Diurnal rhythm in endogenous glucose production is a major contributor to fasting hyperglycaemia in type 2 diabetes. Suprachiasmatic deficit or limit cycle behaviour?

Abstract:

AIMS/HYPOTHESIS:An increase in endogenous glucose production (EGP) is a major contributor to fasting morning hyperglycaemia in type 2 diabetes. This increase is dissipated with fasting, later in the day. To understand its origin, EGP, gluconeogenesis and hormones that regulate metabolism were measured over 24 h. We hypothesised that EGP, and therefore glycaemia, would demonstrate a centrally mediated circadian rhythm in type 2 diabetes. SUBJECTS AND METHODS:Seven subjects with type 2 diabetes and six age- and BMI-matched control subjects, fasting after breakfast (08.00 h), underwent a further 24-h fast, with the infusion of [U-(13)C]glucose and [3-(14)C]lactate, starting at 14.00 h. The MCR and production of total and gluconeogenic glucose were determined from the tracer concentrations using compartmental analysis. RESULTS:MCR was near constant: 1.73+/-0.10 in control and 1.40+/-0.14 ml kg(-1) min(-1) in diabetic subjects (p=0.04). EGP in diabetes rose gradually overnight from 8.2+/-0.7 to 11.3+/-0.5 micromol kg(-1) min(-1) at 06.00 h (p<0.05). Glucose utilisation lagged EGP, rising from 8.5+/-0.6 to 10.5+/-0.4 micromol kg(-1) min(-1) (p<0.05), inducing a fall in glycaemia from a peak of 8.0+/-0.5 mmol/l to 6.3+/-0.4 mmol/l (p<0.05). Cortisol and melatonin showed diurnal variations, whereas insulin, glucagon and leptin did not. Melatonin was most closely related to EGP, but its secretion was attenuated in diabetes (p<0.05). CONCLUSIONS/INTERPRETATION:In type 2 diabetes, EGP and gluconeogenesis display diurnal rhythms that drive the fasting hyperglycaemia and are absent in healthy control subjects. The rise in EGP may be related to a deficit in suprachiasmatic nucleus activity in diabetes, or result from non-linear behaviour plus a transition from a normal steady state to a limit cycle pattern in diabetes, or both.

journal_name

Diabetologia

journal_title

Diabetologia

authors

Radziuk J,Pye S

doi

10.1007/s00125-006-0273-9

subject

Has Abstract

pub_date

2006-07-01 00:00:00

pages

1619-28

issue

7

eissn

0012-186X

issn

1432-0428

journal_volume

49

pub_type

杂志文章
  • The metabolic syndrome in pregnancy and its association with child telomere length.

    abstract:AIMS/HYPOTHESIS:The aim of this study was to determine whether presence of the metabolic syndrome in pregnancy associates with child telomere length or child anthropometry (weight, BMI) and BP, measured at 10 years of age. METHODS:The Screening for Pregnancy Endpoints study (SCOPE) was a multicentre, international pro...

    journal_title:Diabetologia

    pub_type: 杂志文章

    doi:10.1007/s00125-020-05242-0

    authors: McAninch D,Bianco-Miotto T,Gatford KL,Leemaqz SY,Andraweera PH,Garrett A,Plummer MD,Dekker GA,Roberts CT,Smithers LG,Grieger JA

    更新日期:2020-10-01 00:00:00

  • Murine streptozotocin diabetes: influences of the major histocompatibility complex, genetic background and blood transfusion.

    abstract::Major histocompatibility complex-linked immune response genes are thought to influence susceptibility to induction of both human insulin-dependent diabetes and murine streptozotocin-induced diabetes. To clarify this relationship, we administered streptozotocin intravenously in two doses (120 and 240 mg/kg body weight)...

    journal_title:Diabetologia

    pub_type: 杂志文章

    doi:10.1007/BF00275678

    authors: Weber C,Pernis B,Ting W,Rosenkrantz K,Reemtsma K

    更新日期:1984-07-01 00:00:00

  • Insulin binding capacity in patients changed from conventional to highly purified insulins. An indicator of likely response.

