Upregulation of adiponectin receptor 1 and 2 mRNA and protein in adipose tissue and adipocytes in insulin-resistant women with polycystic ovary syndrome.

abstract：:Insulin and somatostatin reportedly affect pancreatic acinar cell function via specific receptor binding. Theoretically peri-insular levels depend on the islet-acinar portal system, but the actual hormone levels have never been demonstrated. Rat pancreata were perfused anterogradely or retrogradely with 125I-insulin, ...

journal_title：Diabetologia

authors： Nakagawa A,Stagner JI,Samols E

更新日期：1995-03-01 00:00:00

abstract：:Fifty-nine Type 1 (insulin-dependent) diabetic patients with (group I) and 59 patients without nephropathy (group II) pair-matched according to sex (30 males and 29 females), age (33 years, range 15-48) and diabetes duration (19 years, range 6-42) were followed for a period of 10 years from about 5 years before to 5 y...

journal_title：Diabetologia

authors： Jensen T,Borch-Johnsen K,Kofoed-Enevoldsen A,Deckert T

更新日期：1987-03-01 00:00:00

abstract：AIMS/HYPOTHESIS:It is difficult to use HbA(1c) as an indicator of glycaemic control in patients with neonatal diabetes mellitus (NDM) because of high levels of fetal haemoglobin (HbF) remaining in the blood. In this study, glycated albumin (GA), which is not affected by HbF, and HbA(1c) were compared to evaluate whethe...

journal_title：Diabetologia

authors： Suzuki S,Koga M,Amamiya S,Nakao A,Wada K,Okuhara K,Hayano S,Sarhat AR,Takahashi H,Matsuo K,Tanahashi Y,Fujieda K

更新日期：2011-09-01 00:00:00

abstract：:We describe a patient who had an anaphylactic reaction to highly purified pork insulin; he was not allergic however to beef insulin. The sensitivity to pork but not to beef insulin was confirmed by skin testing, radioallergosorbent test (RAST) and RAST inhibition. A scheme is suggested for the investigation of such pa...

journal_title：Diabetologia

authors： Carini C,Brostoff J,Kurtz AB

更新日期：1982-05-01 00:00:00

abstract：AIMS/HYPOTHESIS:Urinary orosomucoid excretion rate is increased in a substantial proportion of patients with Type II (non-insulin-dependent) diabetes mellitus and normal urinary albumin excretion rate. The aim of this study was to determine whether increased urinary orosomucoid excretion rate is predictive of increased...

journal_title：Diabetologia

authors： Christiansen MS,Hommel E,Magid E,Feldt-Rasmussen B

更新日期：2002-01-01 00:00:00

abstract：:Free-radical scavengers and inhibitors of tumour necrosis factor-alpha (TNF-alpha) such as N-acetylcysteine and pentoxifylline have been shown to inhibit the development of peripheral neuropathy in streptozotocin(STZ)-induced diabetic rats. In this study we examined the effect of troglitazone, an anti-diabetic thiazol...

journal_title：Diabetologia

authors： Qiang X,Satoh J,Sagara M,Fukuzawa M,Masuda T,Sakata Y,Muto G,Muto Y,Takahashi K,Toyota T

更新日期：1998-11-01 00:00:00

abstract：UNLABELLED:AIMS/HYPOTHESIS; The aim of the Diabetes Prevention Study is to assess the efficacy of an intensive diet-exercise programme in preventing or delaying Type II (non-insulin-dependent) diabetes mellitus in subjects with impaired glucose tolerance, to evaluate the effects of the intervention programme on cardiov...

journal_title：Diabetologia

authors： Eriksson J,Lindström J,Valle T,Aunola S,Hämäläinen H,Ilanne-Parikka P,Keinänen-Kiukaanniemi S,Laakso M,Lauhkonen M,Lehto P,Lehtonen A,Louheranta A,Mannelin M,Martikkala V,Rastas M,Sundvall J,Turpeinen A,Viljanen T,Uus

