Abstract:
AIMS/HYPOTHESIS:We evaluated and compared the effects on glycaemic control of two different exercise protocols in elderly men with type 2 diabetes mellitus. METHODS:Eighteen patients with type 2 diabetes mellitus carried out home-based bicycle training for 5 weeks. Patients were randomly assigned to one of two training programmes at 60% of maximal oxygen uptake: three 10 min sessions per day (3 x 10) or one 30 min session per day (1 x 30). Plasma insulin, C-peptide and glucose concentrations were measured during a 3 h oral glucose tolerance test (OGTT). Insulin sensitivity index (ISI(composite)), pre-hepatic insulin secretion rates (ISR) and change in insulin secretion per unit change in glucose concentrations (B(total)) were calculated. RESULTS:Cardiorespiratory fitness increased in response to training in both groups. In group 3 x 10 (n = 9) fasting plasma glucose (p = 0.01), 120 min glucose OGTT (p = 0.04) and plasma glucose concentration areas under the curve at 120 min (p < 0.04) and 180 min (p = 0.07) decreased. These parameters remained unchanged in group 1 x 30 (n = 9). No significant changes were found in ISI(composite), ISR and B(total) in either of the exercise groups. In a matched time-control group (n = 10), glycaemic control did not change. CONCLUSIONS/INTERPRETATION:Moderate to high-intensity training performed at 3 x 10 min/day is preferable to 1 x 30 min/day with regard to effects on glycaemic control. This is in spite of the fact that cardiorespiratory fitness increased similarly in both exercise groups. A possible explanation is that the energy expenditure associated with multiple short daily sessions may be greater than that in a single daily session.
journal_name
Diabetologiajournal_title
Diabetologiaauthors
Eriksen L,Dahl-Petersen I,Haugaard SB,Dela Fdoi
10.1007/s00125-007-0783-0subject
Has Abstractpub_date
2007-11-01 00:00:00pages
2245-53issue
11eissn
0012-186Xissn
1432-0428journal_volume
50pub_type
杂志文章,随机对照试验相关文献
DIABETOLOGIA文献大全abstract:AIMS/HYPOTHESIS:Diabetes mellitus erectile dysfunction (DMED) is a common complication of diabetes. The level of pigment epithelium-derived factor (PEDF) is significantly upregulated in the serum of individuals with obesity and diabetes. However, whether elevated PEDF levels contribute to DMED remains unknown. This stu...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-020-05147-y
更新日期:2020-09-01 00:00:00
abstract::The development of proteinuria and its response to insulin therapy in acute experimental diabetes was examined in 11 female rats by sequentially measuring 24 h excretion of glucose and total protein before diabetes, during 5-37 days of acute streptozotocin diabetes, during and after 7-14 days of continuous subcutaneou...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF03216225
更新日期:1981-07-01 00:00:00
abstract:AIMS/HYPOTHESIS:We examined the acute postprandial effects of meals containing unsaturated fatty acids on flow-mediated dilation (FMD) of the brachial artery and triacylglycerols in individuals with type 2 diabetes. We hypothesised that consumption of omega-3 fatty acids would enhance vascular function. Saturated fat r...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-004-1600-7
更新日期:2005-01-01 00:00:00
abstract:AIMS/HYPOTHESIS:Endothelial glycocalyx perturbation contributes to increased vascular permeability. In the present study we set out to evaluate whether: (1) glycocalyx is perturbed in individuals with type 2 diabetes mellitus, and (2) oral glycocalyx precursor treatment improves glycocalyx properties. METHODS:Male par...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-010-1910-x
更新日期:2010-12-01 00:00:00
abstract::We studied the effect of chronic exposure to high glucose on the glucose transport regulation in hamster pancreatic Beta cells in permanent culture (HIT). Cells were exposed to either 5.5 mmol/l or 16.7 mmol/l glucose for 48 h and then glucose transport was studied by measuring the (3H)-2-deoxyglucose uptake for 5 and...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF00405011
更新日期:1991-05-01 00:00:00
abstract:AIMS/HYPOTHESIS:High sodium (HS) effects on hypertension are well established. Recent evidence implicates a relationship between HS intake and insulin resistance, even in the absence of hypertension. The aim of the current study was to determine whether loss of the vascular actions of insulin may be the driving factor ...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-014-3373-y
更新日期:2014-12-01 00:00:00
abstract:AIMS/HYPOTHESIS:Activation of the G protein-coupled receptor (GPR)40 by long-chain fatty acids potentiates glucose-stimulated insulin secretion (GSIS) from pancreatic beta cells, and GPR40 agonists are in clinical development for type 2 diabetes therapy. GPR40 couples to the G protein subunit Gα(q/11) but the signallin...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-012-2650-x
更新日期:2012-10-01 00:00:00
abstract:AIMS/HYPOTHESIS:Semaglutide is a glucagon-like peptide-1 analogue in development for the treatment of type 2 diabetes. Its effects on first- and second-phase insulin secretion and other measures of beta cell function and glycaemic control were assessed. METHODS:In this single-centre, double-blind, placebo-controlled, ...
