A prospective study of endometriosis and risk of type 2 diabetes.

Abstract:

AIMS/HYPOTHESIS:The objective of this study was to investigate the association between laparoscopically confirmed endometriosis and risk of type 2 diabetes. METHODS:We used data from the Nurses' Health Study II, a prospective cohort of female nurses followed for >25 years (N = 112,037). We used Cox proportional hazards models to estimate the HRs and 95% CIs of incident, confirmed type 2 diabetes (n = 8496 participants) adjusted a priori for confounding factors. We additionally investigated differences in the relationship between endometriosis and type 2 diabetes by age (<50 or ≥50 years), BMI (<30 or ≥30 kg/m2), infertility history, menopausal status and history of gestational diabetes mellitus (GDM; restricted to parous women). RESULTS:We saw no association between laparoscopically confirmed endometriosis and risk of type 2 diabetes in multivariable confounder-adjusted models (HR 1.06 [95% CI 0.98, 1.13]) or models accounting for potential mediating factors (HR 0.94 [95% CI 0.87, 1.00]). However, we observed modest differences in the association between endometriosis and type 2 diabetes by BMI group, history of infertility and history of GDM. Among non-obese women (HR 1.17 [95% CI 1.02, 1.35]), women who never experienced infertility (HR 1.14 [95% CI 1.04, 1.25]) and women who never experienced GDM (HR 1.11 [95% CI 1.01, 1.22]), endometriosis was associated with greater risk of type 2 diabetes. CONCLUSIONS/INTERPRETATION:Overall, women with endometriosis were not at increased risk of type 2 diabetes. However, among subgroups at low risk for type 2 diabetes (i.e. non-obese women and women with no prior history of infertility or GDM), endometriosis was associated with a modest increased risk of type 2 diabetes.

journal_name

Diabetologia

journal_title

Diabetologia

authors

Farland LV,Degnan WJ,Harris HR,Tobias DK,Missmer SA

doi

10.1007/s00125-020-05347-6

subject

Has Abstract

pub_date

2021-01-05 00:00:00

eissn

0012-186X

issn

1432-0428

pii

10.1007/s00125-020-05347-6

pub_type

杂志文章
  • Plasma corticosterone concentrations in diabetic (db) mice.

    abstract::Plasma corticosterone concentrations in diabetic (db) mice maintained on two different inbred backgrounds were found to be elevated significantly when compared to normal controls. These data are similar to that reported with the phenotypically similar obese (ob) mouse. These results suggest that the hyperadrenolcortic...

    journal_title:Diabetologia

    pub_type: 杂志文章

    doi:10.1007/BF00996323

    authors: Coleman DL,Burkart DL

    更新日期:1977-01-01 00:00:00

  • Regression of albuminuria and its association with incident cardiovascular outcomes and mortality in type 1 diabetes: the FinnDiane Study.

    abstract:AIMS/HYPOTHESIS:Our aim was to assess regression of albuminuria and its clinical consequences in type 1 diabetes. METHODS:The analysis included 3642 participants from the Finnish Diabetic Nephropathy (FinnDiane) Study with a 24 h urine sample and a history of albuminuria available at baseline. A total of 2729 individu...

    journal_title:Diabetologia

    pub_type: 杂志文章

    doi:10.1007/s00125-018-4564-8

    authors: Jansson FJ,Forsblom C,Harjutsalo V,Thorn LM,Wadén J,Elonen N,Ahola AJ,Saraheimo M,Groop PH,FinnDiane Study Group.

