当前位置： SCI文献检索 > DIABETOLOGIA期刊下所有文献 > A simulation model of the cost of the incidence of IDDM in Spain.

A simulation model of the cost of the incidence of IDDM in Spain.

Abstract：

:This study estimates the direct health care costs of the incidence of insulin-dependent diabetes mellitus (IDDM) in Spain. A discrete event simulation model was developed to approximate the natural history of a cohort of newly diagnosed patients in a given year and used to calculate the average costs which would accumulate during the lifetime of the group of patients. The model takes into account both the underlying costs of control and maintenance of the disease plus the additional costs of long-term complications that are likely to develop as the disease progresses. The model is based on national and international epidemiological and demographic information combined with local cost data. The number of newly diagnosed cases of IDDM each year, based on Spanish epidemiological data, was calculated to be approximately 1791 cases in 1994. The baseline results from the model indicate that the average life expectancy of an IDDM patient is approximately 59.6 years with an average lifetime cost of 12.7 million pesetas per individual (1994 undiscounted values), 5.1 million pesetas per individual when discounted at a rate of 6% and 8060 million pesetas for the entire newly diagnosed cohort discounted at a rate of 6%. Sensitivity analysis was undertaken in order to observe the effect on the result of changes in the values of key variables.

journal_name

Diabetologia

journal_title

Diabetologia

authors

Hart WM,Espinosa C,Rovira J

doi

10.1007/s001250050680

subject

Has Abstract

pub_date

1997-03-01 00:00:00

pages

311-8

issue

3

eissn

0012-186X

issn

1432-0428

journal_volume

40

pub_type

杂志文章

相关文献

DIABETOLOGIA文献大全
  • Lowering of postprandial lipids in individuals with type 2 diabetes treated with alogliptin and/or pioglitazone: a randomised double-blind placebo-controlled study.

    abstract：AIMS/HYPOTHESIS:Pharmacological augmentation of glucagon-like peptide 1 receptor signalling by dipeptidyl peptidase 4 (DPP-4) inhibition reduced intestinal lipoprotein secretion in experimental studies, suggesting that DPP-4 inhibitors may ameliorate dyslipidaemia and thus reduce cardiovascular risk in patients with ty...

    journal_title：Diabetologia

    pub_type： 杂志文章,多中心研究,随机对照试验

    doi：10.1007/s00125-011-2447-3

    authors： Eliasson B,Möller-Goede D,Eeg-Olofsson K,Wilson C,Cederholm J,Fleck P,Diamant M,Taskinen MR,Smith U

    更新日期：2012-04-01 00:00:00

  • Outcomes of surgical treatment of diabetic foot osteomyelitis: a series of 185 patients with histopathological confirmation of bone involvement.

    abstract：AIMS/HYPOTHESIS:We analysed the factors that determine the outcomes of surgical treatment of osteomyelitis of the foot in diabetic patients given early surgical treatment within 12 h of admission and treated with prioritisation of foot-sparing surgery and avoidance of amputation. METHODS:A consecutive series of 185 di...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/s00125-008-1131-8

    authors： Aragón-Sánchez FJ,Cabrera-Galván JJ,Quintana-Marrero Y,Hernández-Herrero MJ,Lázaro-Martínez JL,García-Morales E,Beneit-Montesinos JV,Armstrong DG

    更新日期：2008-11-01 00:00:00

  • Cyclophosphamide treatment of female non-obese diabetic mice causes enhanced expression of inducible nitric oxide synthase and interferon-gamma, but not of interleukin-4.

    abstract：:In pancreatic lesions of non-obese diabetic (NOD) mice the expression of inducible nitric oxide synthase (iNOS) and of the cytokines interferon-gamma and interleukin-4 were studied. Strong iNOS expression as determined at the level of transcription, translation and of enzyme activity was associated with destructive in...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/BF00418380

    authors： Rothe H,Faust A,Schade U,Kleemann R,Bosse G,Hibino T,Martin S,Kolb H

    更新日期：1994-11-01 00:00:00

  • Targeting insulin-producing beta cells for regenerative therapy.

    abstract：:Pancreatic beta cells differ in terms of glucose responsiveness, insulin secretion and proliferative capacity; however, the molecular pathways that regulate this cellular heterogeneity are unknown. We have identified the Wnt-planar cell polarity (PCP) effector Flattop (FLTP) as a biomarker that identifies mature beta ...

