Functional alterations of G-proteins in diabetic rat retina: a possible explanation for the early visual abnormalities in diabetes mellitus.

abstract：:It has been proposed that the development of diabetic complications may involve a depletion of cellular myo-inositol due to an increase in polyol (sorbitol) formation. We therefore initially examined the effect of diabetes on levels of these metabolites in isolated cerebral microvessels. Compared with microvessels fro...

journal_title：Diabetologia

authors： Sussman I,Carson MP,Schultz V,Wu XP,McCall AL,Ruderman NB,Tornheim K

更新日期：1988-10-01 00:00:00

abstract：AIMS/HYPOTHESIS:Insulin-like growth factor-1 is a major childhood growth factor and promotes pancreatic islet cell survival and growth in vitro. We hypothesised that genetic variation in IGF1 might be associated with childhood growth, glucose metabolism and type 1 diabetes risk. We therefore examined the association be...

journal_title：Diabetologia

authors： Vella A,Bouatia-Naji N,Heude B,Cooper JD,Lowe CE,Petry C,Ring SM,Dunger DB,Todd JA,Ong KK

更新日期：2008-05-01 00:00:00

abstract：:Glomerular basement membrane thickness (GBMT) has been measured in streptozotocin diabetic rats treated with insulin. The study included 3 groups of 8 rats each: 1) a 'well-controlled' group of diabetic rats under insulin treatment with a plasma glucose level reasonable close to normal values, 2) a 'poorly-controlled'...

journal_title：Diabetologia

authors： Rasch R

更新日期：1979-05-01 00:00:00

abstract：AIMS/HYPOTHESIS:Insulin resistance is recognised as the core factor in the pathogenesis of Type II (non-insulin-dependent) diabetes mellitus, hypertension and atherosclerosis. Several studies indicate the possible role of mutations of the insulin receptor substrate-1 (IRS-1) gene in the pathogenesis of insulin-resistan...

journal_title：Diabetologia

authors： Baroni MG,Arca M,Sentinelli F,Buzzetti R,Capici F,Lovari S,Vitale M,Romeo S,Di Mario U

更新日期：2001-03-01 00:00:00

abstract：:Little is known about the immunological impact of insulin administration other than it can boost insulin autoantibody levels. In particular, while the subcutaneous administration of a soluble foreign antigen (without adjuvant) is generally only weakly immunogenic in a naive animal, it is unknown what effect the subcut...

journal_title：Diabetologia

authors： Tian J,Chau C,Kaufman DL

更新日期：1998-02-01 00:00:00

abstract：:We report the clinical characteristics of all insulin-treated diabetic patients (783 males and 716 females) living on July 1 1973 in a Danish county. In 18 patients diabetes was believed to be secondary to another disease or condition. Of all patients, 43% of the males and 55% of the females were greater than age 50 y...

journal_title：Diabetologia

authors： Green A,Hougaard P

更新日期：1983-09-01 00:00:00

abstract：:In order to establish a model for the in vivo assessment of islet function we have used the Rowett nude rat with transplantation of allogeneic and xenogeneic (mouse) islets into the renal subcapsular space following a minimal period of diabetic induction. Thirty-one nude rats were given streptozotocin and 30 became di...

journal_title：Diabetologia

authors： Lake SP,Chamberlain J,Husken P,Bell PR,James RF

更新日期：1988-06-01 00:00:00

abstract：AIMS/HYPOTHESIS:Direct infection of beta cells could explain the diabetogenic effect of enteroviruses. Primary adult human beta cells are susceptible to coxsackievirus infections, which could result in impaired beta-cell function or cell death (coxsackieviruses B3, B4, B5) or both, or no apparent immediate adverse effe...

journal_title：Diabetologia

authors： Roivainen M,Ylipaasto P,Savolainen C,Galama J,Hovi T,Otonkoski T

更新日期：2002-05-01 00:00:00

abstract：:The objective of the present study was to assess the prevalence of familial aggregation of Type 1 (insulin-dependent) diabetes mellitus among Danish families with a diabetic child aged 20 years or less and to compare epidemiological data for familial and sporadic cases. We attempted to identify all patients with Type ...

journal_title：Diabetologia

authors： Pociot F,Nørgaard K,Hobolth N,Andersen O,Nerup J

更新日期：1993-09-01 00:00:00

abstract：:We performed i.v. insulin tolerance test in 30 non-obese (BMI < 30 male and < 28 female) non-diabetic (by oral glucose tolerance test) subjects and subdivided them into three groups of 10 subjects each, according to their insulin sensitivity (K(itt) values). Then we compared the tyrosine-kinase activity of immunopurif...

journal_title：Diabetologia

authors： Grasso G,Frittitta L,Anello M,Russo P,Sesti G,Trischitta V

更新日期：1995-01-01 00:00:00

abstract：:Treatment of diabetic rats with octreotide can inhibit early diabetic renal hypertrophy. Octreotide administration for 6 months from the day of diabetes induction inhibits renal hypertrophy and diminishes increase in urinary albumin excretion. To investigate the effect of octreotide on manifest diabetic renal changes,...