    更新日期:2018-05-01 00:00:00

  • Inhibitory effect of troglitazone on diabetic neuropathy in streptozotocin-induced diabetic rats.

    abstract::Free-radical scavengers and inhibitors of tumour necrosis factor-alpha (TNF-alpha) such as N-acetylcysteine and pentoxifylline have been shown to inhibit the development of peripheral neuropathy in streptozotocin(STZ)-induced diabetic rats. In this study we examined the effect of troglitazone, an anti-diabetic thiazol...

    journal_title:Diabetologia

    pub_type: 杂志文章

    doi:10.1007/s001250051072

    authors: Qiang X,Satoh J,Sagara M,Fukuzawa M,Masuda T,Sakata Y,Muto G,Muto Y,Takahashi K,Toyota T

    更新日期:1998-11-01 00:00:00

  • Variants of ADRA2A are associated with fasting glucose, blood pressure, body mass index and type 2 diabetes risk: meta-analysis of four prospective studies.

    abstract:AIMS/HYPOTHESIS:We quantified the effect of ADRA2A (encoding α-2 adrenergic receptor) variants on metabolic traits and type 2 diabetes risk, as reported in four studies. METHODS:Genotype data for ADRA2A single nucleotide polymorphisms (SNPs) rs553668 and rs10885122 were analysed in >17,000 individuals (1,307 type 2 di...

    journal_title:Diabetologia

    pub_type: 杂志文章,meta分析

    doi:10.1007/s00125-011-2108-6

    authors: Talmud PJ,Cooper JA,Gaunt T,Holmes MV,Shah S,Palmen J,Drenos F,Shah T,Kumari M,Kivimaki M,Whittaker J,Lawlor DA,Day IN,Hingorani AD,Casas JP,Humphries SE

    更新日期:2011-07-01 00:00:00

  • Abnormal glutathione metabolism and increased cytotoxicity caused by H2O2 in human umbilical vein endothelial cells cultured in high glucose medium.

    abstract::To determine whether increased oxidative stress in diabetes mellitus is due to an impaired free-radical scavenger function in endothelial cells, GSH-dependent H2O2 degradation in human umbilical vein endothelial cells was studied. The GSH-dependent, NaN3-uninhibitable H2O2-degradation in endothelial cells was reduced ...

    journal_title:Diabetologia

    pub_type: 杂志文章

    doi:10.1007/BF00398053

    authors: Kashiwagi A,Asahina T,Ikebuchi M,Tanaka Y,Takagi Y,Nishio Y,Kikkawa R,Shigeta Y

    更新日期:1994-03-01 00:00:00

  • Predictive power of screening for antibodies against insulinoma-associated protein 2 beta (IA-2beta) and zinc transporter-8 to select first-degree relatives of type 1 diabetic patients with risk of rapid progression to clinical onset of the disease: impli

    abstract:AIMS/HYPOTHESIS:We investigated whether screening for insulinoma-associated protein (IA-2) beta (IA-2beta) autoantibodies (IA-2betaA) and zinc transporter-8 (ZnT8) autoantibodies (ZnT8A) improves identification of first-degree relatives of type 1 diabetic patients with a high 5-year disease risk, which to date has been...

    journal_title:Diabetologia

    pub_type: 杂志文章

    doi:10.1007/s00125-009-1618-y

    authors: De Grijse J,Asanghanwa M,Nouthe B,Albrecher N,Goubert P,Vermeulen I,Van Der Meeren S,Decochez K,Weets I,Keymeulen B,Lampasona V,Wenzlau J,Hutton JC,Pipeleers D,Gorus FK,Belgian Diabetes Registry.

    更新日期:2010-03-01 00:00:00

  • Cellular proliferation in mouse and human pancreatic islets is regulated by serpin B13 inhibition and downstream targeting of E-cadherin by cathepsin L.

    abstract:AIMS/HYPOTHESIS:We previously reported that exposure to antibodies neutralising serpin B13, a protease inhibitor expressed in exocrine pancreatic ducts, promotes beta cell proliferation, underscoring the importance of a functional relationship between exocrine and endocrine pancreas. The aim of the present study was to...

    journal_title:Diabetologia

    pub_type: 杂志文章

    doi:10.1007/s00125-019-4834-0

    authors: Lo CW,Kryvalap Y,Sheu TJ,Chang CH,Czyzyk J

    更新日期:2019-05-01 00:00:00

  • Stromal cell-derived factor-1 (SDF-1)/chemokine (C-X-C motif) receptor 4 (CXCR4) axis activation induces intra-islet glucagon-like peptide-1 (GLP-1) production and enhances beta cell survival.