    journal_title：Diabetologia

    pub_type： 杂志文章,评审

    doi：10.1007/s00125-016-3949-9

    authors： Migliorini A,Roscioni SS,Lickert H

    更新日期：2016-09-01 00:00:00

  • Differential expression of fructosyllysine-specific receptors on monocytes and macrophages and possible pathophysiological significance.

    abstract：:A differing individual expression of fructosyllysine-specific receptors has been found on the monocytes of 90 insulin-dependent diabetic patients and 101 healthy control subjects. The degree of receptor expression is neither age- nor sex-dependent; however, in the diabetic group it correlates significantly with the se...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/BF02658499

    authors： Brandt R,Landmesser C,Vogt L,Hehmke B,Hanschke R,Kasbohm J,Hartmann K,Jäger B,Krantz S,Michaelis D

    更新日期：1996-10-01 00:00:00

  • A prospective study of endometriosis and risk of type 2 diabetes.

    abstract：AIMS/HYPOTHESIS:The objective of this study was to investigate the association between laparoscopically confirmed endometriosis and risk of type 2 diabetes. METHODS:We used data from the Nurses' Health Study II, a prospective cohort of female nurses followed for >25 years (N = 112,037). We used Cox proportional hazard...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/s00125-020-05347-6

    authors： Farland LV,Degnan WJ,Harris HR,Tobias DK,Missmer SA

    更新日期：2021-01-05 00:00:00

  • Lifestyle factors and mortality risk in individuals with diabetes mellitus: are the associations different from those in individuals without diabetes?

    abstract：AIMS/HYPOTHESIS:Thus far, it is unclear whether lifestyle recommendations for people with diabetes should be different from those for the general public. We investigated whether the associations between lifestyle factors and mortality risk differ between individuals with and without diabetes. METHODS:Within the Europe...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/s00125-013-3074-y

    authors： Sluik D,Boeing H,Li K,Kaaks R,Johnsen NF,Tjønneland A,Arriola L,Barricarte A,Masala G,Grioni S,Tumino R,Ricceri F,Mattiello A,Spijkerman AM,van der A DL,Sluijs I,Franks PW,Nilsson PM,Orho-Melander M,Fhärm E,Roland

    更新日期：2014-01-01 00:00:00

  • Insulin pump use in pregnancy is associated with lower HbA1c without increasing the rate of severe hypoglycaemia or diabetic ketoacidosis in women with type 1 diabetes.

    abstract：AIMS/HYPOTHESIS:The aim of this study was to compare glycaemic control and maternal-fetal outcomes in women with type 1 diabetes managed on insulin pumps compared with multiple daily injections of insulin (MDI). METHODS:In a retrospective study, glycaemic control and outcomes of 387 consecutive pregnancies in women wi...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/s00125-014-3163-6

    authors： Kallas-Koeman MM,Kong JM,Klinke JA,Butalia S,Lodha AK,Lim KI,Duan QM,Donovan LE

    更新日期：2014-04-01 00:00:00

  • Saturated non-esterified fatty acids stimulate de novo diacylglycerol synthesis and protein kinase c activity in cultured aortic smooth muscle cells.

    abstract：AIMS/HYPOTHESIS:Insulin resistance is linked with a cluster of multiple risk factors and excessive acceleration of atherosclerosis. The underlying mechanism is not, however, fully understood. METHODS:To determine the link between insulin resistance and altered vascular function, we focused on the effect of various non...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/s001250051668

    authors： Yu HY,Inoguchi T,Kakimoto M,Nakashima N,Imamura M,Hashimoto T,Umeda F,Nawata H

    更新日期：2001-05-01 00:00:00

  • Small-molecule inhibitors of the cystic fibrosis transmembrane conductance regulator increase pancreatic endocrine cell development in rat and mouse.

    abstract：AIMS/HYPOTHESIS:The main objective of this work was to discover new drugs that can activate the differentiation of multipotent pancreatic progenitors into endocrine cells. METHODS:In vitro experiments were performed using fetal pancreatic explants from rats and mice. In this assay, we examined the actions on pancreati...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/s00125-012-2778-8

    authors： Zertal-Zidani S,Busiah K,Edelman A,Polak M,Scharfmann R

    更新日期：2013-02-01 00:00:00

  • Nitric oxide is not involved in the initiation of insulin secretion from rat islets of Langerhans.