    abstract::Highly purified insulins offer the possibility of reducing insulin antibody levels and insulin requirement. Those likely to respond cannot be predicted on clinical grounds and a simple laboratory test is recommended for this purpose. This is based on insulin binding capacity (IBC) of plasma and has been used to follow...

    journal_title:Diabetologia

    pub_type: 杂志文章

    doi:10.1007/BF01223271

    authors: Mustaffa BE,Daggett PR,Nabarro JD

    更新日期:1977-08-01 00:00:00

  • The effects of a specific growth hormone antagonist on overnight insulin requirements and insulin sensitivity in young adults with Type 1 diabetes mellitus.

    abstract:AIMS/HYPOTHESIS:Growth hormone hypersecretion in Type 1 diabetes could exacerbate insulin resistance and contribute to declining glycaemic control. Our aim was to determine the effects of specific growth hormone blockade on insulin sensitivity and lipolysis in young adults with Type 1 diabetes. METHODS:We studied the ...

    journal_title:Diabetologia

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1007/s00125-003-1175-8

    authors: Williams RM,Amin R,Shojaee-Moradie F,Umpleby AM,Acerini CL,Dunger DB

    更新日期:2003-09-01 00:00:00

  • Attenuation of Armanni-Ebstein lesions in a rat model of diabetes by a new anti-fibrotic, anti-inflammatory agent, FT011.

    abstract:AIMS/HYPOTHESIS:A key morphological feature of diabetic nephropathy is the accumulation and deposition of glycogen in renal tubular cells, known as Armanni-Ebstein lesions. While this observation has been consistently reported for many years, the molecular basis of these lesions remains unclear. METHODS:Using biochemi...

    journal_title:Diabetologia

    pub_type: 杂志文章

    doi:10.1007/s00125-012-2805-9

    authors: Lau X,Zhang Y,Kelly DJ,Stapleton DI

    更新日期:2013-03-01 00:00:00

  • Increased insulin demand promotes while pioglitazone prevents pancreatic beta cell apoptosis in Wfs1 knockout mice.

    abstract:AIMS/HYPOTHESIS:The WFS1 gene encodes an endoplasmic reticulum (ER) membrane-embedded protein called Wolfram syndrome 1 protein, homozygous mutations of which cause selective beta cell loss in humans. The function(s) of this protein and the mechanism by which the mutations of this gene cause beta cell death are still n...

    journal_title:Diabetologia

    pub_type: 杂志文章

    doi:10.1007/s00125-009-1270-6

    authors: Akiyama M,Hatanaka M,Ohta Y,Ueda K,Yanai A,Uehara Y,Tanabe K,Tsuru M,Miyazaki M,Saeki S,Saito T,Shinoda K,Oka Y,Tanizawa Y

    更新日期:2009-04-01 00:00:00

  • Altered immunoreactivity of islet amyloid polypeptide (IAPP) may reflect major modifications of the IAPP molecule in amyloidogenesis.

    abstract::We have developed a mouse monoclonal antibody against rat/mouse islet amyloid polypeptide (IAPP). The antibody recognises an epitope in the N-terminal part of the molecule, which is conserved between different species. The antibody immunohistochemically labelled beta cells in normal islets of most different mammalian ...

    journal_title:Diabetologia

    pub_type: 杂志文章

    doi:10.1007/s001250050751

    authors: Ma Z,Westermark GT,Li ZC,Engström U,Westermark P

    更新日期:1997-07-01 00:00:00

  • Carbohydrate response element-binding protein (ChREBP) plays a pivotal role in beta cell glucotoxicity.

    abstract:AIMS/HYPOTHESIS:This study was aimed at the elucidation of the pathogenesis of glucotoxicity, i.e. the mechanism whereby hyperglycaemia damages pancreatic beta cells. The identification of pathways in the process may help identify targets for beta cell-protective therapy. Carbohydrate response element-binding protein (...

