当前位置： SCI文献检索 > DIABETOLOGIA期刊下所有文献 > The putative role of the hormone-sensitive lipase gene in the pathogenesis of Type II diabetes mellitus and abdominal obesity.

The putative role of the hormone-sensitive lipase gene in the pathogenesis of Type II diabetes mellitus and abdominal obesity.

Abstract：

:Impaired lipolysis has been proposed as a pathogenic factor contributing to clustering of abdominal obesity and dyslipidaemia in Type II (non-insulin-dependent) diabetes mellitus--that is, the metabolic syndrome (MSDR). As this syndrome clusters in families, alterations in the hormone-sensitive lipase (HSL) gene could contribute to the genetic predisposition to MSDR. To test this hypothesis we carried out population and intrafamily association studies in individuals with MSDR, using a polymorphic marker (LIPE) in the HSL gene. There was a significant difference in allele frequency distribution between 235 Type II diabetic patients and 146 control subjects (p = 0.002), particularly between 78 abdominally obese Type II diabetic patients with MSDR and the control group (p = 0.010). An extended transmission disequilibrium test (TDT) showed transmission disequilibrium of 66 alleles to 42 nondiabetic, abdominally obese offspring in families with Type II diabetes (p < 0.05). A slight difference in allele frequency distribution was seen between 71 individuals from the lowest and 71 from the highest tertile of isoprenaline-induced lipolysis in fat tissue (p = 0.07). No missense mutations were found with single-strand conformational polymorphism (SSCP) in 20 abdominally obese subjects with MSDR. In conclusion, our population and intrafamily association studies suggest that the LIPE marker in the HSL gene is in linkage disequilibrium with an allele and/or gene which increases susceptibility to abdominal obesity and thereby possibly to Type II diabetes.

journal_name

Diabetologia

journal_title

Diabetologia

authors

Klannemark M,Orho M,Langin D,Laurell H,Holm C,Reynisdottir S,Arner P,Groop L

doi

10.1007/s001250051099

subject

Has Abstract

pub_date

1998-12-01 00:00:00

pages

1516-22

issue

12

eissn

0012-186X

issn

1432-0428

journal_volume

41

pub_type

杂志文章

相关文献

DIABETOLOGIA文献大全
  • Genetic associations in diabetic nephropathy: a meta-analysis.

    abstract：AIMS/HYPOTHESIS:This meta-analysis assessed the pooled effect of each genetic variant reproducibly associated with diabetic nephropathy. METHODS:PubMed, EMBASE and Web of Science were searched for articles assessing the association between genes and diabetic nephropathy. All genetic variants statistically associated w...

    journal_title：Diabetologia

    pub_type： 杂志文章,meta分析

    doi：10.1007/s00125-010-1996-1

    authors： Mooyaart AL,Valk EJ,van Es LA,Bruijn JA,de Heer E,Freedman BI,Dekkers OM,Baelde HJ

    更新日期：2011-03-01 00:00:00

  • Functional studies in patients with the glucagonoma syndrome.

    abstract：:Four patients with glucagon-producing tumours of the pancreas were investigated. Fasting plasma glucagon concentrations ranged from 209--625 pmol/l. Plasma insulin concentrations were normal except in one patient, where the tumour also produced insulin (558 pmol/l). Intravenous glucose (25 g/m2) depressed the glucagon...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/BF01219741

    authors： Holst JJ,Helland S,Ingemannson S,Pedersen NB,von Schenck H

    更新日期：1979-09-01 00:00:00

  • Familial risk of type I diabetes in European children. The Eurodiab Ace Study Group and The Eurodiab Ace Substudy 2 Study Group.

    abstract：:The characteristics of familial Type I (insulin-dependent) diabetes mellitus-that is Type I diabetes in a first degree relative were investigated for children diagnosed before the age of 15 years using data from an international network of population-based registries (the EURODIAB ACE network) and from a case-control ...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/s001250051044

    authors：

    更新日期：1998-10-01 00:00:00

  • Secular trend for mortality from breast cancer and the association between diabetes and breast cancer in Taiwan between 1995 and 2006.

