The limited storage capacity of gonadal adipose tissue directs the development of metabolic disorders in male C57Bl/6J mice.

abstract：AIMS/HYPOTHESIS:Higher habitual coffee drinking has been associated with a lower risk of developing type 2 diabetes. The relation between coffee consumption and risk of cardiovascular disease (CVD) has been examined in many studies, but the issue remains controversial. This study was designed to assess the association ...

journal_title：Diabetologia

authors： Bidel S,Hu G,Qiao Q,Jousilahti P,Antikainen R,Tuomilehto J

更新日期：2006-11-01 00:00:00

abstract：AIMS/HYPOTHESIS:Knowledge of the within-subject variability of a parameter is required to properly design and calculate sample sizes for longitudinal studies. We sought to determine the day-to-day variability of measures of beta cell function derived from an OGTT. METHODS:Thirty-seven adults (13 with normal glucose to...

journal_title：Diabetologia

authors： Utzschneider KM,Prigeon RL,Tong J,Gerchman F,Carr DB,Zraika S,Udayasankar J,Montgomery B,Mari A,Kahn SE

更新日期：2007-12-01 00:00:00

abstract：:In the isolated perfused rat pancreas various sulfonylurea drugs were tested with a basal glucose level of 1 mg/ml in the perfusion buffer and were found to cause a biphasic insulin response. NOVOCS 476, a new and potent sulfonylurea, and glibenclamide qualitatively differed from tolbutamide, glibornuride, glipizide, ...

journal_title：Diabetologia

authors： Gotfredsen CF

更新日期：1976-08-01 00:00:00

abstract：:Plasma glucose control and arterial pressure were assessed in 28 Type 1 (insulin-dependent) diabetic patients with different degrees of micro-albuminuria. They were divided into two groups according to their urinary albumin excretion rate: a low micro-albuminuria group (n = 16) with albumin excretion ranging between 1...

journal_title：Diabetologia

authors： Wiseman M,Viberti G,Mackintosh D,Jarrett RJ,Keen H

更新日期：1984-06-01 00:00:00

abstract：AIMS/HYPOTHESIS:Type 2 diabetes is an established risk factor for cardiovascular disease (CVD). This increased risk may be due in part to the increased levels of inflammatory factors associated with diabetes. Lipoprotein-associated phospholipase A(2) (Lp-PLA(2)) is a risk marker for CVD and has pro-inflammatory effects...

journal_title：Diabetologia

authors： Nelson TL,Kamineni A,Psaty B,Cushman M,Jenny NS,Hokanson J,Furberg C,Mukamal KJ

更新日期：2011-02-01 00:00:00

abstract：:To evaluate the behaviour and predictive value of islet cell and insulin autoantibodies in patients with organ-specific autoimmune diseases, we followed 21 non-diabetic subjects for a mean period of 84 +/- 27 months. Ten patients were persistently seropositive for complement-fixing islet cell antibodies and high titre...

journal_title：Diabetologia

authors： Betterle C,Presotto F,Pedini B,Moro L,Slack RS,Zanette F,Zanchetta R

更新日期：1987-05-01 00:00:00

abstract：UNLABELLED:AIMS/HYPOTHESIS; The aim of the Diabetes Prevention Study is to assess the efficacy of an intensive diet-exercise programme in preventing or delaying Type II (non-insulin-dependent) diabetes mellitus in subjects with impaired glucose tolerance, to evaluate the effects of the intervention programme on cardiov...

journal_title：Diabetologia

authors： Eriksson J,Lindström J,Valle T,Aunola S,Hämäläinen H,Ilanne-Parikka P,Keinänen-Kiukaanniemi S,Laakso M,Lauhkonen M,Lehto P,Lehtonen A,Louheranta A,Mannelin M,Martikkala V,Rastas M,Sundvall J,Turpeinen A,Viljanen T,Uus

