Abstract:
:We compared urinary albumin excretion during and after pregnancy in 30 insulin-dependent diabetic (IDDM) women with normoalbuminuria and in 12 IDDM women with microalbuminuria (> 15 micrograms.min-1) prior to conception. There was a 6.7-fold increase in the urinary albumin excretion up until the third trimester in the women with pre-existing microalbuminuria, compared with a 3.8-fold increase in the normoalbuminuric women. In both groups of patients the urinary albumin excretion reached a peak during the third trimester with 492 +/- 404 micrograms.min-1 in the microalbuminuric women vs 43 +/- 36 micrograms.min-1 in the normoalbuminuric women (p < 0.0005). Two women from each of the groups developed eclampsia with diastolic blood pressure over 90 mm Hg, mild or moderate oedema and macroproteinuria. Four of the pregnant women with pre-existing microalbuminuria showed a transient nephrotic syndrome (33.3%) with protein excretion over 3 g in 24-h urine samples during the third trimester. In contrast, this was not observed in any of the normoalbuminuric women (p < 0.05). Within 12 weeks after delivery the urinary albumin excretion rates dropped to the pre-conception values in both patient groups. Renal function remained normal during pregnancy in both of the groups, with a physiological increase in creatinine clearance up until the third trimester (26% increase in the normoalbuminuric women vs 22% in the microalbuminuric women). In conclusion, the effect of pregnancy on the urinary albumin excretion in diabetic women with pre-existing microalbuminuria is an exaggeration of the increase of albuminuria in diabetic women with normoalbuminuria; normalization occurs within 12 weeks after delivery in all cases.(ABSTRACT TRUNCATED AT 250 WORDS)
journal_name
Diabetologiajournal_title
Diabetologiaauthors
Biesenbach G,Zazgornik J,Stöger H,Grafinger P,Hubmann R,Kaiser W,Janko O,Stuby Udoi
10.1007/BF00400946subject
Has Abstractpub_date
1994-09-01 00:00:00pages
905-10issue
9eissn
0012-186Xissn
1432-0428journal_volume
37pub_type
临床试验,杂志文章相关文献
DIABETOLOGIA文献大全abstract:AIMS/HYPOTHESIS:Obesity is a major risk factor for type 2 diabetes, but little is known about the contribution of BMI-associated loci to type 2 diabetes risk in East Asian populations. METHODS:In this study, 30 known BMI-associated variants and a genetic risk score (GRS) calculated by summing the BMI-increasing allele...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-014-3308-7
更新日期:2014-09-01 00:00:00
abstract:AIMS/HYPOTHESIS:Mutations in the GCK and HNF1A genes are the most common cause of the monogenic forms of diabetes known as 'maturity-onset diabetes of the young'. GCK encodes the glucokinase enzyme, which acts as the pancreatic glucose sensor, and mutations result in stable, mild fasting hyperglycaemia. A progressive i...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-008-0942-y
更新日期:2008-04-01 00:00:00
abstract:AIMS/HYPOTHESIS:As one of the key adipokines, retinol binding protein 4 (RBP4) is suggested to positively correlate with insulin resistance; however, not all clinical studies support this association. Although some explanations are proposed for this discrepancy, the temporal aspect of RBP4 secretion has not been consid...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-015-3807-1
更新日期:2016-02-01 00:00:00
abstract:AIMS/HYPOTHESIS:The UK Prospective Diabetes Study (UKPDS) risk engine has become a standard for cardiovascular risk assessment in type 2 diabetes mellitus. Skin autofluorescence was recently introduced as an alternative tool for cardiovascular risk assessment in diabetes. We investigated the prognostic value of skin au...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-009-1308-9
更新日期:2009-05-01 00:00:00
abstract:AIM/HYPOTHESIS:The distinct metabolic properties of visceral and subcutaneous adipocytes may be due to inherent characteristics of the cells that are resident in each fat depot. To test this hypothesis, human adipocytes were differentiated in vitro from precursor stromal cells obtained from visceral and subcutaneous fa...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-007-0841-7
更新日期:2008-01-01 00:00:00
abstract::A method has been developed for the purification of single A, B and D cells and for the isolation of coupled islet cells. Isolated rat islets were dissociated by repeated pipetting in the presence of trypsin and ethylene glycol bis (beta-aminoethyl ether) N,N' tetra-acetic acid (EGTA), and then filtered through nylon ...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF00257436
更新日期:1981-06-01 00:00:00
abstract::Hyperglycaemia has been shown to play a central part in diabetic vascular disease, which is also influenced by individual background. Hyperglycaemia initiates the pathogenetic sequence through a series of interrelated biochemical abnormalities, including increased flux through the polyol and hexosamine pathways, oxida...