    abstract：:The involvement of nitric oxide as an intracellular messenger in the control of insulin secretion from pancreatic Beta cells was studied in rat islets of Langerhans by measuring: (i) nitric oxide generation in response to physiological insulin secretagogues; (ii) the effects of inhibitors of nitric oxide synthesis on ...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/BF02221676

    authors： Jones PM,Persaud SJ,Bjaaland T,Pearson JD,Howell SL

    更新日期：1992-11-01 00:00:00

  • Peptides in metabolic autonomic nerves.

    abstract：:Most polypeptides originally assigned to a specific organ and a specific effect seem to occur in many different parts of the body, in neurons as well as in endocrine cells. Thus gastrin and insulin, or very similar peptides can be demonstrated in extracts of the vagal nerves and of peripheral somatic nerves. Electrica...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/BF00254501

    authors： Uvnäs-Wallensten K

    更新日期：1981-03-01 00:00:00

  • Polymorphism in the Calpain 10 gene influences glucose metabolism in human fat cells.

    abstract：AIMS/HYPOTHESIS:A common G to A polymorphism ( UCSNP-43) in the Calpain 10 gene was recently found to be associated with Type II (non-insulin-dependent) diabetes mellitus and variations in post-absorptive and insulin stimulated glucose metabolism in vivo. We aimed to study the influence of Calpain 10 polymorphism on in...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/s00125-001-0732-2

    authors： Hoffstedt J,Rydén M,Löfgren P,Orho-Melander M,Groop L,Arner P

    更新日期：2002-02-01 00:00:00

  • Human mesenchymal stem cells and derived extracellular vesicles induce regulatory dendritic cells in type 1 diabetic patients.

    abstract：AIMS/HYPOTHESIS:Mesenchymal stem cells (MSCs) can exert an immunosuppressive effect on any component of the immune system, including dendritic cells (DCs), by direct contact, the release of soluble markers and extracellular vesicles (EVs). We evaluated whether MSCs and MSC-derived EVs have an immunomodulatory effect on...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/s00125-015-3808-0

    authors： Favaro E,Carpanetto A,Caorsi C,Giovarelli M,Angelini C,Cavallo-Perin P,Tetta C,Camussi G,Zanone MM

    更新日期：2016-02-01 00:00:00

  • Association of diabetes mellitus and dementia: the Rotterdam Study.

    abstract：:Dementia and non-insulin-dependent diabetes mellitus (NIDDM) are highly prevalent disorders in the elderly. Diabetes has repeatedly been reported to affect cognition, but its relation with dementia is uncertain. We therefore studied the association between diabetes and dementia in the Rotterdam Study, a large populati...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/s001250050588

    authors： Ott A,Stolk RP,Hofman A,van Harskamp F,Grobbee DE,Breteler MM

    更新日期：1996-11-01 00:00:00

  • Beta cell compensation for insulin resistance in Zucker fatty rats: increased lipolysis and fatty acid signalling.

    abstract：AIMS/HYPOTHESIS:The aim of this study was to determine the role of fatty acid signalling in islet beta cell compensation for insulin resistance in the Zucker fatty fa/fa (ZF) rat, a genetic model of severe obesity, hyperlipidaemia and insulin resistance that does not develop diabetes. MATERIALS AND METHODS:NEFA augmen...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/s00125-006-0305-5

    authors： Nolan CJ,Leahy JL,Delghingaro-Augusto V,Moibi J,Soni K,Peyot ML,Fortier M,Guay C,Lamontagne J,Barbeau A,Przybytkowski E,Joly E,Masiello P,Wang S,Mitchell GA,Prentki M

    更新日期：2006-09-01 00:00:00

  • Chronic exposure to high glucose decreases myo-inositol in cultured cerebral microvascular pericytes but not in endothelium.

    abstract：:It has been proposed that the development of diabetic complications may involve a depletion of cellular myo-inositol due to an increase in polyol (sorbitol) formation. We therefore initially examined the effect of diabetes on levels of these metabolites in isolated cerebral microvessels. Compared with microvessels fro...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/BF00274782

    authors： Sussman I,Carson MP,Schultz V,Wu XP,McCall AL,Ruderman NB,Tornheim K

    更新日期：1988-10-01 00:00:00

  • High-fat diet increases autophagic flux in pancreatic beta cells in vivo and ex vivo in mice.

