Metabolic surgery for the treatment of type 2 diabetes in obese individuals.

abstract：:Chronic diseases arising from obesity will continue to escalate over coming decades. Current approaches to combating obesity include lifestyle measures, surgical interventions and drugs that target weight reduction or the metabolic consequences of obesity. Lifestyle measures including physical activity are usually the...

journal_title：Diabetologia

authors： Carey AL,Kingwell BA

更新日期：2009-10-01 00:00:00

abstract：:Bone remodelling, which maintains bone mass constant during adulthood, is an energy-demanding process. This, together with the observation that the adipocyte-derived hormone leptin is a major inhibitor of bone remodelling, led to the hypothesis that bone cells regulate energy metabolism through an endocrine mechanism....

journal_title：Diabetologia

authors： Ducy P

更新日期：2011-06-01 00:00:00

abstract：AIMS/HYPOTHESIS:The aims of the study were to examine whether type 2 diabetes mellitus is associated with greater brain atrophy and cognitive decline, and whether brain atrophy mediates associations between type 2 diabetes and cognitive decline. METHODS:Participants without dementia aged 55-90 years from the Cognition...

journal_title：Diabetologia

authors： Callisaya ML,Beare R,Moran C,Phan T,Wang W,Srikanth VK

更新日期：2019-03-01 00:00:00

abstract：:Cases of malnutrition-related diabetes mellitus conforming to the description of the protein deficient pancreatic diabetes type in Ethiopian patients were compared with Type 1 (insulin-dependent) and Type 2 (non-insulin-dependent) diabetic. Fourteen of 39 malnutrition-related diabetes mellitus patients had fat malabso...

journal_title：Diabetologia

authors： Abdulkadir J,Mengesha B,Welde Gebriel Z,Keen H,Worku Y,Gebre P,Bekele A,Urga K,Taddesse AS

更新日期：1990-04-01 00:00:00

abstract：AIMS/HYPOTHESIS:The Cost of Diabetes in Europe-Type II study is the first coordinated attempt to assess the total costs of Type II (non-insulin-dependent) diabetes mellitus in Europe. Although gaining a clearer understanding of the economics of diabetes was the goal of the study, a secondary objective was to consider t...

journal_title：Diabetologia

authors： Koopmanschap M

更新日期：2002-07-01 00:00:00

abstract：:Clinical and biochemical studies were carried out in 33 patients with diabetes secondary to chronic calcific, non-alcoholic pancreatitis (tropical pancreatic diabetes) and in 35 Type 2 (non-insulin-dependent) diabetic patients and 35 non-diabetic subjects. Despite lower body mass indices, only 25% of patients with tro...

journal_title：Diabetologia

authors： Mohan V,Mohan R,Susheela L,Snehalatha C,Bharani G,Mahajan VK,Ramachandran A,Viswanathan M,Kohner EM

更新日期：1985-04-01 00:00:00

abstract：:Diabetes mellitus in Macaca mulatta rhesus monkeys is preceded by phases of obesity and hyperinsulinaemia and is similar to Type 2 (non-insulin-dependent) diabetes mellitus in man. To relate the progression of the disease to quantitative changes in islet morphology, post-mortem pancreatic tissue from 26 monkeys was ex...

journal_title：Diabetologia

authors： de Koning EJ,Bodkin NL,Hansen BC,Clark A

更新日期：1993-05-01 00:00:00

abstract：AIMS/HYPOTHESIS:Our aims were to compare osteoclastic activity between patients with acute Charcot's osteoarthropathy and diabetic and healthy controls, and to determine the effect of the receptor activator of nuclear factor-kappaB ligand (RANKL) and its decoy receptor osteoprotegerin (OPG). METHODS:Peripheral blood m...

journal_title：Diabetologia

authors： Mabilleau G,Petrova NL,Edmonds ME,Sabokbar A

更新日期：2008-06-01 00:00:00

abstract：:The selective permeability of alginate microcapsules, containing isolated rat islets of Langerhans or insulin secreting RINm5F cells, was investigated in vitro. An increase in insulin release was observed when microencapsulated islets were stimulated by glucose+theophylline, and when microencapsulated RINm5F cells wer...

journal_title：Diabetologia

authors： Darquy S,Reach G

更新日期：1985-10-01 00:00:00

abstract：AIMS/HYPOTHESIS:This 52-week multinational, randomised, open-label, parallel-group, non-inferiority trial compared clinical outcomes following supplementation of oral glucose-lowering drugs with basal insulin analogues detemir and glargine in type 2 diabetic patients. METHODS:Insulin-naive adults (n=582, HbA(1c) 7.5-1...

journal_title：Diabetologia

authors： Rosenstock J,Davies M,Home PD,Larsen J,Koenen C,Schernthaner G

更新日期：2008-03-01 00:00:00

abstract：AIM/HYPOTHESIS:Although mitochondrial oxidative phosphorylation (OxPhos) dysfunction is believed to be responsible for beta cell dysfunction in insulin resistance and mitochondrial diabetes, the mechanisms underlying progressive beta cell failure caused by defective mitochondrial OxPhos are largely unknown. METHODS:We...

