Abstract:
:Hypoglycaemic sulphonamides stimulate net uptake of 45Ca++ and insulin release in isolated pancreatic islets. These effects are antagonized by organic calcium-antagonists (e.g. suloctidil). In an artificial system, hypoglycaemic sulphonamides, such as gliclazide, stimulate the translocation of calcium into or across a hydrophobic immiscible domain, a process enhanced by the antibiotic ionophore A 23187 and antagonized by suloctidil. In this artificial system, the A 23187-mediated process of calcium countertransport is stimulated by gliclazide and inhibited by diazoxide. It is postulated that the insulinotropic action of hypoglycaemic and hyperglycaemic sulphonamides is primarily attributable to the ionophoretic action of these drugs.
journal_name
Diabetologiajournal_title
Diabetologiaauthors
Couturier E,Malaisse WJdoi
10.1007/BF00280516subject
Has Abstractpub_date
1980-10-01 00:00:00pages
335-40issue
4eissn
0012-186Xissn
1432-0428journal_volume
19pub_type
杂志文章相关文献
DIABETOLOGIA文献大全abstract:AIMS/HYPOTHESIS:New genetic variants associated with susceptibility to type 2 diabetes mellitus have been discovered in recent genome-wide association (GWA) studies. The aim of the present study was to examine the association between these diabetogenic variants and gestational diabetes mellitus (GDM). METHODS:The stud...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-008-1196-4
更新日期:2009-02-01 00:00:00
abstract::The spontaneous hypertensive rat is an animal model characterized by a syndrome of hypertension, insulin resistance and hyperinsulinaemia. To elucidate whether in analogy to other insulin resistant animal models an inactivity of the insulin receptor kinase or an alteration of the glucose transporter (GLUT 4) level in ...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF00429089
更新日期:1992-08-01 00:00:00
abstract:AIMS/HYPOTHESIS:Insulin-mediated glucose transport and utilisation are decreased in skeletal muscle from type 2 diabetic and glucose-intolerant individuals because of alterations in insulin receptor signalling, GLUT4 translocation to the plasma membrane and microvascular blood flow. Catalytic activity of the muscle-spe...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-013-3084-9
更新日期:2014-01-01 00:00:00
abstract::We investigated the regulation of the mRNA expression of the insulin receptor, insulin receptor substrate-1 (IRS-1) and p85alpha-phosphatidylinositol-3-kinase (PI-3K), three major actors of insulin action, in skeletal muscle from 10 healthy lean volunteers, 13 obese patients with Type II (non-insulin-dependent) diabet...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s001250051163
更新日期:1999-03-01 00:00:00
abstract:AIMS/HYPOTHESIS:To determine the effects of marine-derived n-3 polyunsaturated fatty acids (PUFA) on established and emerging lipid and lipoprotein cardiovascular risk markers in patients with type 2 diabetes. MATERIALS AND METHODS:We performed a systematic review and meta-analysis of randomised controlled trials comp...
journal_title:Diabetologia
pub_type: 杂志文章,meta分析,评审
doi:10.1007/s00125-007-0695-z
更新日期:2007-08-01 00:00:00
abstract:AIMS/HYPOTHESIS:Peroxisome proliferator-activated receptor (PPAR)-gamma coactivator-1 (PPARGC1), a coactivator regulating the transcription of genes involved in oxidative metabolism, is downregulated in patients with type 2 diabetes and in their first-degree relatives. Whether this downregulation is a cause or effect o...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-006-0369-2
更新日期:2006-10-01 00:00:00
abstract::Barium x-ray patterns of ketonuric diabetic Chinese hamsters displayed marked dilatation of the stomach, small and large intestine. Hypomotility was manifested by flocculation of barium in the small and large bowel. Impaired transit time was further characterized by prolonged emptying of the stomach (mean 570 min diab...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF01222975
更新日期:1979-07-01 00:00:00
abstract::To study the effect of E. Coli L-asparaginase on glucose tolerance and insulin release, 6 patients with neoplastic disease were subjected to 3 hour oral glucose tolerance tests with simultaneous measurement of serum immunoreactive insulin (IRI) levels before and following the intravenous administration of 5000 I. U. L...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF00422255
更新日期:1978-08-01 00:00:00
abstract:AIMS/HYPOTHESIS:Thus far, it is unclear whether lifestyle recommendations for people with diabetes should be different from those for the general public. We investigated whether the associations between lifestyle factors and mortality risk differ between individuals with and without diabetes. METHODS:Within the Europe...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-013-3074-y
更新日期:2014-01-01 00:00:00
abstract::Insulin dependent (IDD) and non-insulin dependent diabetes (NIDD) are separate disorders. Twin studies show that IDD cannot be entirely due to genetic causes as concordance is no more than about 50%, but there is some inherited predisposition to it as shown by HLA patterns. NIDD, on the other hand, is predominantly du...
