当前位置： SCI文献检索 > DIABETOLOGIA期刊下所有文献 > A systems view of type 2 diabetes-associated metabolic perturbations in saliva, blood and urine at different timescales of glycaemic control.

A systems view of type 2 diabetes-associated metabolic perturbations in saliva, blood and urine at different timescales of glycaemic control.

Abstract：

AIMS/HYPOTHESIS:Metabolomics has opened new avenues for studying metabolic alterations in type 2 diabetes. While many urine and blood metabolites have been associated individually with diabetes, a complete systems view analysis of metabolic dysregulations across multiple biofluids and over varying timescales of glycaemic control is still lacking. METHODS:Here we report a broad metabolomics study in a clinical setting, covering 2,178 metabolite measures in saliva, blood plasma and urine from 188 individuals with diabetes and 181 controls of Arab and Asian descent. Using multivariate linear regression we identified metabolites associated with diabetes and markers of acute, short-term and long-term glycaemic control. RESULTS:Ninety-four metabolite associations with diabetes were identified at a Bonferroni level of significance (p < 2.3 × 10(-5)), 16 of which have never been reported. Sixty-five of these diabetes-associated metabolites were associated with at least one marker of glycaemic control in the diabetes group. Using Gaussian graphical modelling, we constructed a metabolic network that links diabetes-associated metabolites from three biofluids across three different timescales of glycaemic control. CONCLUSIONS/INTERPRETATION:Our study reveals a complex network of biochemical dysregulation involving metabolites from different pathways of diabetes pathology, and provides a reference framework for future diabetes studies with metabolic endpoints.

journal_name

Diabetologia

journal_title

Diabetologia

authors

Yousri NA,Mook-Kanamori DO,Selim MM,Takiddin AH,Al-Homsi H,Al-Mahmoud KA,Karoly ED,Krumsiek J,Do KT,Neumaier U,Mook-Kanamori MJ,Rowe J,Chidiac OM,McKeon C,Al Muftah WA,Kader SA,Kastenmüller G,Suhre K

doi

10.1007/s00125-015-3636-2

subject

Has Abstract

pub_date

2015-08-01 00:00:00

pages

1855-67

issue

8

eissn

0012-186X

issn

1432-0428

journal_volume

58

pub_type

杂志文章

相关文献

DIABETOLOGIA文献大全
  • Influence of a transplantable insulinoma on the pancreatic status of insulin and pancreatic polypeptide in the rat.

    abstract：:The effect of endogenous hyperinsulinaemia, produced by syngeneic transplantation of rat insulinoma at an extrapancreatic site, on pancreatic insulin and pancreatic polypeptide has been examined by radioimmunoassay and immunohistochemistry. Twenty days after subcutaneous transplantation, tumour-bearing rats exhibited ...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/BF00273864

    authors： O'Hare MM,Shaw C,Swanston-Flatt SK,Marcelli M,Buchanan KD,Flatt PR

    更新日期：1985-03-01 00:00:00

  • Insulin regulation of glucose and lipid metabolism in massive obesity.

    abstract：:Eight obese patients and 12 normal individuals underwent a euglycaemic insulin clamp (20 and 40 mU m2-1.min-1) along with continuous infusion of 3-3H-glucose and 1-14C-palmitate and indirect calorimetry. Basal plasma glucose concentration (4.7 +/- 0.3 vs 4.4 +/- 0.2 mmol/l) was similar in the two groups, whereas hepat...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/BF00404801

    authors： Del Prato S,Enzi G,Vigili de Kreutzenberg S,Lisato G,Riccio A,Maifreni L,Iori E,Zurlo F,Sergi G,Tiengo A

    更新日期：1990-04-01 00:00:00

  • Effect of past and concurrent body mass index on prevalence of glucose intolerance and type 2 (non-insulin-dependent) diabetes and on insulin response. The Israel study of glucose intolerance, obesity and hypertension.

    abstract：:A representative sample (n = 2140) of the Israeli Jewish population aged 40-70 (excluding known diabetic patients), whose body mass index had been measured 10 years earlier, underwent an oral glucose tolerance test and redetermination of body mass index. Irrespective of weight changes, high concurrent and high past bo...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/BF00456115

    authors： Modan M,Karasik A,Halkin H,Fuchs Z,Lusky A,Shitrit A,Modan B

    更新日期：1986-02-01 00:00:00

  • Use of class I and class II HLA loci for predicting age at onset of type 1 diabetes in multiple populations.