更新日期：1999-07-01 00:00:00

abstract：:Glycosylated haemoglobin (HbA1) was measured serially by microcolumn chromatography in 38 children with newly diagnosed insulin-dependent diabetes. Initial HbA1 levels of 13.6 +/- 0.5% fell signficiantly from day 0 (prior to therapy) both to day 1 (1.6 +/- 0.2% decrease) and to day 3-5 (2.6 +/- 0.4% decrease) (P < 0.0...

journal_title：Diabetologia

authors： Daneman D,Tsalikian E,Hengstenberg F,Becker DJ,Drash AL

更新日期：1980-11-01 00:00:00

abstract：:The authors have been made aware that the following sentence is incorrect: 'Like IIK7, both ramelteon and tasimelteon have a greater affinity for the MT2 receptor [162].' ...

journal_title：Diabetologia

authors： Forrestel AC,Miedlich SU,Yurcheshen M,Wittlin SD,Sellix MT

更新日期：2018-05-01 00:00:00

abstract：AIMS/HYPOTHESIS:We determined the effects of 6 years of lifestyle intervention in persons with impaired glucose tolerance (IGT) on the development of retinopathy, nephropathy and neuropathy over a 20 year period. METHODS:In 1986, 577 adults with IGT from 33 clinics in Da Qing, China were randomly assigned by clinic to...

journal_title：Diabetologia

authors： Gong Q,Gregg EW,Wang J,An Y,Zhang P,Yang W,Li H,Li H,Jiang Y,Shuai Y,Zhang B,Zhang J,Gerzoff RB,Roglic G,Hu Y,Li G,Bennett PH

更新日期：2011-02-01 00:00:00

abstract：AIMS/HYPOTHESIS:B-type natriuretic peptide (BNP) is a hormone released from cardiomyocytes in response to cell stretching and elevated in heart failure. Recent observations indicate a distinct connection between chronic heart failure and diabetes mellitus. This study investigated the role of BNP on glucose metabolism. ...

journal_title：Diabetologia

authors： Heinisch BB,Vila G,Resl M,Riedl M,Dieplinger B,Mueller T,Luger A,Pacini G,Clodi M

更新日期：2012-05-01 00:00:00

abstract：AIMS/HYPOTHESIS:Reactive oxygen species (ROS) contribute to diabetes-induced glomerular injury and endoplasmic reticulum (ER) stress-induced beta cell dysfunction, but the source of ROS has not been fully elucidated. Our aim was to determine whether p47(phox)-dependent activation of NADPH oxidase is responsible for hyp...

journal_title：Diabetologia

authors： Liu GC,Fang F,Zhou J,Koulajian K,Yang S,Lam L,Reich HN,John R,Herzenberg AM,Giacca A,Oudit GY,Scholey JW

更新日期：2012-09-01 00:00:00

abstract：:This paper presents a survey of the biological potencies of a variety of naturally-occurring and semi-synthetic insulin analogues and a study of the joint biological action of some of these materials with native insulin. Biological activity was tested on isolated rat fat cells using lipogenesis from glucose as the met...

journal_title：Diabetologia

authors： Ellis MJ,Darby SC,Jones RH,Sönksen PH

更新日期：1978-11-01 00:00:00

abstract：AIMS/HYPOTHESIS:The aim of this study was to examine the association between lifetime breast-feeding and the incidence of type 2 diabetes mellitus in a large population-based cohort study of middle-aged women. METHODS:This was a prospective study of 62,095 middle-aged parous women in Shanghai, China, who had no prior ...

journal_title：Diabetologia

authors： Villegas R,Gao YT,Yang G,Li HL,Elasy T,Zheng W,Shu XO

更新日期：2008-02-01 00:00:00

abstract：:Plasma corticosterone concentrations in diabetic (db) mice maintained on two different inbred backgrounds were found to be elevated significantly when compared to normal controls. These data are similar to that reported with the phenotypically similar obese (ob) mouse. These results suggest that the hyperadrenolcortic...

