The GCKR rs780094 polymorphism is associated with elevated fasting serum triacylglycerol, reduced fasting and OGTT-related insulinaemia, and reduced risk of type 2 diabetes.

abstract：:The incorporation of [35S]sulfate into heart proteoglycans has been studied in normal and alloxan-diabetic rats by perfusion and in vivo administration of the isotope; in the latter situation, comparison was also made of radiolabeled sulfate utilization by several other tissues (kidney, liver, lung, muscle, testes and...

journal_title：Diabetologia

authors： Spiro MJ

更新日期：1987-04-01 00:00:00

abstract：AIMS/HYPOTHESIS:In our previous studies a low protein diet (8% vs 20%) given during foetal and early postnatal life induced abnormal development of the endocrine pancreas; beta-cell mass and islet-cell proliferation were reduced while apoptosis was increased. Taurine, an important amino acid for development was also re...

journal_title：Diabetologia

authors： Boujendar S,Reusens B,Merezak S,Ahn MT,Arany E,Hill D,Remacle C

更新日期：2002-06-01 00:00:00

abstract：:Closure of ATP-regulated K(+) channels (K(ATP) channels) plays a central role in glucose-stimulated insulin secretion in beta cells. K(ATP) channels are also highly expressed in glucagon-producing alpha cells, where their function remains unresolved. Under hypoglycaemic conditions, K(ATP) channels are open in alpha ce...

journal_title：Diabetologia

authors： Rorsman P,Ramracheya R,Rorsman NJ,Zhang Q

更新日期：2014-09-01 00:00:00

abstract：AIM/HYPOTHESIS:The distinct metabolic properties of visceral and subcutaneous adipocytes may be due to inherent characteristics of the cells that are resident in each fat depot. To test this hypothesis, human adipocytes were differentiated in vitro from precursor stromal cells obtained from visceral and subcutaneous fa...

journal_title：Diabetologia

authors： Perrini S,Laviola L,Cignarelli A,Melchiorre M,De Stefano F,Caccioppoli C,Natalicchio A,Orlando MR,Garruti G,De Fazio M,Catalano G,Memeo V,Giorgino R,Giorgino F

更新日期：2008-01-01 00:00:00

abstract：AIMS/HYPOTHESIS:The study was designed to identify the key metabolic signals of glucose-stimulated proinsulin gene transcription and translation, focusing on the mechanism of succinate stimulation of insulin production. METHODS:Wistar rat islets were incubated in 3.3 mmol/l glucose with and without esters of different...

journal_title：Diabetologia

authors： Leibowitz G,Khaldi MZ,Shauer A,Parnes M,Oprescu AI,Cerasi E,Jonas JC,Kaiser N

更新日期：2005-08-01 00:00:00

abstract：AIMS/HYPOTHESIS:Our aim was to examine the association between markers of insulin resistance and: (1) body fat and waist circumference, taking into account cardiorespiratory fitness in school-aged children; and (2) cardiorespiratory fitness at differing levels of body fat and waist circumference. SUBJECTS AND METHODS:...

journal_title：Diabetologia

authors： Ruiz JR,Rizzo NS,Ortega FB,Loit HM,Veidebaum T,Sjöström M

更新日期：2007-07-01 00:00:00

abstract：AIMS/HYPOTHESIS:One major objective of the St Vincent Declaration was to reduce the excess risk of myocardial infarction in patients with diabetes mellitus. We estimated the trend of the incidence and relative risk of myocardial infarction in the diabetic and non-diabetic populations in southern Germany from 1985 to 20...

journal_title：Diabetologia

authors： Icks A,Dickhaus T,Hörmann A,Heier M,Giani G,Kuch B,Meisinger C

更新日期：2009-09-01 00:00:00

abstract：:The concentrations of zinc, copper, and chromium in liver, kidney, muscle, bone and serum from control normoinsulinaemic and hyperinsulinaemic sand rats (Psammomys obesus) and from untreated spontaneously hyperinsulinaemic-hyperglycaemic sand rats were compared. A chronic hyperinsulinaemic-hyperglycaemic state was ass...