journal_title:Diabetologia
pub_type: 杂志文章,评审
doi:10.1007/BF01236266
更新日期:1979-12-01 00:00:00
abstract:UNLABELLED:125I-insulin binding and receptor-mediated insulin degradation were studied in isolated human fat cells from subcutaneous tissue. A high albumin concentration during cell isolation and incubation protected the fragile human adipocyte from lysis. Binding of tracer was pH dependent with an optimum between 7.4 ...
journal_title:Diabetologia
pub_type: 杂志文章
doi:
更新日期:1981-06-01 00:00:00
abstract::High levels of gluconeogenic precursors have been reported in patients with long-term diabetes secondary to total pancreatectomy. In the present study, blood concentrations of alanine, lactate and pyruvate were measured in six patients undergoing total pancreatectomy and in nine control subjects undergoing major abdom...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF00271685
更新日期:1985-05-01 00:00:00
abstract:AIMS/HYPOTHESIS:Roux-en-Y gastric bypass (RYGB) surgery is characterised by glycaemic variability. Prospective studies of glucose metabolism in pregnancy after RYGB are not available, therefore this study aimed to evaluate physiological alterations in glucose metabolism in pregnancy following RYGB. METHODS:Sixty-three...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-017-4437-6
更新日期:2017-12-01 00:00:00
abstract::This paper presents a survey of the biological potencies of a variety of naturally-occurring and semi-synthetic insulin analogues and a study of the joint biological action of some of these materials with native insulin. Biological activity was tested on isolated rat fat cells using lipogenesis from glucose as the met...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF01219650
更新日期:1978-11-01 00:00:00
abstract::The effect of acute lowering of arterial blood pressure upon kidney function in nephropathy was studied in 13 patients with long-term Type 1 (insulin-dependent) diabetes. Ten normal subjects (six normotensive and four hypertensive) and five short-term Type 1 diabetic patients without nephropathy served as controls. Re...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF00276965
更新日期:1984-12-01 00:00:00
abstract::The concentration of biologically active insulin was measured by the isolated fat cell method in serum and urine from healthy subjects and compared with the concentration of immunoreactive insulin. In both urine and serum the values obtained by the two methods correlated closely; In addition, there was a close correla...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF01219518
更新日期:1976-10-01 00:00:00
abstract::Non-obese diabetic mice were treated daily with a mixture of gangliosides from day 30 until day 250 of life or until the mice became diabetic. Ganglioside treatment reduced diabetes incidence from 80-90% to 47% and from 20-30% to zero in female and male mice respectively. Gangliosides did not affect the frequency of p...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF00277490
更新日期:1988-11-01 00:00:00
abstract:AIMS/HYPOTHESIS:The conversion of D-[3-(3)H]glucose to (3) HOH is currently measured to assess D-glucose utilisation. The validity of such a procedure was re-evaluated. METHODS:The conversion of D-[3-(3)H]glucose and D-[5-(3)H]glucose to (3) HOH was measured in rat pancreatic islets, parotid cells and erythrocytes. Th...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-002-0907-5
更新日期:2002-09-01 00:00:00
abstract:AIMS/HYPOTHESIS:Statins and niacin (nicotinic acid) reduce circulating LDL-cholesterol (LDL-C) levels by different mechanisms. Yet, both increase the risk of diabetes mellitus. Our objective was to relate blood LDL-C concentrations and a genetic risk score (GRS) for LDL-C to the risk of incident diabetes in individuals...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-015-3762-x
更新日期:2015-12-01 00:00:00
abstract:AIMS/HYPOTHESIS:The process of islet isolation can cause chemical and mechanical injury to beta cells. In addition, hyperglycaemia after islet transplantation can compromise beta cell function. The aim of this experiment was to evaluate changes in gene expression in endogenous islets using laser-capture microdissection...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-006-0536-5
更新日期:2007-02-01 00:00:00
abstract::An incidence of 9.0 out of 100,000 children under 19 years of age with Type 1 (insulin-dependent) diabetes was detected in Toronto during a 2 year prospective study. An increased number of cases occurred in the winter months of one of the years but not of the other during the study. The annual incidence was the same i...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF00281308
更新日期:1982-04-01 00:00:00
abstract:AIMS/HYPOTHESIS:The aim was to conduct a systematic review and meta-analysis of randomised controlled clinical trials assessing the effect of probiotic, prebiotic or synbiotic supplementation on gut microbiota and glucose control and lipid levels in individuals with diabetes. METHODS:MEDLINE, EMBASE and the Cochrane L...