journal_title：Diabetologia

authors： Coleman DL,Burkart DL

更新日期：1977-01-01 00:00:00

abstract：AIMS/HYPOTHESIS:Gestational diabetes mellitus (GDM) is a risk factor for perinatal complications. In several countries, the criteria for the diagnosis of GDM have been in flux, the American Diabetes Association (ADA) thresholds recommended in 2000 being lower than those of the National Diabetes Data Group (NDDG) that h...

journal_title：Diabetologia

authors： Ferrara A,Weiss NS,Hedderson MM,Quesenberry CP Jr,Selby JV,Ergas IJ,Peng T,Escobar GJ,Pettitt DJ,Sacks DA

更新日期：2007-02-01 00:00:00

abstract：AIMS/HYPOTHESIS:In our previous studies a low protein diet (8% vs 20%) given during foetal and early postnatal life induced abnormal development of the endocrine pancreas; beta-cell mass and islet-cell proliferation were reduced while apoptosis was increased. Taurine, an important amino acid for development was also re...

journal_title：Diabetologia

authors： Boujendar S,Reusens B,Merezak S,Ahn MT,Arany E,Hill D,Remacle C

更新日期：2002-06-01 00:00:00

abstract：AIMS/HYPOTHESIS:Chronic hyperglycaemia in patients with Type II (non-insulin-dependent) diabetes mellitus often leads to a decline in glucose-responsive insulin secretion from pancreatic beta cells, a phenomenon called glucose toxicity. Upon hyperglycaemia, glycation reaction occurs in the beta cells and induces oxidat...

journal_title：Diabetologia

authors： Kajimoto Y,Matsuoka T,Kaneto H,Watada H,Fujitani Y,Kishimoto M,Sakamoto K,Matsuhisa M,Kawamori R,Yamasaki Y,Hori M

更新日期：1999-12-01 00:00:00

abstract：AIMS/HYPOTHESIS:Metabolomics has opened new avenues for studying metabolic alterations in type 2 diabetes. While many urine and blood metabolites have been associated individually with diabetes, a complete systems view analysis of metabolic dysregulations across multiple biofluids and over varying timescales of glycaem...

journal_title：Diabetologia

authors： Yousri NA,Mook-Kanamori DO,Selim MM,Takiddin AH,Al-Homsi H,Al-Mahmoud KA,Karoly ED,Krumsiek J,Do KT,Neumaier U,Mook-Kanamori MJ,Rowe J,Chidiac OM,McKeon C,Al Muftah WA,Kader SA,Kastenmüller G,Suhre K

更新日期：2015-08-01 00:00:00

abstract：:T cells taken from normal rats treated with an exogenous source of bacterial superantigen in vivo specifically failed to proliferate following re-stimulation with the same superantigen in vitro. Responsiveness was restored following the addition of an exogenous source of interleukin-2 indicating that the T cells had b...

journal_title：Diabetologia

authors： Sellins KS,Gold DP,Bellgrau D

更新日期：1996-01-01 00:00:00

abstract：:Diabetic retinopathy was found to be present in 12 out of a group of 67 diabetic patients supervised by us during 92 pregnancies, and 3 further pregnant diabetics were referred to us because of retinopathy. The mean duration of diabetes was 13 years (range 3--25 years). Nine patients had minimal retinopathy, 2 had bac...

journal_title：Diabetologia

authors： Cassar J,Kohner EM,Hamilton AM,Gordon H,Joplin GF

更新日期：1978-08-01 00:00:00

abstract：:The 10-year follow-up of the Munich General Practitioner Project was designed as a long-term prospective study to evaluate factors predicting macrovascular and overall mortality in a random cohort of non-insulin-dependent diabetic (NIDDM) patients. Of the original 290 patients (103 males, 187 females, median age 65 ye...

journal_title：Diabetologia

authors： Standl E,Balletshofer B,Dahl B,Weichenhain B,Stiegler H,Hörmann A,Holle R