journal_title：Diabetologia

authors： Raz I,Adler JH,Havivi E

更新日期：1988-05-01 00:00:00

abstract：AIMS/HYPOTHESIS:The islet microcirculation has morphological characteristics resembling those of renal glomeruli. Transcription of the nephrin gene, a highly specific barrier protein of the slit diaphragm of podocyte foot processes, has been reported in the pancreas, although its cellular localisation and function rema...

journal_title：Diabetologia

authors： Zanone MM,Favaro E,Doublier S,Lozanoska-Ochser B,Deregibus MC,Greening J,Huang GC,Klein N,Cavallo Perin P,Peakman M,Camussi G

更新日期：2005-09-01 00:00:00

abstract：AIMS/HYPOTHESIS:Depression and glucose intolerance commonly co-occur among non-pregnant individuals; however, the temporal relationship between gestational diabetes (GDM) and depression during pregnancy and the postpartum period is less understood. Our objective was to assess longitudinal associations between depressio...

journal_title：Diabetologia

authors： Hinkle SN,Buck Louis GM,Rawal S,Zhu Y,Albert PS,Zhang C

更新日期：2016-12-01 00:00:00

abstract：AIMS/HYPOTHESIS:Serum potassium has been found to be a significant predictor of diabetes risk, but the effect of dietary potassium on diabetes risk is not clear. We sought to determine if dietary potassium is associated with risk of incident type 2 diabetes in young adults. METHODS:We used data from the Coronary Arter...

journal_title：Diabetologia

authors： Chatterjee R,Colangelo LA,Yeh HC,Anderson CA,Daviglus ML,Liu K,Brancati FL

更新日期：2012-05-01 00:00:00

abstract：AIMS/HYPOTHESIS:Non-alcoholic fatty liver disease (NAFLD) has been associated with the metabolic syndrome. However, it is not clear whether insulin resistance is an independent feature of NAFLD, and it remains to be determined which of the in vivo actions of insulin are impaired in this condition. METHODS:We performed...

journal_title：Diabetologia

authors： Bugianesi E,Gastaldelli A,Vanni E,Gambino R,Cassader M,Baldi S,Ponti V,Pagano G,Ferrannini E,Rizzetto M

更新日期：2005-04-01 00:00:00

abstract：:Human crude and recombinant interleukin 1 (IL-1) was found to dose- and time-dependently affect the biosynthesis of (pro)insulin in isolated rat islets of Langerhans. Incubation of rat islets with either 0.5 U/ml or 5 U/ml of crude IL-1 for 1 h had no detectable effect on (pro)insulin biosynthesis. After 24 hours of e...

journal_title：Diabetologia

authors： Spinas GA,Hansen BS,Linde S,Kastern W,Mølvig J,Mandrup-Poulsen T,Dinarello CA,Nielsen JH,Nerup J

更新日期：1987-07-01 00:00:00

abstract：AIMS/HYPOTHESIS:An isoform of glutamic acid decarboxylase, (GAD)65 has been identified as a pancreatic beta-cell autoantigen in Type I (insulin dependent) diabetes mellitus. We investigated the expression of GAD isoforms among single rat beta cells in culture, under different conditions and the correlation between GAD6...

journal_title：Diabetologia

authors： Sánchez-Soto MC,Larrieta ME,Vidaltamayo R,Hiriart M

更新日期：1999-09-01 00:00:00

abstract：AIMS/HYPOTHESIS:Endothelial cell (EC) damage is a key mechanism causing retinal microvascular injury in diabetes. Several microRNAs (miRNAs) have been found to regulate sirtuin 1 (SIRT1, which is involved in regulation of the cell cycle, survival and metabolism) in various tissues and disease states, but no studies hav...