    abstract：AIMS/HYPOTHESIS:Studies have identified an association between diabetes and breast cancer in postmenopausal women in Western countries. Such an association needs to be confirmed in an Asian population. The aim of this study was to evaluate the secular trend for breast cancer mortality in Taiwanese women in the general ...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/s00125-008-1204-8

    authors： Tseng CH,Chong CK,Tai TY

    更新日期：2009-02-01 00:00:00

  • Differential white cell count and incident type 2 diabetes: the Insulin Resistance Atherosclerosis Study.

    abstract：AIMS/HYPOTHESIS:White cell count has been shown to predict incident type 2 diabetes, but differential white cell count has received scant attention. We examined the risk of developing diabetes associated with differential white cell count and neutrophil:lymphocyte ratio and the effect of insulin sensitivity and subclin...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/s00125-013-3080-0

    authors： Lorenzo C,Hanley AJ,Haffner SM

    更新日期：2014-01-01 00:00:00

  • Stromal cell-derived factor-1 (SDF-1)/chemokine (C-X-C motif) receptor 4 (CXCR4) axis activation induces intra-islet glucagon-like peptide-1 (GLP-1) production and enhances beta cell survival.

    abstract：AIMS/HYPOTHESIS:The endogenous production of stromal cell-derived factor-1 (SDF-1) in beta cells in transgenic mice attenuates the development of diabetes in response to streptozotocin. Here we propose that beta cell injury induces SDF-1 production, and the SDF-1/chemokine (C-X-C motif) receptor 4 (CXCR4) interaction a...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/s00125-011-2181-x

    authors： Liu Z,Stanojevic V,Avadhani S,Yano T,Habener JF

    更新日期：2011-08-01 00:00:00

  • The prenatal environment and type 1 diabetes.

    abstract：:There is ample evidence that environmental factors are involved in the aetiology of type 1 diabetes, but the nature and timing of the interactions are poorly understood. The intrauterine environment is known to play a role in the later development of type 2 diabetes, and this review considers a possible role in type 1...

    journal_title：Diabetologia

    pub_type： 杂志文章,评审

    doi：10.1007/s00125-013-2929-6

    authors： Stene LC,Gale EA

    更新日期：2013-09-01 00:00:00

  • The impact of diabetes on productivity in China.

    abstract：AIMS/HYPOTHESIS:Diabetes increases the risk of premature death and reduces work productivity. We estimated the impact of diabetes in China in terms of mortality, years of life lost, and productivity-adjusted life years (PALYs) lost in the Chinese population. METHODS:Life table modelling was used with simulated follow-...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/s00125-019-4875-4

    authors： Hird TR,Zomer E,Owen A,Chen L,Ademi Z,Magliano DJ,Liew D

    更新日期：2019-07-01 00:00:00

  • Elevated GLUT 1 level in crude muscle membranes from diabetic Zucker rats despite a normal GLUT 1 level in perineurial sheaths.

    abstract：:Recently, we demonstrated that approximately 60% of GLUT 1 in a crude membrane fraction of rat skeletal muscle originates from perineurial sheaths. To study the in vivo regulation of GLUT 1 expression in different tissues in muscles, we measured the level of GLUT 1 in crude muscle membranes and in perineurial sheaths ...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/s001250050130

    authors： Handberg A,Kayser L,Høyer PE,Micheelsen J,Vinten J

    更新日期：1994-05-01 00:00:00

  • Coping with Type II diabetes: the patient's perspective.

    abstract：AIMS/HYPOTHESIS:The Cost of Diabetes in Europe-Type II study is the first coordinated attempt to assess the total costs of Type II (non-insulin-dependent) diabetes mellitus in Europe. Although gaining a clearer understanding of the economics of diabetes was the goal of the study, a secondary objective was to consider t...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/s00125-002-0861-2

    authors： Koopmanschap M

    更新日期：2002-07-01 00:00:00

  • γ-Glutamyltransferase, but not markers of hepatic fibrosis, is associated with cardiovascular disease in older people with type 2 diabetes mellitus: the Edinburgh Type 2 Diabetes Study.

    abstract：AIMS/HYPOTHESIS:We examined the association of prevalent and incident cardiovascular disease (CVD) with chronic liver disease in a cohort of community-based people with type 2 diabetes, in order to clarify the relationship between these two important conditions. METHODS:1,066 participants with type 2 diabetes aged 60-...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/s00125-015-3575-y

    authors： Morling JR,Fallowfield JA,Williamson RM,Robertson CM,Glancy S,Guha IN,Strachan MW,Price JF