journal_title:Diabetologia
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00125-017-4289-0
更新日期:2017-08-01 00:00:00
abstract::A previous study of low density lipoprotein metabolism by cultured cells focused on the metabolism of normal lipoproteins in vitro by fibroblasts isolated from diabetic patients. No abnormalities were found. We have followed the opposite approach. Using normal human fibroblasts as test cells we compared the metabolism...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF00282585
更新日期:1982-06-01 00:00:00
abstract:AIMS/HYPOTHESIS:We assessed secular trends of cardiovascular outcomes following first diagnosis of myocardial infarction (MI) or diabetes in an unselected population. METHODS:All Danish residents aged > or = 30 years without prior diabetes or MI were identified by individual-level linkage of nationwide registers. Indi...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-010-1783-z
更新日期:2010-08-01 00:00:00
abstract:AIMS/HYPOTHESIS:Cerebral oedema complicating diabetic ketoacidosis (DKA) remains the major cause of morbidity and mortality in children with type 1 diabetes, but its aetiology remains unknown. Our objective was to determine the impact of baseline biochemical factors and of treatment-related variables on risk of the dev...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-006-0363-8
更新日期:2006-09-01 00:00:00
abstract::The NOD mouse, which shows many features of human IDDM, is extensively used to evaluate the role of T lymphocytes in the pathogenesis of autoimmune diabetes. The development of diabetes in this model appears to be controlled by a finely tuned immunoregulatory balance between autoaggressive T cells and regulatory immun...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF00408468
更新日期:1994-04-01 00:00:00
abstract:AIMS/HYPOTHESIS:The aim of this work was to examine the progression to type 1 and type 2 diabetes after gestational diabetes mellitus (GDM) in a 23 year follow-up study. METHODS:We carried out a cohort study of 391 women with GDM diagnosed by an OGTT or the use of insulin treatment during pregnancy, and 391 age- and p...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-020-05215-3
更新日期:2020-10-01 00:00:00
abstract:AIMS/HYPOTHESIS:Mitochondrial oxidative phosphorylation (OXPHOS) plays an important role in the pathophysiology of type 2 diabetes. Genes involved in OXPHOS have been reported to be down-regulated in skeletal muscle from patients with type 2 diabetes; however, hepatic regulation is unknown. MATERIALS AND METHODS:We an...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-006-0489-8
更新日期:2007-02-01 00:00:00
abstract:AIMS/HYPOTHESIS:Elevated plasma levels of NEFA impair insulin action. Given the positive linear correlation between NEFA released by adipocytes and plasma NEFA levels, identification of mechanisms controlling adipocyte lipolysis and NEFA release could provide a guide to new therapies for insulin resistance and type 2 d...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-008-1036-6
更新日期:2008-08-01 00:00:00
abstract::People with type 2 diabetes have an increased risk of cardiovascular disease (CVD). Multivariate cardiovascular risk scores have been used in many countries to identify individuals who are at high risk of CVD. These risk scores include those originally developed in individuals with diabetes and those developed in a ge...
journal_title:Diabetologia
pub_type: 杂志文章,评审
doi:10.1007/s00125-009-1454-0
更新日期:2009-10-01 00:00:00
abstract:AIMS/HYPOTHESIS:As vascular endothelial growth factor (VEGF) plays a pivotal role in the development of diabetic retinopathy, inhibition of angiogenesis induced by VEGF is crucial to treat diabetic retinopathy. HGF (hepatocyte growth factor)/NK4, containing the N-terminal hairpin domain and the four subsequent kringle ...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-002-0954-y
更新日期:2003-01-01 00:00:00
abstract::Over a century ago, inquisitive physicians made remarkable discoveries regarding pancreatic pathology in individuals with diabetes, including those who were likely afflicted with the type 1 (autoimmune) form of the disease. Those studies of post-mortem tissues noted unique anatomical changes in islet architecture as w...