    journal_title:Diabetologia

    pub_type: 杂志文章

    doi:10.1007/s00125-012-2506-4

    authors: Poungvarin N,Lee JK,Yechoor VK,Li MV,Assavapokee T,Suksaranjit P,Thepsongwajja JJ,Saha PK,Oka K,Chan L

    更新日期:2012-06-01 00:00:00

  • Association of variants of transcription factor 7-like 2 (TCF7L2) with susceptibility to type 2 diabetes in the Dutch Breda cohort.

    abstract:AIM/HYPOTHESIS:A strong association between susceptibility to type 2 diabetes and common variants of transcription factor 7-like 2 (TCF7L2), encoding an enteroendocrine transcription factor involved in glucose homeostasis, has been reported in three different populations (Iceland, Denmark and USA) by Grant et al. We ai...

    journal_title:Diabetologia

    pub_type: 杂志文章

    doi:10.1007/s00125-006-0477-z

    authors: van Vliet-Ostaptchouk JV,Shiri-Sverdlov R,Zhernakova A,Strengman E,van Haeften TW,Hofker MH,Wijmenga C

    更新日期:2007-01-01 00:00:00

  • Microvascular permeability to albumin and glomerular filtration rate in diabetic and normal children.

    abstract::In order to examine the permeability of microvessels in diabetic children, the glomerular filtration rate, urinary excretion rates of albumin and beta 2-microglobulin, intravascular mass of albumin, and transcapillary escape rate of albumin were studied in 26 diabetic children without clinical signs of microangiopathy...

    journal_title:Diabetologia

    pub_type: 杂志文章

    doi:10.1007/BF01223619

    authors: Brøchner-Mortensen J,Ditzel J,Mogensen CE,Rødbro P

    更新日期:1979-05-01 00:00:00

  • Raised serum apolipoprotein (a) in active diabetic retinopathy.

    abstract::Progressive capillary occlusion often leads to severe retinopathy within 15-20 years of the onset of Type 1 (insulin-dependent) diabetes mellitus. Lipoprotein(a), a complex formed by apolipoprotein(a), apo B-100 and lipids, is considered an independent, genetically determined, predictor of cardiovascular disease. It m...

    journal_title:Diabetologia

    pub_type: 杂志文章

    doi:10.1007/BF00399100

    authors: Maioli M,Tonolo G,Pacifico A,Ciccarese M,Brizzi P,Kohner EM,Porta M

    更新日期:1993-01-01 00:00:00

  • Delta cell secretory responses to insulin secretagogues are not mediated indirectly by insulin.

    abstract:AIMS/HYPOTHESIS:Somatostatin from islet delta cells inhibits insulin and glucagon secretion, but knowledge of the regulation of pancreatic somatostatin release is limited. Some insulin secretagogues stimulate somatostatin secretion, and here we investigated whether delta cell secretory responses are indirectly regulate...

    journal_title:Diabetologia

    pub_type: 杂志文章

    doi:10.1007/s00125-012-2546-9

    authors: Hauge-Evans AC,Anderson RL,Persaud SJ,Jones PM

    更新日期:2012-07-01 00:00:00

  • Short-term moderate sodium restriction induces relative hyperfiltration in normotensive normoalbuminuric Type I diabetes mellitus.

    abstract:AIMS/HYPOTHESIS:Type I (insulin-dependent) diabetes mellitus is associated with an increased extracellular volume. Sodium restriction might seem a logical form of treatment but data on its renal effects is conflicting. We therefore studied the effects of sodium restriction on renal haemodynamics in uncomplicated Type I...

    journal_title:Diabetologia

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1007/s00125-001-0763-8

    authors: Luik PT,Hoogenberg K,Van Der Kleij FG,Beusekamp BJ,Kerstens MN,De Jong PE,Dullaart RP,Navis GJ

    更新日期:2002-04-01 00:00:00

  • The effects of glucose-induced oxidative stress on growth and extracellular matrix gene expression of vascular smooth muscle cells.

    abstract::Vascular smooth muscle cell (VSMC) dysfunction plays a role in diabetic macrovasculopathy and this may include abnormalities in growth characteristics and the extracellular matrix. As the actual mechanisms by which glucose induces VSMC dysfunction remain unclear, the aim of this study was to assess the potential role ...