    更新日期：2015-07-01 00:00:00

  • Effects of L-leucine on the insulin production, oxidative metabolism and mitochondrial ultrastructure of isolated mouse pancreatic islets in tissue culture.

    abstract：:This study was performed to evaluate whether L-leucine is able to relieve the structural and functional alterations previously described in pancreatic islets exposed in vitro for a prolonged time to a subnormal glucose concentration (3.3 mM). It was found that both the impairment of secretion and the decreased rate of...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/BF00996329

    authors： Andersson A,Höiriis-Nielsen J,Borg LA

    更新日期：1977-01-01 00:00:00

  • Oxidative stress induces insulin resistance by activating the nuclear factor-kappa B pathway and disrupting normal subcellular distribution of phosphatidylinositol 3-kinase.

    abstract：AIMS/HYPOTHESIS:Oxidative stress is associated with diabetes, hypertension and atherosclerosis. Insulin resistance is implicated in the development of these disorders. We tested the hypothesis that oxidative stress induces insulin resistance in rats, and endeavoured to identify mechanisms linking the two. METHODS:Buth...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/s00125-004-1391-x

    authors： Ogihara T,Asano T,Katagiri H,Sakoda H,Anai M,Shojima N,Ono H,Fujishiro M,Kushiyama A,Fukushima Y,Kikuchi M,Noguchi N,Aburatani H,Gotoh Y,Komuro I,Fujita T

    更新日期：2004-05-01 00:00:00

  • Beta cell compensation for insulin resistance in Zucker fatty rats: increased lipolysis and fatty acid signalling.

    abstract：AIMS/HYPOTHESIS:The aim of this study was to determine the role of fatty acid signalling in islet beta cell compensation for insulin resistance in the Zucker fatty fa/fa (ZF) rat, a genetic model of severe obesity, hyperlipidaemia and insulin resistance that does not develop diabetes. MATERIALS AND METHODS:NEFA augmen...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/s00125-006-0305-5

    authors： Nolan CJ,Leahy JL,Delghingaro-Augusto V,Moibi J,Soni K,Peyot ML,Fortier M,Guay C,Lamontagne J,Barbeau A,Przybytkowski E,Joly E,Masiello P,Wang S,Mitchell GA,Prentki M

    更新日期：2006-09-01 00:00:00

  • Vascular damage induced by type 2 diabetes mellitus as a risk factor for benign prostatic hyperplasia.

    abstract：AIMS/HYPOTHESIS:The aim of this study was to evaluate the relationship between benign prostatic hyperplasia (BPH) and arteriosclerosis shown in a model of type 2 diabetes in a trans-sectional population study using contrast-enhanced colour Doppler ultrasound for exact assessment of prostatic blood flow. METHODS:Contra...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/s00125-005-1678-6

    authors： Berger AP,Deibl M,Halpern EJ,Lechleitner M,Bektic J,Horninger W,Fritsche G,Steiner H,Pelzer A,Bartsch G,Frauscher F

    更新日期：2005-04-01 00:00:00

  • Reduced size at birth and persisting reductions in adiposity in recent, compared with earlier, cohorts of infants born to mothers with gestational diabetes mellitus.

    abstract：AIMS/HYPOTHESIS:This study aimed to explore the infancy growth trajectories of 'recent' and 'earlier' offspring of mothers with gestational diabetes mellitus (OGDM), each compared with the same control infants, and investigate whether 'recent' OGDM still exhibit a classical phenotype, with macrosomia and increased adip...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/s00125-019-4970-6

    authors： Prentice PM,Olga L,Petry CJ,Simmons D,Murphy HR,Hughes IA,Acerini CL,Ong KK,Dunger DB

    更新日期：2019-11-01 00:00:00

  • Amelioration of nerve conduction velocity following simultaneous kidney/pancreas transplantation is due to the glycaemic control provided by the pancreas.

    abstract：:Diabetic polyneuropathy is a common, disabling chronic complication of diabetes mellitus. Previous studies have suggested that combined pancreas-kidney transplantation can ameliorate nerve conduction. The relative contribution of the correction of hyperglycaemia and uraemia on nerve function is still a matter of debat...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/s001250050795

    authors： Martinenghi S,Comi G,Galardi G,Di Carlo V,Pozza G,Secchi A

    更新日期：1997-09-01 00:00:00

  • Lack of glucagon response in glucose counter-regulation in type 1 (insulin-dependent) diabetics: absence of recovery after prolonged optimal insulin therapy.