更新日期：1999-07-01 00:00:00

abstract：AIMS/HYPOTHESIS:In order to identify type 2 diabetes disease susceptibility gene(s) in a Japanese population, we applied a region-wide case-control association test to the 20.4 Mb region between D3S1293 and D3S2319 on chromosome 3p24.3-22.1, supported by linkage to type 2 diabetes and its related traits in Japanese and...

journal_title：Diabetologia

authors： Moritani M,Nomura K,Tanahashi T,Osabe D,Fujita Y,Shinohara S,Yamaguchi Y,Keshavarz P,Kudo E,Nakamura N,Yoshikawa T,Ichiishi E,Takata Y,Yasui N,Shiota H,Kunika K,Inoue H,Itakura M

更新日期：2007-06-01 00:00:00

abstract：AIMS/HYPOTHESIS:The gene encoding the beta(3)-subunit (GPIIIa) of the platelet alpha(2)beta(3)-integrin (fibrinogen receptor) shows a polymorphism PlA1/A2 with the A2 allele putatively associated with an increased risk of acute ischaemic events. This study investigated whether Type 2 diabetes as a particular macrovascu...

journal_title：Diabetologia

authors： Tschoepe D,Menart B,Ferber P,Altmann C,Haude M,Haastert B,Roesen P

更新日期：2003-07-01 00:00:00

abstract：AIMS/HYPOTHESIS:This study estimated the economic efficiency (1) of intensive blood glucose control and tight blood pressure control in patients with type 2 diabetes who also had hypertension, and (2) of metformin therapy in type 2 diabetic patients who were overweight. METHODS:We conducted cost-utility analysis based...

journal_title：Diabetologia

authors： Clarke PM,Gray AM,Briggs A,Stevens RJ,Matthews DR,Holman RR,UKPDS 72 United Kingdom Prospective Diabetes Study.

更新日期：2005-05-01 00:00:00

abstract：:Eight diabetics were found among 464 children, mean age 11.2 years, of 311 unselected insulin-treated mothers. By a method of age correction the total diabetes prevalence among the children at the age of 25 years was calculated as 3.4%. Three children were non-insulin dependent and these patients and their mothers may...

journal_title：Diabetologia

authors： Köbberling J,Brüggeboes B

更新日期：1980-06-01 00:00:00

abstract：AIMS/HYPOTHESIS:To provide a nonenzymatic sensor for glucose monitoring in subcutaneous tissue. METHODS:A continuously working affinity sensor based on the glucose-dependent viscosity of a sensitive liquid containing dextran and concanavalin A has been designed by arranging a microdialysis probe, two flow-resisting ca...

journal_title：Diabetologia

authors： Beyer U,Schäfer D,Thomas A,Aulich H,Haueter U,Reihl B,Ehwald R

更新日期：2001-04-01 00:00:00

abstract：AIMS/HYPOTHESIS:The aim of this study was to examine the prevalence and nature of mutations in HNF4alpha/MODY1, GCK/MODY2 and HNF-1alpha/MODY3 genes in Czech subjects with clinical diagnosis of MODY. METHODS:We studied 61 unrelated index probands of Czech origin (28 males, 33 females) with a clinical diagnosis of MODY...

journal_title：Diabetologia

authors： Pruhova S,Ek J,Lebl J,Sumnik Z,Saudek F,Andel M,Pedersen O,Hansen T

更新日期：2003-02-01 00:00:00

abstract：:The characteristics, progressivity and reversibility of the changes in glucose homeostasis brought about by chronic protein-calorie malnutrition were studied in the rat. Four-week-old male rats received a control diet (15% protein) or a low-protein diet (5% protein) until the age of 28 weeks. Other rats received the l...

journal_title：Diabetologia

authors： Okitolonda W,Brichard SM,Henquin JC

更新日期：1987-12-01 00:00:00

abstract：:Potassium homeostasis during a 50-g oral glucose tolerance test was studied in 14 newly diagnosed, untreated Type 2 (non-insulin-dependent) diabetics. They showed a rise in plasma potassium from a mean +/- SEM basal of 3.9 +/- 0.1 to 4.4 +/- 0.1 mmol/l at 60 min and to 4.6 +/- 0.1 mmol/l at 90 min (p less than 0.01), ...

