当前位置： SCI文献检索 > DIABETOLOGIA期刊下所有文献 > Coping with Type II diabetes: the patient's perspective.

Coping with Type II diabetes: the patient's perspective.

Abstract：

AIMS/HYPOTHESIS:The Cost of Diabetes in Europe-Type II study is the first coordinated attempt to assess the total costs of Type II (non-insulin-dependent) diabetes mellitus in Europe. Although gaining a clearer understanding of the economics of diabetes was the goal of the study, a secondary objective was to consider the impact of Type II diabetes from the patient's perspective. METHODS:The protocol included a health status questionnaire completed by the patient, the EQ-5D instrument, which assessed health-related quality of life by asking the patient to consider five dimensions: mobility, self-care, usual activities, pain and discomfort, as well as anxiety and depression. RESULTS:A total of 4189 patients in five of the eight countries completed the EQ-5D questionnaire for assessing the quality of life. Overall, patients with Type II diabetes reported scores between good and fair states of health, although the average score (0.69) was lower than that of the similarly aged, healthy population in the United Kingdom. However, these values were higher (0.76) in Type II diabetic patients without complications. The onset of either microvascular or macrovascular complications adversely affected quality of life (0.69 and 0.69, respectively), and the presence of both types of complications further reduced the quality of life score to 0.59. Treatment with insulin was also associated with a reduced quality of life (0.62). Multivariate analysis showed that the following factors, in order of importance, independently pre-dict a poorer quality of life: gender, complications, treatment type, age, obesity and hyperglycaemia. CONCLUSION/INTERPRETATION:The results showed that health-related quality of life is an important issue in Type II diabetes and this decreases with disease progression. The implication for policy-makers is that reducing or preventing the complications of diabetes is the key to improving patient quality of life.

journal_name

Diabetologia

journal_title

Diabetologia

authors

Koopmanschap M

doi

10.1007/s00125-002-0861-2

subject

Has Abstract

pub_date

2002-07-01 00:00:00

pages

S21-S22

issue

Suppl 1

eissn

0012-186X

issn

1432-0428

pii

10.1007/s00125-002-0861-2

journal_volume

45

pub_type

杂志文章

相关文献

DIABETOLOGIA文献大全
  • Genome-wide association and meta-analysis in populations from Starr County, Texas, and Mexico City identify type 2 diabetes susceptibility loci and enrichment for expression quantitative trait loci in top signals.

    abstract：AIMS/HYPOTHESIS:We conducted genome-wide association studies (GWASs) and expression quantitative trait loci (eQTL) analyses to identify and characterise risk loci for type 2 diabetes in Mexican-Americans from Starr County, TX, USA. METHOD:Using 1.8 million directly interrogated and imputed genotypes in 837 unrelated t...

    journal_title：Diabetologia

    pub_type： 杂志文章,meta分析

    doi：10.1007/s00125-011-2188-3

    authors： Below JE,Gamazon ER,Morrison JV,Konkashbaev A,Pluzhnikov A,McKeigue PM,Parra EJ,Elbein SC,Hallman DM,Nicolae DL,Bell GI,Cruz M,Cox NJ,Hanis CL

    更新日期：2011-08-01 00:00:00

  • Fasting proinsulin levels are significantly associated with 20 year cancer mortality rates. The Hoorn Study.

    abstract：AIMS/HYPOTHESIS:Proinsulin is possibly associated with cancer through activation of insulin receptor isoform A. We sought to investigate the associations between proinsulin and 20 year cancer mortality rates. METHODS:The study was performed within the Hoorn Study, a population-based study of glucose metabolism in indi...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/s00125-013-2864-6

    authors： Walraven I,van 't Riet E,Stehouwer CD,Polak BC,Moll AC,Dekker JM,Nijpels G

    更新日期：2013-05-01 00:00:00

  • A missense mutation in the CD38 gene, a novel factor for insulin secretion: association with Type II diabetes mellitus in Japanese subjects and evidence of abnormal function when expressed in vitro.