    abstract：AIMS/HYPOTHESIS:Defective beta cell function during lipid oversupply and type 2 diabetes is associated with dysregulation of lysosomal function and autophagy. Whether this dysregulation represents augmentation or inhibition is unclear because of technical limitations in assaying autophagy. The current aim was to determ...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/s00125-015-3665-x

    authors： Chu KY,O'Reilly L,Ramm G,Biden TJ

    更新日期：2015-09-01 00:00:00

  • Acute effects of monounsaturated fatty acids with and without omega-3 fatty acids on vascular reactivity in individuals with type 2 diabetes.

    abstract：AIMS/HYPOTHESIS:We examined the acute postprandial effects of meals containing unsaturated fatty acids on flow-mediated dilation (FMD) of the brachial artery and triacylglycerols in individuals with type 2 diabetes. We hypothesised that consumption of omega-3 fatty acids would enhance vascular function. Saturated fat r...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/s00125-004-1600-7

    authors： West SG,Hecker KD,Mustad VA,Nicholson S,Schoemer SL,Wagner P,Hinderliter AL,Ulbrecht J,Ruey P,Kris-Etherton PM

    更新日期：2005-01-01 00:00:00

  • Visual sensitivity loss in the central 30° of visual field is associated with diabetic peripheral neuropathy.

    abstract：AIMS/HYPOTHESIS:Impaired central vision has been shown to predict diabetic peripheral neuropathy (DPN). Several studies have demonstrated diffuse retinal neurodegenerative changes in diabetic patients prior to retinopathy development, raising the prospect that non-central vision may also be compromised by primary neura...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/s00125-012-2457-9

    authors： Sampson GP,Shahidi AM,Vagenas D,Pritchard N,Edwards K,Russell AW,Malik RA,Efron N

    更新日期：2012-04-01 00:00:00

  • The incidence of type 1 (insulin-dependent) diabetes in Toronto.

    abstract：:An incidence of 9.0 out of 100,000 children under 19 years of age with Type 1 (insulin-dependent) diabetes was detected in Toronto during a 2 year prospective study. An increased number of cases occurred in the winter months of one of the years but not of the other during the study. The annual incidence was the same i...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/BF00281308

    authors： Ehrlich RM,Walsh LJ,Falk JA,Middleton PJ,Simpson NE

    更新日期：1982-04-01 00:00:00

  • Axonal swellings are related to type 2 diabetes, but not to distal diabetic sensorimotor polyneuropathy.

    abstract：AIMS/HYPOTHESIS:Distal diabetic sensorimotor polyneuropathy (DSP) is a common complication of diabetes with many patients showing a reduction of intraepidermal nerve fibre density (IENFD) from skin biopsy, a validated and sensitive diagnostic tool for the assessment of DSP. Axonal swelling ratio is a morphological quan...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/s00125-020-05352-9

    authors： Karlsson P,Gylfadottir SS,Kristensen AG,Ramirez JD,Cruz P,Le N,Shillo PR,Tesfaye S,Rice ASC,Tankisi H,Finnerup NB,Nyengaard JR,Jensen TS,Bennett DLH,Themistocleous AC

    更新日期：2021-01-23 00:00:00

  • Alloxan-induced alteration of insulin release, rubidium efflux and glucose metabolism in rat islets stimulated by various secretagogues.

    abstract：:Insulin release and 86Rb efflux were studied in perifused rat islets exposed in vitro to alloxan (2 mmol/l) for 5 min. At a low glucose concentration, alloxan transiently increased 86Rb efflux. Alloxan immediately and completely abolished the secretory response to glucose (15 mmol/l) and markedly delayed the reduction...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/BF01221952

    authors： Henquin JC,Malvaux P,Lambert AE

    更新日期：1979-04-01 00:00:00

  • Assessment of urinary microparticles in normotensive patients with type 1 diabetes.