    abstract:AIMS/HYPOTHESIS:The endogenous production of stromal cell-derived factor-1 (SDF-1) in beta cells in transgenic mice attenuates the development of diabetes in response to streptozotocin. Here we propose that beta cell injury induces SDF-1 production, and the SDF-1/chemokine (C-X-C motif) receptor 4 (CXCR4) interaction a...

    journal_title:Diabetologia

    pub_type: 杂志文章

    doi:10.1007/s00125-011-2181-x

    authors: Liu Z,Stanojevic V,Avadhani S,Yano T,Habener JF

    更新日期:2011-08-01 00:00:00

  • Islet-intrinsic effects of CFTR mutation.

    abstract::Cystic fibrosis-related diabetes (CFRD) is the most significant extra-pulmonary comorbidity in cystic fibrosis (CF) patients, and accelerates lung decline. In addition to the traditional view that CFRD is a consequence of fibrotic destruction of the pancreas as a whole, emerging evidence may implicate a role for cysti...

    journal_title:Diabetologia

    pub_type: 杂志文章,评审

    doi:10.1007/s00125-016-3936-1

    authors: Koivula FNM,McClenaghan NH,Harper AGS,Kelly C

    更新日期:2016-07-01 00:00:00

  • Duration of breast-feeding and the incidence of type 2 diabetes mellitus in the Shanghai Women's Health Study.

    abstract:AIMS/HYPOTHESIS:The aim of this study was to examine the association between lifetime breast-feeding and the incidence of type 2 diabetes mellitus in a large population-based cohort study of middle-aged women. METHODS:This was a prospective study of 62,095 middle-aged parous women in Shanghai, China, who had no prior ...

    journal_title:Diabetologia

    pub_type: 杂志文章

    doi:10.1007/s00125-007-0885-8

    authors: Villegas R,Gao YT,Yang G,Li HL,Elasy T,Zheng W,Shu XO

    更新日期:2008-02-01 00:00:00

  • Proinsulin in development: New roles for an ancient prohormone.

    abstract::In postnatal organisms, insulin is well known as an essential anabolic hormone responsible for maintaining glucose homeostasis. Its biosynthesis by the pancreatic beta cell has been considered a model of tissue-specific gene expression. However, proinsulin mRNA and protein have been found in embryonic stages before th...

    journal_title:Diabetologia

    pub_type: 杂志文章,评审

    doi:10.1007/s00125-006-0232-5

    authors: Hernández-Sánchez C,Mansilla A,de la Rosa EJ,de Pablo F

    更新日期:2006-06-01 00:00:00

  • Extracellular matrix in human diabetic nephropathy: reduced expression of heparan sulphate in skin basement membrane.

    abstract::In diabetic nephropathy, expression of glycosaminoglycan side chains of heparan sulphate proteoglycan in the glomerular basement membrane is reduced proportionally to the degree of proteinuria. We performed a cross-sectional study to evaluate whether non-vascular basement membranes also show a decrease in heparan sulp...

    journal_title:Diabetologia

    pub_type: 杂志文章

    doi:10.1007/s001250050989

    authors: van der Pijl JW,Daha MR,van den Born J,Verhagen NA,Lemkes HH,Bucala R,Berden JH,Zwinderman AH,Bruijn JA,van Es LA,van der Woude FJ

    更新日期:1998-07-01 00:00:00

  • Neuronal control of peripheral nutrient partitioning.

    abstract::The appropriate utilisation, storage and conversion of nutrients in peripheral tissues, referred to as nutrient partitioning, is a fundamental process to adapt to nutritional and metabolic challenges and is thus critical for the maintenance of a healthy energy balance. Alterations in this process during nutrient exces...

    journal_title:Diabetologia

    pub_type: 杂志文章,评审

    doi:10.1007/s00125-020-05104-9

    authors: Manceau R,Majeur D,Alquier T

    更新日期:2020-04-01 00:00:00

  • Dynamics of sulfonylurea-induced insulin release from the isolated perfused rat pancreas.

