Evidence for a placento-insular axis in the rat fetus.

abstract：:Four patients with glucagon-producing tumours of the pancreas were investigated. Fasting plasma glucagon concentrations ranged from 209--625 pmol/l. Plasma insulin concentrations were normal except in one patient, where the tumour also produced insulin (558 pmol/l). Intravenous glucose (25 g/m2) depressed the glucagon...

journal_title：Diabetologia

authors： Holst JJ,Helland S,Ingemannson S,Pedersen NB,von Schenck H

更新日期：1979-09-01 00:00:00

abstract：:Liver protein kinase was determined in the absence and presence of cAMP4. Experimental alloxan diabetes resulted in a decrease in total protein kinase (+cAMP) and an increase in the activity ratio (-cAMP) divided by (+cAMP) in liver. Insulin treatment of diabetic rats reversed the observed changes in protein kinase in...

journal_title：Diabetologia

authors： Weber HE,Menahan LA,Chaudhuri SN,Shipp JC

更新日期：1977-04-01 00:00:00

abstract：AIMS/HYPOTHESIS:We evaluated the intake of vitamin D by pregnant Finnish women and examined associations between maternal intake of vitamin D and the development of advanced beta cell autoimmunity and type 1 diabetes in their offspring. METHODS:The research was carried out within the Diabetes Prediction and Prevention...

journal_title：Diabetologia

authors： Marjamäki L,Niinistö S,Kenward MG,Uusitalo L,Uusitalo U,Ovaskainen ML,Kronberg-Kippilä C,Simell O,Veijola R,Ilonen J,Knip M,Virtanen SM

更新日期：2010-08-01 00:00:00

abstract：AIMS/HYPOTHESIS:To determine whether the clinical heterogeneity observed in the development of Type I (insulin-dependent) diabetes mellitus correlates with immunohistochemical differences observed at diagnosis. METHODS:Patients (n = 17) with recent-onset diabetes clinically considered to be insulin dependent (Type I),...

journal_title：Diabetologia

authors： Imagawa A,Hanafusa T,Itoh N,Waguri M,Yamamoto K,Miyagawa J,Moriwaki M,Yamagata K,Iwahashi H,Sada M,Tsuji T,Tamura S,Kawata S,Kuwajima M,Nakajima H,Namba M,Matsuzawa Y

更新日期：1999-05-01 00:00:00

abstract：:Diabetic nephropathy is the main cause of increased mortality and morbidity in IDDM patients. The effect of antihypertensive treatment on the progression of the nephropathy is highly variable. The aim of this study was to evaluate putative predictors of the progression in diabetic nephropathy during long-term antihyp...

journal_title：Diabetologia

authors： Rossing P,Hommel E,Smidt UM,Parving HH

更新日期：1994-05-01 00:00:00

abstract：AIMS/HYPOTHESIS:The study was designed to identify the key metabolic signals of glucose-stimulated proinsulin gene transcription and translation, focusing on the mechanism of succinate stimulation of insulin production. METHODS:Wistar rat islets were incubated in 3.3 mmol/l glucose with and without esters of different...

journal_title：Diabetologia

authors： Leibowitz G,Khaldi MZ,Shauer A,Parnes M,Oprescu AI,Cerasi E,Jonas JC,Kaiser N

更新日期：2005-08-01 00:00:00

abstract：AIM/HYPOTHESIS:Diabetic neuropathy is accompanied by a range of positive (paresthaesia, dysesthaesia, pain) and negative (hypesthaesia, anesthaesia) neurological symptoms suggesting widespread alterations in axonal excitability. The nature and the mechanisms underlying these alterations in axonal excitability are not w...

journal_title：Diabetologia

authors： Kriz J,Padjen AL

更新日期：2003-02-01 00:00:00

abstract：AIMS/HYPOTHESIS:The aim of this study was to estimate the heritability of quantitative measures of glucose regulation obtained from a tolbutamide-modified frequently sampled IVGTT (t-FSIGT) and to correlate the heritability of the glucose-stimulated beta cell response to the tolbutamide-induced beta cell response. In a...

journal_title：Diabetologia

authors： Gjesing AP,Hornbak M,Allin KH,Ekstrøm CT,Urhammer SA,Eiberg H,Pedersen O,Hansen T

更新日期：2014-06-01 00:00:00

abstract：:The development of proteinuria and its response to insulin therapy in acute experimental diabetes was examined in 11 female rats by sequentially measuring 24 h excretion of glucose and total protein before diabetes, during 5-37 days of acute streptozotocin diabetes, during and after 7-14 days of continuous subcutaneou...

journal_title：Diabetologia

authors： Pennell JP,Millard MM,Ashby MH

更新日期：1981-07-01 00:00:00

abstract：AIM/HYPOTHESIS:Altered adipose tissue secretory profile contributes to insulin resistance and type 2 diabetes in obesity. Preclinical studies have identified senescent cells as a cellular source of proinflammatory factors in adipose tissue of obese mice. In humans, potential links with obesity comorbidities are poorly ...