journal_title：Diabetologia

authors： Mortuza R,Feng B,Chakrabarti S

更新日期：2014-05-01 00:00:00

abstract：AIMS/HYPOTHESIS:We assessed the effects of vildagliptin, a novel dipeptidyl peptidase IV inhibitor, on postprandial lipid and lipoprotein metabolism in patients with type 2 diabetes. SUBJECTS, MATERIALS AND METHODS:This was a single-centre, randomised, double-blind study in drug-naive patients with type 2 diabetes. Pa...

journal_title：Diabetologia

authors： Matikainen N,Mänttäri S,Schweizer A,Ulvestad A,Mills D,Dunning BE,Foley JE,Taskinen MR

更新日期：2006-09-01 00:00:00

abstract：:The development of diabetic glomerulopathy in kidneys transplanted to diabetic patients was estimated in transplant biopsies and evaluated in relation to suspected clinical risk factors for diabetic nephropathy. Surgical biopsies were taken at baseline and at 24-36 months post-transplantation in 16 Type 1 (insulin-dep...

journal_title：Diabetologia

authors： Osterby R,Nyberg G,Hedman L,Karlberg I,Persson H,Svalander C

更新日期：1991-09-01 00:00:00

abstract：AIMS/HYPOTHESIS:The aim of this study was to assess whether the diabetogenicity of areca nut (Areca catechu or 'betel-nut'), which has previously been demonstrated experimentally in mice, independently contributes to the risk of hyperglycaemia or type 2 diabetes in men in Taiwan, where the habit has become established ...

journal_title：Diabetologia

authors： Tung TH,Chiu YH,Chen LS,Wu HM,Boucher BJ,Chen TH,Keelung Community-based Integrated Screening programme No. 2.

更新日期：2004-10-01 00:00:00

abstract：:Most polypeptides originally assigned to a specific organ and a specific effect seem to occur in many different parts of the body, in neurons as well as in endocrine cells. Thus gastrin and insulin, or very similar peptides can be demonstrated in extracts of the vagal nerves and of peripheral somatic nerves. Electrica...

journal_title：Diabetologia

authors： Uvnäs-Wallensten K

更新日期：1981-03-01 00:00:00

abstract：AIMS/HYPOTHESIS:Potential differences in cardiovascular risk by ethnicity remain uncertain. We evaluated the association of ethnicity with cardiovascular disease (CVD) incidence in a large cohort of people with type 2 diabetes living in Scotland. METHODS:Data from Scottish Care Information-Diabetes (SCI-Diabetes) were...

journal_title：Diabetologia

authors： Malik MO,Govan L,Petrie JR,Ghouri N,Leese G,Fischbacher C,Colhoun H,Philip S,Wild S,McCrimmon R,Sattar N,Lindsay RS,Scottish Diabetes Research Network Epidemiology Group.

更新日期：2015-04-01 00:00:00

abstract：:Insulin and somatostatin reportedly affect pancreatic acinar cell function via specific receptor binding. Theoretically peri-insular levels depend on the islet-acinar portal system, but the actual hormone levels have never been demonstrated. Rat pancreata were perfused anterogradely or retrogradely with 125I-insulin, ...

journal_title：Diabetologia

authors： Nakagawa A,Stagner JI,Samols E

更新日期：1995-03-01 00:00:00

abstract：:The aim of the study was to evaluate an acute decrease in NEFA levels during an oral glucose tolerance test and its effects on glucose tolerance, muscle glucose uptake and muscle indirect calorimetry in ten lean non-insulin-dependent diabetic subjects. Two 75-g oral glucose tolerance tests were performed in random ord...

journal_title：Diabetologia

authors： Piatti PM,Monti LD,Davis SN,Conti M,Brown MD,Pozza G,Alberti KG

更新日期：1996-01-01 00:00:00

abstract：:Amylin is a 37-amino acid pancreatic polypeptide, probably involved in the pathophysiology of Type 2 (non-insulin-dependent) diabetes mellitus. We have determined amylin in human plasma by extraction-based radioimmunoassay (Sep-Pak C18). Of 23 healthy control subjects plasma amylin was determined as 11.9 +/- 3.5 ng/l....