    abstract：AIMS/HYPOTHESIS:Assessment of urinary extracellular vesicles including exosomes and microparticles (MPs) is an emerging approach for non-invasive detection of renal injury. We have previously reported that podocyte-derived MPs are increased in diabetic mice in advance of albuminuria. Here, we hypothesised that type 1 d...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/s00125-016-4190-2

    authors： Lytvyn Y,Xiao F,Kennedy CR,Perkins BA,Reich HN,Scholey JW,Cherney DZ,Burger D

    更新日期：2017-03-01 00:00:00

  • Metabolic actions of insulin-like growth factor II in cultured adult rat hepatocytes are not mediated through the insulin-like growth factor II receptor.

    abstract：:Short- and long-term regulation of hepatic carbohydrate metabolism by insulin-like growth factor II was studied in primary cultures of adult rat hepatocytes and compared to the metabolic potency of insulin. Insulin-like growth factor II stimulated glycogen synthesis from [14C]glucose, uptake of [3H]aminoisobutyric aci...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/BF00400920

    authors： Hartmann H,Meyer-Alber A,Braulke T

    更新日期：1992-03-01 00:00:00

  • Favourable effects of fenofibrate on lipids and cardiovascular disease in women with type 2 diabetes: results from the Fenofibrate Intervention and Event Lowering in Diabetes (FIELD) study.

    abstract：AIMS/HYPOTHESIS:In the double-blind placebo-controlled Fenofibrate Intervention and Event Lowering in Diabetes trial (n = 9,795), fenofibrate reduced major cardiovascular events in type 2 diabetes. Sex-related differences in fenofibrate response could be clinically relevant and were pre-specified analyses. METHODS:Wom...

    journal_title：Diabetologia

    pub_type： 杂志文章,随机对照试验

    doi：10.1007/s00125-014-3344-3

    authors： d'Emden MC,Jenkins AJ,Li L,Zannino D,Mann KP,Best JD,Stuckey BG,Park K,Saltevo J,Keech AC,FIELD Study Investigators.

    更新日期：2014-11-01 00:00:00

  • Adeno-associated viral vector-mediated human vascular endothelial growth factor gene transfer stimulates angiogenesis and wound healing in the genetically diabetic mouse.

    abstract：AIMS/HYPOTHESIS:We studied the gene therapy efficacy of diabetes-associated wound healing disorder with an adeno-associated virus (AAV) vector expressing the 165-amino acid isoform of human vascular endothelial growth factor-A (VEGF-A) by using an incisional skin-wound model produced on the back of female diabetic C57B...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/s00125-003-1064-1

    authors： Galeano M,Deodato B,Altavilla D,Cucinotta D,Arsic N,Marini H,Torre V,Giacca M,Squadrito F

    更新日期：2003-04-01 00:00:00

  • Oestrogens improve human pancreatic islet transplantation in a mouse model of insulin deficient diabetes.

    abstract：AIMS/HYPOTHESIS:Pancreatic islet transplantation (PIT) offers a physiological treatment for type 1 diabetes, but the failure of islet engraftment hinders its application. The female hormone 17β-oestradiol (E2) favours islet survival and stimulates angiogenesis, raising the possibility that E2 may enhance islet engraftm...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/s00125-012-2764-1

    authors： Liu S,Kilic G,Meyers MS,Navarro G,Wang Y,Oberholzer J,Mauvais-Jarvis F

    更新日期：2013-02-01 00:00:00

  • Delta cell secretory responses to insulin secretagogues are not mediated indirectly by insulin.

    abstract：AIMS/HYPOTHESIS:Somatostatin from islet delta cells inhibits insulin and glucagon secretion, but knowledge of the regulation of pancreatic somatostatin release is limited. Some insulin secretagogues stimulate somatostatin secretion, and here we investigated whether delta cell secretory responses are indirectly regulate...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/s00125-012-2546-9

    authors： Hauge-Evans AC,Anderson RL,Persaud SJ,Jones PM

    更新日期：2012-07-01 00:00:00

  • Cardiovascular and alcohol-related deaths in abnormal glucose tolerant and diabetic subjects.

    abstract：:The aim of this study was to compare the causes of death and parameters related to alcohol consumption, between subjects diagnosed as diabetic, clinically by their general practitioner, or glucose intolerant and in particular as diabetic, using the epidemiological criteria of an abnormal glucose level following an ora...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/BF00400850

    authors： Balkau B,Eschwège E,Fontbonne A,Claude JR,Warnet JM

    更新日期：1992-01-01 00:00:00