Antioxidant treatment of experimental diabetic retinopathy in rats with nicanartine.

abstract：AIMS/HYPOTHESIS:Changes in kidney function in diabetes could be due to changes in the kidney basement membranes. Proteoglycans are important constituents of this kidney extracellular matrix. This study explored the possibility that advanced glycation end products affect proteoglycan synthesis in cultured kidney epithel...

journal_title：Diabetologia

authors： Borrebaek J,Prydz K,Fjeldstad K,Vuong TT,Berg TJ,Holkov C,Kolset SO

更新日期：2001-04-01 00:00:00

abstract：AIMS/HYPOTHESIS:We sought to elucidate whether excess glucocorticoids and increased dietary lipids act synergistically to impair glucose tolerance and, if so, whether activation of peroxisome proliferator-activated receptor alpha (PPARalpha) has an adverse or beneficial effect on glucose tolerance. METHODS:Dexamethaso...

journal_title：Diabetologia

authors： Holness MJ,Smith ND,Greenwood GK,Sugden MC

更新日期：2005-10-01 00:00:00

abstract：:The recent recognition that humans possess active depots of brown adipose tissue has boosted the interest in this tissue as a potential target for the prevention and treatment of obesity and related metabolic disorders. Furthermore, it was also revealed that brown adipose tissue (BAT) in humans may consist of so-calle...

journal_title：Diabetologia

authors： Schrauwen P,van Marken Lichtenbelt WD,Spiegelman BM

更新日期：2015-08-01 00:00:00

abstract：AIMS/HYPOTHESIS:The role of infections in the aetiology of Type I diabetes is controversial. Certain enteroviral infections might be involved in triggering the beta-cell destruction but insufficient exposure to early infections might increase the risk. We studied how the number of infections experienced during several ...

journal_title：Diabetologia

authors： Pundziute-Lyckå A,Urbonaite B,Dahlquist G

更新日期：2000-10-01 00:00:00

abstract：AIMS/HYPOTHESIS:Roux-en-Y gastric bypass (RYGB) surgery is characterised by glycaemic variability. Prospective studies of glucose metabolism in pregnancy after RYGB are not available, therefore this study aimed to evaluate physiological alterations in glucose metabolism in pregnancy following RYGB. METHODS:Sixty-three...

journal_title：Diabetologia

authors： Göbl CS,Bozkurt L,Tura A,Leutner M,Andrei L,Fahr L,Husslein P,Eppel W,Kautzky-Willer A

更新日期：2017-12-01 00:00:00

abstract：:The insulin-like growth factor I receptor and the activity of its associated tyrosine kinase activity were characterised in wheat germ agglutinin extracts from skeletal muscle biopsies from nine control and ten obese Type 2 (non-insulin-dependent) diabetic subjects, who had marked peripheral in vivo insulin resistance...

journal_title：Diabetologia

authors： Livingston N,Pollare T,Lithell H,Arner P

更新日期：1988-12-01 00:00:00

abstract：:Non-obese diabetic mice were treated daily with a mixture of gangliosides from day 30 until day 250 of life or until the mice became diabetic. Ganglioside treatment reduced diabetes incidence from 80-90% to 47% and from 20-30% to zero in female and male mice respectively. Gangliosides did not affect the frequency of p...

journal_title：Diabetologia

authors： Wilberz S,Herberg L,Renold AE

更新日期：1988-11-01 00:00:00

abstract：AIMS/HYPOTHESIS:The aim of this study was to examine the effects of childhood BMI growth dynamics on the risk of developing young adult-onset type 1 and type 2 diabetes. METHODS:Finnish national healthcare registers were used to identify individuals with diabetes diagnosed between 1992 and 1996 at 15-39 years of age. ...

journal_title：Diabetologia

authors： Lammi N,Moltchanova E,Blomstedt PA,Tuomilehto J,Eriksson JG,Karvonen M

更新日期：2009-03-01 00:00:00

abstract：AIMS/HYPOTHESIS:The aim of this study was to test the hypothesis that intensive glycaemic control (INT) and higher plasma C-peptide levels in patients with poorly controlled diabetes would be associated with better eye outcomes. METHODS:The incidence and progression of diabetic retinopathy (DR) was assessed by grading...

journal_title：Diabetologia

authors： Azad N,Agrawal L,Emanuele NV,Klein R,Bahn GD,Reaven P,VADT Study Group.