journal_title:Diabetologia
pub_type:
doi:10.1007/s001250051676
更新日期:2001-06-01 00:00:00
abstract:AIMS/HYPOTHESIS:The study aimed to investigate whether baseline physical activity protects against the occurrence of type 2 diabetes during a 28 year follow-up, after controlling for childhood environment and genetic predisposition. METHODS:At baseline in 1975 same-sex twin pairs born in Finland before 1958 were sent ...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-010-1875-9
更新日期:2010-12-01 00:00:00
abstract::The polymerization and precipitation of highly purified insulins which causes major problems in portable infusion systems does not occur with sulphated insulin. To compare the biological behaviour of sulphated insulin with that of a neutral highly purified monocomponent insulin, insulin receptor studies were performed...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF00273803
更新日期:1984-08-01 00:00:00
abstract::Type I diabetes mellitus may represent a heterogeneous disorder with a distinct pathogenesis in patients with young and adult onset of the disease. To investigate whether serological markers directed to different autoantigens have the potential to distinguish acute onset from slowly progressive Type I diabetes we anal...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s001250051004
更新日期:1998-08-01 00:00:00
abstract:AIMS/HYPOTHESIS:Accurate prevalence estimates for gestational diabetes mellitus (GDM) among pregnant women in Europe are lacking owing to the use of a multitude of diagnostic criteria and screening strategies in both high-risk women and the general pregnant population. Our aims were to report important risk factors for...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-017-4353-9
更新日期:2017-10-01 00:00:00
abstract::QT intervals were measured over RR intervals ranging from 500 ms to 1000 ms in 13 normal male subjects, 13 male diabetic subjects without and 13 with autonomic neuropathy. There was a close linear relationship between QT and RR in all subjects. The slope of the regression line was significantly greater in the autonomi...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF00418273
更新日期:1991-03-01 00:00:00
abstract::Patients with Type II (non-insulin-dependent) diabetes mellitus manifest abnormalities in insulin action and insulin secretion. It is widely accepted that insulin resistance is an early finding, evident before the onset of hyperglycaemia and predictive of the subsequent development of diabetes. Whether abnormalities i...
journal_title:Diabetologia
pub_type: 杂志文章,评审
doi:10.1007/s001250100580
更新日期:2001-08-01 00:00:00
abstract:AIMS/HYPOTHESIS:Diabetes mellitus erectile dysfunction (DMED) is a common complication of diabetes. The level of pigment epithelium-derived factor (PEDF) is significantly upregulated in the serum of individuals with obesity and diabetes. However, whether elevated PEDF levels contribute to DMED remains unknown. This stu...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-020-05147-y
更新日期:2020-09-01 00:00:00
abstract:AIMS/HYPOTHESIS:Mitochondrial oxidative phosphorylation (OXPHOS) plays an important role in the pathophysiology of type 2 diabetes. Genes involved in OXPHOS have been reported to be down-regulated in skeletal muscle from patients with type 2 diabetes; however, hepatic regulation is unknown. MATERIALS AND METHODS:We an...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-006-0489-8
更新日期:2007-02-01 00:00:00
abstract::In order to study the contribution of oxidant stress to the pathogenesis of experimental diabetic retinopathy, male streptozotocin diabetic Lewis rats were treated with the antioxidant and lipid-lowering compound nicanartine (80 mg/kg; n = 8, blood glucose level 16.7 +/- 3.9 mmol/l; HbA1 11.8 +/- 1.6%) by oral supplem...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s001250050726
更新日期:1997-06-01 00:00:00
abstract::We have studied the epidemiologic characteristics of insulin-dependent (Type 1) diabetic patients aged 0-19 in a city (San Diego, southern California, USA) characterized by an impressive racial diversity and especially mild and constant climatic conditions. Ascertainment was through retrospective review of medical rec...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF00265020
更新日期:1985-10-01 00:00:00
abstract:AIMS/HYPOTHESIS:Glomerular matrix accumulation is a hallmark of diabetic nephropathy. Recent data have linked the serine/threonine kinase protein kinase B (Akt) to matrix modulation. Here, we studied its role in high glucose-induced collagen elaboration by mesangial cells. METHODS:Primary rat mesangial cells were trea...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-007-0721-1
更新日期:2007-09-01 00:00:00
abstract::To learn more about the preclinical phase of IDDM we observed for a median period of 46.5 months (range 0.5-69 months) a group of 57 siblings positive for ICA and/or IAA when first screened within 6 months of the diagnosis of the proband. Sequential blood samples and IVGTTs were obtained at intervals of 6-12 months. S...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s001250050122
更新日期:1994-04-01 00:00:00
abstract::To assess in vivo effects of antioxidants on vascular cell adhesion molecule (VCAM)-1 expression, circulating soluble VCAM-1 and intraerythrocytic reduced glutathione (GSH) and GSH disulphide (GSSG) concentrations were evaluated in non-insulin-dependent diabetic patients without complications (9 men, 6 women, 48 +/- 6...
