Abstract：
:The characteristics, progressivity and reversibility of the changes in glucose homeostasis brought about by chronic protein-calorie malnutrition were studied in the rat. Four-week-old male rats received a control diet (15% protein) or a low-protein diet (5% protein) until the age of 28 weeks. Other rats received the low-protein diet until 12-15 weeks, and then the control diet. In malnourished rats, fasting plasma glucose levels and both fasting and fed plasma insulin levels were lower than in control rats. At the age of 15 weeks, tolerance to oral glucose was slightly poorer, whereas tolerance to intravenous glucose was slightly better in rats receiving the low-protein diet than in control rats. During both tests the insulin response of malnourished rats was severely blunted. This inhibition largely exceeded the small decrease in their pancreatic insulin reserves. Similar results were obtained when the same test was repeated 9 weeks later. If the rats were transferred from a low-protein to a control diet for these 9 weeks, the changes in glucose tolerance were partially corrected, but the insulin response remained inhibited. Though hepatic glycogen stores were increased in malnourished rats, i.v. glucagon or arginine caused a smaller rise in plasma glucose levels than in control rats. The insulin response was also impaired and, unlike the glucose response, was not restored by 6 weeks on a control diet. The hypoglycaemia induced by intravenous insulin was more sustained in malnourished than in control rats, but this abnormality was corrected by refeeding a control diet for 6 weeks.(ABSTRACT TRUNCATED AT 250 WORDS)
journal_name
Diabetologiajournal_title
Diabetologiaauthors
Okitolonda W,Brichard SM,Henquin JCdoi
10.1007/BF00295879subject
Has Abstractpub_date
1987-12-01 00:00:00pages
946-51issue
12eissn
0012-186Xissn
1432-0428journal_volume
30pub_type
杂志文章相关文献
DIABETOLOGIA文献大全abstract：:The human insulin receptor exists in two isoforms (HIR-A alpha-subunit 719 amino acids and HIR-B alpha-subunit 731 amino acids) which are generated by alternative splicing of a small exon and display distinct patterns of tissue-specific expression. Using the polymerase chain reaction we have recently shown that skelet...
journal_title：Diabetologia
pub_type： 杂志文章
doi：10.1007/BF00404072
更新日期：1993-07-01 00:00:00
abstract：:Microencapsulation has been proposed to protect islets of Langerhans against immune rejection in xenogenic transplantation. However, to achieve glucose homeostasis in human diabetic patients, insulin release by microencapsulated islets must increase in response to a glucose load. We microencapsulated isolated rat isle...
journal_title：Diabetologia
pub_type： 杂志文章
doi：10.1007/BF00279134
更新日期：1988-01-01 00:00:00
abstract：:The effect of the alpha-glucosidase inhibitor acarbose on postprandial hyperglycaemia was explored in the spontaneously diabetic BB/W-rat. Acarbose-treatment (5 mg.kg body weight-1.day-1) of diabetic BB/W-rats maintained on small doses of insulin, was associated with a 40% reduction in the 24-h glucose area compared t...
journal_title：Diabetologia
pub_type： 杂志文章
doi：10.1007/BF00401199
更新日期：1992-04-01 00:00:00
abstract：:Epigenetics encapsulates a group of molecular mechanisms including DNA methylation, histone modification and microRNAs (miRNAs). Gestational diabetes (GDM) increases the risk of adverse perinatal outcomes and is associated with future offspring risk of obesity and type 2 diabetes. It has been hypothesised that epigene...
journal_title：Diabetologia
pub_type： 杂志文章,评审
doi：10.1007/s00125-019-05011-8
更新日期：2019-12-01 00:00:00
abstract：AIMS:This prospective case-control study aimed at evaluating the time course of serum concentrations of soluble adhesion molecules; intercellular adhesion molecule-1 and L-selectin in siblings with signs of pre-clinical Type 1 diabetes in order to relate these concentrations to autoantibody status and to assess whether...
journal_title：Diabetologia
pub_type： 杂志文章
doi：10.1007/s00125-003-1072-1
更新日期：2003-04-01 00:00:00
abstract：:AbstractIn Table 1 the data for age group, sex and Townsend index were incorrectly identified as mean ± SD instead of n (%). The table is corrected here. ...
journal_title：Diabetologia
pub_type： 杂志文章,已发布勘误
doi：10.1007/s00125-018-4620-4
更新日期：2018-07-01 00:00:00
abstract：AIMS/HYPOTHESIS:This study compared the incidence rate of type 1 diabetes in children diagnosed with enterovirus (EV) infections with that in age- and sex-matched children without EV infection in a population-based cohort. In addition, we examined whether the direction or magnitude of the association between EV infecti...
journal_title：Diabetologia
pub_type： 杂志文章
doi：10.1007/s00125-014-3400-z
更新日期：2015-01-01 00:00:00
abstract：AIMS/HYPOTHESIS:Diabetes increases the risk of premature death and reduces work productivity. We estimated the impact of diabetes in China in terms of mortality, years of life lost, and productivity-adjusted life years (PALYs) lost in the Chinese population. METHODS:Life table modelling was used with simulated follow-...