    abstract：AIMS/HYPOTHESIS:The study aimed to assess, in multiple populations, the role of HLA alleles on early and late age at onset of type 1 diabetes. METHODS:Stepwise linear regression models were used to determine which HLA class I and class II risk alleles to include. High-resolution genotyping data for patients from the T...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/s00125-012-2608-z

    authors： Valdes AM,Erlich HA,Carlson J,Varney M,Moonsamy PV,Noble JA

    更新日期：2012-09-01 00:00:00

  • Familial risk of type I diabetes in European children. The Eurodiab Ace Study Group and The Eurodiab Ace Substudy 2 Study Group.

    abstract：:The characteristics of familial Type I (insulin-dependent) diabetes mellitus-that is Type I diabetes in a first degree relative were investigated for children diagnosed before the age of 15 years using data from an international network of population-based registries (the EURODIAB ACE network) and from a case-control ...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/s001250051044

    authors：

    更新日期：1998-10-01 00:00:00

  • Diabetes mellitus in Macaca mulatta monkeys is characterised by islet amyloidosis and reduction in beta-cell population.

    abstract：:Diabetes mellitus in Macaca mulatta rhesus monkeys is preceded by phases of obesity and hyperinsulinaemia and is similar to Type 2 (non-insulin-dependent) diabetes mellitus in man. To relate the progression of the disease to quantitative changes in islet morphology, post-mortem pancreatic tissue from 26 monkeys was ex...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/BF00402271

    authors： de Koning EJ,Bodkin NL,Hansen BC,Clark A

    更新日期：1993-05-01 00:00:00

  • Cellular proliferation in mouse and human pancreatic islets is regulated by serpin B13 inhibition and downstream targeting of E-cadherin by cathepsin L.

    abstract：AIMS/HYPOTHESIS:We previously reported that exposure to antibodies neutralising serpin B13, a protease inhibitor expressed in exocrine pancreatic ducts, promotes beta cell proliferation, underscoring the importance of a functional relationship between exocrine and endocrine pancreas. The aim of the present study was to...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/s00125-019-4834-0

    authors： Lo CW,Kryvalap Y,Sheu TJ,Chang CH,Czyzyk J

    更新日期：2019-05-01 00:00:00

  • LXRα improves myocardial glucose tolerance and reduces cardiac hypertrophy in a mouse model of obesity-induced type 2 diabetes.

    abstract：AIMS/HYPOTHESIS:Diabetic cardiomyopathy is a myocardial disease triggered by impaired insulin signalling, increased fatty acid uptake and diminished glucose utilisation. Liver X receptors (LXRs) are key transcriptional regulators of metabolic homeostasis. However, their effect in the diabetic heart is largely unknown. ...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/s00125-015-3827-x

    authors： Cannon MV,Silljé HH,Sijbesma JW,Khan MA,Steffensen KR,van Gilst WH,de Boer RA

    更新日期：2016-03-01 00:00:00

  • Is grand multiparity associated with an increased risk of dysglycaemia?

    abstract：AIMS/HYPOTHESIS:We sought to determine the risk of diabetes and IGT/IFG with grand multiparity. SUBJECTS, MATERIALS AND METHODS:Women, aged > or =25 years, from the Australian Diabetes, Obesity and Lifestyle Study and the Crossroads Undiagnosed Disease Study (a rural study in Victoria, Australia), participated in a ho...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/s00125-006-0276-6

    authors： Simmons D,Shaw J,McKenzie A,Eaton S,Cameron AJ,Zimmet P

    更新日期：2006-07-01 00:00:00

  • A follow-up of 93 newly diagnosed African diabetics for 6 years.

    abstract：:In 1971, 107 newly diagnosed black diabetics admitted to Harare Central Hospital, Rhodesia, were studied. Nine died before discharge. In 1977, 93 of the 98 patients discharged alive were traced but of these 38 (41%) had since died. Of 18 autopsies performed the cause of death was hypoglycaemia in 8 patients and hyperg...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/BF00290487

    authors： Castle WM,Wicks AC

    更新日期：1980-01-01 00:00:00

  • The effects of glucose-induced oxidative stress on growth and extracellular matrix gene expression of vascular smooth muscle cells.