更新日期：1996-12-01 00:00:00

abstract：:In 1971, 107 newly diagnosed black diabetics admitted to Harare Central Hospital, Rhodesia, were studied. Nine died before discharge. In 1977, 93 of the 98 patients discharged alive were traced but of these 38 (41%) had since died. Of 18 autopsies performed the cause of death was hypoglycaemia in 8 patients and hyperg...

journal_title：Diabetologia

authors： Castle WM,Wicks AC

更新日期：1980-01-01 00:00:00

abstract：:Blood glucose values close to normal reduce the microvascular complications of insulin-dependent diabetes mellitus. The Stockholm study of this effect continued after the initial 7.5-year period in order to see what happened when intensively treated patients were left to control their own treatment while treatment was...

journal_title：Diabetologia

authors： Reichard P,Pihl M,Rosenqvist U,Sule J

更新日期：1996-12-01 00:00:00

abstract：AIMS/HYPOTHESIS:Islet autoantibodies are important in diabetes classification and risk assessment, and as endpoints in observational studies. The Diabetes Autoantibody Standardization Program (DASP) aims to improve and standardise measurement of autoantibodies associated with type 1 diabetes. We report results for glut...

journal_title：Diabetologia

authors： Törn C,Mueller PW,Schlosser M,Bonifacio E,Bingley PJ,Participating Laboratories.

更新日期：2008-05-01 00:00:00

abstract：AIMS/HYPOTHESIS:We sought to determine the risk of diabetes and IGT/IFG with grand multiparity. SUBJECTS, MATERIALS AND METHODS:Women, aged > or =25 years, from the Australian Diabetes, Obesity and Lifestyle Study and the Crossroads Undiagnosed Disease Study (a rural study in Victoria, Australia), participated in a ho...

journal_title：Diabetologia

authors： Simmons D,Shaw J,McKenzie A,Eaton S,Cameron AJ,Zimmet P

更新日期：2006-07-01 00:00:00

abstract：:The glucose phosphorylating enzyme glucokinase plays an important role in the regulation of glucose homeostasis. Studies in rodents indicate that pancreatic Beta cells and hepatocytes express different isoforms of this protein as a consequence of the presence of tissue-specific promoters and exon 1 sequences which are...

journal_title：Diabetologia

authors： Nishi S,Stoffel M,Xiang K,Shows TB,Bell GI,Takeda J

更新日期：1992-08-01 00:00:00

abstract：:It has been proposed that the development of diabetic complications may involve a depletion of cellular myo-inositol due to an increase in polyol (sorbitol) formation. We therefore initially examined the effect of diabetes on levels of these metabolites in isolated cerebral microvessels. Compared with microvessels fro...

journal_title：Diabetologia

authors： Sussman I,Carson MP,Schultz V,Wu XP,McCall AL,Ruderman NB,Tornheim K

更新日期：1988-10-01 00:00:00

abstract：AIMS/HYPOTHESIS:Pancreatic beta cells play a central role in the control of glucose homeostasis by secreting insulin to stimulate glucose uptake by peripheral tissues. Understanding the molecular mechanisms that control beta cell function and plasticity has critical implications for the pathophysiology and therapy of m...

journal_title：Diabetologia

authors： Thorens B,Tarussio D,Maestro MA,Rovira M,Heikkilä E,Ferrer J

更新日期：2015-03-01 00:00:00

abstract：AIMS/HYPOTHESIS:Type 1 diabetes increases the risk of peripheral ischaemia and impairs recovery once ischaemia occurs, probably because the healing process is hampered by diabetes-induced endothelial dysfunction. In normoglycaemic mice subjected to limb ischaemia, blockade of nerve growth factor (NGF) compromises repar...

journal_title：Diabetologia

authors： Salis MB,Graiani G,Desortes E,Caldwell RB,Madeddu P,Emanueli C

更新日期：2004-06-01 00:00:00