Diurnal rhythm in endogenous glucose production is a major contributor to fasting hyperglycaemia in type 2 diabetes. Suprachiasmatic deficit or limit cycle behaviour?

abstract：:Severe microvascular disease exists at the stage of clinical diabetic neuropathy. A non-invasive test that will identify those diabetic subjects who will eventually develop neuropathy is essential for early intervention. Sural sensory conduction velocity was recorded (x3) in 12 non-neuropathic diabetic subjects, 15 di...

journal_title：Diabetologia

authors： Tesfaye S,Harris ND,Wilson RM,Ward JD

更新日期：1992-02-01 00:00:00

abstract：:Diabetes affects 4 to 5% of the population worldwide and is the most common metabolic disorder. The number of individuals diagnosed with diabetes is rapidly increasing, especially in the developed countries and the disorder frequently leads to secondary complications such as retinopathy, nephropathy, neuropathy and ca...

journal_title：Diabetologia

authors： Edlund H

更新日期：2001-09-01 00:00:00

abstract：AIMS/HYPOTHESIS:Enterovirus infections are among the environmental risk factors potentially contributing to the pathogenesis of Type 1 diabetes. The aim of this study was to evaluate virus-host interaction by analysing the enterovirus antibody levels in subjects carrying different HLA-DR alleles associated with either ...

journal_title：Diabetologia

authors： Sadeharju K,Knip M,Hiltunen M,Akerblom HK,Hyöty H

更新日期：2003-08-01 00:00:00

abstract：AIMS/HYPOTHESIS:FTO harbours the strongest known obesity-susceptibility locus in Europeans. While there is growing evidence for a role for FTO in obesity risk in Asians, its association with type 2 diabetes, independently of BMI, remains inconsistent. To test whether there is an association of the FTO locus with obesit...

journal_title：Diabetologia

authors： Li H,Kilpeläinen TO,Liu C,Zhu J,Liu Y,Hu C,Yang Z,Zhang W,Bao W,Cha S,Wu Y,Yang T,Sekine A,Choi BY,Yajnik CS,Zhou D,Takeuchi F,Yamamoto K,Chan JC,Mani KR,Been LF,Imamura M,Nakashima E,Lee N,Fujisawa T,Ka

更新日期：2012-04-01 00:00:00

abstract：:It has been proposed that the development of diabetic complications may involve a depletion of cellular myo-inositol due to an increase in polyol (sorbitol) formation. We therefore initially examined the effect of diabetes on levels of these metabolites in isolated cerebral microvessels. Compared with microvessels fro...

journal_title：Diabetologia

authors： Sussman I,Carson MP,Schultz V,Wu XP,McCall AL,Ruderman NB,Tornheim K

更新日期：1988-10-01 00:00:00

abstract：:Non-diabetic first degree relatives of non-insulin-dependent diabetic (NIDDM) families are at increased risk of developing diabetes mellitus, and have been studied to identify early metabolic abnormalities. Hormone concentrations measured by specific enzyme immunoassays were assessed in non-diabetic relatives of North...

journal_title：Diabetologia

authors： Humphriss DB,Stewart MW,Berrish TS,Barriocanal LA,Trajano LR,Ashworth LA,Brown MD,Miller M,Avery PJ,Alberti KG,Walker M

更新日期：1997-10-01 00:00:00

abstract：:The purpose of this study was to investigate whether young insulin-dependent diabetic patients still develop peripheral nerve dysfunction when using modern multiple insulin injection therapy and to elucidate if this correlated with various disease parameters. Seventy-five patients, 7 to 20 years old with a duration of...

journal_title：Diabetologia

authors： Hyllienmark L,Brismar T,Ludvigsson J

更新日期：1995-06-01 00:00:00

abstract：:The content of phosphoenolpyruvate (PEP) has been measured in isolated rat islets of Langerhans incubated in vitro. Islet PEP was higher in islets incubated with 16.7 mmol/1 glucose than in islets incubated with zero or 2.8 mmol/1 glucose. Islet PEP content was also increased in islet incubated with 5 mmol/1 D-glycera...

