Glycosylated haemoglobin and plasma glycoprotein assays by affinity chromatography.

abstract：AIMS/HYPOTHESIS:The aim of this study was to test the hypothesis that intensive glycaemic control (INT) and higher plasma C-peptide levels in patients with poorly controlled diabetes would be associated with better eye outcomes. METHODS:The incidence and progression of diabetic retinopathy (DR) was assessed by grading...

journal_title：Diabetologia

authors： Azad N,Agrawal L,Emanuele NV,Klein R,Bahn GD,Reaven P,VADT Study Group.

更新日期：2014-06-01 00:00:00

abstract：AIM/HYPOTHESIS:The renin-angiotensin-aldosterone system is important in diabetic nephropathy, with the angiotensin-converting-enzyme DD-genotype being a renal risk factor. The D-allele is associated with higher ACE concentrations, but functional consequences in diabetes mellitus are not known. To analyse these conseque...

journal_title：Diabetologia

authors： Luik PT,Hoogenberg K,Kerstens MN,Beusekamp BJ,De Jong PE,Dullaart RP,Navis GJ

更新日期：2003-08-01 00:00:00

abstract：:For many, the extent to which blood glucose control can be lowered is limited by risk of hypoglycaemia. Hypoglycaemia is feared and carries fiscal, social and medical costs, with risk of death being associated with severe hypoglycaemia in patients with type 2 diabetes at high cardiovascular risk. In this issue of Diab...

journal_title：Diabetologia

authors： Neupane S,Evans ML

更新日期：2015-06-01 00:00:00

abstract：AIMS/HYPOTHESIS:Distal diabetic sensorimotor polyneuropathy (DSP) is a common complication of diabetes with many patients showing a reduction of intraepidermal nerve fibre density (IENFD) from skin biopsy, a validated and sensitive diagnostic tool for the assessment of DSP. Axonal swelling ratio is a morphological quan...

journal_title：Diabetologia

authors： Karlsson P,Gylfadottir SS,Kristensen AG,Ramirez JD,Cruz P,Le N,Shillo PR,Tesfaye S,Rice ASC,Tankisi H,Finnerup NB,Nyengaard JR,Jensen TS,Bennett DLH,Themistocleous AC

更新日期：2021-01-23 00:00:00

abstract：:The effect of early antihypertensive treatment on survival of patients with diabetic nephropathy was evaluated by studying two cohorts of Type 1 (insulin-dependent) diabetic patients developing persistent proteinuria in I: 1957-1973 (late treatment group n = 49) and II: 1979-1983 (early treatment group n = 71). At ons...

journal_title：Diabetologia

authors： Mathiesen ER,Borch-Johnsen K,Jensen DV,Deckert T

更新日期：1989-12-01 00:00:00

abstract：:Serum insulin response to a single bolus of IV glucose or tolbutamide was measured in eight healthy subjects. Insulin disappearance rate was assessed by deconvolution from the serum insulin levels, using the measured insulin disappearance rate. The mean rate constant of insulin disappearance was 0.238 +/- 0.005 min-1 ...

journal_title：Diabetologia

authors： Asano T,Sasaki H,Okumura M

更新日期：1978-09-01 00:00:00

abstract：:The pO2 at which haemoglobin is half-saturated with oxygen (p50) was determined at fixed pCO2 (45 mmHg) and without altering the resulting pH and the level of organic phosphates in heparinized whole blood samples from 26 diabetic patients and 24 normal subjects of both sexes. Diabetic blood p50 was higher (29.79 +/- 1...

journal_title：Diabetologia

authors： Samaja M,Melotti D,Carenini A,Pozza G

更新日期：1982-11-01 00:00:00

abstract：AIMS/HYPOTHESIS:G-protein-coupled receptor kinases (GRKs) play a key role in agonist-induced desensitisation of G-protein-coupled receptors (GPCRs) that are involved in metabolic regulation and glucose homeostasis. Our aim was to examine whether small peptides derived from the catalytic domain of GRK2 and -3 would amel...

journal_title：Diabetologia

authors： Anis Y,Leshem O,Reuveni H,Wexler I,Ben Sasson R,Yahalom B,Laster M,Raz I,Ben Sasson S,Shafrir E,Ziv E

更新日期：2004-07-01 00:00:00

abstract：:We aimed to assess prandial responses, basal glucose turnover and insulin action (euglycaemic clamp) in a very low-dose neonatal streptozotocin model of Type 2 (non-insulin-dependent) diabetes mellitus. Male Wistar rats were injected at 2 days of age with 45 mg/kg streptozotocin or vehicle (control). At 8 weeks, the g...

journal_title：Diabetologia

authors： Pascoe WS,Jenkins AB,Kusunoki M,Storlien LH

更新日期：1992-03-01 00:00:00

abstract：AIMS/HYPOTHESIS:A natural cofactor of mitochondrial dehydrogenase complexes and a potent antioxidant, alpha-lipoic acid improves glucose metabolism in people with Type II (non-insulin-dependent) diabetes mellitus and in animal models of diabetes. In this study we investigated the cellular mechanism of action of alpha-l...