    abstract：:Mild hypoglycaemia was induced using an artificial pancreas in five normal subjects (from 5.00 +/- 0.15 to 2.83 +/- 0.15 mmol/l) by infusing 28 mU/m2 per min soluble insulin for 60 min. Six Type 1 (insulin-dependent) diabetic patients were stabilized for 14h using an artificial pancreas. They were then rendered hypogl...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/BF00254837

    authors： Bolli G,Calabrese G,De Feo P,Compagnucci P,Zega G,Angeletti G,Cartechini MG,Santeusanio F,Brunetti P

    更新日期：1982-02-01 00:00:00

  • Natural history of preclinical IDDM in high risk siblings. Childhood Diabetes in Finland Study Group.

    abstract：:To learn more about the preclinical phase of IDDM we observed for a median period of 46.5 months (range 0.5-69 months) a group of 57 siblings positive for ICA and/or IAA when first screened within 6 months of the diagnosis of the proband. Sequential blood samples and IVGTTs were obtained at intervals of 6-12 months. S...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/s001250050122

    authors： Knip M,Vähäsalo P,Karjalainen J,Lounamaa R,Akerblom HK

    更新日期：1994-04-01 00:00:00

  • A vascular mechanism for high-sodium-induced insulin resistance in rats.

    abstract：AIMS/HYPOTHESIS:High sodium (HS) effects on hypertension are well established. Recent evidence implicates a relationship between HS intake and insulin resistance, even in the absence of hypertension. The aim of the current study was to determine whether loss of the vascular actions of insulin may be the driving factor ...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/s00125-014-3373-y

    authors： Premilovac D,Richards SM,Rattigan S,Keske MA

    更新日期：2014-12-01 00:00:00

  • Disruption of mitochondrial fission in the liver protects mice from diet-induced obesity and metabolic deterioration.

    abstract：AIM/HYPOTHESIS:Mitochondria and the endoplasmic reticulum (ER) physically interact by close structural juxtaposition, via the mitochondria-associated ER membrane. Inter-organelle communication between the ER and mitochondria has been shown to regulate energy metabolism and to be central to the modulation of various key...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/s00125-015-3704-7

    authors： Wang L,Ishihara T,Ibayashi Y,Tatsushima K,Setoyama D,Hanada Y,Takeichi Y,Sakamoto S,Yokota S,Mihara K,Kang D,Ishihara N,Takayanagi R,Nomura M

    更新日期：2015-10-01 00:00:00

  • Does the evidence support population-wide screening for type 2 diabetes? No.

    abstract：:Large-scale, centrally-coordinated screening for undiagnosed type 2 diabetes is an attractive option to reduce the mortality and morbidity resulting from inadequately controlled diabetes. However, there is limited research examining the direct consequences of such screening programmes on outcomes such as cardiovascula...

    journal_title：Diabetologia

    pub_type： 评论,杂志文章

    doi：10.1007/s00125-017-4393-1

    authors： Shaw JE

    更新日期：2017-11-01 00:00:00

  • Effect of methylxanthines on alloxan inhibition of insulin release.

    abstract：:Isloated rat islets were maintained in vitro in a perifusion system, exposed to alloxan (20 mg/100 ml) for 5 minutes in the presence of agents which affect cAMP metabolism and subsequently stimulated with glucose. The rate of insulin secretion was monitored throughout the period of perifusion. Exposure to alloxan alon...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/BF01222099

    authors： Lacy PE,McDaniel ML,Fink CJ,Roth C

    更新日期：1975-12-01 00:00:00

  • Glycosylated haemoglobin in children with insulin-dependent diabetes mellitus.

    abstract：:Glycosylated haemoglobin (HbA1) was measured serially by microcolumn chromatography in 38 children with newly diagnosed insulin-dependent diabetes. Initial HbA1 levels of 13.6 +/- 0.5% fell signficiantly from day 0 (prior to therapy) both to day 1 (1.6 +/- 0.2% decrease) and to day 3-5 (2.6 +/- 0.4% decrease) (P < 0.0...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/BF00281820

    authors： Daneman D,Tsalikian E,Hengstenberg F,Becker DJ,Drash AL

    更新日期：1980-11-01 00:00:00

  • Prevalence of diabetes among children of insulin-dependent diabetic mothers.