    abstract：:Cyclic adenosine 5'diphosphate-ribose (cADPR) is thought to have a second messenger role in insulin secretion through mobilisation of Ca2+. As human lymphocyte antigen CD38 has both ADP-ribosyl cyclase and cADPR hydrolase activity, it may be important in glucose-induced insulin secretion in islets. Thirty one randomly...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/s001250051026

    authors： Yagui K,Shimada F,Mimura M,Hashimoto N,Suzuki Y,Tokuyama Y,Nata K,Tohgo A,Ikehata F,Takasawa S,Okamoto H,Makino H,Saito Y,Kanatsuka A

    更新日期：1998-09-01 00:00:00

  • A missense mutation of the muscle glycogen synthase gene (M416V) is associated with insulin resistance in the Japanese population.

    abstract：:Muscle glycogen synthase (GYS1) is a key enzyme of non-oxidative pathway of glucose metabolism that has been reported to be related to insulin resistance in non-insulin-dependent diabetic (NIDDM) patients. We scanned the GYS1 gene for mutation by single strand conformational polymorphism in 244 non-obese Japanese NIDD...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/s001250050772

    authors： Shimomura H,Sanke T,Ueda K,Hanabusa T,Sakagashira S,Nanjo K

    更新日期：1997-08-01 00:00:00

  • Involvement of tissue bacteria in the onset of diabetes in humans: evidence for a concept.

    abstract：AIMS/HYPOTHESIS:Evidence suggests that bacterial components in blood could play an early role in events leading to diabetes. To test this hypothesis, we studied the capacity of a broadly specific bacterial marker (16S rDNA) to predict the onset of diabetes and obesity in a general population. METHODS:Data from an Epid...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/s00125-011-2329-8

    authors： Amar J,Serino M,Lange C,Chabo C,Iacovoni J,Mondot S,Lepage P,Klopp C,Mariette J,Bouchez O,Perez L,Courtney M,Marre M,Klopp P,Lantieri O,Doré J,Charles M,Balkau B,Burcelin R,D.E.S.I.R. Study Group.

    更新日期：2011-12-01 00:00:00

  • Role of insulin resistance in the pathogenesis of NIDDM.

    abstract：:The above discussion illustrating the multitude of variables which influence insulin sensitivity in normal subjects challenges the prevailing view that insulin sensitivity is genetically determined in patients with NIDDM. The lack of accurate quantitation of all determinants of insulin sensitivity in the cross-section...

    journal_title：Diabetologia

    pub_type： 杂志文章,评审

    doi：10.1007/BF00400597

    authors： Yki-Järvinen H

    更新日期：1995-12-01 00:00:00

  • Myofibroblast progenitor cells are increased in number in patients with type 1 diabetes and express less bone morphogenetic protein 6: a novel clue to adverse tissue remodelling?

    abstract：AIMS/HYPOTHESIS:Growth factor imbalance and endothelial progenitor cell dysfunction are well-known elements of the inappropriate response to injury in human and experimental diabetes. We hypothesised that in diabetes the outgrowth of myofibroblast progenitor cells (MFPCs) is also altered and that this relates to aberra...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/s00125-006-0172-0

    authors： Nguyen TQ,Chon H,van Nieuwenhoven FA,Braam B,Verhaar MC,Goldschmeding R

    更新日期：2006-05-01 00:00:00

  • The effect of insulin on renal sodium metabolism. A review with clinical implications.

    abstract：:Data are discussed which demonstrate that insulin plays an important role in sodium metabolism. The primary action of insulin on sodium balance is exerted on the kidney. Increases in plasma insulin concentration within the physiological range stimulate sodium reabsorption by the distal nephron segments and this effect...

    journal_title：Diabetologia

    pub_type： 杂志文章,评审

    doi：10.1007/BF00252649

    authors： DeFronzo RA

    更新日期：1981-09-01 00:00:00

  • Symptoms, signs and complications in newly diagnosed type 2 diabetic patients, and their relationship to glycaemia, blood pressure and weight.

    abstract：AIMS/HYPOTHESIS:To document the prevalence of typical diabetic symptoms, signs and complications in the diagnosis of type 2 diabetes mellitus, examine their pre-diagnostic duration, and analyse associations with glycaemic level, blood pressure (BP), and weight. METHODS:An epidemiological population-based study of 1137...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/s00125-004-1625-y

    authors： Drivsholm T,de Fine Olivarius N,Nielsen AB,Siersma V

    更新日期：2005-02-01 00:00:00

  • Prolonged but partial impairment of the hypoglycaemic physiological response following short-term hypoglycaemia in normal subjects.