    journal_title:Diabetologia

    pub_type: 杂志文章

    doi:10.1007/s001250051054

    authors: Sharpe PC,Yue KK,Catherwood MA,McMaster D,Trimble ER

    更新日期:1998-10-01 00:00:00

  • Glycosylated haemoglobin in children with insulin-dependent diabetes mellitus.

    abstract::Glycosylated haemoglobin (HbA1) was measured serially by microcolumn chromatography in 38 children with newly diagnosed insulin-dependent diabetes. Initial HbA1 levels of 13.6 +/- 0.5% fell signficiantly from day 0 (prior to therapy) both to day 1 (1.6 +/- 0.2% decrease) and to day 3-5 (2.6 +/- 0.4% decrease) (P < 0.0...

    journal_title:Diabetologia

    pub_type: 杂志文章

    doi:10.1007/BF00281820

    authors: Daneman D,Tsalikian E,Hengstenberg F,Becker DJ,Drash AL

    更新日期:1980-11-01 00:00:00

  • Causal relationship between obesity-related traits and TLR4-driven responses at the maternal-fetal interface.

    abstract:AIMS/HYPOTHESIS:Obesity triggers complex inflammatory networks within the innate immune system. During pregnancy, the placenta amplifies the low-grade inflammation through activation of Toll-like receptor 4 (TLR4) signalling pathways. The purpose of this study was to investigate the impact of obesity on placental TLR4 ...

    journal_title:Diabetologia

    pub_type: 杂志文章

    doi:10.1007/s00125-016-4073-6

    authors: Yang X,Li M,Haghiac M,Catalano PM,O'Tierney-Ginn P,Hauguel-de Mouzon S

    更新日期:2016-11-01 00:00:00

  • Effects of cross-link breakers, glycation inhibitors and insulin sensitisers on HDL function and the non-enzymatic glycation of apolipoprotein A-I.

    abstract:AIMS/HYPOTHESIS:Hyperglycaemia, a key feature of diabetes, is associated with non-enzymatic glycation of plasma proteins. We have shown previously that the reactive alpha-oxoaldehyde, methylglyoxal, non-enzymatically glycates apolipoprotein (Apo)A-I, the main apolipoprotein of HDL, and prevents it from activating lecit...

    journal_title:Diabetologia

    pub_type: 杂志文章

    doi:10.1007/s00125-008-0986-z

    authors: Nobécourt E,Zeng J,Davies MJ,Brown BE,Yadav S,Barter PJ,Rye KA

    更新日期:2008-06-01 00:00:00

  • Indian Asians have poorer cardiovascular autonomic function than Europeans: this is due to greater hyperglycaemia and may contribute to their greater risk of heart disease.

    abstract:AIMS/HYPOTHESIS:A high prevalence of diabetes contributes to excess CHD in Indian Asians, but the underlying mechanisms are unclear. Heart rate, heart rate variability (HRV) and baroreflex sensitivity (BRS) are measures of cardiac autonomic function that are disturbed by hyperglycaemia and predict CHD. We compared thes...

    journal_title:Diabetologia

    pub_type: 杂志文章

    doi:10.1007/s00125-010-1818-5

    authors: Bathula R,Hughes AD,Panerai R,Potter J,Thom SA,Francis DP,Shore AC,Kooner J,Chaturvedi N

    更新日期:2010-10-01 00:00:00

  • Fatty liver and obesity: phenotypically correlated but genetically distinct traits in a mouse model of type 2 diabetes.

    abstract:AIMS/HYPOTHESIS:Obesity and fatty liver are commonly associated with type 2 diabetes, but the genetic and functional bases linking fatty liver with obesity and diabetes are largely unknown. Our aim was to investigate the association of fatty liver with obesity and other diabetes-related phenotypes and to define the gen...

    journal_title:Diabetologia

    pub_type: 杂志文章

    doi:10.1007/s00125-007-0700-6

    authors: Itoi-Babaya M,Ikegami H,Fujisawa T,Ueda H,Nojima K,Babaya N,Kobayashi M,Noso S,Kawaguchi Y,Yamaji K,Shibata M,Ogihara T