journal_title：Diabetologia

authors： Sugden MC,Ashcroft SJ

更新日期：1977-09-01 00:00:00

abstract：AIMS/HYPOTHESIS:The intestine is the main site for glucose absorption and it has been suggested that it exhibits insulin resistance. Bariatric surgery has been shown to reverse insulin resistance and type 2 diabetes, but its effects on human intestinal metabolism are unknown. Our aim was to evaluate the effects of insu...

journal_title：Diabetologia

authors： Mäkinen J,Hannukainen JC,Karmi A,Immonen HM,Soinio M,Nelimarkka L,Savisto N,Helmiö M,Ovaska J,Salminen P,Iozzo P,Nuutila P

更新日期：2015-05-01 00:00:00

abstract：:The importance of both insulin resistance and beta cell dysfunction in the pathogenesis of glucose intolerance is widely recognised. Also popular is the concept that beta cell secretory function must be viewed in the context of extant insulin resistance. This For Debate moves from the premise that, whilst insulin acti...

journal_title：Diabetologia

authors： Ferrannini E,Mari A

更新日期：2004-05-01 00:00:00

abstract：AIMS/HYPOTHESIS:Type I (insulin-dependent) diabetes mellitus is associated with an increased extracellular volume. Sodium restriction might seem a logical form of treatment but data on its renal effects is conflicting. We therefore studied the effects of sodium restriction on renal haemodynamics in uncomplicated Type I...

journal_title：Diabetologia

authors： Luik PT,Hoogenberg K,Van Der Kleij FG,Beusekamp BJ,Kerstens MN,De Jong PE,Dullaart RP,Navis GJ

更新日期：2002-04-01 00:00:00

abstract：AIMS/HYPOTHESIS:Advances in type 2 diabetes genetics have raised hopes that genetic testing will improve disease prediction, prevention and treatment. Little is known about current physician and patient views regarding type 2 diabetes genetic testing. We hypothesised that physician and patient views would differ regard...

journal_title：Diabetologia

authors： Grant RW,Hivert M,Pandiscio JC,Florez JC,Nathan DM,Meigs JB

更新日期：2009-11-01 00:00:00

abstract：AIMS/HYPOTHESIS:Non-alcoholic fatty liver disease (NAFLD) is common in type 2 diabetes but it is unknown whether NAFLD is prevalent in European women at risk of type 2 diabetes. We studied the prevalence of, and risk factors for, NAFLD in European women with previous gestational diabetes (GDM) at high risk of type 2 di...

journal_title：Diabetologia

authors： Forbes S,Taylor-Robinson SD,Patel N,Allan P,Walker BR,Johnston DG

更新日期：2011-03-01 00:00:00

abstract：UNLABELLED:125I-insulin binding and receptor-mediated insulin degradation were studied in isolated human fat cells from subcutaneous tissue. A high albumin concentration during cell isolation and incubation protected the fragile human adipocyte from lysis. Binding of tracer was pH dependent with an optimum between 7.4 ...

journal_title：Diabetologia

authors： Pedersen O,Hjøllund E,Beck-Nielsen H,Lindskov HO,Sonne O,Gliemann J

更新日期：1981-06-01 00:00:00

abstract：:Impaired lipolysis has been proposed as a pathogenic factor contributing to clustering of abdominal obesity and dyslipidaemia in Type II (non-insulin-dependent) diabetes mellitus--that is, the metabolic syndrome (MSDR). As this syndrome clusters in families, alterations in the hormone-sensitive lipase (HSL) gene could...

journal_title：Diabetologia

authors： Klannemark M,Orho M,Langin D,Laurell H,Holm C,Reynisdottir S,Arner P,Groop L

更新日期：1998-12-01 00:00:00

abstract：:Diabetic nephropathy is the main cause of increased mortality and morbidity in IDDM patients. The effect of antihypertensive treatment on the progression of the nephropathy is highly variable. The aim of this study was to evaluate putative predictors of the progression in diabetic nephropathy during long-term antihyp...

