Cellular basis of direct insulin action in the central nervous system.

abstract：AIMS/HYPOTHESIS:Type 1 diabetes increases the risk of peripheral ischaemia and impairs recovery once ischaemia occurs, probably because the healing process is hampered by diabetes-induced endothelial dysfunction. In normoglycaemic mice subjected to limb ischaemia, blockade of nerve growth factor (NGF) compromises repar...

journal_title：Diabetologia

authors： Salis MB,Graiani G,Desortes E,Caldwell RB,Madeddu P,Emanueli C

更新日期：2004-06-01 00:00:00

abstract：AIMS/HYPOTHESIS:FTO harbours the strongest known obesity-susceptibility locus in Europeans. While there is growing evidence for a role for FTO in obesity risk in Asians, its association with type 2 diabetes, independently of BMI, remains inconsistent. To test whether there is an association of the FTO locus with obesit...

journal_title：Diabetologia

authors： Li H,Kilpeläinen TO,Liu C,Zhu J,Liu Y,Hu C,Yang Z,Zhang W,Bao W,Cha S,Wu Y,Yang T,Sekine A,Choi BY,Yajnik CS,Zhou D,Takeuchi F,Yamamoto K,Chan JC,Mani KR,Been LF,Imamura M,Nakashima E,Lee N,Fujisawa T,Ka

更新日期：2012-04-01 00:00:00

abstract：:Blood glucose screening results, obtained using two different screening procedures, are reported from two occupational groups. Post-prandial blood glucose levels were measured in 3346 subjects aged 45 years or more employed by the Greater London Council/Inner London Education Authority. In women, mean blood glucose le...

journal_title：Diabetologia

authors： Jarrett RJ,Murrells TJ,Shipley MJ,Hall T

更新日期：1984-12-01 00:00:00

abstract：:Very low density lipoproteins (VLDL) have an abnormal lipid composition in Type 1 (insulin-dependent) diabetic patients. Since VLDL represent a heterogeneous lipoprotein class, this might be due either to a shift in the distribution or to an abnormal composition of VLDL subclasses or both. In order to investigate thes...

journal_title：Diabetologia

authors： Patti L,Romano G,Di Marino L,Annuzzi G,Mancini M,Riccardi G,Rivellese AA

更新日期：1993-02-01 00:00:00

abstract：AIMS/HYPOTHESIS:Mutations in the GCK and HNF1A genes are the most common cause of the monogenic forms of diabetes known as 'maturity-onset diabetes of the young'. GCK encodes the glucokinase enzyme, which acts as the pancreatic glucose sensor, and mutations result in stable, mild fasting hyperglycaemia. A progressive i...

journal_title：Diabetologia

authors： Ellard S,Bellanné-Chantelot C,Hattersley AT,European Molecular Genetics Quality Network (EMQN) MODY group.

更新日期：2008-04-01 00:00:00

abstract：AIMS/HYPOTHESIS:The aim was to conduct a systematic review and meta-analysis of randomised controlled clinical trials assessing the effect of probiotic, prebiotic or synbiotic supplementation on gut microbiota and glucose control and lipid levels in individuals with diabetes. METHODS:MEDLINE, EMBASE and the Cochrane L...

journal_title：Diabetologia

authors： Bock PM,Telo GH,Ramalho R,Sbaraini M,Leivas G,Martins AF,Schaan BD

更新日期：2021-01-01 00:00:00

abstract：AIMS/HYPOTHESIS:To investigate the pathways by which cyclic AMP (cAMP) stimulates glucagon-like peptide-1 (GLP-1) secretion, using the GLUTag enteroendocrine cell line. MATERIALS AND METHODS:GLP-1 release from GLUTag cells was measured in response to agents that increase cAMP, and single cells were studied by fluoresc...

journal_title：Diabetologia

authors： Simpson AK,Ward PS,Wong KY,Collord GJ,Habib AM,Reimann F,Gribble FM

更新日期：2007-10-01 00:00:00

abstract：:It is increasingly appreciated that the pathogenic mechanisms of type 1 diabetes involve both the autoimmune aggressors and their beta cell targets, which engage in a conflicting dialogue within and possibly outside the pancreas. Indeed, autoimmune CD8+ T cells, which are the final mediators of beta cell destruction, ...