更新日期：2014-06-01 00:00:00

abstract：AIMS/HYPOTHESIS:Endothelial glycocalyx perturbation contributes to increased vascular permeability. In the present study we set out to evaluate whether: (1) glycocalyx is perturbed in individuals with type 2 diabetes mellitus, and (2) oral glycocalyx precursor treatment improves glycocalyx properties. METHODS:Male par...

journal_title：Diabetologia

authors： Broekhuizen LN,Lemkes BA,Mooij HL,Meuwese MC,Verberne H,Holleman F,Schlingemann RO,Nieuwdorp M,Stroes ES,Vink H

更新日期：2010-12-01 00:00:00

abstract：AIMS/HYPOTHESIS:We analysed the cost-effectiveness of intensified prevention in diabetic patients with different risks for foot ulcers and lower extremity amputations. Specifically, we examined whether the additional prevention costs associated with present recommendations would be offset by reduced costs of future foo...

journal_title：Diabetologia

authors： Ragnarson Tennvall G,Apelqvist J

更新日期：2001-11-01 00:00:00

abstract：AIMS/HYPOTHESIS:The gene encoding the beta(3)-subunit (GPIIIa) of the platelet alpha(2)beta(3)-integrin (fibrinogen receptor) shows a polymorphism PlA1/A2 with the A2 allele putatively associated with an increased risk of acute ischaemic events. This study investigated whether Type 2 diabetes as a particular macrovascu...

journal_title：Diabetologia

authors： Tschoepe D,Menart B,Ferber P,Altmann C,Haude M,Haastert B,Roesen P

更新日期：2003-07-01 00:00:00

abstract：:Platelet aggregation in response to collagen, adenosine diphosphate and arachidonic acid was studied prospectively in 30 children with Type 1 (insulin-dependent) diabetes mellitus. The studies began on admission to hospital and continued throughout the two years following diagnosis. The results were compared with thos...

journal_title：Diabetologia

authors： Kobbah AM,Ewald U,Tuvemo T

更新日期：1989-10-01 00:00:00

abstract：:This paper presents a survey of the biological potencies of a variety of naturally-occurring and semi-synthetic insulin analogues and a study of the joint biological action of some of these materials with native insulin. Biological activity was tested on isolated rat fat cells using lipogenesis from glucose as the met...

journal_title：Diabetologia

authors： Ellis MJ,Darby SC,Jones RH,Sönksen PH

更新日期：1978-11-01 00:00:00

abstract：AIMS/HYPOTHESIS:Fenofibrate is a drug used to treat hyperlipidaemia that works by inhibiting hepatic triacylglycerol synthesis. Sterol regulatory element binding protein-1c (SREBP-1c) is a major regulator of the expression of genes involved in hepatic triacylglycerol synthesis. In addition, endoplasmic reticulum (ER)-b...

journal_title：Diabetologia

authors： Min AK,Jeong JY,Go Y,Choi YK,Kim YD,Lee IK,Park KG

更新日期：2013-02-01 00:00:00

abstract：AIMS/HYPOTHESIS:Glucagon-like peptide-2 (GLP-2) is a gut hormone regulating intestinal growth and nutrient absorption. Recently, GLP-2 has been reported to stimulate glucagon secretion in healthy humans. We sought to clarify the mechanism and physiological significance of this endocrine effect. MATERIALS AND METHODS:T...

journal_title：Diabetologia

authors： de Heer J,Pedersen J,Orskov C,Holst JJ

更新日期：2007-10-01 00:00:00

abstract：:Previous studies have suggested that nerve regeneration may be defective in patients with diabetic polyneuropathy. Since insulin-like growth factor I (IGF-I) has been shown to stimulate nerve regeneration, and IGF binding protein-1 is acutely regulated by plasma insulin we have investigated the relationships between p...

journal_title：Diabetologia

authors： Crosby SR,Tsigos C,Anderton CD,Gordon C,Young RJ,White A

更新日期：1992-09-01 00:00:00

abstract：AIMS/HYPOTHESIS:To study if people with Type I (insulin-dependent) or Type II (non-insulin-dependent) diabetes mellitus have increased risk of hip fracture. METHODS:The study population consisted of 35,444 people 50 years of age and older, attending a health screening in a Norwegian county. They were followed up with ...

journal_title：Diabetologia

authors： Forsén L,Meyer HE,Midthjell K,Edna TH

更新日期：1999-08-01 00:00:00

abstract：AIMS/HYPOTHESIS:We analysed the factors that determine the outcomes of surgical treatment of osteomyelitis of the foot in diabetic patients given early surgical treatment within 12 h of admission and treated with prioritisation of foot-sparing surgery and avoidance of amputation. METHODS:A consecutive series of 185 di...

journal_title：Diabetologia

authors： Aragón-Sánchez FJ,Cabrera-Galván JJ,Quintana-Marrero Y,Hernández-Herrero MJ,Lázaro-Martínez JL,García-Morales E,Beneit-Montesinos JV,Armstrong DG

更新日期：2008-11-01 00:00:00

abstract：AIMS/HYPOTHESIS:B-type natriuretic peptide (BNP) is a hormone released from cardiomyocytes in response to cell stretching and elevated in heart failure. Recent observations indicate a distinct connection between chronic heart failure and diabetes mellitus. This study investigated the role of BNP on glucose metabolism. ...