    abstract：:Recent studies have reported reduced endocrine and symptomatic responses to hypoglycaemia 18-24 h after antecedent hypoglycaemia in both non-diabetic subjects and those with insulin-dependent diabetes mellitus. We examined these and peripheral physiological responses in eight non-diabetic subjects aged 23-35 years in ...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/BF00422367

    authors： George E,Harris N,Bedford C,Macdonald IA,Hardisty CA,Heller SR

    更新日期：1995-10-01 00:00:00

  • Diabetes as a risk factor for stroke. A population perspective.

    abstract：:Stroke incidence, case fatality and mortality in diabetic patients were compared to non-diabetic subjects in a 35-74-year-old population in northern Sweden (target population 241,000). During an 8-year period, 1,544 stroke events in diabetic patients and 4,826 events in non-diabetic subjects were recorded. The crude i...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/BF00402176

    authors： Stegmayr B,Asplund K

    更新日期：1995-09-01 00:00:00

  • Heterogeneous nuclear ribonucleoproteins F and K mediate insulin inhibition of renal angiotensinogen gene expression and prevention of hypertension and kidney injury in diabetic mice.

    abstract：AIMS/HYPOTHESIS:We investigated whether heterogeneous nuclear ribonucleoproteins F and K (hnRNP F, hnRNP K) mediate insulin inhibition of renal Agt expression and prevention of hypertension and kidney injury in an Akita mouse model of type 1 diabetes. METHODS:Adult male Akita mice (12 weeks old) were treated with insu...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/s00125-013-2910-4

    authors： Abdo S,Lo CS,Chenier I,Shamsuyarova A,Filep JG,Ingelfinger JR,Zhang SL,Chan JS

    更新日期：2013-07-01 00:00:00

  • Properties of isolated human islets of Langerhans: insulin secretion, glucose oxidation and protein phosphorylation.

    abstract：:In the present study, human islets were isolated by collagenase digestion from the pancreases of three kidney donors. Maintainance of the islets in tissue culture enabled insulin release, glucose oxidation and Ca2+ -calmodulin-dependent protein phosphorylation to be determined using the same islets. Increasing glucose...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/BF00279924

    authors： Harrison DE,Christie MR,Gray DW

    更新日期：1985-02-01 00:00:00

  • High saturated fat and low starch and fibre are associated with hyperinsulinaemia in a non-diabetic population: the San Luis Valley Diabetes Study.

    abstract：:A geographically based sample of 1069 Hispanic and non-Hispanic white persons aged 20-74 years, living in southern Colorado and who tested normal on an oral glucose tolerance test (World Health Organization criteria) were evaluated to determine associations of dietary factors with fasting serum insulin concentrations....

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/s001250050697

    authors： Marshall JA,Bessesen DH,Hamman RF

    更新日期：1997-04-01 00:00:00

  • Insulin and non-esterified fatty acid relations to alimentary lipaemia and plasma concentrations of postprandial triglyceride-rich lipoproteins in healthy middle-aged men.

    abstract：AIMS/HYPOTHESIS:Enhanced and prolonged postprandial lipaemia is related to cardiovascular disease but how postprandial lipaemia is regulated is poorly known. We therefore determined the relations of fasting insulin concentrations to fasting and postprandial lipids, lipoproteins and non-esterified fatty acids in middle-...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/s001250050028

    authors： Boquist S,Hamsten A,Karpe F,Ruotolo G

    更新日期：2000-02-01 00:00:00

  • The impact of diabetes on productivity in China.

    abstract：AIMS/HYPOTHESIS:Diabetes increases the risk of premature death and reduces work productivity. We estimated the impact of diabetes in China in terms of mortality, years of life lost, and productivity-adjusted life years (PALYs) lost in the Chinese population. METHODS:Life table modelling was used with simulated follow-...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/s00125-019-4875-4

    authors： Hird TR,Zomer E,Owen A,Chen L,Ademi Z,Magliano DJ,Liew D

    更新日期：2019-07-01 00:00:00

  • Urinary sodium and potassium excretion and the risk of type 2 diabetes: a prospective study in Finland.