journal_title：Diabetologia

authors： Mallone R,Eizirik DL

更新日期：2020-10-01 00:00:00

abstract：AIMS/HYPOTHESIS:We aimed to describe the prevalence of retinopathy in an aged cohort of Icelanders with and without diabetes mellitus. METHODS:The study population consisted of 4,994 persons aged ≥ 67 years, who participated in the Age, Gene/Environment Susceptibility-Reykjavik Study (AGES-R). Type 2 diabetes mellitus...

journal_title：Diabetologia

authors： Gunnlaugsdottir E,Halldorsdottir S,Klein R,Eiriksdottir G,Klein BE,Benediktsson R,Harris TB,Launer LJ,Aspelund T,Gudnason V,Cotch MF,Jonasson F

更新日期：2012-03-01 00:00:00

abstract：AIMS/HYPOTHESIS:It is thought that enterovirus infections initiate or facilitate the pathogenetic processes leading to type 1 diabetes. Exposure of cultured human islets to cytolytic enterovirus strains kills beta cells after a protracted period, suggesting a role for secondary virus-induced factors such as cytokines. ...

journal_title：Diabetologia

authors： Ylipaasto P,Kutlu B,Rasilainen S,Rasschaert J,Salmela K,Teerijoki H,Korsgren O,Lahesmaa R,Hovi T,Eizirik DL,Otonkoski T,Roivainen M

更新日期：2005-08-01 00:00:00

abstract：AIMS/HYPOTHESIS:Somatostatin from islet delta cells inhibits insulin and glucagon secretion, but knowledge of the regulation of pancreatic somatostatin release is limited. Some insulin secretagogues stimulate somatostatin secretion, and here we investigated whether delta cell secretory responses are indirectly regulate...

journal_title：Diabetologia

authors： Hauge-Evans AC,Anderson RL,Persaud SJ,Jones PM

更新日期：2012-07-01 00:00:00

abstract：AIMS/HYPOTHESIS:This study was aimed at the elucidation of the pathogenesis of glucotoxicity, i.e. the mechanism whereby hyperglycaemia damages pancreatic beta cells. The identification of pathways in the process may help identify targets for beta cell-protective therapy. Carbohydrate response element-binding protein (...

journal_title：Diabetologia

authors： Poungvarin N,Lee JK,Yechoor VK,Li MV,Assavapokee T,Suksaranjit P,Thepsongwajja JJ,Saha PK,Oka K,Chan L

更新日期：2012-06-01 00:00:00

abstract：AIMS/HYPOTHESIS:Oxidative stress is associated with diabetes, hypertension and atherosclerosis. Insulin resistance is implicated in the development of these disorders. We tested the hypothesis that oxidative stress induces insulin resistance in rats, and endeavoured to identify mechanisms linking the two. METHODS:Buth...

journal_title：Diabetologia

authors： Ogihara T,Asano T,Katagiri H,Sakoda H,Anai M,Shojima N,Ono H,Fujishiro M,Kushiyama A,Fukushima Y,Kikuchi M,Noguchi N,Aburatani H,Gotoh Y,Komuro I,Fujita T

更新日期：2004-05-01 00:00:00

abstract：:We compared urinary albumin excretion during and after pregnancy in 30 insulin-dependent diabetic (IDDM) women with normoalbuminuria and in 12 IDDM women with microalbuminuria (> 15 micrograms.min-1) prior to conception. There was a 6.7-fold increase in the urinary albumin excretion up until the third trimester in the...

journal_title：Diabetologia

authors： Biesenbach G,Zazgornik J,Stöger H,Grafinger P,Hubmann R,Kaiser W,Janko O,Stuby U