journal_title：Diabetologia

authors： Grønbaek H,Nielsen B,Osterby R,Harris A,Orskov H,Flyvbjerg A

更新日期：1995-02-01 00:00:00

abstract：AIMS/HYPOTHESIS:Diabetes is induced by multiple low doses of streptozotocin (MLD-STZ) in male mice of susceptible strains. In this model beta-cell injury and T-cell-mediated inflammatory reactions are induced. Probably, reactive oxygen species (ROS) participate in the destruction of beta cells. The effects of ROS can b...

journal_title：Diabetologia

authors： Ohly P,Dohle C,Abel J,Seissler J,Gleichmann H

更新日期：2000-08-01 00:00:00

abstract：:Cystic fibrosis-related diabetes (CFRD) is the most significant extra-pulmonary comorbidity in cystic fibrosis (CF) patients, and accelerates lung decline. In addition to the traditional view that CFRD is a consequence of fibrotic destruction of the pancreas as a whole, emerging evidence may implicate a role for cysti...

journal_title：Diabetologia

authors： Koivula FNM,McClenaghan NH,Harper AGS,Kelly C

更新日期：2016-07-01 00:00:00

abstract：AIMS/HYPOTHESIS:The pathogenesis of vascular complications in type 1 diabetes is poorly understood, but may involve chronic, low-grade inflammation. We investigated the association of markers of inflammation with vascular complications in type 1 diabetes. METHODS:A cross-sectional nested case-control study of the foll...

journal_title：Diabetologia

authors： Schram MT,Chaturvedi N,Schalkwijk CG,Fuller JH,Stehouwer CD,EURODIAB Prospective Complications Study Group.

更新日期：2005-02-01 00:00:00

abstract：AIMS/HYPOTHESIS:Elevated circulating adipocyte fatty acid-binding protein (AFABP) levels have been found to correlate with diabetic nephropathy staging in cross-sectional studies. However, it remains unclear whether these higher serum levels reflect a role of AFABP in the development of diabetic kidney disease (DKD), o...

journal_title：Diabetologia

authors： Lee CH,Cheung CYY,Woo YC,Lui DTW,Yuen MMA,Fong CHY,Chow WS,Xu A,Lam KSL

更新日期：2019-01-01 00:00:00

abstract：AIMS/HYPOTHESIS:Hyperglycaemia in diabetes is associated with increased glycation, oxidative stress and nitrosative stress. Proteins modified consequently contain glycation, oxidation and nitration adduct residues, and undergo cellular proteolysis with release of corresponding free adducts. These free adducts leak into...

journal_title：Diabetologia

authors： Ahmed N,Babaei-Jadidi R,Howell SK,Beisswenger PJ,Thornalley PJ

更新日期：2005-08-01 00:00:00

abstract：AIMS/HYPOTHESIS:Metabolomics has opened new avenues for studying metabolic alterations in type 2 diabetes. While many urine and blood metabolites have been associated individually with diabetes, a complete systems view analysis of metabolic dysregulations across multiple biofluids and over varying timescales of glycaem...

journal_title：Diabetologia

authors： Yousri NA,Mook-Kanamori DO,Selim MM,Takiddin AH,Al-Homsi H,Al-Mahmoud KA,Karoly ED,Krumsiek J,Do KT,Neumaier U,Mook-Kanamori MJ,Rowe J,Chidiac OM,McKeon C,Al Muftah WA,Kader SA,Kastenmüller G,Suhre K

更新日期：2015-08-01 00:00:00

abstract：AIMS/HYPOTHESIS:Several publications suggest an association between certain types of insulin and cancer, but with conflicting results. We investigated whether insulin glargine (A21Gly,B31Arg,B32Arg human insulin) is associated with an increased risk of cancer in a large population-based cohort study. METHODS:Data for ...

journal_title：Diabetologia

authors： Ruiter R,Visser LE,van Herk-Sukel MP,Coebergh JW,Haak HR,Geelhoed-Duijvestijn PH,Straus SM,Herings RM,Stricker BH

更新日期：2012-01-01 00:00:00

abstract：AIMS/HYPOTHESIS:The cardiometabolic risk associated with metabolically healthy obesity (MHO) remains the subject of debate. It is unclear whether MHO is a transient condition that affects subclinical atherosclerosis risk. In this study, we aimed to investigate the association of MHO and its transition over time with in...

journal_title：Diabetologia

authors： Lin L,Zhang J,Jiang L,Du R,Hu C,Lu J,Wang T,Li M,Zhao Z,Xu Y,Xu M,Bi Y,Ning G,Wang W,Chen Y

更新日期：2020-07-01 00:00:00

abstract：AIMS/HYPOTHESIS:Several investigations have shown that the renal medulla has a greater capacity to generate nitric oxide than the renal cortex. To further evaluate the changes of nitric oxide synthesis in the kidney, particularly in the outer medulla, in disorders involving fluid and electrolyte imbalances, we sought t...

