The immune response to influenza vaccination in diabetic patients.

abstract：AIMS/HYPOTHESIS:The Ca2+/calmodulin-dependent protein kinase II (CaMK II) is highly expressed in pancreatic islets and associated with insulin secretion vesicles. The suppression of CaMK II disturbs insulin secretion and insulin gene expression. There are four isoforms of CaMK II, alpha to delta, that are expressed fro...

journal_title：Diabetologia

authors： Rochlitz H,Voigt A,Lankat-Buttgereit B,Göke B,Heimberg H,Nauck MA,Schiemann U,Schatz H,Pfeiffer AF

更新日期：2000-04-01 00:00:00

abstract：:Streptozotocin diabetic rats have larger kidneys than non-diabetic rats. In the present study the rate of kidney growth during the first seven days of diabetes was correlated with the blood glucose concentration. Over a wide range of blood glucose concentrations (116-340 mg/100 ml) the kidney weight, protein content a...

journal_title：Diabetologia

authors： Seyer-Hansen K

更新日期：1977-04-01 00:00:00

abstract：AIMS/HYPOTHESIS:Preferential visceral adipose tissue (VAT) accumulation has been clearly associated with insulin resistance. In contrast, the impact of visceral obesity on beta cell function is controversial. METHODS:In 62 non-diabetic women and men (age 24-69 years, BMI 21-39 kg/m2), we measured VAT and subcutaneous ...

journal_title：Diabetologia

authors： Gastaldelli A,Sironi AM,Ciociaro D,Positano V,Buzzigoli E,Giannessi D,Lombardi M,Mari A,Ferrannini E

更新日期：2005-10-01 00:00:00

abstract：:The damaging effects of glucose on the cells which contribute to the development of diabetic complications are ill-understood. There are three major hypotheses - the sorbitol pathway, non-enzymatic glycation of proteins and increased oxidative stress - and many examples illustrate inter-connections between the three. ...

journal_title：Diabetologia

authors： Tomlinson DR

更新日期：1999-11-01 00:00:00

abstract：AIMS/HYPOTHESIS:Perinatal exposure to bisphenol A (BPA), a widely distributed environmental endocrine disruptor, is associated with insulin resistance and diabetes in offspring. The underlying molecular mechanisms could involve epigenetics, as adverse effects induced by environmental exposure in early life are suggeste...

journal_title：Diabetologia

authors： Ma Y,Xia W,Wang DQ,Wan YJ,Xu B,Chen X,Li YY,Xu SQ

更新日期：2013-09-01 00:00:00

abstract：:In healthy subjects hypoglycaemia causes a fall in body temperature through increased sweating and limb blood flow, and despite increased metabolic heat production. We studied thermoregulatory responses to hyperinsulinaemic (100 mU.m-2.min-1) (a) hypoglycaemia (2.5 mmol/l) and (b) euglycaemia (4.5 mmol/l) in insulin-d...

journal_title：Diabetologia

authors： Maggs DG,Macdonald IA,Tattersall RB

更新日期：1994-07-01 00:00:00

abstract：:In order to characterize pancreatic beta cell function in Geneva bred spiny mice (acomys cahirinus), the dynamics of immunoreactive insulin release were examined during perifusion of pancreatic islets isolated from normoglycemic acomys. The initial insulin response of acomys was slow: no clear-cut early (1 to 10 min) ...

journal_title：Diabetologia

authors： Rabinovitch A,Gutzeit A,Kikuchi M,Cerasi E,Renold AE

更新日期：1975-10-01 00:00:00

abstract：:Eight obese patients and 12 normal individuals underwent a euglycaemic insulin clamp (20 and 40 mU m2-1.min-1) along with continuous infusion of 3-3H-glucose and 1-14C-palmitate and indirect calorimetry. Basal plasma glucose concentration (4.7 +/- 0.3 vs 4.4 +/- 0.2 mmol/l) was similar in the two groups, whereas hepat...

journal_title：Diabetologia

authors： Del Prato S,Enzi G,Vigili de Kreutzenberg S,Lisato G,Riccio A,Maifreni L,Iori E,Zurlo F,Sergi G,Tiengo A

更新日期：1990-04-01 00:00:00

abstract：AIMS/HYPOTHESIS:Reduced oxidative capacity of the mitochondria in skeletal muscle has been suggested to contribute to insulin resistance and type 2 diabetes. Moreover, a set of genes influencing oxidative phosphorylation (OXPHOS) is downregulated in diabetic muscle. Here we studied whether genetic, epigenetic and non-g...

journal_title：Diabetologia

authors： Rönn T,Poulsen P,Hansson O,Holmkvist J,Almgren P,Nilsson P,Tuomi T,Isomaa B,Groop L,Vaag A,Ling C

更新日期：2008-07-01 00:00:00

abstract：:Bone remodelling, which maintains bone mass constant during adulthood, is an energy-demanding process. This, together with the observation that the adipocyte-derived hormone leptin is a major inhibitor of bone remodelling, led to the hypothesis that bone cells regulate energy metabolism through an endocrine mechanism....