更新日期：1994-09-01 00:00:00

abstract：AIMS/HYPOTHESIS:Increased plasma plasminogen activator inhibitor-1 (PAI-1) concentrations are characteristic for subjects with insulin resistance and could contribute to the increased cardiovascular risk in this state. In this study, we investigated the effect of troglitazone, a ligand of the nuclear receptor peroxisom...

journal_title：Diabetologia

authors： Gottschling-Zeller H,Röhrig K,Hauner H

更新日期：2000-03-01 00:00:00

abstract：AIMS/HYPOTHESIS:Growth hormone hypersecretion in Type 1 diabetes could exacerbate insulin resistance and contribute to declining glycaemic control. Our aim was to determine the effects of specific growth hormone blockade on insulin sensitivity and lipolysis in young adults with Type 1 diabetes. METHODS:We studied the ...

journal_title：Diabetologia

authors： Williams RM,Amin R,Shojaee-Moradie F,Umpleby AM,Acerini CL,Dunger DB

更新日期：2003-09-01 00:00:00

abstract：AIMS/HYPOTHESIS:Intraportal human islet cell grafts do not consistently and sustainably induce insulin-independency in type 1 diabetic patients. The reasons for losses in donor cells are difficult to assess in patients. This study in streptozotocin-diabetic nude rats examines whether outcome is better in an extra-hepat...

journal_title：Diabetologia

authors： Jacobs-Tulleneers-Thevissen D,Bartholomeus K,Suenens K,Vermeulen I,Ling Z,Hellemans KH,In't Veld P,Pipeleers-Marichal M,Pipeleers D

更新日期：2010-08-01 00:00:00

abstract：AIMS/HYPOTHESIS:Human embryonic stem cells (hESCs) and human induced pluripotent stem cells (hIPSCs) offer unique opportunities for regenerative medicine and for the study of mammalian development. However, developing methods to differentiate hESCs/hIPSCs into specific cell types following a natural pathway of developm...

journal_title：Diabetologia

authors： Cho CH,Hannan NR,Docherty FM,Docherty HM,Joåo Lima M,Trotter MW,Docherty K,Vallier L

更新日期：2012-12-01 00:00:00

abstract：AIMS/HYPOTHESIS:Insulin enhances coronary vasodilation in healthy subjects. We tested whether insulin is able to induce coronary vasodilation in Type I (insulin-dependent) diabetic mellitus patients. Additionally, the effect of short-term hyperglycaemia on myocardial perfusion was studied. METHODS:Myocardial blood flo...

journal_title：Diabetologia

authors： Sundell J,Laine H,Nuutila P,Rönnemaa T,Luotolahti M,Raitakari O,Knuuti J

更新日期：2002-06-01 00:00:00

abstract：AIMS/HYPOTHESIS:Empagliflozin (EMPA), an inhibitor of the renal sodium-glucose cotransporter (SGLT) 2, reduces the risk of cardiovascular death in patients with type 2 diabetes. The underlying mechanism of this effect is unknown. Elevated cardiac cytoplasmic Na+ ([Na+]c) and Ca2+ ([Ca2+]c) concentrations and decreased ...

journal_title：Diabetologia

authors： Baartscheer A,Schumacher CA,Wüst RC,Fiolet JW,Stienen GJ,Coronel R,Zuurbier CJ

更新日期：2017-03-01 00:00:00

abstract：:Glomerular basement membrane thickness (GBMT) has been measured in streptozotocin diabetic rats treated with insulin. The study included 3 groups of 8 rats each: 1) a 'well-controlled' group of diabetic rats under insulin treatment with a plasma glucose level reasonable close to normal values, 2) a 'poorly-controlled'...

journal_title：Diabetologia

authors： Rasch R

更新日期：1979-05-01 00:00:00

abstract：:In this study, we found that the ratio of proinsulin to total immunoreactive insulin was much higher in 22 patients with Type 2 (non-insulin-dependent) diabetes mellitus than in 28 non-diabetic control subjects of similar age and adiposity (32 +/- 3 vs 15 +/- 1%, p less than 0.001). In addition, the arginine-induced a...