journal_title：Diabetologia

authors： Yaworsky K,Somwar R,Ramlal T,Tritschler HJ,Klip A

更新日期：2000-03-01 00:00:00

abstract：:Immunoelectrophoresis of glomerular basement membrane antigens in the urine of 20 Type 1 (insulin-dependent) diabetic and 10 healthy children was performed. In 10 of the diabetic children, there was altered alpha-1-mobility, while the other diabetic and normal children showed alpha-2-mobility. After incubation with gl...

journal_title：Diabetologia

authors： Schober E,Pollak A,Coradello H,Lubec G

更新日期：1982-12-01 00:00:00

abstract：AIMS/HYPOTHESIS:Results from animal models and some clinical work suggest a role for the central nervous system (CNS) in glucose regulation and type 2 diabetes pathogenesis by modulation of glucoregulatory hormones and the autonomic nervous system (ANS). The aim of this study was to characterise the neuroendocrine resp...

journal_title：Diabetologia

authors： Lundqvist MH,Almby K,Wiklund U,Abrahamsson N,Kamble PG,Pereira MJ,Eriksson JW

更新日期：2020-11-26 00:00:00

abstract：AIMS/OBJECTIVE:Nephropathy, a major complication of diabetes, is the leading cause of end-stage renal disease. Recent studies have demonstrated that podocyte injury is involved in the onset of and progression to renal insufficiency. Here, we describe a novel, highly sensitive ELISA for detecting urinary podocalyxin, a ...

journal_title：Diabetologia

authors： Hara M,Yamagata K,Tomino Y,Saito A,Hirayama Y,Ogasawara S,Kurosawa H,Sekine S,Yan K

更新日期：2012-11-01 00:00:00

abstract：AIMS/HYPOTHESIS:The aim of this study was to assess the predictive role of autonomic reactivity in body weight loss induced by gastric bypass. METHODS:A group of 22 morbidly obese subjects, who were due to undergo a gastric bypass, were submitted, before surgery, to a euglycaemic-hyperinsulinaemic clamp, during which ...

journal_title：Diabetologia

authors： Bobbioni-Harsch E,Sztajzel J,Barthassat V,Lehmann TN,Sievert K,Chassot G,Huber O,Morel P,Golay A,Assimacopoulos-Jeannet F

更新日期：2005-07-01 00:00:00

abstract：AIMS/HYPOTHESIS:We determined the effects of 6 years of lifestyle intervention in persons with impaired glucose tolerance (IGT) on the development of retinopathy, nephropathy and neuropathy over a 20 year period. METHODS:In 1986, 577 adults with IGT from 33 clinics in Da Qing, China were randomly assigned by clinic to...

journal_title：Diabetologia

authors： Gong Q,Gregg EW,Wang J,An Y,Zhang P,Yang W,Li H,Li H,Jiang Y,Shuai Y,Zhang B,Zhang J,Gerzoff RB,Roglic G,Hu Y,Li G,Bennett PH

更新日期：2011-02-01 00:00:00

abstract：:A copy deoxyribonucleic acid (cDNA) clone of the immediate early growth response gene, egr-1 (Krox-24, Zif268, NGFI-1), was isolated through subtractive hybridization screening to identify glucose-induced genes in pancreatic beta cells. Glucose rapidly and transiently induced egr-1 mRNA in the SV40-transformed murine ...

journal_title：Diabetologia

authors： Josefsen K,Sørensen LR,Buschard K,Birkenbach M

更新日期：1999-02-01 00:00:00

abstract：:Abnormal vascular endothelium function may contribute to the reduced nerve perfusion implicated in the aetiology of neuropathy in diabetes mellitus. The aim was to test the hypothesis that a powerful vasoconstrictor, endothelin-1, could be involved in nerve dysfunction in streptozotocin-diabetic rats. After 6 weeks of...

journal_title：Diabetologia

authors： Cameron NE,Dines KC,Cotter MA

更新日期：1994-12-01 00:00:00

abstract：AIMS/HYPOTHESIS:Diabetic retinopathy is the most common complication of diabetes and a leading cause of blindness among working-age adults. Anatomical and functional changes occur in the retina and retinal pigment epithelium (RPE) prior to clinical symptoms of the disease. However, the molecular mechanisms responsible ...

journal_title：Diabetologia

authors： Decanini A,Karunadharma PR,Nordgaard CL,Feng X,Olsen TW,Ferrington DA

更新日期：2008-06-01 00:00:00

abstract：AIMS/HYPOTHESIS:The aim of this study was to evaluate the prognostic significance of autoantibodies to IA-2beta (IA2betaA) in a large, well-characterised population of islet cell antibody (ICA)-positive relatives followed for 5 years in the European Nicotinamide Diabetes Intervention Trial. METHODS:Autoantibodies to i...

journal_title：Diabetologia

authors： Achenbach P,Bonifacio E,Williams AJ,Ziegler AG,Gale EA,Bingley PJ,ENDIT Group.