    abstract：:Vascular smooth muscle cell (VSMC) dysfunction plays a role in diabetic macrovasculopathy and this may include abnormalities in growth characteristics and the extracellular matrix. As the actual mechanisms by which glucose induces VSMC dysfunction remain unclear, the aim of this study was to assess the potential role ...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/s001250051054

    authors： Sharpe PC,Yue KK,Catherwood MA,McMaster D,Trimble ER

    更新日期：1998-10-01 00:00:00

  • C-reactive protein and the development of the metabolic syndrome and diabetes in middle-aged men.

    abstract：AIMS/HYPOTHESIS:Low-grade inflammation has been implicated in the development of Type 2 diabetes and cardiovascular disease, but its role in the pathogenesis of the metabolic syndrome is unclear. We investigated the association between C-reactive protein (CRP) levels and the development of the metabolic syndrome and di...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/s00125-004-1472-x

    authors： Laaksonen DE,Niskanen L,Nyyssönen K,Punnonen K,Tuomainen TP,Valkonen VP,Salonen R,Salonen JT

    更新日期：2004-08-01 00:00:00

  • Family history of myocardial infarction, stroke and diabetes and cardiometabolic markers in children.

    abstract：AIMS/HYPOTHESIS:Despite the overlap in occurrence of cardiovascular disease (CVD) and type 2 diabetes and their risk factors, family history of these diseases has not yet been investigated simultaneously in relation to cardiometabolic markers in offspring. We examined how a family history of CVD and/or diabetes relates...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/s00125-016-3988-2

    authors： Berentzen NE,Wijga AH,van Rossem L,Koppelman GH,van Nieuwenhuizen B,Gehring U,Spijkerman AM,Smit HA

    更新日期：2016-08-01 00:00:00

  • Single-cell transcriptome analysis of the Akimba mouse retina reveals cell-type-specific insights into the pathobiology of diabetic retinopathy.

    abstract：AIMS/HYPOTHESIS:Diabetic retinopathy is a common complication of diabetes and a leading cause of visual impairment and blindness. Despite recent advances, our understanding of its pathophysiology remains incomplete. The aim of this study was to provide deeper insight into the complex network of molecular and cellular c...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/s00125-020-05218-0

    authors： Van Hove I,De Groef L,Boeckx B,Modave E,Hu TT,Beets K,Etienne I,Van Bergen T,Lambrechts D,Moons L,Feyen JHM,Porcu M

    更新日期：2020-10-01 00:00:00

  • The metabolic response to hyperglycaemic clamping in insulin-dependent diabetes.

    abstract：:The metabolic and hormonal effects of stable hyperglycaemia (10-12 mmol/l) have been examined in five insulin-dependent diabetics and compared with the results of 8 h (1200 to 2000 h) normoglycaemic (5-6 mmol/l) clamping. Glucose levels were maintained using a glucose controlled insulin infusion system. Mean blood lac...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/BF00262012

    authors： Nosadini R,Noy GA,Alberti KG,Hodson A,Orskoy H

    更新日期：1981-02-01 00:00:00

  • Peptides in metabolic autonomic nerves.

    abstract：:Most polypeptides originally assigned to a specific organ and a specific effect seem to occur in many different parts of the body, in neurons as well as in endocrine cells. Thus gastrin and insulin, or very similar peptides can be demonstrated in extracts of the vagal nerves and of peripheral somatic nerves. Electrica...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/BF00254501

    authors： Uvnäs-Wallensten K

    更新日期：1981-03-01 00:00:00

  • Neuronal control of peripheral nutrient partitioning.

    abstract：:The appropriate utilisation, storage and conversion of nutrients in peripheral tissues, referred to as nutrient partitioning, is a fundamental process to adapt to nutritional and metabolic challenges and is thus critical for the maintenance of a healthy energy balance. Alterations in this process during nutrient exces...

    journal_title：Diabetologia

    pub_type： 杂志文章,评审

    doi：10.1007/s00125-020-05104-9

    authors： Manceau R,Majeur D,Alquier T

    更新日期：2020-04-01 00:00:00

  • Variants of ADRA2A are associated with fasting glucose, blood pressure, body mass index and type 2 diabetes risk: meta-analysis of four prospective studies.

    abstract：AIMS/HYPOTHESIS:We quantified the effect of ADRA2A (encoding α-2 adrenergic receptor) variants on metabolic traits and type 2 diabetes risk, as reported in four studies. METHODS:Genotype data for ADRA2A single nucleotide polymorphisms (SNPs) rs553668 and rs10885122 were analysed in >17,000 individuals (1,307 type 2 di...