    更新日期:2007-08-01 00:00:00

  • G protein-coupled receptors as new therapeutic targets for type 2 diabetes.

    abstract::G protein-coupled receptors (GPCRs) in the gut-brain-pancreatic axis are key players in the postprandial control of metabolism and food intake. A number of intestinally located receptors have been implicated in the chemo-detection of ingested nutrients, and in the pancreatic islets and nervous system GPCRs play essent...

    journal_title:Diabetologia

    pub_type: 杂志文章,评审

    doi:10.1007/s00125-015-3825-z

    authors: Reimann F,Gribble FM

    更新日期:2016-02-01 00:00:00

  • Engagement of the insulin-sensitive pathway in the stimulation of glucose transport by alpha-lipoic acid in 3T3-L1 adipocytes.

    abstract:AIMS/HYPOTHESIS:A natural cofactor of mitochondrial dehydrogenase complexes and a potent antioxidant, alpha-lipoic acid improves glucose metabolism in people with Type II (non-insulin-dependent) diabetes mellitus and in animal models of diabetes. In this study we investigated the cellular mechanism of action of alpha-l...

    journal_title:Diabetologia

    pub_type: 杂志文章

    doi:10.1007/s001250050047

    authors: Yaworsky K,Somwar R,Ramlal T,Tritschler HJ,Klip A

    更新日期:2000-03-01 00:00:00

  • Neuronal control of peripheral nutrient partitioning.

    abstract::The appropriate utilisation, storage and conversion of nutrients in peripheral tissues, referred to as nutrient partitioning, is a fundamental process to adapt to nutritional and metabolic challenges and is thus critical for the maintenance of a healthy energy balance. Alterations in this process during nutrient exces...

    journal_title:Diabetologia

    pub_type: 杂志文章,评审

    doi:10.1007/s00125-020-05104-9

    authors: Manceau R,Majeur D,Alquier T

    更新日期:2020-04-01 00:00:00

  • Effect of glucagon antibodies on plasma glucose, insulin and somatostatin in the fasting and fed rat.

    abstract::A potent high-titre glucagon antibody pool was used to induce a state of acute glucagon deficiency in order to investigate the importance of glucagon in maintaining euglycaemia in the fed and fasted anaesthetised rat. Binding characteristics of the antiserum and evidence of its neutralisation of the biological effects...

    journal_title:Diabetologia

    pub_type: 杂志文章

    doi:10.1007/BF00280887

    authors: Tan K,Tsiolakis D,Marks V

    更新日期:1985-07-01 00:00:00

  • The AGE product N epsilon-(carboxymethyl)lysine serum albumin is a modulator of proteoglycan expression in polarized cultured kidney epithelial cells.

    abstract:AIMS/HYPOTHESIS:Changes in kidney function in diabetes could be due to changes in the kidney basement membranes. Proteoglycans are important constituents of this kidney extracellular matrix. This study explored the possibility that advanced glycation end products affect proteoglycan synthesis in cultured kidney epithel...

    journal_title:Diabetologia

    pub_type: 杂志文章

    doi:10.1007/s001250051647

    authors: Borrebaek J,Prydz K,Fjeldstad K,Vuong TT,Berg TJ,Holkov C,Kolset SO

    更新日期:2001-04-01 00:00:00

  • Antidiabetic effect of novel modulating peptides of G-protein-coupled kinase in experimental models of diabetes.

    abstract:AIMS/HYPOTHESIS:G-protein-coupled receptor kinases (GRKs) play a key role in agonist-induced desensitisation of G-protein-coupled receptors (GPCRs) that are involved in metabolic regulation and glucose homeostasis. Our aim was to examine whether small peptides derived from the catalytic domain of GRK2 and -3 would amel...

    journal_title:Diabetologia

    pub_type: 杂志文章

    doi:10.1007/s00125-004-1444-1

    authors: Anis Y,Leshem O,Reuveni H,Wexler I,Ben Sasson R,Yahalom B,Laster M,Raz I,Ben Sasson S,Shafrir E,Ziv E