    abstract::In the isolated perfused rat pancreas various sulfonylurea drugs were tested with a basal glucose level of 1 mg/ml in the perfusion buffer and were found to cause a biphasic insulin response. NOVOCS 476, a new and potent sulfonylurea, and glibenclamide qualitatively differed from tolbutamide, glibornuride, glipizide, ...

    journal_title:Diabetologia

    pub_type: 杂志文章

    doi:10.1007/BF00420977

    authors: Gotfredsen CF

    更新日期:1976-08-01 00:00:00

  • Associations of total amount and patterns of sedentary behaviour with type 2 diabetes and the metabolic syndrome: The Maastricht Study.

    abstract:AIMS/HYPOTHESIS:The study investigated cross-sectional associations of total amount and patterns of sedentary behaviour with glucose metabolism status and the metabolic syndrome. METHODS:We included 2,497 participants (mean age 60.0 ± 8.1 years, 52% men) from The Maastricht Study who were asked to wear an activPAL acc...

    journal_title:Diabetologia

    pub_type: 杂志文章

    doi:10.1007/s00125-015-3861-8

    authors: van der Berg JD,Stehouwer CD,Bosma H,van der Velde JH,Willems PJ,Savelberg HH,Schram MT,Sep SJ,van der Kallen CJ,Henry RM,Dagnelie PC,Schaper NC,Koster A

    更新日期:2016-04-01 00:00:00

  • In situ binding of islet hormones in the isolated perfused rat pancreas: evidence for local high concentrations of islet hormones via the islet-acinar axis.

    abstract::Insulin and somatostatin reportedly affect pancreatic acinar cell function via specific receptor binding. Theoretically peri-insular levels depend on the islet-acinar portal system, but the actual hormone levels have never been demonstrated. Rat pancreata were perfused anterogradely or retrogradely with 125I-insulin, ...

    journal_title:Diabetologia

    pub_type: 杂志文章

    doi:10.1007/BF00400628

    authors: Nakagawa A,Stagner JI,Samols E

    更新日期:1995-03-01 00:00:00

  • Identification of particular groups of microRNAs that positively or negatively impact on beta cell function in obese models of type 2 diabetes.

    abstract:AIMS/HYPOTHESIS:MicroRNAs are key regulators of gene expression involved in health and disease. The goal of our study was to investigate the global changes in beta cell microRNA expression occurring in two models of obesity-associated type 2 diabetes and to assess their potential contribution to the development of the ...

    journal_title:Diabetologia

    pub_type: 杂志文章

    doi:10.1007/s00125-013-2993-y

    authors: Nesca V,Guay C,Jacovetti C,Menoud V,Peyot ML,Laybutt DR,Prentki M,Regazzi R

    更新日期:2013-10-01 00:00:00

  • Diabetes as a risk factor for heart failure in women and men: a systematic review and meta-analysis of 47 cohorts including 12 million individuals.

    abstract:AIMS/HYPOTHESIS:The prevalence of diabetes and heart failure is increasing, and diabetes has been associated with an increased risk of heart failure. However, whether diabetes confers the same excess risk of heart failure in women and men is unknown. The aim of this study was to conduct a comprehensive systematic revie...

    journal_title:Diabetologia

    pub_type: 杂志文章,meta分析,评审

    doi:10.1007/s00125-019-4926-x

    authors: Ohkuma T,Komorita Y,Peters SAE,Woodward M

    更新日期:2019-09-01 00:00:00

  • Hyperinsulinaemia: the key feature of a cardiovascular and metabolic syndrome.

    abstract::In a population-based survey of 2,930 subjects, prevalence rates for obesity, Type 2 (non-insulin-dependent) diabetes mellitus, impaired glucose tolerance, hypertension, hypertriglyceridaemia, and hypercholesterolaemia were 54.3, 9.3, 11.1, 9.8, 10.3 and 9.2%, respectively. The prevalence, however, of each of these co...