journal_title：Diabetologia

authors： Rossing P,Hommel E,Smidt UM,Parving HH

更新日期：1994-05-01 00:00:00

abstract：AIMS/HYPOTHESIS:Although insulin resistance has been associated with accumulations of specific intramuscular fatty acids and altered subcellular localisation of lipid droplets, these concepts remain controversial. Therefore, we aimed to identify specific intramuscular fatty acids and subcellular lipid localisations ass...

journal_title：Diabetologia

authors： Holloway GP,Han XX,Jain SS,Bonen A,Chabowski A

更新日期：2014-04-01 00:00:00

abstract：:Rheological studies were made on the blood of 12 diabetic patients after a period of poor diabetic control (HbA1 12.6 +/- 0.7% (mean +/- SD); mean home capillary blood glucose level 11.7 +/- 1.2 mmol/l), and after at least three months of improved control (HbA1 9.1 +/- 0.4%, p < 0.01; mean home capillary blood glucose...

journal_title：Diabetologia

authors： Paisey RB,Harkness J,Hartog M,Chadwick T

更新日期：1980-10-01 00:00:00

abstract：AIMS/HYPOTHESIS:Cardiovascular disease in diabetes is linked to increased risk of atherosclerosis, increased levels of triglyceride-rich lipoproteins and enhanced hepatic lipogenesis. The hepatic hexosamine pathway has been implicated in signalling for de novo lipogenesis by the liver. In this study, we assessed if dec...

journal_title：Diabetologia

authors： Babaei-Jadidi R,Karachalias N,Kupich C,Ahmed N,Thornalley PJ

更新日期：2004-12-01 00:00:00

abstract：AIMS/HYPOTHESIS:A reduction in retinal blood flow occurs early in diabetes and is likely to be involved in the development of diabetic retinopathy. We hypothesise that activation of the arginase pathway could have a role in the vascular dysfunction of diabetic retinopathy. METHODS:Experiments were performed using a mo...

journal_title：Diabetologia

authors： Elms SC,Toque HA,Rojas M,Xu Z,Caldwell RW,Caldwell RB

更新日期：2013-03-01 00:00:00

abstract：AIMS/HYPOTHESIS:Microvascular endothelial hyperpermeability, mainly caused by claudin-5 deficiency, is the initial pathological change that occurs in diabetes-associated cardiovascular disease. The ketone body β-hydroxybutyrate (BHB) exerts unique beneficial effects on the cardiovascular system, but the involvement of ...

journal_title：Diabetologia

authors： Li B,Yu Y,Liu K,Zhang Y,Geng Q,Zhang F,Li Y,Qi J

更新日期：2021-01-01 00:00:00

abstract：:The nerve fibre loss, atrophy and injury of diabetic peripheral polyneuropathy and their responses to metabolic intervention have been studied by morphometric analysis of sural nerve biopsies. The magnitudes and sources of intra- and inter-individual variation in these morphometric measures have not been investigated ...

journal_title：Diabetologia

authors： Sima AA,Brown MB,Prashar A,Chakrabarti S,Laudadio C,Greene DA

更新日期：1992-06-01 00:00:00

abstract：AIMS/HYPOTHESIS:The aim of this study was to evaluate the effects of oxygen consumption-matched short-term interval walking training (IWT) vs continuous walking training (CWT) on glycaemic control, including glycaemic variability, in individuals with type 2 diabetes. We also assessed whether any training-induced improv...

journal_title：Diabetologia

authors： Karstoft K,Clark MA,Jakobsen I,Müller IA,Pedersen BK,Solomon TP,Ried-Larsen M

更新日期：2017-03-01 00:00:00

abstract：AIMS/HYPOTHESIS:Improvements in islet transplantation require clinical series large enough to implement controlled new strategies. The goal of this study was to demonstrate the feasibility of a multicentre network for islet transplantation in Type I (insulin-dependent) diabetic patients. METHODS:The five centres (Besa...

journal_title：Diabetologia

authors： Benhamou PY,Oberholzer J,Toso C,Kessler L,Penfornis A,Bayle F,Thivolet C,Martin X,Ris F,Badet L,Colin C,Morel P,GRAGIL consortium.

