Abstract:
:The insulin storage granule of the pancreatic beta cell is assembled within the trans Golgi network from around 50 or so gene products many of which are synthesized coordinately with the major component, proinsulin. An important contribution to our understanding of the regulation of this process has come from studies of the post-translational processing of proinsulin and of other proteins which are stored in the granule, particularly the processing enzymes themselves. The present review focusses on recent insights into the molecular nature of the processing machinery, and the granule Ca(2+)-dependent subtilisin-related endopeptidases which catalyse the initial rate-limiting step in the enzymic conversion of proinsulin.
journal_name
Diabetologiajournal_title
Diabetologiaauthors
Hutton JCdoi
10.1007/BF00400826subject
Has Abstractpub_date
1994-09-01 00:00:00pages
S48-56eissn
0012-186Xissn
1432-0428journal_volume
37 Suppl 2pub_type
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