control and ten obese Type 2 (non-insulin-dependent) diabetic subjects, who had marked peripheral in vivo insulin resistance...

journal_title：Diabetologia

authors： Livingston N,Pollare T,Lithell H,Arner P

更新日期：1988-12-01 00:00:00

abstract：:Serum high density lipoprotein cholesterol, total cholesterol, triglyceride and apolipoproteins A-I and B were studied at diagnosis and after 12 months conventional treatment in a group of Type 2 (non-insulin-dependent) diabetic patients. No significant deleterious effect on serum lipids and apolipoproteins was seen i...

journal_title：Diabetologia

authors： Taylor KG,John WG,Matthews KA,Wright AD

更新日期：1982-12-01 00:00:00

abstract：:Oral (o.GTT) and intravenous glucose tolerance tests (i.v. GTT) were carried out on 492 patients of both sexes, aged from 5 to 78 years. Three hundred and fifty-nine non-diabetics in all were suspected clinically of reduced carbohydrate tolerance leaving 133 patients for comparison (controls). In 102 obesity was noted...

journal_title：Diabetologia

authors： Schilling WH,Oberdisse K,Hüter KA,Blank H

更新日期：1966-04-01 00:00:00

abstract：AIMS/HYPOTHESIS:We investigated of the effects of fatty acid composition of the maternal diet on fetal and postnatal growth, morphology of the pancreas and glucose metabolism and muscle hexosamine concentrations in the adult offspring of rats. METHODS:High-fat diets enriched with either saturated or unsaturated fatty ...

journal_title：Diabetologia

authors： Siemelink M,Verhoef A,Dormans JA,Span PN,Piersma AH

更新日期：2002-10-01 00:00:00

abstract：:Free-radical scavengers and inhibitors of tumour necrosis factor-alpha (TNF-alpha) such as N-acetylcysteine and pentoxifylline have been shown to inhibit the development of peripheral neuropathy in streptozotocin(STZ)-induced diabetic rats. In this study we examined the effect of troglitazone, an anti-diabetic thiazol...

journal_title：Diabetologia

authors： Qiang X,Satoh J,Sagara M,Fukuzawa M,Masuda T,Sakata Y,Muto G,Muto Y,Takahashi K,Toyota T

更新日期：1998-11-01 00:00:00

abstract：AIMS/HYPOTHESIS:Cerebral oedema complicating diabetic ketoacidosis (DKA) remains the major cause of morbidity and mortality in children with type 1 diabetes, but its aetiology remains unknown. Our objective was to determine the impact of baseline biochemical factors and of treatment-related variables on risk of the dev...

journal_title：Diabetologia

authors： Edge JA,Jakes RW,Roy Y,Hawkins M,Winter D,Ford-Adams ME,Murphy NP,Bergomi A,Widmer B,Dunger DB

更新日期：2006-09-01 00:00:00

abstract：AIMS/HYPOTHESIS:Increased NEFA levels, characteristic of type 2 diabetes mellitus, contribute to skeletal muscle insulin resistance. While NEFA-induced insulin resistance was formerly attributed to decreased glycolysis, it is likely that glucose transport is the rate-limiting defect. Recently, the plant-derived sugar a...

journal_title：Diabetologia

authors： Kishore P,Kehlenbrink S,Hu M,Zhang K,Gutierrez-Juarez R,Koppaka S,El-Maghrabi MR,Hawkins M

更新日期：2012-06-01 00:00:00

abstract：AIMS/HYPOTHESIS:Enhanced and prolonged postprandial lipaemia is related to cardiovascular disease but how postprandial lipaemia is regulated is poorly known. We therefore determined the relations of fasting insulin concentrations to fasting and postprandial lipids, lipoproteins and non-esterified fatty acids in middle-...

journal_title：Diabetologia

authors： Boquist S,Hamsten A,Karpe F,Ruotolo G

更新日期：2000-02-01 00:00:00

abstract：AIMS/HYPOTHESIS:IRS2 is an important molecular switch that mediates insulin signalling in the liver. IRS2 dysregulation is responsible for the phenomenon of selective insulin resistance that is observed in type 2 diabetes. We hypothesise that epigenetic mechanisms are involved in the regulation of IRS2 in the liver of ...

journal_title：Diabetologia

authors： Krause C,Geißler C,Tackenberg H,El Gammal AT,Wolter S,Spranger J,Mann O,Lehnert H,Kirchner H

更新日期：2020-10-01 00:00:00

abstract：AIMS/HYPOTHESIS:Among diabetic patients, glucose homeostasis may be affected by abnormal gastrointestinal motility and autonomic neuropathy. This study analysed whether oesophageal dysmotility, delayed gastric emptying or autonomic neuropathy affect glucose homeostasis. MATERIALS AND METHODS:Oesophageal manometry and ...

journal_title：Diabetologia

authors： Ohlsson B,Melander O,Thorsson O,Olsson R,Ekberg O,Sundkvist G

更新日期：2006-09-01 00:00:00

abstract：AIMS/HYPOTHESIS:Recent genome-wide association studies have suggested that a polymorphism in GCKR, the gene encoding the glucokinase regulatory protein, is involved in triacylglycerol regulation. Our aim was to examine in large-scale studies the common GCKR rs780094 polymorphism in relation to metabolic traits (mainly ...

journal_title：Diabetologia

authors： Sparsø T,Andersen G,Nielsen T,Burgdorf KS,Gjesing AP,Nielsen AL,Albrechtsen A,Rasmussen SS,Jørgensen T,Borch-Johnsen K,Sandbaek A,Lauritzen T,Madsbad S,Hansen T,Pedersen O