更新日期：2008-03-01 00:00:00

abstract：:Forearm perfusion studies were carried out to determine the responsiveness to insulin of the superficial forearm tissues in non-obese Type 2 (non-insulin-dependent) diabetics, and the interrelationships among plasma concentrations of glucose, insulin and non-esterified fatty acids (NEFA), tissue uptake of glucose and ...

journal_title：Diabetologia

authors： Kalant N,Leibovici D,Fukushima N,Kuyumjian J,Ozaki S

更新日期：1982-04-01 00:00:00

abstract：:Insulin secretion from pancreatic beta cells is dependent on membrane potential changes that result from the concerted regulation of multiple ion channels. Among the distinct K+ channels known to be expressed in beta cells, large conductance Ca(2+)-activated K+ channels have been suggested to play an important role in...

journal_title：Diabetologia

authors： Ferrer J,Wasson J,Salkoff L,Permutt MA

更新日期：1996-08-01 00:00:00

abstract：:Platelet aggregation in response to collagen, adenosine diphosphate and arachidonic acid was studied prospectively in 30 children with Type 1 (insulin-dependent) diabetes mellitus. The studies began on admission to hospital and continued throughout the two years following diagnosis. The results were compared with thos...

journal_title：Diabetologia

authors： Kobbah AM,Ewald U,Tuvemo T

更新日期：1989-10-01 00:00:00

abstract：AIMS/HYPOTHESIS:Pancreatic beta cells play a central role in the control of glucose homeostasis by secreting insulin to stimulate glucose uptake by peripheral tissues. Understanding the molecular mechanisms that control beta cell function and plasticity has critical implications for the pathophysiology and therapy of m...

journal_title：Diabetologia

authors： Thorens B,Tarussio D,Maestro MA,Rovira M,Heikkilä E,Ferrer J

更新日期：2015-03-01 00:00:00

abstract：:Large-scale, centrally-coordinated screening for undiagnosed type 2 diabetes is an attractive option to reduce the mortality and morbidity resulting from inadequately controlled diabetes. However, there is limited research examining the direct consequences of such screening programmes on outcomes such as cardiovascula...

journal_title：Diabetologia

authors： Shaw JE

更新日期：2017-11-01 00:00:00

abstract：AIMS/HYPOTHESIS:Insulin-like growth factor-1 is a major childhood growth factor and promotes pancreatic islet cell survival and growth in vitro. We hypothesised that genetic variation in IGF1 might be associated with childhood growth, glucose metabolism and type 1 diabetes risk. We therefore examined the association be...

journal_title：Diabetologia

authors： Vella A,Bouatia-Naji N,Heude B,Cooper JD,Lowe CE,Petry C,Ring SM,Dunger DB,Todd JA,Ong KK

更新日期：2008-05-01 00:00:00

abstract：:The effect of hyperglycaemia on islet transplantation in the rat has been examined in two ways, using syngeneic transplantation of 400 islets to the kidney capsule and subsequent measurement of kidney insulin content as a measurement of B-cell survival. Firstly, islets were transplanted into either diabetic or normal ...

journal_title：Diabetologia

authors： Gray DW,Cranston D,McShane P,Sutton R,Morris PJ

更新日期：1989-09-01 00:00:00

abstract：:An incidence of 9.0 out of 100,000 children under 19 years of age with Type 1 (insulin-dependent) diabetes was detected in Toronto during a 2 year prospective study. An increased number of cases occurred in the winter months of one of the years but not of the other during the study. The annual incidence was the same i...

journal_title：Diabetologia

authors： Ehrlich RM,Walsh LJ,Falk JA,Middleton PJ,Simpson NE

更新日期：1982-04-01 00:00:00

abstract：:Non-diabetic first degree relatives of non-insulin-dependent diabetic (NIDDM) families are at increased risk of developing diabetes mellitus, and have been studied to identify early metabolic abnormalities. Hormone concentrations measured by specific enzyme immunoassays were assessed in non-diabetic relatives of North...

journal_title：Diabetologia

authors： Humphriss DB,Stewart MW,Berrish TS,Barriocanal LA,Trajano LR,Ashworth LA,Brown MD,Miller M,Avery PJ,Alberti KG,Walker M

更新日期：1997-10-01 00:00:00

abstract：AIMS/HYPOTHESIS:Neurogenin 3 (NEUROG3), a basic helix-loop-helix transcription factor that is needed for endocrine cell development in the embryonic pancreas, has been shown to induce transdifferentiation of duct cells from adult pancreas towards a neuro-endocrine phenotype. Our study explored the endocrine transdiffer...

journal_title：Diabetologia

authors： Harb G,Heremans Y,Heimberg H,Korbutt GS

更新日期：2006-08-01 00:00:00

abstract：AIMS/HYPOTHESIS:Our recent studies suggest that activation of the wingless-type MMTV integration site (WNT) pathway plays pathogenic roles in diabetic retinopathy and age-related macular degeneration. Here we investigated the causative role of oxidative stress in retinal WNT pathway activation in an experimental model ...

journal_title：Diabetologia

authors： Zhou T,Zhou KK,Lee K,Gao G,Lyons TJ,Kowluru R,Ma JX

更新日期：2011-02-01 00:00:00