    journal_title：Diabetologia

    pub_type： 杂志文章,meta分析

    doi：10.1007/s00125-011-2108-6

    authors： Talmud PJ,Cooper JA,Gaunt T,Holmes MV,Shah S,Palmen J,Drenos F,Shah T,Kumari M,Kivimaki M,Whittaker J,Lawlor DA,Day IN,Hingorani AD,Casas JP,Humphries SE

    更新日期：2011-07-01 00:00:00

  • Markedly increased renal disease mortality and incidence of renal replacement therapy among IDDM patients in Japan in contrast to Allegheny County, Pennsylvania, USA. Diabetes Epidemiology Research International (DERI) U.S.-Japan Mortality Study Group.

    abstract：:The aim of this study was to evaluate factors related to the markedly increased risk of dying from diabetic renal disease in Japanese insulin-dependent diabetic patients compared to those in the USA. The study was based on two population-based cohorts consisting of 1374 cases from Japan and 995 cases from Allegheny Co...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/BF00400100

    authors： Matsushima M,Tajima N,LaPorte RE,Orchard TJ,Tull ES,Gower IF,Kitagawa T

    更新日期：1995-02-01 00:00:00

  • Pioglitazone elicits long-term improvements in insulin sensitivity in patients with type 2 diabetes: comparisons with gliclazide-based regimens.

    abstract：AIMS/HYPOTHESIS:Recent studies have demonstrated that pioglitazone (PIO) has beneficial effects on insulin sensitivity compared with placebo in patients with type 2 diabetes. The effects of PIO and gliclazide (GLIC)-based therapy on insulin sensitivity have not previously been directly compared. This analysis aimed to ...

    journal_title：Diabetologia

    pub_type： 临床试验,杂志文章,meta分析,随机对照试验

    doi：10.1007/s00125-004-1651-9

    authors： Charbonnel B,Roden M,Urquhart R,Mariz S,Johns D,Mihm M,Widel M,Tan M

    更新日期：2005-03-01 00:00:00

  • Glucose tolerance is associated with differential expression of microRNAs in skeletal muscle: results from studies of twins with and without type 2 diabetes.

    abstract：AIMS/HYPOTHESIS:We aimed to identify microRNAs (miRNAs) associated with type 2 diabetes and risk of developing the disease in skeletal muscle biopsies from phenotypically well-characterised twins. METHODS:We measured muscle miRNA levels in monozygotic (MZ) twins discordant for type 2 diabetes using arrays. Further inv...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/s00125-014-3434-2

    authors： Bork-Jensen J,Scheele C,Christophersen DV,Nilsson E,Friedrichsen M,Fernandez-Twinn DS,Grunnet LG,Litman T,Holmstrøm K,Vind B,Højlund K,Beck-Nielsen H,Wojtaszewski J,Ozanne SE,Pedersen BK,Poulsen P,Vaag A

    更新日期：2015-02-01 00:00:00

  • The effects of insulin and short-term hyperglycaemia on myocardial blood flow in young men with uncomplicated Type I diabetes.

    abstract：AIMS/HYPOTHESIS:Insulin enhances coronary vasodilation in healthy subjects. We tested whether insulin is able to induce coronary vasodilation in Type I (insulin-dependent) diabetic mellitus patients. Additionally, the effect of short-term hyperglycaemia on myocardial perfusion was studied. METHODS:Myocardial blood flo...

    journal_title：Diabetologia

    pub_type： 临床试验,杂志文章

    doi：10.1007/s00125-002-0819-4

    authors： Sundell J,Laine H,Nuutila P,Rönnemaa T,Luotolahti M,Raitakari O,Knuuti J

    更新日期：2002-06-01 00:00:00

  • Expression of matrix-metalloproteinases and their inhibitors in the wounds of diabetic and non-diabetic patients.

    abstract：AIMS/HYPOTHESIS:The molecular factors that cause an acute wound in diabetic patients to become chronic have not yet been established. Wound healing is known to require a balance between the accumulation of collagenous and non-collagenous extracellular matrix components and their remodelling by matrix metalloproteinases...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/s00125-002-0868-8

    authors： Lobmann R,Ambrosch A,Schultz G,Waldmann K,Schiweck S,Lehnert H

    更新日期：2002-07-01 00:00:00

  • The contribution of naturally labelled 13C fructose to glucose appearance in humans.