journal_title：Diabetologia

authors： Kim YK,Joung KH,Ryu MJ,Kim SJ,Kim H,Chung HK,Lee MH,Lee SE,Choi MJ,Chang JY,Hong HJ,Kim KS,Lee SH,Kweon GR,Kim H,Lee CH,Kim HJ,Shong M

更新日期：2015-04-01 00:00:00

abstract：:A controlled trial of oral nicotinamide to prevent the onset of diabetes mellitus in high risk children was conducted in two centres. The selection criteria were age less than 16 years, islet cell antibody greater than or equal to 80 IUs, and first phase insulin release less than 5th percentile. All of eight untreated...

journal_title：Diabetologia

authors： Elliott RB,Chase HP

更新日期：1991-05-01 00:00:00

abstract：:Renal injury in diabetes mellitus is associated with progressive interstitial fibrosis and extracellular matrix accumulation. However, the phenotypes of cells forming the interstitial infiltrate in diabetic nephropathy have not been precisely defined. There is increasing evidence for the association of mast cells with...

journal_title：Diabetologia

authors： Rüger BM,Hasan Q,Greenhill NS,Davis PF,Dunbar PR,Neale TJ

更新日期：1996-10-01 00:00:00

abstract：AIMS/HYPOTHESIS:The aim was to conduct a systematic review and meta-analysis of randomised controlled clinical trials assessing the effect of probiotic, prebiotic or synbiotic supplementation on gut microbiota and glucose control and lipid levels in individuals with diabetes. METHODS:MEDLINE, EMBASE and the Cochrane L...

journal_title：Diabetologia

authors： Bock PM,Telo GH,Ramalho R,Sbaraini M,Leivas G,Martins AF,Schaan BD

更新日期：2021-01-01 00:00:00

abstract：AIMS/HYPOTHESIS:Among diabetic patients, glucose homeostasis may be affected by abnormal gastrointestinal motility and autonomic neuropathy. This study analysed whether oesophageal dysmotility, delayed gastric emptying or autonomic neuropathy affect glucose homeostasis. MATERIALS AND METHODS:Oesophageal manometry and ...

journal_title：Diabetologia

authors： Ohlsson B,Melander O,Thorsson O,Olsson R,Ekberg O,Sundkvist G

更新日期：2006-09-01 00:00:00

abstract：:Peritoneal glucose kinetics were evaluated in the anaesthetized rat, to assess whether the peritoneal cavity would be a suitable site for the implantation of membrane-protected islets of Langerhans (bioartificial pancreas) or the glucose sensor of an artificial B cell. Glucose was measured in peritoneal fluid samples ...

journal_title：Diabetologia

authors： Velho G,Froguel P,Reach G

更新日期：1989-06-01 00:00:00

abstract：:The insulin-like growth factor I receptor and the activity of its associated tyrosine kinase activity were characterised in wheat germ agglutinin extracts from skeletal muscle biopsies from nine control and ten obese Type 2 (non-insulin-dependent) diabetic subjects, who had marked peripheral in vivo insulin resistance...

journal_title：Diabetologia

authors： Livingston N,Pollare T,Lithell H,Arner P

更新日期：1988-12-01 00:00:00

abstract：:From December, 1966 through 1990, 3082 pancreas transplants were reported to the International Registry. A detailed analysis was performed on the 2087 transplants in the 1986-90 data base; during this time the overall one year recipient and graft functional survival rates were 89% and 62%. Univariate analyses showed g...

journal_title：Diabetologia

authors： Sutherland DE

更新日期：1991-08-01 00:00:00

abstract：:Mild hypoglycaemia was induced using an artificial pancreas in five normal subjects (from 5.00 +/- 0.15 to 2.83 +/- 0.15 mmol/l) by infusing 28 mU/m2 per min soluble insulin for 60 min. Six Type 1 (insulin-dependent) diabetic patients were stabilized for 14h using an artificial pancreas. They were then rendered hypogl...

journal_title：Diabetologia

authors： Bolli G,Calabrese G,De Feo P,Compagnucci P,Zega G,Angeletti G,Cartechini MG,Santeusanio F,Brunetti P

更新日期：1982-02-01 00:00:00

abstract：AIMS/HYPOTHESIS:We aimed to assess whether persistence of C-peptide secretion is associated with less glucose variability and fewer low-glucose events in adults with type 1 diabetes who use flash monitoring. METHODS:We performed a cross-sectional study of 290 adults attending a university teaching hospital diabetes cl...