journal_title：Diabetologia

authors： Rouault C,Marcelin G,Adriouch S,Rose C,Genser L,Ambrosini M,Bichet JC,Zhang Y,Marquet F,Aron-Wisnewsky J,Poitou C,André S,Dérumeaux G,Guerre-Millo M,Clément K

更新日期：2021-01-01 00:00:00

abstract：AIMS/HYPOTHESIS:We studied the gene therapy efficacy of diabetes-associated wound healing disorder with an adeno-associated virus (AAV) vector expressing the 165-amino acid isoform of human vascular endothelial growth factor-A (VEGF-A) by using an incisional skin-wound model produced on the back of female diabetic C57B...

journal_title：Diabetologia

authors： Galeano M,Deodato B,Altavilla D,Cucinotta D,Arsic N,Marini H,Torre V,Giacca M,Squadrito F

更新日期：2003-04-01 00:00:00

abstract：AIMS/HYPOTHESIS:Neuronal dorsal root ganglion (DRG) cells seem to be vulnerable in diabetes. The aim of this study was to determine whether the p75 neurotrophin receptor stimulates perikaryal shrinkage and neuronal death, and further accelerates neuronal DRG cell loss after axotomy in a mouse model of diabetes. METHOD...

journal_title：Diabetologia

authors： Jiang Y,Jakobsen J

更新日期：2004-09-01 00:00:00

abstract：AIMS/HYPOTHESIS:As glycaemia and the incidence of microvascular diabetes complications follow a log-linear relationship, it becomes increasingly difficult to demonstrate a microvascular benefit of glucose-lowering when the HbA1c level is close to normal. METHODS:The Outcome Reduction with an Initial Glargine Intervent...

journal_title：Diabetologia

authors： ORIGIN trial investigators.,Gilbert RE,Mann JF,Hanefeld M,Spinas G,Bosch J,Yusuf S,Gerstein HC

更新日期：2014-07-01 00:00:00

abstract：:46Sc-and 99mTc-labelled microspheres were used to measure the effects of noradrenaline infusion on cardiac output and its regional distribution in 10 control and 10 streptozotocin-diabetic pithed rats. Plasma noradrenaline concentrations during the infusion were similar in both groups. Pressor responses were significa...

journal_title：Diabetologia

authors： Lucas PD

更新日期：1985-02-01 00:00:00

abstract：AIMS/HYPOTHESIS:Both obesity and genetics contribute to cardiovascular disease (CVD). We examined whether a genetic risk score (GRS) prospectively predicted cardiovascular morbidity and mortality among overweight/obese individuals with type 2 diabetes and whether behavioural weight loss could diminish this association....

journal_title：Diabetologia

authors： Look AHEAD Research Group.

更新日期：2015-08-01 00:00:00

abstract：:People with type 2 diabetes have an increased risk of cardiovascular disease (CVD). Multivariate cardiovascular risk scores have been used in many countries to identify individuals who are at high risk of CVD. These risk scores include those originally developed in individuals with diabetes and those developed in a ge...

journal_title：Diabetologia

authors： Chamnan P,Simmons RK,Sharp SJ,Griffin SJ,Wareham NJ

更新日期：2009-10-01 00:00:00

abstract：:We have investigated whether and how the elevated glucose concentrations characteristic of diabetes may alter the interaction of endothelial cells with low-density lipoproteins (LDL). Protracted exposure of cultured human endothelial cells to 20 mmol/l glucose failed to affect either the relationship between the degre...

journal_title：Diabetologia

authors： Lorenzi M,Cagliero E,Markey B,Henriksen T,Witztum JL,Sampietro T

更新日期：1984-03-01 00:00:00

abstract：:The insulin-like growth factor I receptor and the activity of its associated tyrosine kinase activity were characterised in wheat germ agglutinin extracts from skeletal muscle biopsies from nine control and ten obese Type 2 (non-insulin-dependent) diabetic subjects, who had marked peripheral in vivo insulin resistance...

journal_title：Diabetologia

authors： Livingston N,Pollare T,Lithell H,Arner P

更新日期：1988-12-01 00:00:00

abstract：:The Neurometer is a variable constant current sine wave stimulator, and has recently been proposed as a simple non-invasive and quantitative measure of peripheral nerve function. The device is portable and battery operated; assessment of upper and lower extremities takes only a few min, in contrast to conventional ass...

journal_title：Diabetologia

authors： Masson EA,Veves A,Fernando D,Boulton AJ

更新日期：1989-10-01 00:00:00

abstract：AIMS/HYPOTHESIS:White cell count has been shown to predict incident type 2 diabetes, but differential white cell count has received scant attention. We examined the risk of developing diabetes associated with differential white cell count and neutrophil:lymphocyte ratio and the effect of insulin sensitivity and subclin...