journal_title：Diabetologia

authors： Ducy P

更新日期：2011-06-01 00:00:00

abstract：:We report the clinical characteristics of all insulin-treated diabetic patients (783 males and 716 females) living on July 1 1973 in a Danish county. In 18 patients diabetes was believed to be secondary to another disease or condition. Of all patients, 43% of the males and 55% of the females were greater than age 50 y...

journal_title：Diabetologia

authors： Green A,Hougaard P

更新日期：1983-09-01 00:00:00

abstract：:The incorporation of [35S]sulfate into heart proteoglycans has been studied in normal and alloxan-diabetic rats by perfusion and in vivo administration of the isotope; in the latter situation, comparison was also made of radiolabeled sulfate utilization by several other tissues (kidney, liver, lung, muscle, testes and...

journal_title：Diabetologia

authors： Spiro MJ

更新日期：1987-04-01 00:00:00

abstract：AIMS/HYPOTHESIS:The aim of this study was to demonstrate that hormonal vitamin D (calcitriol) modulates the local pancreatic islet renin-angiotensin system (RAS) whilst improving islet beta cell secretory function. METHODS:Isolated islets cultured ex vivo under high- or low-glucose conditions and treated with or witho...

journal_title：Diabetologia

authors： Cheng Q,Li YC,Boucher BJ,Leung PS

更新日期：2011-08-01 00:00:00

abstract：:Aspects of the regulation of the glucose transport by perfused hearts of normal rats have been studied by measuring glucose transport (via the efflux of labelled 3-O-methyl-D-glucose) and glucose transporters (via the labelled cytochalasin B binding assay). Similarly to what is observed with insulin, increasing worklo...

journal_title：Diabetologia

authors： Zaninetti D,Greco-Perotto R,Jeanrenaud B

更新日期：1988-02-01 00:00:00

abstract：AIMS/HYPOTHESIS:Thickening of the basement membrane and selective loss of pericytes occur early in diabetic retinopathy. As we showed previously that pericyte adhesion is impaired on extracellular matrix produced by endothelial cells in high hexose concentrations, we aimed to verify if altered adhesion could influence ...

journal_title：Diabetologia

authors： Beltramo E,Buttiglieri S,Pomero F,Allione A,D'Alù F,Ponte E,Porta M

更新日期：2003-03-01 00:00:00

abstract：:Monolayer cell cultures from pancreatic islets of aging 129/J strain diabetes (db3J/db3J) and lean littermate control mice were tested for differences in glucagon and insulin secretion in either serum-free Eagle's minimal essential medium (MEM) or Dulbecco's modified minimal essential medium (DMEM). There was a highly...

journal_title：Diabetologia

authors： Leiter EH,Strack I,Eisenstein AB

更新日期：1980-07-01 00:00:00

abstract：AIMS/HYPOTHESIS:The rs1990760 polymorphism (Ala946Thr) of interferon induced with helicase C domain 1 (IFIH1) has been proposed to associate with type 1 diabetes. In this study, association between IFIH1 Ala946Thr and type 1 diabetes was investigated in two distinct white populations, the Hungarians and Finns. METHODS...

journal_title：Diabetologia

authors： Jermendy A,Szatmári I,Laine AP,Lukács K,Horváth KH,Körner A,Madácsy L,Veijola R,Simell O,Knip M,Ilonen J,Hermann R,Finnish Paediatric Diabetes Registry.,HUNT1DGENES Programme.

更新日期：2010-01-01 00:00:00

abstract：AIMS/HYPOTHESIS:Proliferative diabetic retinopathy is a major debilitating disease causing most cases of blindness in humans in the Western world. Photocoagulation is the established therapy of proliferative diabetic retinopathy, although the molecular mechanisms of its effects are still not known. Recently angiostatin...

journal_title：Diabetologia

authors： Spranger J,Hammes HP,Preissner KT,Schatz H,Pfeiffer AF

更新日期：2000-11-01 00:00:00

abstract：AIMS/HYPOTHESIS:Our aims were to compare osteoclastic activity between patients with acute Charcot's osteoarthropathy and diabetic and healthy controls, and to determine the effect of the receptor activator of nuclear factor-kappaB ligand (RANKL) and its decoy receptor osteoprotegerin (OPG). METHODS:Peripheral blood m...

journal_title：Diabetologia

authors： Mabilleau G,Petrova NL,Edmonds ME,Sabokbar A

更新日期：2008-06-01 00:00:00

abstract：AIMS/HYPOTHESIS:In the double-blind placebo-controlled Fenofibrate Intervention and Event Lowering in Diabetes trial (n = 9,795), fenofibrate reduced major cardiovascular events in type 2 diabetes. Sex-related differences in fenofibrate response could be clinically relevant and were pre-specified analyses. METHODS:Wom...

journal_title：Diabetologia

authors： d'Emden MC,Jenkins AJ,Li L,Zannino D,Mann KP,Best JD,Stuckey BG,Park K,Saltevo J,Keech AC,FIELD Study Investigators.