journal_title：Diabetologia

authors： Gibb FW,McKnight JA,Clarke C,Strachan MWJ

更新日期：2020-05-01 00:00:00

abstract：:It is suggested that amylin (islet associated polypeptide), co-secreted with insulin from the pancreatic beta cells acts as a circulating hormone which opposes the action of insulin on muscle and increases hepatic glucose production. We have tested the effect of amylin in human subjects on postabsorptive glucose homeo...

journal_title：Diabetologia

authors： Wilding JP,Khandan-Nia N,Bennet WM,Gilbey SG,Beacham J,Ghatei MA,Bloom SR

更新日期：1994-02-01 00:00:00

abstract：:The relationship between plasma glucose, serum insulin, serum C-peptide and obesity was studied in 320 fasting high school students (13-18 years old), as part of a Busselton population study. For males and females respectively plasma glucose was 4.5 +/- 0.4 and 4.4 +/- 0.5 mmol/l (mean +/- SD), serum insulin 0.51 +/- ...

journal_title：Diabetologia

authors： Garcia-Webb P,Bonser A,Wearne KL,Gracey M

更新日期：1980-09-01 00:00:00

abstract：:Hypothalamic and autonomic nervous regulation of carbohydrate and amino acid metabolism in the liver and of lipid metabolism in adipose tissues is described. The direct neural mechanism underlying this regulation has been evaluated. Electrical stimulation of the ventromedial hypothalamic nucleus (VMH)-splanchnic nerve...

journal_title：Diabetologia

authors： Shimazu T

更新日期：1981-03-01 00:00:00

abstract：:It has been proposed that the development of diabetic complications may involve a depletion of cellular myo-inositol due to an increase in polyol (sorbitol) formation. We therefore initially examined the effect of diabetes on levels of these metabolites in isolated cerebral microvessels. Compared with microvessels fro...

journal_title：Diabetologia

authors： Sussman I,Carson MP,Schultz V,Wu XP,McCall AL,Ruderman NB,Tornheim K

更新日期：1988-10-01 00:00:00

abstract：AIMS/HYPOTHESIS:Coronary heart disease is the leading cause of mortality among people with type 1 diabetes. Diet is an important lifestyle factor that relates to risk of CHD. The aim of this study was to examine how diet and adherence to dietary guidelines differ between adults with and without type 1 diabetes, and the...

journal_title：Diabetologia

authors： Snell-Bergeon JK,Chartier-Logan C,Maahs DM,Ogden LG,Hokanson JE,Kinney GL,Eckel RH,Ehrlich J,Rewers M

更新日期：2009-05-01 00:00:00

abstract：AIMS/HYPOTHESIS:Pregnancies complicated by diabetes have a higher risk of adverse outcomes for mothers and children, including predisposition to disease later in life, e.g. metabolic syndrome and hypertension. We hypothesised that adverse outcomes from diabetic pregnancies may be linked to compromised placental functio...

journal_title：Diabetologia

authors： Salbaum JM,Kruger C,Zhang X,Delahaye NA,Pavlinkova G,Burk DH,Kappen C

更新日期：2011-07-01 00:00:00

abstract：:IDDM is associated with an increase in kidney size, which is due to cellular hypertrophy and progressive matrix accumulation within the glomerulus and throughout the tubulo-interstitium. The present study addressed the potential role of cysteine and metalloproteinases in renal hypertrophy of short-term diabetes. Three...

journal_title：Diabetologia

authors： Schaefer L,Schaefer RM,Ling H,Teschner M,Heidland A

更新日期：1994-06-01 00:00:00

abstract：AIMS/HYPOTHESIS:Studies have shown that dipeptidyl peptidase-4 (DPP4) inhibitors stimulate insulin secretion and increase beta cell mass in rodents. However, in these models hyperglycaemia has been induced early on in life and the treatment periods have been short. To explore the long-term effects of DPP4 inhibition on...

journal_title：Diabetologia

authors： Omar BA,Vikman J,Winzell MS,Voss U,Ekblad E,Foley JE,Ahrén B

更新日期：2013-08-01 00:00:00

abstract：AIMS/HYPOTHESIS:The aim of this study was to test the hypothesis that intensive glycaemic control (INT) and higher plasma C-peptide levels in patients with poorly controlled diabetes would be associated with better eye outcomes. METHODS:The incidence and progression of diabetic retinopathy (DR) was assessed by grading...

journal_title：Diabetologia

authors： Azad N,Agrawal L,Emanuele NV,Klein R,Bahn GD,Reaven P,VADT Study Group.

更新日期：2014-06-01 00:00:00

abstract：:The M variant of encephalomyocarditis virus (EMC) produces a disease similar to human insulin-dependent diabetes mellitus in some but not all strains of mice. This diabetogenic M variant was found to induce fivefold more interferon than non-diabetogenic strains of EMC in cultures of mouse L 929 fibroblasts. When inter...

journal_title：Diabetologia

authors： Wilson GL,Bellomo SC,Craighead JE

更新日期：1983-01-01 00:00:00