journal_title:Diabetologia
pub_type: 杂志文章,评审
doi:10.1007/s00125-020-05295-1
更新日期:2021-01-01 00:00:00
abstract::A method has been developed for the purification of single A, B and D cells and for the isolation of coupled islet cells. Isolated rat islets were dissociated by repeated pipetting in the presence of trypsin and ethylene glycol bis (beta-aminoethyl ether) N,N' tetra-acetic acid (EGTA), and then filtered through nylon ...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF00257436
更新日期:1981-06-01 00:00:00
abstract::In the present study the antepartum relationship between maternal diabetic glucose control and fetal hypoxaemia was examined in 44 Type 1 (insulin-dependent) diabetic and 23 non-diabetic control pregnancies. Maternal HbA1C was used to assess maternal integrated blood glucose control while fetal metabolic control was e...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF00404643
更新日期:1990-06-01 00:00:00
abstract:AIMS/HYPOTHESIS:We sought to assess the role of coronary artery calcification (CAC) and its progression in predicting incident coronary artery disease (CAD) in individuals with type 1 diabetes using data from the Pittsburgh Epidemiology of Diabetes Complications (EDC) Study. METHODS:The present study examined 292 part...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-018-4764-2
更新日期:2019-02-01 00:00:00
abstract:UNLABELLED:AIMS/HYPOTHESIS. We investigated whether the reported HLA-DQ/DR restricted male-to-female (M:F) excess in Type I (insulin-dependent) diabetes mellitus also exists in Belgian patients, is specific for immune-mediated diabetes, remains genotype-restricted after adjustment for age at diagnosis, and is associate...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s001250051578
更新日期:2001-01-01 00:00:00
abstract::Under strict balance conditions we studied the effect of phenformin in 5 patients with diabetes mellitus. In all cases phenformin lowered the blood glucose values, and all patients showed a reduction of glycosuria. Contrary to other reports body weight increased during phenformin treatment. This was accompanied by pos...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF00429918
更新日期:1975-10-01 00:00:00
abstract::Closure of ATP-regulated K(+) channels (K(ATP) channels) plays a central role in glucose-stimulated insulin secretion in beta cells. K(ATP) channels are also highly expressed in glucagon-producing alpha cells, where their function remains unresolved. Under hypoglycaemic conditions, K(ATP) channels are open in alpha ce...
journal_title:Diabetologia
pub_type: 杂志文章,评审
doi:10.1007/s00125-014-3279-8
更新日期:2014-09-01 00:00:00
abstract::In order to study the contribution of oxidant stress to the pathogenesis of experimental diabetic retinopathy, male streptozotocin diabetic Lewis rats were treated with the antioxidant and lipid-lowering compound nicanartine (80 mg/kg; n = 8, blood glucose level 16.7 +/- 3.9 mmol/l; HbA1 11.8 +/- 1.6%) by oral supplem...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s001250050726
更新日期:1997-06-01 00:00:00
abstract::The effects of four sulphonylureas (gliclazide, glibenclamide, chlorpropamide and glipizide) on insulin binding and insulin action were studied in vitro using primary cultured rat hepatocytes. Cells were cultured for 20 h in the absence or presence of the sulphonylurea. The binding of insulin to rat hepatocyte monolay...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF00257344
更新日期:1983-06-01 00:00:00