journal_title：Diabetologia

authors： Hartter E,Svoboda T,Ludvik B,Schuller M,Lell B,Kuenburg E,Brunnbauer M,Woloszczuk W,Prager R

更新日期：1991-01-01 00:00:00

abstract：AIMS/HYPOTHESIS:We sought to elucidate whether excess glucocorticoids and increased dietary lipids act synergistically to impair glucose tolerance and, if so, whether activation of peroxisome proliferator-activated receptor alpha (PPARalpha) has an adverse or beneficial effect on glucose tolerance. METHODS:Dexamethaso...

journal_title：Diabetologia

authors： Holness MJ,Smith ND,Greenwood GK,Sugden MC

更新日期：2005-10-01 00:00:00

abstract：:Treatment of diabetic rats with octreotide can inhibit early diabetic renal hypertrophy. Octreotide administration for 6 months from the day of diabetes induction inhibits renal hypertrophy and diminishes increase in urinary albumin excretion. To investigate the effect of octreotide on manifest diabetic renal changes,...

journal_title：Diabetologia

authors： Grønbaek H,Nielsen B,Osterby R,Harris A,Orskov H,Flyvbjerg A

更新日期：1995-02-01 00:00:00

abstract：:A previous study of low density lipoprotein metabolism by cultured cells focused on the metabolism of normal lipoproteins in vitro by fibroblasts isolated from diabetic patients. No abnormalities were found. We have followed the opposite approach. Using normal human fibroblasts as test cells we compared the metabolism...

journal_title：Diabetologia

authors： Lopes-Virella MF,Sherer GK,Lees AM,Wohltmann H,Mayfield R,Sagel J,LeRoy EC,Colwell JA

更新日期：1982-06-01 00:00:00

abstract：AIMS/HYPOTHESIS:This meta-analysis assessed the pooled effect of each genetic variant reproducibly associated with diabetic nephropathy. METHODS:PubMed, EMBASE and Web of Science were searched for articles assessing the association between genes and diabetic nephropathy. All genetic variants statistically associated w...

journal_title：Diabetologia

authors： Mooyaart AL,Valk EJ,van Es LA,Bruijn JA,de Heer E,Freedman BI,Dekkers OM,Baelde HJ

更新日期：2011-03-01 00:00:00

abstract：AIMS/HYPOTHESIS:Reactive oxygen species (ROS) contribute to diabetes-induced glomerular injury and endoplasmic reticulum (ER) stress-induced beta cell dysfunction, but the source of ROS has not been fully elucidated. Our aim was to determine whether p47(phox)-dependent activation of NADPH oxidase is responsible for hyp...

journal_title：Diabetologia

authors： Liu GC,Fang F,Zhou J,Koulajian K,Yang S,Lam L,Reich HN,John R,Herzenberg AM,Giacca A,Oudit GY,Scholey JW

更新日期：2012-09-01 00:00:00

abstract：AIMS/HYPOTHESIS:In this study we investigated whether chronic fetal hypoxia, as indicated by amniotic fluid erythropoietin levels, is associated with perinatal morbidity in type 1 diabetic pregnancies. METHODS:A total of 331 women with type 1 diabetes had at least one childbirth between 1995 and 2000. The amniotic flu...

journal_title：Diabetologia

authors： Teramo K,Kari MA,Eronen M,Markkanen H,Hiilesmaa V

更新日期：2004-10-01 00:00:00

abstract：:Several bariatric operations originally designed to promote weight loss have been found to powerfully treat type 2 diabetes, causing remission in most cases, through diverse mechanisms additional to the secondary consequences of weight loss. These observations have prompted consideration of such operations as 'metabol...

journal_title：Diabetologia

authors： Cummings DE,Rubino F

更新日期：2018-02-01 00:00:00