journal_title：Diabetologia

authors： Shin SJ,Lai FJ,Wen JD,Hsiao PJ,Hsieh MC,Tzeng TF,Chen HC,Guh JY,Tsai JH

更新日期：2000-05-01 00:00:00

abstract：AIMS/HYPOTHESIS:Increased expression and decreased degradation of extracellular matrix (ECM) proteins are key features of chronic diabetic complications. Fibronectin, a predominant ECM protein, has been shown to be overexpressed in all target organs of diabetic complications and in endothelial cells cultured in high le...

journal_title：Diabetologia

authors： Xin X,Khan ZA,Chen S,Chakrabarti S

更新日期：2005-11-01 00:00:00

abstract：:The past decade has resulted in multiple new findings of potential proteomic biomarkers of diabetic kidney disease (DKD). Many of these biomarkers reflect an important role in the (patho)physiology and biological processes of DKD. Situations in which proteomics could be applied in clinical practice include the identif...

journal_title：Diabetologia

authors： Pena MJ,Mischak H,Heerspink HJ

更新日期：2016-09-01 00:00:00

abstract：:Analysis of the plasma from a totally pancreatectomized patient, with antiserum 30 K, has demonstrated basal glucagon immunoreactivity (GIR) levels in the normal range (80-110 pg/ml). Neither i. v. arginine nor oral glucose affected these GIR values, thus indicating the absence of functioning pancreatic or gastrointes...

journal_title：Diabetologia

authors： Villanueva ML,Hedo JA,Marco J

更新日期：1976-12-01 00:00:00

abstract：:The International Insulin Foundation (IIF) has developed and validated a needs-assessment instrument called the Rapid Assessment Protocol for Insulin Access (RAPIA) which has been used in seven countries in four continents to analyse the constraints to delivering effective continuing care for people with diabetes. One...

journal_title：Diabetologia

authors： Gill GV,Yudkin JS,Keen H,Beran D

更新日期：2011-01-01 00:00:00

abstract：AIMS/HYPOTHESIS:Among diabetic patients, glucose homeostasis may be affected by abnormal gastrointestinal motility and autonomic neuropathy. This study analysed whether oesophageal dysmotility, delayed gastric emptying or autonomic neuropathy affect glucose homeostasis. MATERIALS AND METHODS:Oesophageal manometry and ...

journal_title：Diabetologia

authors： Ohlsson B,Melander O,Thorsson O,Olsson R,Ekberg O,Sundkvist G

更新日期：2006-09-01 00:00:00

abstract：AIMS/HYPOTHESIS:Enhanced and prolonged postprandial lipaemia is related to cardiovascular disease but how postprandial lipaemia is regulated is poorly known. We therefore determined the relations of fasting insulin concentrations to fasting and postprandial lipids, lipoproteins and non-esterified fatty acids in middle-...

journal_title：Diabetologia

authors： Boquist S,Hamsten A,Karpe F,Ruotolo G

更新日期：2000-02-01 00:00:00

abstract：AIMS/HYPOTHESIS:Augmented oxidative stress induced by hyperglycaemia possibly contributes to the pathogenesis of diabetic complications. Oxidative stress is known to increase the conversion of deoxyguanosine to 8-oxo, 2'-deoxyguanosine in DNA. To investigate the possible contribution of oxidative DNA damage to the path...

journal_title：Diabetologia

authors： Hinokio Y,Suzuki S,Hirai M,Chiba M,Hirai A,Toyota T

更新日期：1999-08-01 00:00:00

abstract：:The appropriate utilisation, storage and conversion of nutrients in peripheral tissues, referred to as nutrient partitioning, is a fundamental process to adapt to nutritional and metabolic challenges and is thus critical for the maintenance of a healthy energy balance. Alterations in this process during nutrient exces...

journal_title：Diabetologia

authors： Manceau R,Majeur D,Alquier T

更新日期：2020-04-01 00:00:00

abstract：:Residual beta cell function was studied in 18 juvenile-onset diabetics by measuring serum C-peptide immunoreactivity (CPR) fasting, and after IV injection of glucagon (1 mg). This was compared with the exocrine pancreatic response to an IV infusion of secretin and cholecystokinin-pancreozymin. Outputs of pancreatic bi...

journal_title：Diabetologia

authors： Frier BM,Faber OK,Binder C,Elliot HL

更新日期：1978-05-01 00:00:00

abstract：AIMS/HYPOTHESIS:A reduction in retinal blood flow occurs early in diabetes and is likely to be involved in the development of diabetic retinopathy. We hypothesise that activation of the arginase pathway could have a role in the vascular dysfunction of diabetic retinopathy. METHODS:Experiments were performed using a mo...

journal_title：Diabetologia

authors： Elms SC,Toque HA,Rojas M,Xu Z,Caldwell RW,Caldwell RB

更新日期：2013-03-01 00:00:00