    abstract：:Among monosaccharides, fructose has a small hyperglycaemic effect. In order to better explain the mechanisms which cause this metabolic property, we used tracers labelled with stable isotopes (deuterated glucose and naturally 13C labelled fructose) to quantify the overall glucose appearance, the rate of appearance in ...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/BF00400238

    authors： Delarue J,Normand S,Pachiaudi C,Beylot M,Lamisse F,Riou JP

    更新日期：1993-04-01 00:00:00

  • Selective proteinuria in diabetic nephropathy in the rat is associated with a relative decrease in glomerular basement membrane heparan sulphate.

    abstract：:In the present study we investigated whether glomerular hyperfiltration and albuminuria in streptozotocin-induced diabetic nephropathy in male Wistar-Münich rats are associated with changes in the heparan sulphate content of the glomerular basement membrane. Rats with a diabetes mellitus duration of 8 months, treated ...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/BF00400090

    authors： van den Born J,van Kraats AA,Bakker MA,Assmann KJ,van den Heuvel LP,Veerkamp JH,Berden JH

    更新日期：1995-02-01 00:00:00

  • Renal clearance of glycolaldehyde- and methylglyoxal-modified proteins in mice is mediated by mesangial cells through a class A scavenger receptor (SR-A).

    abstract：AIMS/HYPOTHESIS:Glomerular mesangial expansion is a characteristic feature of diabetic nephropathy, and the accumulation of AGE in the mesangial lesion has been implicated as one of its potential causes. However, the route for the AGE accumulation in mesangial lesions in diabetic patients is poorly established. METHOD...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/s00125-004-1646-6

    authors： Nakajou K,Horiuchi S,Sakai M,Haraguchi N,Tanaka M,Takeya M,Otagiri M

    更新日期：2005-02-01 00:00:00

  • Upregulation of adiponectin receptor 1 and 2 mRNA and protein in adipose tissue and adipocytes in insulin-resistant women with polycystic ovary syndrome.

    abstract：AIMS/HYPOTHESIS:Polycystic ovary syndrome (PCOS) is a multifaceted metabolic disease linked with insulin resistance (IR) and obesity. Adiponectin, which is lower in IR states, exerts its glucose-lowering and anti-inflammatory effects by activating two receptors, ADIPOR1 and ADIPOR2. There are no data on the relative ex...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/s00125-006-0419-9

    authors： Tan BK,Chen J,Digby JE,Keay SD,Kennedy CR,Randeva HS

    更新日期：2006-11-01 00:00:00

  • Adipocyte STAT5 deficiency promotes adiposity and impairs lipid mobilisation in mice.

    abstract：AIMS/HYPOTHESIS:Dysfunction of lipid metabolism in white adipose tissue can substantially interfere with health and quality of life, for example in obesity and associated metabolic diseases. Therefore, it is important to characterise pathways that regulate lipid handling in adipocytes and determine how they affect meta...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/s00125-016-4152-8

    authors： Kaltenecker D,Mueller KM,Benedikt P,Feiler U,Themanns M,Schlederer M,Kenner L,Schweiger M,Haemmerle G,Moriggl R

    更新日期：2017-02-01 00:00:00

  • Cytochrome P450 epoxygenase-derived epoxyeicosatrienoic acids contribute to insulin sensitivity in mice and in humans.

    abstract：AIMS/HYPOTHESIS:Insulin resistance is frequently associated with hypertension and type 2 diabetes. The cytochrome P450 (CYP) arachidonic acid epoxygenases (CYP2C, CYP2J) and their epoxyeicosatrienoic acid (EET) products lower blood pressure and may also improve glucose homeostasis. However, the direct contribution of e...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/s00125-017-4260-0

    authors： Gangadhariah MH,Dieckmann BW,Lantier L,Kang L,Wasserman DH,Chiusa M,Caskey CF,Dickerson J,Luo P,Gamboa JL,Capdevila JH,Imig JD,Yu C,Pozzi A,Luther JM

    更新日期：2017-06-01 00:00:00

  • Rosiglitazone modifies the adipogenic potential of human muscle satellite cells.

    abstract：AIMS/HYPOTHESIS:Satellite cells are responsible for postnatal skeletal muscle regeneration. It has been demonstrated that mouse satellite cells behave as multipotent stem cells. We studied the differentiation capacities of human satellite cells and evaluated the effect of the insulin sensitiser rosiglitazone, a well kn...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/s00125-006-0304-6

    authors： De Coppi P,Milan G,Scarda A,Boldrin L,Centobene C,Piccoli M,Pozzobon M,Pilon C,Pagano C,Gamba P,Vettor R

    更新日期：2006-08-01 00:00:00