journal_title：Diabetologia

authors： Heinisch BB,Vila G,Resl M,Riedl M,Dieplinger B,Mueller T,Luger A,Pacini G,Clodi M

更新日期：2012-05-01 00:00:00

abstract：AIMS/HYPOTHESIS:In the double-blind placebo-controlled Fenofibrate Intervention and Event Lowering in Diabetes trial (n = 9,795), fenofibrate reduced major cardiovascular events in type 2 diabetes. Sex-related differences in fenofibrate response could be clinically relevant and were pre-specified analyses. METHODS:Wom...

journal_title：Diabetologia

authors： d'Emden MC,Jenkins AJ,Li L,Zannino D,Mann KP,Best JD,Stuckey BG,Park K,Saltevo J,Keech AC,FIELD Study Investigators.

更新日期：2014-11-01 00:00:00

abstract：AIMS/HYPOTHESIS:The aim of this study was to estimate absolute and relative mortality rates in patients with type 1 diabetes at the Steno Diabetes Centre relative to the general Danish background population. METHODS:Patients with type 1 diabetes (n = 4,821) were followed from 1 January 2002 until 1 January 2011, with ...

journal_title：Diabetologia

authors： Jørgensen ME,Almdal TP,Carstensen B

更新日期：2013-11-01 00:00:00

abstract：AIMS/HYPOTHESIS:This study aimed to evaluate associations of height as well as components of height (sitting height and leg length) with risk of type 2 diabetes and to explore to what extent associations are explainable by liver fat and cardiometabolic risk markers. METHODS:A case-cohort study within the European Pros...

journal_title：Diabetologia

authors： Wittenbecher C,Kuxhaus O,Boeing H,Stefan N,Schulze MB

更新日期：2019-12-01 00:00:00

abstract：:Insulin resistance of the skeletal muscle plays a key role in the development of the metabolic endocrine syndrome and its further progression to non-insulin dependent diabetes (NIDDM). Available data suggest that insulin resistance is caused by an impaired signal from the insulin receptor to the glucose transport syst...

journal_title：Diabetologia

authors： Häring HU,Kellerer M,Mosthaf L

更新日期：1994-09-01 00:00:00

abstract：:The insulin storage granule of the pancreatic beta cell is assembled within the trans Golgi network from around 50 or so gene products many of which are synthesized coordinately with the major component, proinsulin. An important contribution to our understanding of the regulation of this process has come from studies ...

journal_title：Diabetologia

authors： Hutton JC

更新日期：1994-09-01 00:00:00

abstract：:Using 3H-thymidine labeling techniques, we found that rates of DNA synthesis in islet cells doubled when mouse pancreatic islets were cultured for 1 week with 10 mmol/l nicotinamide, a potent poly(ADP-ribose) synthetase inhibitor. Culture with nicotinamide partially inhibited glucose-stimulated insulin release, wherea...

journal_title：Diabetologia

authors： Sandler S,Andersson A

更新日期：1986-03-01 00:00:00

abstract：:The influence of sex on pancreatic islet B cell susceptibility to streptozotocin was studied in mice given multiple low doses of streptozotocin. Male C3 D2 F1 mice developed a steadily increasing blood glucose level after a lag period of about 3 weeks, in contrast to females who were resistant. Spleen cells from strep...

journal_title：Diabetologia

authors： Kromann H,Christy M,Lernmark A,Nedergaard M,Nerup J

更新日期：1982-03-01 00:00:00

abstract：:To test the hypothesis that interaction between genetic, immunological, clinical and metabolic risk factors influences the outcome of Type II (non-insulin-dependent) diabetes mellitus, we examined which of the above factors present at baseline were associated with mortality in 134 Type II diabetic patients followed fo...

journal_title：Diabetologia

authors： Forsblom CM,Sane T,Groop PH,Tötterman KJ,Kallio M,Saloranta C,Laasonen L,Summanen P,Lepäntalo M,Laatikainen L,Matikainen E,Teppo AM,Koskimies S,Groop L

更新日期：1998-11-01 00:00:00

abstract：AIMS/HYPOTHESIS:Maternal Type I (insulin-dependent) diabetes mellitus is associated with an increased risk for fetal malformations and spontaneous abortions. Although the pathogenic mechanism is not fully understood, reactive oxygen species have been shown to contribute to the pathogenesis in experimental studies. By m...

journal_title：Diabetologia

authors： Cederberg J,Basu S,Eriksson UJ

更新日期：2001-06-01 00:00:00

abstract：AIMS/HYPOTHESIS:The aim of this study was to investigate molecular mechanisms of glucose-induced changes in islets of Langerhans by analysing global changes in protein patterns of islets exposed to elevated glucose concentrations. METHODS:Islets were isolated from C57BL/6J mice and used either directly or after exposu...

journal_title：Diabetologia

authors： Ahmed M,Bergsten P

更新日期：2005-03-01 00:00:00