    journal_title:Diabetologia

    pub_type: 杂志文章

    doi:10.1007/BF00403180

    authors: Ferrannini E,Haffner SM,Mitchell BD,Stern MP

    更新日期:1991-06-01 00:00:00

  • Beta-cell proliferation in normal and streptozotocin-treated newborn rats: site, dynamics and capacity.

    abstract::Regeneration of neonatal beta cells after streptozotocin (STZ)-induced destruction may be due to either replication from pre-existing intra-islet beta cells or extra-islet precursor cells. To further investigate this issue, beta-cell growth was analysed in normal and streptozotocin-treated newborn rats (100 micrograms...

    journal_title:Diabetologia

    pub_type: 杂志文章

    doi:10.1007/BF00418372

    authors: Wang RN,Bouwens L,Klöppel G

    更新日期:1994-11-01 00:00:00

  • Nutritional strategy to prevent fatty liver and insulin resistance independent of obesity by reducing glucose-dependent insulinotropic polypeptide responses in mice.

    abstract:AIMS/HYPOTHESIS:High intake of carbohydrates, particularly sucrose, in western societies is associated with the development of non-alcoholic fatty liver (NAFL) and diabetes mellitus. It is unclear whether this is related primarily to the carbohydrate quantity or to the hormonal responses, particularly glucose-dependent...

    journal_title:Diabetologia

    pub_type: 杂志文章

    doi:10.1007/s00125-014-3423-5

    authors: Keyhani-Nejad F,Irmler M,Isken F,Wirth EK,Beckers J,Birkenfeld AL,Pfeiffer AF

    更新日期:2015-02-01 00:00:00

  • Soluble CD163: a biomarker linking macrophages and insulin resistance.

    abstract:AIMS/HYPOTHESIS:Soluble CD163 (sCD163) was recently identified as a strong risk marker for developing type 2 diabetes. We hypothesised that sCD163 independently associates with insulin resistance. METHODS:This cross-sectional study includes 234 participants: 96 with type 2 diabetes, 34 with impaired glucose tolerance ...

    journal_title:Diabetologia

    pub_type: 杂志文章

    doi:10.1007/s00125-012-2533-1

    authors: Parkner T,Sørensen LP,Nielsen AR,Fischer CP,Bibby BM,Nielsen S,Pedersen BK,Møller HJ

    更新日期:2012-06-01 00:00:00

  • Platelet aggregability during the first two years of type 1 (insulin-dependent) diabetes mellitus in children.

    abstract::Platelet aggregation in response to collagen, adenosine diphosphate and arachidonic acid was studied prospectively in 30 children with Type 1 (insulin-dependent) diabetes mellitus. The studies began on admission to hospital and continued throughout the two years following diagnosis. The results were compared with thos...

    journal_title:Diabetologia

    pub_type: 杂志文章

    doi:10.1007/BF00274532

    authors: Kobbah AM,Ewald U,Tuvemo T

    更新日期:1989-10-01 00:00:00

  • Effect of age on the association of non-high-density-lipoprotein cholesterol and apolipoprotein B with cardiovascular mortality in a Mediterranean population with type 2 diabetes: the Casale Monferrato study.

    abstract:AIMS/HYPOTHESIS:Measurement of plasma apolipoprotein (Apo) B may improve prediction of cardiovascular risk, as it provides a measure of the total number of atherogenic particles. The aim of this population-based study was to compare the association of non-HDL-cholesterol, ApoB and the ApoB:ApoA-I ratio with cardiovascu...

    journal_title:Diabetologia

    pub_type: 杂志文章,多中心研究

    doi:10.1007/s00125-006-0195-6

    authors: Bruno G,Merletti F,Biggeri A,Bargero G,Prina-Cerai S,Pagano G,Cavallo-Perin P

    更新日期:2006-05-01 00:00:00

  • Influence of affinity of antibodies upon their detection by liquid phase radiobinding assay and solid phase enzyme linked immunosorbent assay. Demonstration using monoclonal antibodies raised against rDNA human proinsulin.