journal_title:Diabetologia
pub_type: 评论,杂志文章
doi:10.1007/s00125-013-3159-7
更新日期:2014-04-01 00:00:00
abstract::Circulating somatomedin-C/insulin-like growth factor-I levels are low in the diabetic rat and unresponsive to exogenous growth hormone. However, the nature of this defect in growth hormone action remains unclear and there is little data on insulin-like growth factor-I gene expression in response to other stimuli and i...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF00277488
更新日期:1988-11-01 00:00:00
abstract::The effects of four sulphonylureas (gliclazide, glibenclamide, chlorpropamide and glipizide) on insulin binding and insulin action were studied in vitro using primary cultured rat hepatocytes. Cells were cultured for 20 h in the absence or presence of the sulphonylurea. The binding of insulin to rat hepatocyte monolay...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF00257344
更新日期:1983-06-01 00:00:00
abstract::The prevalence of Type 2 (non-insulin-dependent) diabetes mellitus is high in Mauritius, a multiethnic island nation in the southwestern Indian Ocean. Evaluation of candidate genes in the different ethnic groups represents a means of assessing the genetic component. As glucokinase is known to be a key regulator of glu...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF00400254
更新日期:1992-07-01 00:00:00
abstract:AIMS/HYPOTHESIS:Despite the overlap in occurrence of cardiovascular disease (CVD) and type 2 diabetes and their risk factors, family history of these diseases has not yet been investigated simultaneously in relation to cardiometabolic markers in offspring. We examined how a family history of CVD and/or diabetes relates...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-016-3988-2
更新日期:2016-08-01 00:00:00
abstract::The effect of human growth hormone on arterial basement membrane-like (BM) material was studied. BM-like material was obtained from the cell layer of cultured aortic myomedial cells using a sonication-differential centrifugation technique. After the addition of small amounts of growth hormone (1 ng/ml) to the cultures...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF00703138
更新日期:1985-12-01 00:00:00
abstract::Insulin binding and the effect of insulin on the transport of 3-O-methylglucose, lipogenesis from glucose, glucose oxidation and lipolysis was studied in fat cells of adrenalectomised rats and of a control group of sham-operated rats. The serum insulin level of the adrenalectomised rats (0.7 ng/ml) was lower than that...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF00280524
更新日期:1980-10-01 00:00:00
abstract::The incidence, prevalence, and ages and dates of onset of diabetes, were studied in 184 families with 2 or more affected children. Results suggested that the siblings of children who developed diabetes before the age of 16 years were 26 times more likely to develop diabetes than other children. Of all siblings surveye...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF00280517
更新日期:1980-10-01 00:00:00
abstract:AIMS/HYPOTHESIS:In the light of a report suggesting that insulin glargine may increase cancer occurrence, the EASD asked us to perform this study. METHODS:We followed 114,841 individuals who had a prescription dispensed for insulin between 1 July and 31 December 2005. From 1 January 2006 to 31 December 2007, we noted ...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-009-1444-2
更新日期:2009-09-01 00:00:00
abstract:AIMS/HYPOTHESIS:Glucose-dependent insulinotropic polypeptide (GIP) is a peptide hormone released from gut K cells. While the predominant form is GIP(1-42), a shorter form, GIP(1-30), is produced by pancreatic alpha cells and promotes insulin secretion in a paracrine manner. Here, we elucidated whether GIP(1-30) express...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-015-3842-y
更新日期:2016-03-01 00:00:00
abstract:AIMS/HYPOTHESIS:Several publications suggest an association between certain types of insulin and cancer, but with conflicting results. We investigated whether insulin glargine (A21Gly,B31Arg,B32Arg human insulin) is associated with an increased risk of cancer in a large population-based cohort study. METHODS:Data for ...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-011-2312-4
更新日期:2012-01-01 00:00:00
abstract:AIMS/HYPOTHESIS:MicroRNAs are key regulators of gene expression involved in health and disease. The goal of our study was to investigate the global changes in beta cell microRNA expression occurring in two models of obesity-associated type 2 diabetes and to assess their potential contribution to the development of the ...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-013-2993-y
更新日期:2013-10-01 00:00:00
abstract:AIMS/HYPOTHESIS:Our aim was to compare the therapeutic effect of thalidomide and rosiglitazone on the prevention of diabetic retinopathy in streptozotocin-induced diabetic rats. METHODS:Male Holtzman rats of 6 to 8 weeks of age and weighing 170+/-30 g were randomly divided into four groups: control ( n=13), untreated ...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-003-1234-1
更新日期:2003-12-01 00:00:00