journal_title：Diabetologia
pub_type： 杂志文章
doi：10.1007/s00125-019-4875-4
更新日期：2019-07-01 00:00:00
abstract：AIMS/HYPOTHESIS:Higher habitual coffee drinking has been associated with a lower risk of developing type 2 diabetes. The relation between coffee consumption and risk of cardiovascular disease (CVD) has been examined in many studies, but the issue remains controversial. This study was designed to assess the association ...
journal_title：Diabetologia
pub_type： 杂志文章,多中心研究
doi：10.1007/s00125-006-0435-9
更新日期：2006-11-01 00:00:00
abstract：AIMS/HYPOTHESIS:Patients treated with human immunodeficiency virus-1 protease inhibitors often develop impaired glucose tolerance or diabetes, most likely due to an induction of insulin resistance. We therefore investigated whether the protease inhibitor indinavir alters insulin signalling. METHODS:We incubated HepG2 ...
journal_title：Diabetologia
pub_type： 杂志文章
doi：10.1007/s001250051505
更新日期：2000-09-01 00:00:00
abstract：AIMS/HYPOTHESIS:The aim of this study was to examine the effects of childhood BMI growth dynamics on the risk of developing young adult-onset type 1 and type 2 diabetes. METHODS:Finnish national healthcare registers were used to identify individuals with diabetes diagnosed between 1992 and 1996 at 15-39 years of age. ...
journal_title：Diabetologia
pub_type： 杂志文章
doi：10.1007/s00125-008-1244-0
更新日期：2009-03-01 00:00:00
abstract：AIMS/HYPOTHESIS:Differences in seasonality of birth patterns between the general population and the group who develop Type I (insulin-dependent) diabetes mellitus indicate that environmental factors operating around the antenatal and perinatal period could be important. We investigated whether the same unsual patterns ...
journal_title：Diabetologia
pub_type： 杂志文章,多中心研究
doi：10.1007/pl00002957
更新日期：2001-10-01 00:00:00
abstract：AIMS/HYPOTHESIS:Glucagon-like peptide-2 (GLP-2) is a gut hormone regulating intestinal growth and nutrient absorption. Recently, GLP-2 has been reported to stimulate glucagon secretion in healthy humans. We sought to clarify the mechanism and physiological significance of this endocrine effect. MATERIALS AND METHODS:T...
journal_title：Diabetologia
pub_type： 杂志文章
doi：10.1007/s00125-007-0761-6
更新日期：2007-10-01 00:00:00
abstract：:We aimed to assess prandial responses, basal glucose turnover and insulin action (euglycaemic clamp) in a very low-dose neonatal streptozotocin model of Type 2 (non-insulin-dependent) diabetes mellitus. Male Wistar rats were injected at 2 days of age with 45 mg/kg streptozotocin or vehicle (control). At 8 weeks, the g...
journal_title：Diabetologia
pub_type： 杂志文章
doi：10.1007/BF00400919
更新日期：1992-03-01 00:00:00
abstract：:The damaging effects of glucose on the cells which contribute to the development of diabetic complications are ill-understood. There are three major hypotheses - the sorbitol pathway, non-enzymatic glycation of proteins and increased oxidative stress - and many examples illustrate inter-connections between the three. ...
journal_title：Diabetologia
pub_type： 杂志文章,评审
doi：10.1007/s001250051439
更新日期：1999-11-01 00:00:00
abstract：AIMS/HYPOTHESIS:Peroxisome proliferator-activated receptor gamma (PPARgamma), encoded by the PPARG gene, regulates insulin sensitivity and adipogenesis, and may bind polyunsaturated fatty acids (PUFA) and thiazolidinediones in a ligand-dependent manner. The PPARG proline for alanine substitution at position 12 (Pro12Al...
journal_title：Diabetologia
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1007/s00125-007-0826-6
更新日期：2007-12-01 00:00:00
abstract：AIMS/HYPOTHESIS:Type 2 diabetes is an established risk factor for cardiovascular disease (CVD). This increased risk may be due in part to the increased levels of inflammatory factors associated with diabetes. Lipoprotein-associated phospholipase A(2) (Lp-PLA(2)) is a risk marker for CVD and has pro-inflammatory effects...
journal_title：Diabetologia
pub_type： 杂志文章
doi：10.1007/s00125-010-1969-4
更新日期：2011-02-01 00:00:00
abstract：AIMS/HYPOTHESIS:Abnormal gut microbiota and blood metabolome profiles have been reported both in children and adults with uncomplicated type 1 diabetes as well as in adults with type 1 diabetes and advanced stages of diabetic nephropathy. In this study we aimed to investigate the gut microbiota and a panel of targeted ...
journal_title：Diabetologia
pub_type： 杂志文章
doi：10.1007/s00125-020-05260-y
更新日期：2020-12-01 00:00:00
abstract：:From December, 1966 through 1990, 3082 pancreas transplants were reported to the International Registry. A detailed analysis was performed on the 2087 transplants in the 1986-90 data base; during this time the overall one year recipient and graft functional survival rates were 89% and 62%. Univariate analyses showed g...