    abstract：AIMS/HYPOTHESIS:No previous studies on the association between salt intake and the risk of type 2 diabetes have been reported. The aim of this study was to assess whether high salt intake, measured by 24-h urinary sodium excretion, is an independent risk factor for type 2 diabetes. METHODS:We followed prospectively 93...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/s00125-005-1824-1

    authors： Hu G,Jousilahti P,Peltonen M,Lindström J,Tuomilehto J

    更新日期：2005-08-01 00:00:00

  • A longitudinal study of depression and gestational diabetes in pregnancy and the postpartum period.

    abstract：AIMS/HYPOTHESIS:Depression and glucose intolerance commonly co-occur among non-pregnant individuals; however, the temporal relationship between gestational diabetes (GDM) and depression during pregnancy and the postpartum period is less understood. Our objective was to assess longitudinal associations between depressio...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/s00125-016-4086-1

    authors： Hinkle SN,Buck Louis GM,Rawal S,Zhu Y,Albert PS,Zhang C

    更新日期：2016-12-01 00:00:00

  • Differential white cell count and incident type 2 diabetes: the Insulin Resistance Atherosclerosis Study.

    abstract：AIMS/HYPOTHESIS:White cell count has been shown to predict incident type 2 diabetes, but differential white cell count has received scant attention. We examined the risk of developing diabetes associated with differential white cell count and neutrophil:lymphocyte ratio and the effect of insulin sensitivity and subclin...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/s00125-013-3080-0

    authors： Lorenzo C,Hanley AJ,Haffner SM

    更新日期：2014-01-01 00:00:00

  • Multiple metabolic abnormalities in normal glucose tolerant relatives of NIDDM families.

    abstract：:Non-diabetic first degree relatives of non-insulin-dependent diabetic (NIDDM) families are at increased risk of developing diabetes mellitus, and have been studied to identify early metabolic abnormalities. Hormone concentrations measured by specific enzyme immunoassays were assessed in non-diabetic relatives of North...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/s001250050805

    authors： Humphriss DB,Stewart MW,Berrish TS,Barriocanal LA,Trajano LR,Ashworth LA,Brown MD,Miller M,Avery PJ,Alberti KG,Walker M

    更新日期：1997-10-01 00:00:00

  • Hepatic DNA methylation modifications in early development of rats resulting from perinatal BPA exposure contribute to insulin resistance in adulthood.

    abstract：AIMS/HYPOTHESIS:Perinatal exposure to bisphenol A (BPA), a widely distributed environmental endocrine disruptor, is associated with insulin resistance and diabetes in offspring. The underlying molecular mechanisms could involve epigenetics, as adverse effects induced by environmental exposure in early life are suggeste...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/s00125-013-2944-7

    authors： Ma Y,Xia W,Wang DQ,Wan YJ,Xu B,Chen X,Li YY,Xu SQ

    更新日期：2013-09-01 00:00:00

  • Genes for systemic vascular complications are differentially expressed in the livers of type 2 diabetic patients.

    abstract：AIMS/HYPOTHESIS:Type 2 diabetes is characterised by excessive hepatic glucose production and frequently leads to systemic vascular complications. We therefore analysed the relationship between the gene expression profile in the liver and the pathophysiology of Type 2 diabetes. METHODS:Liver biopsy samples were obtaine...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/s00125-004-1366-y

    authors： Takamura T,Sakurai M,Ota T,Ando H,Honda M,Kaneko S

    更新日期：2004-04-01 00:00:00

  • The immune response to influenza vaccination in diabetic patients.

    abstract：:The immune response of diabetic patients to influenza vaccination was examined in 31 patients, 10 with Type 1 (insulin-dependent) diabetes and 21 with Type 2 (non-insulin-dependent diabetes), and in 19 normal subjects. Each received a single intramuscular injection of the 3 virus strains (A/Chile,A/Philippines,B/USSR)...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/BF00870139

    authors： Pozzilli P,Gale EA,Visalli N,Baroni M,Crovari P,Frighi V,Cavallo MG,Andreani D

    更新日期：1986-12-01 00:00:00

  • In the lipodystrophy associated with highly active antiretroviral therapy, pseudo-Cushing's syndrome is associated with increased regeneration of cortisol by 11beta-hydroxysteroid dehydrogenase type 1 in adipose tissue.