journal_title：Diabetologia

authors： Rosenstock J,Loizou SA,Brajkovich IE,Mashiter K,Joplin GF

更新日期：1982-03-01 00:00:00

abstract：:This study was performed to evaluate whether L-leucine is able to relieve the structural and functional alterations previously described in pancreatic islets exposed in vitro for a prolonged time to a subnormal glucose concentration (3.3 mM). It was found that both the impairment of secretion and the decreased rate of...

journal_title：Diabetologia

authors： Andersson A,Höiriis-Nielsen J,Borg LA

更新日期：1977-01-01 00:00:00

abstract：:We compared urinary albumin excretion during and after pregnancy in 30 insulin-dependent diabetic (IDDM) women with normoalbuminuria and in 12 IDDM women with microalbuminuria (> 15 micrograms.min-1) prior to conception. There was a 6.7-fold increase in the urinary albumin excretion up until the third trimester in the...

journal_title：Diabetologia

authors： Biesenbach G,Zazgornik J,Stöger H,Grafinger P,Hubmann R,Kaiser W,Janko O,Stuby U

更新日期：1994-09-01 00:00:00

abstract：AIMS/HYPOTHESIS:Type 2 diabetes is characterised by progressive loss of pancreatic beta cell mass and function. Therefore, it is of therapeutic interest to identify factors with the potential to improve beta cell proliferation and insulin secretion. Bone morphogenetic protein 4 (BMP4) expression is increased in diabeti...

journal_title：Diabetologia

authors： Christensen GL,Jacobsen ML,Wendt A,Mollet IG,Friberg J,Frederiksen KS,Meyer M,Bruun C,Eliasson L,Billestrup N

更新日期：2015-06-01 00:00:00

abstract：AIMS/HYPOTHESIS:Non-invasive imaging of the pancreatic beta cell mass (BCM) requires the identification of novel and specific beta cell biomarkers. We have developed a systems biology approach to the identification of promising beta cell markers. METHODS:We followed a functional genomics strategy based on massive para...

journal_title：Diabetologia

authors： Flamez D,Roland I,Berton A,Kutlu B,Dufrane D,Beckers MC,De Waele E,Rooman I,Bouwens L,Clark A,Lonneux M,Jamar JF,Goldman S,Maréchal D,Goodman N,Gianello P,Van Huffel C,Salmon I,Eizirik DL

更新日期：2010-07-01 00:00:00

abstract：AIMS/HYPOTHESIS:Few data are available about intakes and food sources of trans-fatty acids (TFAs) or their associations with cardiometabolic outcomes in Asian people who consume a prudent diet but are experiencing rapid nutritional transitions. We aimed to investigate the relationships between TFA biomarkers and type 2...

journal_title：Diabetologia

authors： Yu DX,Sun Q,Ye XW,Pan A,Zong G,Zhou YH,Li HX,Hu FB,Lin X

更新日期：2012-11-01 00:00:00

abstract：AIMS/HYPOTHESIS:In the light of a report suggesting that insulin glargine may increase cancer occurrence, the EASD asked us to perform this study. METHODS:We followed 114,841 individuals who had a prescription dispensed for insulin between 1 July and 31 December 2005. From 1 January 2006 to 31 December 2007, we noted ...

journal_title：Diabetologia

authors： Jonasson JM,Ljung R,Talbäck M,Haglund B,Gudbjörnsdòttir S,Steineck G

更新日期：2009-09-01 00:00:00

abstract：:Cases of malnutrition-related diabetes mellitus conforming to the description of the protein deficient pancreatic diabetes type in Ethiopian patients were compared with Type 1 (insulin-dependent) and Type 2 (non-insulin-dependent) diabetic. Fourteen of 39 malnutrition-related diabetes mellitus patients had fat malabso...