journal_title：Diabetologia
pub_type： 杂志文章
doi：10.1007/BF00587615
更新日期：1991-08-01 00:00:00
abstract：:We have suggested that the order of cellular vascular perfusion within the islet is important in the regulation of islet hormone secretion. Anatomically, the A and D cells appear to be randomly dispersed throughout the mantle. Although islet capillary blood flow is known to be from the B-cell core to the A- and D-cell...
journal_title：Diabetologia
pub_type： 杂志文章
doi：10.1007/BF00265095
更新日期：1989-03-01 00:00:00
abstract：:Rheological studies were made on the blood of 12 diabetic patients after a period of poor diabetic control (HbA1 12.6 +/- 0.7% (mean +/- SD); mean home capillary blood glucose level 11.7 +/- 1.2 mmol/l), and after at least three months of improved control (HbA1 9.1 +/- 0.4%, p < 0.01; mean home capillary blood glucose...
journal_title：Diabetologia
pub_type： 杂志文章
doi：10.1007/BF00280518
更新日期：1980-10-01 00:00:00
abstract：AIMS/HYPOTHESIS:This study aimed to evaluate associations of height as well as components of height (sitting height and leg length) with risk of type 2 diabetes and to explore to what extent associations are explainable by liver fat and cardiometabolic risk markers. METHODS:A case-cohort study within the European Pros...
journal_title：Diabetologia
pub_type： 杂志文章
doi：10.1007/s00125-019-04978-8
更新日期：2019-12-01 00:00:00
abstract：:Insulin antibodies expressed as insulin binding capacity of IgG were determined in 50 Type 1 (insulin-dependent) diabetic children who have been treated with monocomponent porcine insulin from the onset of the disease. During the follow-up period of 0.5-5.5 years (mean +/- SD: 3.2 +/- 1.6 years), 26 out of 50 patients...
journal_title：Diabetologia
pub_type： 杂志文章
doi：10.1007/BF00281121
更新日期：1984-02-01 00:00:00
abstract：AIMS/HYPOTHESIS:Monogenic diabetes (MD) might be misdiagnosed as type 1 diabetes. The prevalence of MD among children with apparent type 1 diabetes has not been established. Our aim was to estimate the prevalence of common forms of MD in childhood diabetes. METHODS:We investigated 2,756 children aged 0-14 years with n...
journal_title：Diabetologia
pub_type： 杂志文章
doi：10.1007/s00125-013-2916-y
更新日期：2013-07-01 00:00:00
abstract：:For the normalisation of blood glucose levels in diabetic patients by feedback controlled insulin delivery, a self-manageable and reliable method for continuous glucose estimation is still not available. By combining a commercially available needle type dialysis probe (molecular cutoff 20,000 Da) with a sensitive gluc...
journal_title：Diabetologia
pub_type： 杂志文章
doi：10.1007/BF02221686
更新日期：1992-11-01 00:00:00
abstract：AIMS/HYPOTHESIS:Type I (insulin-dependent) diabetes mellitus is associated with an increased extracellular volume. Sodium restriction might seem a logical form of treatment but data on its renal effects is conflicting. We therefore studied the effects of sodium restriction on renal haemodynamics in uncomplicated Type I...
journal_title：Diabetologia
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/s00125-001-0763-8
更新日期：2002-04-01 00:00:00
abstract：AIMS/HYPOTHESIS:To provide a nonenzymatic sensor for glucose monitoring in subcutaneous tissue. METHODS:A continuously working affinity sensor based on the glucose-dependent viscosity of a sensitive liquid containing dextran and concanavalin A has been designed by arranging a microdialysis probe, two flow-resisting ca...
journal_title：Diabetologia
pub_type： 临床试验,杂志文章
doi：10.1007/s001250051637
更新日期：2001-04-01 00:00:00
abstract：:Light and electron microscopic studies of diploid, tetraploid and octaploid B-cells in the islets of normal C57BL/KsJ mice revealed that polyploid cells were characterized by a wider range of granulated states than diploid B-cells. The maximum granule densities were similar for polyploid and diploid cells; however, so...
journal_title：Diabetologia
pub_type： 杂志文章
doi：10.1007/BF00428985
更新日期：1976-05-01 00:00:00
abstract：AIMS/HYPOTHESIS:High levels of inflammation locally in the graft during the initial days after transplantation can cause primary non-function (PNF) of grafted xenogeneic islets in NOD mice. The aim of this study was to explore in a model of spontaneous diabetes, the NOD mouse, the potential of anti-inflammatory agents ...
journal_title：Diabetologia
pub_type： 杂志文章
doi：10.1007/s00125-003-1154-0
更新日期：2003-08-01 00:00:00
abstract：:The 497 members of the London Cohort of the WHO Multinational Study of Vascular Disease in Diabetics have been followed for mortality from 1975 to 1987. During this period 92 patients died. The most common cause of death was myocardial infarction: 36 (39.1%) deaths, heart disease was responsible for 51.1% of deaths an...
journal_title：Diabetologia
pub_type： 杂志文章
doi：10.1007/BF00404141
更新日期：1990-09-01 00:00:00