更新日期：2014-11-01 00:00:00

abstract：AIMS/HYPOTHESIS:The aim of this study was to determine the role of fatty acid signalling in islet beta cell compensation for insulin resistance in the Zucker fatty fa/fa (ZF) rat, a genetic model of severe obesity, hyperlipidaemia and insulin resistance that does not develop diabetes. MATERIALS AND METHODS:NEFA augmen...

journal_title：Diabetologia

authors： Nolan CJ,Leahy JL,Delghingaro-Augusto V,Moibi J,Soni K,Peyot ML,Fortier M,Guay C,Lamontagne J,Barbeau A,Przybytkowski E,Joly E,Masiello P,Wang S,Mitchell GA,Prentki M

更新日期：2006-09-01 00:00:00

abstract：:To test the hypothesis that interaction between genetic, immunological, clinical and metabolic risk factors influences the outcome of Type II (non-insulin-dependent) diabetes mellitus, we examined which of the above factors present at baseline were associated with mortality in 134 Type II diabetic patients followed fo...

journal_title：Diabetologia

authors： Forsblom CM,Sane T,Groop PH,Tötterman KJ,Kallio M,Saloranta C,Laasonen L,Summanen P,Lepäntalo M,Laatikainen L,Matikainen E,Teppo AM,Koskimies S,Groop L

更新日期：1998-11-01 00:00:00

abstract：:Specific insulin receptors are present in the liver and brain of the lizard Anolis carolinesis. In this study, the specific binding of 125I-insulin to the receptors showed time, temperature and pH dependency. Specific binding to crude membranes prepared from brain was 1-2% of the total radioactivity added compared to ...

journal_title：Diabetologia

authors： Shemer J,Penhos JC,LeRoith D

更新日期：1986-05-01 00:00:00

abstract：AIMS/HYPOTHESIS:Pancreatic beta cells play a central role in the control of glucose homeostasis by secreting insulin to stimulate glucose uptake by peripheral tissues. Understanding the molecular mechanisms that control beta cell function and plasticity has critical implications for the pathophysiology and therapy of m...

journal_title：Diabetologia

authors： Thorens B,Tarussio D,Maestro MA,Rovira M,Heikkilä E,Ferrer J

更新日期：2015-03-01 00:00:00

abstract：:Diabetic nephropathy is the main cause of increased mortality and morbidity in IDDM patients. The effect of antihypertensive treatment on the progression of the nephropathy is highly variable. The aim of this study was to evaluate putative predictors of the progression in diabetic nephropathy during long-term antihyp...

journal_title：Diabetologia

authors： Rossing P,Hommel E,Smidt UM,Parving HH

更新日期：1994-05-01 00:00:00

abstract：:In order to assess the possible progression of neurological abnormalities over time and the value of visual evoked potential alterations in predicting stability and severity of diabetes-related optic pathway disease, a longitudinal study in non-insulin-dependent diabetic patients was performed. Neurological examinatio...

journal_title：Diabetologia

authors： Moreo G,Mariani E,Pizzamiglio G,Colucci GB

更新日期：1995-05-01 00:00:00

abstract：AIM/HYPOTHESIS:Single-nucleotide polymorphisms (SNPs) in the protein tyrosine phosphatase 1B gene (PTPN1) have been reported to be associated with type 2 diabetes in white subjects, and insulin sensitivity and fasting glucose levels in Hispanic Americans. In this study, we determined whether SNPs in PTPN1 also have a r...

journal_title：Diabetologia

authors： Traurig M,Hanson RL,Kobes S,Bogardus C,Baier LJ

更新日期：2007-05-01 00:00:00

abstract：:We examined changes in guanosine triphosphate-dependent signal transduction mechanisms in the retina from the early stages of the streptozotocin-diabetic rat, a model for Type 1 (insulin-dependent) diabetes mellitus. Guanosine triphosphate binding, guanosine triphosphatase activity, and binding of (azido) guanosine tr...

journal_title：Diabetologia

authors： Kowluru A,Kowluru RA,Yamazaki A

更新日期：1992-07-01 00:00:00

abstract：:The aim of the study was to evaluate an acute decrease in NEFA levels during an oral glucose tolerance test and its effects on glucose tolerance, muscle glucose uptake and muscle indirect calorimetry in ten lean non-insulin-dependent diabetic subjects. Two 75-g oral glucose tolerance tests were performed in random ord...

journal_title：Diabetologia

authors： Piatti PM,Monti LD,Davis SN,Conti M,Brown MD,Pozza G,Alberti KG

更新日期：1996-01-01 00:00:00

abstract：:The purpose of this study was to investigate whether young insulin-dependent diabetic patients still develop peripheral nerve dysfunction when using modern multiple insulin injection therapy and to elucidate if this correlated with various disease parameters. Seventy-five patients, 7 to 20 years old with a duration of...

journal_title：Diabetologia

authors： Hyllienmark L,Brismar T,Ludvigsson J

更新日期：1995-06-01 00:00:00