journal_title：Diabetologia

authors： Abdulkadir J,Mengesha B,Welde Gebriel Z,Keen H,Worku Y,Gebre P,Bekele A,Urga K,Taddesse AS

更新日期：1990-04-01 00:00:00

abstract：AIMS/HYPOTHESIS:The aims of this work were to assess glycaemic control in metformin users receiving their first add-on glucose-lowering therapy and to examine the real-life effectiveness of different add-on drugs. METHODS:We carried out a population-based cohort study using healthcare databases in northern Denmark dur...

journal_title：Diabetologia

authors： Thomsen RW,Baggesen LM,Søgaard M,Pedersen L,Nørrelund H,Buhl ES,Haase CL,Johnsen SP

更新日期：2015-10-01 00:00:00

abstract：AIMS/HYPOTHESIS:The main objective of this work was to discover new drugs that can activate the differentiation of multipotent pancreatic progenitors into endocrine cells. METHODS:In vitro experiments were performed using fetal pancreatic explants from rats and mice. In this assay, we examined the actions on pancreati...

journal_title：Diabetologia

authors： Zertal-Zidani S,Busiah K,Edelman A,Polak M,Scharfmann R

更新日期：2013-02-01 00:00:00

abstract：AIMS/HYPOTHESIS:The aim of this study was to investigate whether components of the renin-angiotensin system and semicarbazide-sensitive amine oxidase (SSAO) are associated with the development of pre-eclampsia in women with type 1 diabetes. METHODS:This was an observational study of 107 consecutive pregnant women with...

journal_title：Diabetologia

authors： Ringholm L,Pedersen-Bjergaard U,Thorsteinsson B,Boomsma F,Damm P,Mathiesen ER

更新日期：2011-07-01 00:00:00

abstract：:Families (n = 14) with more than 1 sibling with insulin dependent diabetes were matched with families of similar size and age distribution containing only 1 affected child. The distribution of HLA haplotypes, age of onset of disease, and seasonal onset of disease were compared in the two groups. The data are not consi...

journal_title：Diabetologia

authors： Jaworski MA,Colle E,Guttmann RD,Belmonte MM,Taylor B,Crepeau MP,Wilkins J,Poirier R

更新日期：1980-08-01 00:00:00

abstract：AIMS/HYPOTHESIS:Cre-loxP systems are frequently used in mouse genetics as research tools for studying tissue-specific functions of numerous genes/proteins. However, the expression of Cre recombinase in a tissue-specific manner often produces undesirable changes in mouse biology that can confound data interpretation whe...

journal_title：Diabetologia

authors： Al Batran R,Gopal K,Martin MD,Ho KL,Almutairi M,Aburasayn H,Eaton F,Campbell JE,Ussher JR

更新日期：2018-08-01 00:00:00

abstract：:A rapid chromatography method for separating glycosylated protein from non-glycosylated protein, using a boronate-agarose affinity medium which selectively binds the cis-diol groups of glycoproteins, was used to quantitate plasma glycoprotein as well as glycohaemoglobin. The results were found to be independent of: (1...

journal_title：Diabetologia

authors： Willey DG,Rosenthal MA,Caldwell S

更新日期：1984-07-01 00:00:00

abstract：:Bone remodelling, which maintains bone mass constant during adulthood, is an energy-demanding process. This, together with the observation that the adipocyte-derived hormone leptin is a major inhibitor of bone remodelling, led to the hypothesis that bone cells regulate energy metabolism through an endocrine mechanism....

journal_title：Diabetologia

authors： Ducy P

更新日期：2011-06-01 00:00:00

abstract：:Groups of normal rats and of normal and insulin-immunized guinea pigs were injected intravasculary with mixtures of radio-iodinated and unlabelled porcine insulins. No differences could be discerned between the fates of radio-iodinated and unlabelled insulins in normal or immune guinea pigs except with respect to the ...

journal_title：Diabetologia

authors： Wright PH,Gingerich RL,Oliver JR

更新日期：1975-08-01 00:00:00