    abstract：:Eight diabetics were found among 464 children, mean age 11.2 years, of 311 unselected insulin-treated mothers. By a method of age correction the total diabetes prevalence among the children at the age of 25 years was calculated as 3.4%. Three children were non-insulin dependent and these patients and their mothers may...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/BF00261701

    authors： Köbberling J,Brüggeboes B

    更新日期：1980-06-01 00:00:00

  • Vanadate treatment rapidly improves glucose transport and activates 6-phosphofructo-1-kinase in diabetic rat intestine.

    abstract：:The effect of oral vanadate on intestinal sodium-dependent glucose transport and 6-phosphofructo-1-kinase (EC 2.7.1.11) activity was examined in male Sprague-Dawley rats following a 30-day period of non-treated streptozotocin-induced diabetes. Non-treated diabetic rats were hyperglycaemic and demonstrated increased in...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/BF00410277

    authors： Madsen KL,Ariano D,Fedorak RN

    更新日期：1995-04-01 00:00:00

  • Peroxisome proliferator-activated receptor-gamma coactivator-1 and insulin resistance: acute effect of fatty acids.

    abstract：AIMS/HYPOTHESIS:Peroxisome proliferator-activated receptor (PPAR)-gamma coactivator-1 (PPARGC1), a coactivator regulating the transcription of genes involved in oxidative metabolism, is downregulated in patients with type 2 diabetes and in their first-degree relatives. Whether this downregulation is a cause or effect o...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/s00125-006-0369-2

    authors： Hoeks J,Hesselink MK,Russell AP,Mensink M,Saris WH,Mensink RP,Schrauwen P

    更新日期：2006-10-01 00:00:00

  • Safety of high-dose nicotinamide: a review.

    abstract：:Nicotinamide, the amide derivative of nicotinic acid, has over the past forty years been given at high doses for a variety of therapeutic applications. It is currently in trial as a potential means of preventing the onset of Type I (insulin-dependent) diabetes mellitus in high-risk, first-degree relatives. Nicotinamid...

    journal_title：Diabetologia

    pub_type： 杂志文章,评审

    doi：10.1007/s001250051536

    authors： Knip M,Douek IF,Moore WP,Gillmor HA,McLean AE,Bingley PJ,Gale EA,European Nicotinamide Diabetes Intervention Trial Group.

    更新日期：2000-11-01 00:00:00

  • Variants of transcription factor 7-like 2 (TCF7L2) gene predict conversion to type 2 diabetes in the Finnish Diabetes Prevention Study and are associated with impaired glucose regulation and impaired insulin secretion.

    abstract：AIMS/HYPOTHESIS:We investigated the association of variants of the transcription factor 7-like 2 (TCF7L2) gene with: (1) incident diabetes in the Finnish Diabetes Prevention Study (DPS, Study I); (2) type 2 diabetes and impaired glucose regulation (i.e. IGT or IFG) in a cross-sectional study (Study II); and (3) insulin...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/s00125-007-0656-6

    authors： Wang J,Kuusisto J,Vänttinen M,Kuulasmaa T,Lindström J,Tuomilehto J,Uusitupa M,Laakso M

    更新日期：2007-06-01 00:00:00

  • Meta-analysis of the effects of n-3 polyunsaturated fatty acids on lipoproteins and other emerging lipid cardiovascular risk markers in patients with type 2 diabetes.

    abstract：AIMS/HYPOTHESIS:To determine the effects of marine-derived n-3 polyunsaturated fatty acids (PUFA) on established and emerging lipid and lipoprotein cardiovascular risk markers in patients with type 2 diabetes. MATERIALS AND METHODS:We performed a systematic review and meta-analysis of randomised controlled trials comp...

    journal_title：Diabetologia

    pub_type： 杂志文章,meta分析,评审

    doi：10.1007/s00125-007-0695-z

    authors： Hartweg J,Farmer AJ,Perera R,Holman RR,Neil HA

    更新日期：2007-08-01 00:00:00