journal_title：Diabetologia

authors： Ward WK,LaCava EC,Paquette TL,Beard JC,Wallum BJ,Porte D Jr

更新日期：1987-09-01 00:00:00

abstract：AIMS/HYPOTHESIS:B-type natriuretic peptide (BNP) is a hormone released from cardiomyocytes in response to cell stretching and elevated in heart failure. Recent observations indicate a distinct connection between chronic heart failure and diabetes mellitus. This study investigated the role of BNP on glucose metabolism. ...

journal_title：Diabetologia

authors： Heinisch BB,Vila G,Resl M,Riedl M,Dieplinger B,Mueller T,Luger A,Pacini G,Clodi M

更新日期：2012-05-01 00:00:00

abstract：:The characteristics, progressivity and reversibility of the changes in glucose homeostasis brought about by chronic protein-calorie malnutrition were studied in the rat. Four-week-old male rats received a control diet (15% protein) or a low-protein diet (5% protein) until the age of 28 weeks. Other rats received the l...

journal_title：Diabetologia

authors： Okitolonda W,Brichard SM,Henquin JC

更新日期：1987-12-01 00:00:00

abstract：AIMS/HYPOTHESIS:We evaluated and compared the effects on glycaemic control of two different exercise protocols in elderly men with type 2 diabetes mellitus. METHODS:Eighteen patients with type 2 diabetes mellitus carried out home-based bicycle training for 5 weeks. Patients were randomly assigned to one of two trainin...

journal_title：Diabetologia

authors： Eriksen L,Dahl-Petersen I,Haugaard SB,Dela F

更新日期：2007-11-01 00:00:00

abstract：:The response of Gastric Inhibitory Polypeptide (GIP) and insulin to a 50 g oral glucose tolerance test (OGTT) and an intravenous glucose infusion (IVGI), which copied the changes in plasma glucose concentrations during the OGTT, were measured in 10 patients with duodenal ulcer and in 10 healthy control subjects. The m...

journal_title：Diabetologia

authors： Lauritsen KB,Moody AJ

更新日期：1978-03-01 00:00:00

abstract：AIMS/HYPOTHESIS:To identify the possible causes of the lengthening of the action potential duration described in patients affected by diabetes mellitus. METHODS:We studied the effects of streptozotocin-induced diabetes on the current density of the repolarising potassium currents It(o), IK, Iss and IK1 in enzymaticall...

journal_title：Diabetologia

authors： Casis O,Gallego M,Iriarte M,Sánchez-Chapula JA

更新日期：2000-01-01 00:00:00

abstract：AIMS/HYPOTHESIS:Impaired glucose uptake in skeletal muscle is an important contributor to glucose intolerance in type 2 diabetes. The aspartate protease, beta-site APP-cleaving enzyme 1 (BACE1), a critical regulator of amyloid precursor protein (APP) processing, modulates in vivo glucose disposal and insulin sensitivit...

journal_title：Diabetologia

authors： Hamilton DL,Findlay JA,Montagut G,Meakin PJ,Bestow D,Jalicy SM,Ashford ML

更新日期：2014-08-01 00:00:00

abstract：AIMS/HYPOTHESIS:Abnormal serum IGF-1 levels are associated with an increased risk of type 2 diabetes and cardiovascular disease. However, the causal role of IGF-1 levels within the normal range in cardiometabolic disease remains unclear. We employed Mendelian randomisation to explore the associations between geneticall...

journal_title：Diabetologia

authors： Larsson SC,Michaëlsson K,Burgess S

更新日期：2020-09-01 00:00:00

abstract：AIMS/HYPOTHESIS:The islet microcirculation has morphological characteristics resembling those of renal glomeruli. Transcription of the nephrin gene, a highly specific barrier protein of the slit diaphragm of podocyte foot processes, has been reported in the pancreas, although its cellular localisation and function rema...

journal_title：Diabetologia

authors： Zanone MM,Favaro E,Doublier S,Lozanoska-Ochser B,Deregibus MC,Greening J,Huang GC,Klein N,Cavallo Perin P,Peakman M,Camussi G

更新日期：2005-09-01 00:00:00