    abstract：AIMS/HYPOTHESIS:Highly active antiretroviral therapy (HAART) in patients infected with human immunodeficiency virus (HIV) is associated with a poorly understood lipodystrophic and hypertriglyceridaemic syndrome, which resembles Cushing's syndrome, but in which plasma cortisol is not elevated. We tested the hypothesis t...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/s00125-004-1508-2

    authors： Sutinen J,Kannisto K,Korsheninnikova E,Nyman T,Ehrenborg E,Andrew R,Wake DJ,Hamsten A,Walker BR,Yki-Järvinen H

    更新日期：2004-10-01 00:00:00

  • Prevention of diabetic glomerulopathy in streptozotocin diabetic rats by insulin treatment.

    abstract：:Glomerular basement membrane thickness (GBMT) has been measured in streptozotocin diabetic rats treated with insulin. The study included 3 groups of 8 rats each: 1) a 'well-controlled' group of diabetic rats under insulin treatment with a plasma glucose level reasonable close to normal values, 2) a 'poorly-controlled'...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/BF01223621

    authors： Rasch R

    更新日期：1979-05-01 00:00:00

  • Effects of insulin on the disposal of 14C-labelled very low density lipoprotein triglycerides in intact and hepatectomized rats.

    abstract：:In sham-operated rats, intravenous administration of 14C-very low density lipoprotein triglycerides (with labelled esterified fatty acids) caused an initial decrease and subsequent increase in plasma 14C-lipids of both very low density lipoproteins (VLDL) (density less than 1.006) and lipoproteins of density greater t...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/BF00282718

    authors： Argilés J,Herrera E

    更新日期：1983-04-01 00:00:00

  • Type 2 (non-insulin-dependent) diabetes mellitus, migration and westernisation: the Tokelau Island Migrant Study.

    abstract：:The migration of Tokelauans from a traditional atoll in the Pacific to urban New Zealand is associated with an increased prevalence and incidence of Type 2 (non-insulin-dependent) diabetes mellitus over the period 1968-1982. During the same period, a lesser but definite increase is seen among non-migrants in Tokelau. ...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/BF00285332

    authors： Ostbye T,Welby TJ,Prior IA,Salmond CE,Stokes YM

    更新日期：1989-08-01 00:00:00

  • Surface binding, internalization and degradation by cultured human fibroblasts of low density lipoproteins isolated from type 1 (insulin-dependent) diabetic patients: changes with metabolic control.

    abstract：:A previous study of low density lipoprotein metabolism by cultured cells focused on the metabolism of normal lipoproteins in vitro by fibroblasts isolated from diabetic patients. No abnormalities were found. We have followed the opposite approach. Using normal human fibroblasts as test cells we compared the metabolism...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/BF00282585

    authors： Lopes-Virella MF,Sherer GK,Lees AM,Wohltmann H,Mayfield R,Sagel J,LeRoy EC,Colwell JA

    更新日期：1982-06-01 00:00:00

  • Human mesenchymal stem cell-derived microvesicles modulate T cell response to islet antigen glutamic acid decarboxylase in patients with type 1 diabetes.

    abstract：AIMS/HYPOTHESIS:Mesenchymal stem cells (MSCs) have been shown to abrogate in vitro the proinflammatory response in type 1 diabetes. The mechanism involves paracrine factors, which may include microvesicles (MVs). We evaluated whether MVs derived from heterologous bone-marrow MSCs exert an immunomodulatory effect on T c...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/s00125-014-3262-4

    authors： Favaro E,Carpanetto A,Lamorte S,Fusco A,Caorsi C,Deregibus MC,Bruno S,Amoroso A,Giovarelli M,Porta M,Perin PC,Tetta C,Camussi G,Zanone MM

    更新日期：2014-08-01 00:00:00

  • Obesity and insulin secretion in fasting high school students.

    abstract：:The relationship between plasma glucose, serum insulin, serum C-peptide and obesity was studied in 320 fasting high school students (13-18 years old), as part of a Busselton population study. For males and females respectively plasma glucose was 4.5 +/- 0.4 and 4.4 +/- 0.5 mmol/l (mean +/- SD), serum insulin 0.51 +/- ...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/BF00275268

    authors： Garcia-Webb P,Bonser A,Wearne KL,Gracey M

    更新日期：1980-09-01 00:00:00