更新日期：2008-01-01 00:00:00

abstract：AIMS/HYPOTHESIS:The molecular factors that cause an acute wound in diabetic patients to become chronic have not yet been established. Wound healing is known to require a balance between the accumulation of collagenous and non-collagenous extracellular matrix components and their remodelling by matrix metalloproteinases...

journal_title：Diabetologia

authors： Lobmann R,Ambrosch A,Schultz G,Waldmann K,Schiweck S,Lehnert H

更新日期：2002-07-01 00:00:00

abstract：:The effect of hyperglycaemia on islet transplantation in the rat has been examined in two ways, using syngeneic transplantation of 400 islets to the kidney capsule and subsequent measurement of kidney insulin content as a measurement of B-cell survival. Firstly, islets were transplanted into either diabetic or normal ...

journal_title：Diabetologia

authors： Gray DW,Cranston D,McShane P,Sutton R,Morris PJ

更新日期：1989-09-01 00:00:00

abstract：AIMS/HYPOTHESIS:Oxidative stress is associated with diabetes, hypertension and atherosclerosis. Insulin resistance is implicated in the development of these disorders. We tested the hypothesis that oxidative stress induces insulin resistance in rats, and endeavoured to identify mechanisms linking the two. METHODS:Buth...

journal_title：Diabetologia

authors： Ogihara T,Asano T,Katagiri H,Sakoda H,Anai M,Shojima N,Ono H,Fujishiro M,Kushiyama A,Fukushima Y,Kikuchi M,Noguchi N,Aburatani H,Gotoh Y,Komuro I,Fujita T

更新日期：2004-05-01 00:00:00

abstract：AIMS/HYPOTHESIS:Levels of ideal cardiovascular health (ICH) and incident type 2 diabetes mellitus have not been examined in a multiethnic population. We assessed the total and race/ethnicity-specific incidence of diabetes based on American Heart Association (AHA) ICH components. METHODS:Incident diabetes was assessed ...

journal_title：Diabetologia

authors： Joseph JJ,Echouffo-Tcheugui JB,Carnethon MR,Bertoni AG,Shay CM,Ahmed HM,Blumenthal RS,Cushman M,Golden SH

更新日期：2016-09-01 00:00:00

abstract：:The spontaneous hypertensive rat is an animal model characterized by a syndrome of hypertension, insulin resistance and hyperinsulinaemia. To elucidate whether in analogy to other insulin resistant animal models an inactivity of the insulin receptor kinase or an alteration of the glucose transporter (GLUT 4) level in ...

journal_title：Diabetologia

authors： Bader S,Scholz R,Kellerer M,Tippmer S,Rett K,Mathaei S,Freund P,Häring HU

更新日期：1992-08-01 00:00:00

abstract：AIMS/HYPOTHESIS:We investigated whether heterogeneous nuclear ribonucleoproteins F and K (hnRNP F, hnRNP K) mediate insulin inhibition of renal Agt expression and prevention of hypertension and kidney injury in an Akita mouse model of type 1 diabetes. METHODS:Adult male Akita mice (12 weeks old) were treated with insu...

journal_title：Diabetologia

authors： Abdo S,Lo CS,Chenier I,Shamsuyarova A,Filep JG,Ingelfinger JR,Zhang SL,Chan JS

更新日期：2013-07-01 00:00:00

abstract：:Glycation of long-lived proteins is an inevitable consequence of aging that is accelerated in patients with diabetes mellitus. Treatment of demineralized bone matrix particles from 35-week-old normal Long-Evans rats with glycoaldehyde, a precursor of advanced glycation end-products, was used to assess the effects of b...

journal_title：Diabetologia

authors： Fong Y,Edelstein D,Wang EA,Brownlee M

更新日期：1993-09-01 00:00:00

abstract：AIMS/HYPOTHESIS:We analysed the cost-effectiveness of intensified prevention in diabetic patients with different risks for foot ulcers and lower extremity amputations. Specifically, we examined whether the additional prevention costs associated with present recommendations would be offset by reduced costs of future foo...

journal_title：Diabetologia

authors： Ragnarson Tennvall G,Apelqvist J

更新日期：2001-11-01 00:00:00

abstract：:Diabetic polyneuropathy is a common, disabling chronic complication of diabetes mellitus. Previous studies have suggested that combined pancreas-kidney transplantation can ameliorate nerve conduction. The relative contribution of the correction of hyperglycaemia and uraemia on nerve function is still a matter of debat...

journal_title：Diabetologia

authors： Martinenghi S,Comi G,Galardi G,Di Carlo V,Pozza G,Secchi A

更新日期：1997-09-01 00:00:00

abstract：AIMS/HYPOTHESIS:Results from animal models and some clinical work suggest a role for the central nervous system (CNS) in glucose regulation and type 2 diabetes pathogenesis by modulation of glucoregulatory hormones and the autonomic nervous system (ANS). The aim of this study was to characterise the neuroendocrine resp...

journal_title：Diabetologia

authors： Lundqvist MH,Almby K,Wiklund U,Abrahamsson N,Kamble PG,Pereira MJ,Eriksson JW

更新日期：2020-11-26 00:00:00

abstract：:We studied thrombin-induced metabolism of phosphoinositide, protein phosphorylation and platelet aggregation in platelets from 32 NIDDM patients and 12 control subjects. To clarify the effect of diet, sulphonylureas, or insulin treatment, the subjects were divided into three groups based on the type of treatment. Thro...

journal_title：Diabetologia

authors： Ishizuka T,Taniguchi O,Yamamoto M,Kajita K,Nagashima T,Takeda N,Inouye H,Yasuda K,Miura K

更新日期：1994-06-01 00:00:00