    abstract::Hybridomas producing proinsulin antibodies were cloned by limiting dilution of cell cultures obtained by fusion of splenocytes of immunized mice with immortal myeloma cells. Some proinsulin monoclonal antibodies crossreacted with labelled insulin but none did with labelled C-peptide indicating that the involved epitop...

    journal_title:Diabetologia

    pub_type: 杂志文章

    doi:10.1007/BF00403281

    authors: Sodoyez JC,Koch M,Lemaire I,Sodoyez-Goffaux F,Rapaille A,François-Gérard C,Sondag D

    更新日期:1991-07-01 00:00:00

  • Islet amyloid: a complication of islet dysfunction or an aetiological factor in Type 2 diabetes?

    abstract::The role of islet amyloidosis in the onset and progression of Type 2 diabetes remains obscure. Islet amyloid polypeptide is a 37 amino-acid, beta-cell peptide which is co-stored and co-released with insulin. Human islet amyloid polypeptide refolds to a beta-conformation and oligomerises to form insoluble fibrils; prol...

    journal_title:Diabetologia

    pub_type: 杂志文章,评审

    doi:10.1007/s00125-003-1304-4

    authors: Clark A,Nilsson MR

    更新日期:2004-02-01 00:00:00

  • Genetic evidence of a causal effect of insulin resistance on branched-chain amino acid levels.

    abstract:AIMS/HYPOTHESIS:Fasting plasma levels of branched-chain amino acids (BCAAs) are associated with insulin resistance, but it remains unclear whether there is a causal relation between the two. We aimed to disentangle the causal relations by performing a Mendelian randomisation study using genetic variants associated with...

    journal_title:Diabetologia

    pub_type: 杂志文章

    doi:10.1007/s00125-017-4222-6

    authors: Mahendran Y,Jonsson A,Have CT,Allin KH,Witte DR,Jørgensen ME,Grarup N,Pedersen O,Kilpeläinen TO,Hansen T

    更新日期:2017-05-01 00:00:00

  • Renal hypertrophy in experimental diabetes: relation to severity of diabetes.

    abstract::Streptozotocin diabetic rats have larger kidneys than non-diabetic rats. In the present study the rate of kidney growth during the first seven days of diabetes was correlated with the blood glucose concentration. Over a wide range of blood glucose concentrations (116-340 mg/100 ml) the kidney weight, protein content a...

    journal_title:Diabetologia

    pub_type: 杂志文章

    doi:10.1007/BF00745142

    authors: Seyer-Hansen K

    更新日期:1977-04-01 00:00:00

  • A high concentration of prorenin in early pregnancy is associated with development of pre-eclampsia in women with type 1 diabetes.

    abstract:AIMS/HYPOTHESIS:The aim of this study was to investigate whether components of the renin-angiotensin system and semicarbazide-sensitive amine oxidase (SSAO) are associated with the development of pre-eclampsia in women with type 1 diabetes. METHODS:This was an observational study of 107 consecutive pregnant women with...

    journal_title:Diabetologia

    pub_type: 杂志文章

    doi:10.1007/s00125-011-2087-7

    authors: Ringholm L,Pedersen-Bjergaard U,Thorsteinsson B,Boomsma F,Damm P,Mathiesen ER

    更新日期:2011-07-01 00:00:00

  • Association between diabetes and haematological malignancies: a population-based study.

    abstract:AIMS/HYPOTHESIS:Contemporary data for the association of diabetes with haematological malignancies are lacking. We evaluated the risk of developing haematological malignancies and subsequent mortality in individuals with diabetes compared with those without diabetes. METHODS:We conducted a population-based observation...

    journal_title:Diabetologia

    pub_type: 杂志文章

    doi:10.1007/s00125-020-05338-7

    authors: Gong IY,Cheung MC,Read S,Na Y,Lega IC,Lipscombe LL

    更新日期:2021-01-06 00:00:00