journal_title:Diabetologia
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/s001250051082
更新日期:1998-11-01 00:00:00
abstract::Hypothalamic and autonomic nervous regulation of carbohydrate and amino acid metabolism in the liver and of lipid metabolism in adipose tissues is described. The direct neural mechanism underlying this regulation has been evaluated. Electrical stimulation of the ventromedial hypothalamic nucleus (VMH)-splanchnic nerve...
journal_title:Diabetologia
pub_type: 杂志文章,评审
doi:
更新日期:1981-03-01 00:00:00
abstract::Alloxan-induced diabetes in rats significantly impaired the capacity of the erythrocytes to metabolise glucose in vitro to either lactic acid or CO2. Both these metabolic activities were initially insensitive to insulin in normal as well as in diabetic animals; but became responsive when these cells were subjected to ...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF00279133
更新日期:1988-01-01 00:00:00
abstract:AIMS/HYPOTHESIS:An isoform of glutamic acid decarboxylase, (GAD)65 has been identified as a pancreatic beta-cell autoantigen in Type I (insulin dependent) diabetes mellitus. We investigated the expression of GAD isoforms among single rat beta cells in culture, under different conditions and the correlation between GAD6...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s001250051275
更新日期:1999-09-01 00:00:00
abstract:AIMS/HYPOTHESIS:Mutations in the HNF-1 alpha gene result in maturity-onset diabetes of the young (MODY); an early-onset, dominantly inherited form of diabetes caused by pancreatic beta-cell dysfunction. Splice site mutations represent approximately 10% of reported HNF-1 alpha mutations. No studies to date have investig...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-002-0919-1
更新日期:2002-10-01 00:00:00
abstract::We have developed a mouse monoclonal antibody against rat/mouse islet amyloid polypeptide (IAPP). The antibody recognises an epitope in the N-terminal part of the molecule, which is conserved between different species. The antibody immunohistochemically labelled beta cells in normal islets of most different mammalian ...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s001250050751
更新日期:1997-07-01 00:00:00
abstract:AIMS/HYPOTHESIS:We have examined the effects of streptozotocin-induced type 1 diabetes on the expression and subcellular distribution of the classic sugar transporters (GLUT-1 to 5 and sodium-dependent glucose transporter-1 [SGLT-1]) in the endothelial cells of an en face preparation of septal coronary artery from Wist...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-004-1583-4
更新日期:2004-12-01 00:00:00
abstract::Cystic fibrosis-related diabetes (CFRD) is the most significant extra-pulmonary comorbidity in cystic fibrosis (CF) patients, and accelerates lung decline. In addition to the traditional view that CFRD is a consequence of fibrotic destruction of the pancreas as a whole, emerging evidence may implicate a role for cysti...
journal_title:Diabetologia
pub_type: 杂志文章,评审
doi:10.1007/s00125-016-3936-1
更新日期:2016-07-01 00:00:00
abstract:AIMS/HYPOTHESIS:Non-invasive imaging of the pancreatic beta cell mass (BCM) requires the identification of novel and specific beta cell biomarkers. We have developed a systems biology approach to the identification of promising beta cell markers. METHODS:We followed a functional genomics strategy based on massive para...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-010-1714-z
更新日期:2010-07-01 00:00:00
abstract:AIMS/HYPOTHESIS:Metabolomics has opened new avenues for studying metabolic alterations in type 2 diabetes. While many urine and blood metabolites have been associated individually with diabetes, a complete systems view analysis of metabolic dysregulations across multiple biofluids and over varying timescales of glycaem...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-015-3636-2
更新日期:2015-08-01 00:00:00
abstract:AIMS/HYPOTHESIS:Glutamic acid decarboxylase autoantibodies (GADA) are the most frequent beta-cell-specific autoantibodies in type 1 diabetes and in latent autoimmune diabetes in adults (LADA). The autoimmune attack on pancreatic islet cells is associated with a T helper 1 cell (T(h)1) response, mainly represented by Ig...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-004-1558-5
更新日期:2004-11-01 00:00:00