journal_title：Diabetologia

authors： Lorenzo C,Hanley AJ,Haffner SM

更新日期：2014-01-01 00:00:00

abstract：AIMS/HYPOTHESIS:Vitamin D deficiency may increase the risk of type 2 diabetes. We therefore investigated whether serum concentrations of 25-hydroxyvitamin D [25(OH)D] would predict the development of prediabetes (impaired fasting glucose, impaired glucose tolerance or the two combined) and type 2 diabetes, either on th...

journal_title：Diabetologia

authors： Deleskog A,Hilding A,Brismar K,Hamsten A,Efendic S,Östenson CG

更新日期：2012-06-01 00:00:00

abstract：:The cardiovascular effects of glibenclamide, gliclazide and carbutamide were studied on myocardial contractile force, cardiac output, mean arterial pressure and heart rate in 43 intact, 14 pancreatectomized and 18 adrenalectomized dogs. It is shown that a positive inotropic and hypertensive effect of hypoglycaemic sul...

journal_title：Diabetologia

authors： Pogátsa G,Dubecz E

更新日期：1977-09-01 00:00:00

abstract：:Chronic diseases arising from obesity will continue to escalate over coming decades. Current approaches to combating obesity include lifestyle measures, surgical interventions and drugs that target weight reduction or the metabolic consequences of obesity. Lifestyle measures including physical activity are usually the...

journal_title：Diabetologia

authors： Carey AL,Kingwell BA

更新日期：2009-10-01 00:00:00

abstract：:The effect of a five day pretreatment with phenformin (3 X 50 mg daily) on hepatic metabolism was studied in six healthy volunteers. Arterial and hepatic venous concentrations of substrates and hepatic blood flow were estimated during a basal period and during a low-dose lactate infusion (0,03 mmol . kg-1 . min-1). Th...

journal_title：Diabetologia

authors： Dietze G,Wicklmayr M,Mehnert H,Czempiel H,Henftling HG

更新日期：1978-04-01 00:00:00

abstract：:Type 1 diabetes is an immune-mediated disease leading to almost total beta cell destruction and permanent exogenous insulin dependency. The appearance of clinical symptoms is preceded by an asymptomatic preclinical period, the duration of which is highly individual. The emergence of diabetes-associated autoantibodies ...

journal_title：Diabetologia

authors： Knip M,Selvenius J,Siljander H,Veijola R

更新日期：2017-01-01 00:00:00

abstract：AIMS/HYPOTHESIS:Levels of ideal cardiovascular health (ICH) and incident type 2 diabetes mellitus have not been examined in a multiethnic population. We assessed the total and race/ethnicity-specific incidence of diabetes based on American Heart Association (AHA) ICH components. METHODS:Incident diabetes was assessed ...

journal_title：Diabetologia

authors： Joseph JJ,Echouffo-Tcheugui JB,Carnethon MR,Bertoni AG,Shay CM,Ahmed HM,Blumenthal RS,Cushman M,Golden SH

更新日期：2016-09-01 00:00:00

abstract：AIMS/HYPOTHESIS:Diabetic cardiomyopathy is a myocardial disease triggered by impaired insulin signalling, increased fatty acid uptake and diminished glucose utilisation. Liver X receptors (LXRs) are key transcriptional regulators of metabolic homeostasis. However, their effect in the diabetic heart is largely unknown. ...

journal_title：Diabetologia

authors： Cannon MV,Silljé HH,Sijbesma JW,Khan MA,Steffensen KR,van Gilst WH,de Boer RA

更新日期：2016-03-01 00:00:00

abstract：AIMS/HYPOTHESIS:Higher concentrations of the adipokine omentin are associated with lower levels of cardiometabolic risk factors in experimental and cross-sectional studies, but with higher risk of type 2 diabetes and cardiovascular diseases in population-based cohort studies. However, it is unknown whether high omentin...

journal_title：Diabetologia

authors： Niersmann C,Carstensen-Kirberg M,Maalmi H,Holleczek B,Roden M,Brenner H,Herder C,Schöttker B

更新日期：2020-02-01 00:00:00

abstract：AIMS/HYPOTHESIS:Pancreatic beta cells play a central role in the control of glucose homeostasis by secreting insulin to stimulate glucose uptake by peripheral tissues. Understanding the molecular mechanisms that control beta cell function and plasticity has critical implications for the pathophysiology and therapy of m...

journal_title：Diabetologia

authors： Thorens B,Tarussio D,Maestro MA,Rovira M,Heikkilä E,Ferrer J

更新日期：2015-03-01 00:00:00

abstract：:Several thrombogenic abnormalities are associated with diabetes. To investigate the underlying molecular mechanisms, we examined the effects of advanced glycation endproducts (AGE), non-enzymatically glycated protein derivatives, on the production of prostacyclin (PGI2), an anti-thrombogenic prostanoid, and of plasmin...

journal_title：Diabetologia

authors： Yamagishi S,Fujimori H,Yonekura H,Yamamoto Y,Yamamoto H

更新日期：1998-12-01 00:00:00