    更新日期:2004-07-01 00:00:00

  • In vitro bioactivity of insulin analogues: lipogenic and anti-lipolytic potency and their interaction with the effect of native insulin.

    abstract::This paper presents a survey of the biological potencies of a variety of naturally-occurring and semi-synthetic insulin analogues and a study of the joint biological action of some of these materials with native insulin. Biological activity was tested on isolated rat fat cells using lipogenesis from glucose as the met...

    journal_title:Diabetologia

    pub_type: 杂志文章

    doi:10.1007/BF01219650

    authors: Ellis MJ,Darby SC,Jones RH,Sönksen PH

    更新日期:1978-11-01 00:00:00

  • Favourable effects of fenofibrate on lipids and cardiovascular disease in women with type 2 diabetes: results from the Fenofibrate Intervention and Event Lowering in Diabetes (FIELD) study.

    abstract:AIMS/HYPOTHESIS:In the double-blind placebo-controlled Fenofibrate Intervention and Event Lowering in Diabetes trial (n = 9,795), fenofibrate reduced major cardiovascular events in type 2 diabetes. Sex-related differences in fenofibrate response could be clinically relevant and were pre-specified analyses. METHODS:Wom...

    journal_title:Diabetologia

    pub_type: 杂志文章,随机对照试验

    doi:10.1007/s00125-014-3344-3

    authors: d'Emden MC,Jenkins AJ,Li L,Zannino D,Mann KP,Best JD,Stuckey BG,Park K,Saltevo J,Keech AC,FIELD Study Investigators.

    更新日期:2014-11-01 00:00:00

  • Xylitol prevents NEFA-induced insulin resistance in rats.

    abstract:AIMS/HYPOTHESIS:Increased NEFA levels, characteristic of type 2 diabetes mellitus, contribute to skeletal muscle insulin resistance. While NEFA-induced insulin resistance was formerly attributed to decreased glycolysis, it is likely that glucose transport is the rate-limiting defect. Recently, the plant-derived sugar a...

    journal_title:Diabetologia

    pub_type: 杂志文章

    doi:10.1007/s00125-012-2527-z

    authors: Kishore P,Kehlenbrink S,Hu M,Zhang K,Gutierrez-Juarez R,Koppaka S,El-Maghrabi MR,Hawkins M

    更新日期:2012-06-01 00:00:00

  • Genome-wide association study of type 2 diabetes in Africa.

    abstract:AIMS/HYPOTHESIS:Genome-wide association studies (GWAS) for type 2 diabetes have uncovered >400 risk loci, primarily in populations of European and Asian ancestry. Here, we aimed to discover additional type 2 diabetes risk loci (including African-specific variants) and fine-map association signals by performing genetic ...

    journal_title:Diabetologia

    pub_type: 杂志文章

    doi:10.1007/s00125-019-4880-7

    authors: Chen J,Sun M,Adeyemo A,Pirie F,Carstensen T,Pomilla C,Doumatey AP,Chen G,Young EH,Sandhu M,Morris AP,Barroso I,McCarthy MI,Mahajan A,Wheeler E,Rotimi CN,Motala AA

    更新日期:2019-07-01 00:00:00

  • Shared genetic susceptibility of type 1 (insulin-dependent) and type 2 (non-insulin-dependent) diabetes mellitus: contributions of HLA and haptoglobin.

    abstract::Epidemiologic data suggest that having a parent with Type 2 (non-insulin-dependent) diabetes mellitus increases the risk for Type 1 (insulin-dependent) diabetes in siblings of a Type 1 diabetes proband. This increase in risk is consistent with a shared genetic susceptibility between Type 1 diabetes and Type 2 diabetes...

    journal_title:Diabetologia

    pub_type: 杂志文章

    doi:10.1007/BF00405008

    authors: Rich SS,Panter SS,Goetz FC,Hedlund B,Barbosa J

    更新日期:1991-05-01 00:00:00