更新日期：2001-07-01 00:00:00

abstract：AIMS/HYPOTHESIS:We assessed secular trends of cardiovascular outcomes following first diagnosis of myocardial infarction (MI) or diabetes in an unselected population. METHODS:All Danish residents aged > or = 30 years without prior diabetes or MI were identified by individual-level linkage of nationwide registers. Indi...

journal_title：Diabetologia

authors： Norgaard ML,Andersen SS,Schramm TK,Folke F,Jørgensen CH,Hansen ML,Andersson C,Bretler DM,Vaag A,Køber L,Torp-Pedersen C,Gislason GH

更新日期：2010-08-01 00:00:00

abstract：AIMS/HYPOTHESIS:Diabetes is associated with a high incidence of ischaemic disease and impaired nitric oxide responses. Therefore, the aim of the present study was to assess the effect of nitric oxide on ischaemia/reperfusion (I/R)-induced microvascular responses in an experimental model of diabetes. METHODS:Leucocyte-...

journal_title：Diabetologia

authors： Salas A,Panés J,Rosenbloom CL,Elizalde JI,Anderson DC,Granger DN,Piqué JM

更新日期：1999-11-01 00:00:00

abstract：AIMS/HYPOTHESIS:Cardiovascular disease (CVD) is the most common cause of premature death and disability among patients with type 1 diabetes. Diabetic nephropathy accounts for the increased cardiovascular morbidity and mortality of these patients. We recently showed that the intensity of exercise predicts the incidence ...

journal_title：Diabetologia

authors： Tikkanen-Dolenc H,Wadén J,Forsblom C,Harjutsalo V,Thorn LM,Saraheimo M,Elonen N,Rosengård-Bärlund M,Gordin D,Tikkanen HO,Groop PH,FinnDiane Study Group.

更新日期：2017-03-01 00:00:00

abstract：AIMS/HYPOTHESIS:This multicentre randomised double-blind placebo-controlled clinical trial assessed the efficacy and safety of a methionine aminopeptidase 2 (MetAP2) inhibitor, beloranib, in individuals with obesity (BMI ≥30 kg/m2) and type 2 diabetes (HbA1c 53-97 mmol/mol [7-11%] and fasting glucose <15.6 mmol/l). ME...

journal_title：Diabetologia

authors： Proietto J,Malloy J,Zhuang D,Arya M,Cohen ND,de Looze FJ,Gilfillan C,Griffin P,Hall S,Nathow T,Oldfield GS,O'Neal DN,Roberts A,Stuckey BGA,Yue D,Taylor K,Kim D

更新日期：2018-09-01 00:00:00

abstract：AIMS/HYPOTHESIS:African-Americans with type 2 diabetes and access to adequate healthcare are at lower risk of clinical coronary artery disease than are white diabetic patients. We evaluated whether ethnic differences in subclinical cardiovascular disease, coronary and carotid artery calcified plaque and carotid artery ...

journal_title：Diabetologia

authors： Freedman BI,Hsu FC,Langefeld CD,Rich SS,Herrington DM,Carr JJ,Xu J,Bowden DW,Wagenknecht LE

更新日期：2005-12-01 00:00:00

abstract：:A prominent feature of Type 2 (non-insulin-dependent) diabetes mellitus is the inability of insulin to appropriately increase the transport of glucose into target tissue. In adipocytes from individuals with Type 2 diabetes, insulin resistance has been shown to be associated with a depletion of glucose transporters. Si...

journal_title：Diabetologia

authors： Handberg A,Vaag A,Damsbo P,Beck-Nielsen H,Vinten J

更新日期：1990-10-01 00:00:00