Abstract：
AIMS/HYPOTHESIS:The aim of this study was to determine whether presence of the metabolic syndrome in pregnancy associates with child telomere length or child anthropometry (weight, BMI) and BP, measured at 10 years of age. METHODS:The Screening for Pregnancy Endpoints study (SCOPE) was a multicentre, international prospective cohort of nulliparous pregnant women recruited from Australia, New Zealand, Ireland and the UK (N = 5628). The current analysis is a 10 year follow-up of SCOPE pregnant women and their children, from the Australian cohort. Clinical data collected at 14-16 weeks' gestation during the SCOPE study were used to diagnose the metabolic syndrome using IDF criteria. Telomere length, a biomarker of ageing, was assessed by quantitative PCR from children's saliva collected at 10 years of age. RESULTS:In women who completed follow-up (n = 255), 20% had the metabolic syndrome in pregnancy. After adjusting for a range of confounders, children of mothers who had the metabolic syndrome in pregnancy had 14% shorter telomeres than children of mothers without the metabolic syndrome in pregnancy (mean difference -0.36 [95% CI -0.74, 0.01]). Height- and weight-for-age, and BMI z scores were similar in children of mothers who did and did not have the metabolic syndrome during pregnancy. CONCLUSIONS/INTERPRETATION:Children of mothers who had the metabolic syndrome in pregnancy have shorter telomeres, a biomarker of accelerated ageing. These findings warrant further studies in larger cohorts of children, as well as investigations into whether telomere length measured in cord blood associates with telomere length in childhood.
journal_name
Diabetologiajournal_title
Diabetologiaauthors
McAninch D,Bianco-Miotto T,Gatford KL,Leemaqz SY,Andraweera PH,Garrett A,Plummer MD,Dekker GA,Roberts CT,Smithers LG,Grieger JAdoi
10.1007/s00125-020-05242-0subject
Has Abstractpub_date
2020-10-01 00:00:00pages
2140-2149issue
10eissn
0012-186Xissn
1432-0428pii
10.1007/s00125-020-05242-0journal_volume
63pub_type
杂志文章相关文献
DIABETOLOGIA文献大全abstract：AIMS/HYPOTHESIS:We aimed to examine whether impaired glucose tolerance is associated with reduced suppression of glucagon concentrations. METHODS:Eighty-four non-diabetic women of Caucasian origin and 61 years of age, of whom 48 had normal glucose tolerance (NGT) and 36 had IGT, underwent a 75 g OGTT and a hyperinsuli...
journal_title：Diabetologia
pub_type： 杂志文章
doi：10.1007/s001250100003
更新日期：2001-11-01 00:00:00
abstract：AIMS/HYPOTHESIS:Simultaneous kidney-pancreas transplantation is an established treatment for patients with type 1 diabetes and end-stage renal failure, even though restored beta cell function may become affected by recurrent islet autoimmunity or graft rejection. We characterised infiltrating lymphocytes isolated from ...
journal_title：Diabetologia
pub_type： 杂志文章
doi：10.1007/s00125-008-1237-z
更新日期：2009-03-01 00:00:00
abstract：:Efforts to phenotype pancreatic islets have contributed tremendously to our present understanding of endocrine function and diabetes. A continued evolution in approaches to study islet physiology is important given the need to establish reference points for mature islet functionality, understanding biological variatio...
journal_title：Diabetologia
pub_type： 杂志文章,评审
doi：10.1007/s00125-020-05159-8
更新日期：2020-10-01 00:00:00
abstract：:Oxidative stress has long been considered a key driving factor of many obesity-related health problems. However, recent work by Merry, Tran et al (Diabetologia DOI 10.1007/s00125-016-4084-3 ) challenges this idea with an interesting study using a hepatocyte-specific Gpx1-knockout (HGKO) mouse. GPX1 is an important det...
journal_title：Diabetologia
pub_type： 评论,社论
doi：10.1007/s00125-016-4117-y
更新日期：2016-12-01 00:00:00
abstract：AIMS/HYPOTHESIS:We assessed the effects of vildagliptin, a novel dipeptidyl peptidase IV inhibitor, on postprandial lipid and lipoprotein metabolism in patients with type 2 diabetes. SUBJECTS, MATERIALS AND METHODS:This was a single-centre, randomised, double-blind study in drug-naive patients with type 2 diabetes. Pa...
journal_title：Diabetologia
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00125-006-0340-2
更新日期：2006-09-01 00:00:00
abstract：AIMS/HYPOTHESIS:Microvascular endothelial hyperpermeability, mainly caused by claudin-5 deficiency, is the initial pathological change that occurs in diabetes-associated cardiovascular disease. The ketone body β-hydroxybutyrate (BHB) exerts unique beneficial effects on the cardiovascular system, but the involvement of ...
journal_title：Diabetologia
pub_type： 杂志文章
doi：10.1007/s00125-020-05305-2
更新日期：2021-01-01 00:00:00
abstract：AIMS/HYPOTHESIS:Studies have identified an association between diabetes and breast cancer in postmenopausal women in Western countries. Such an association needs to be confirmed in an Asian population. The aim of this study was to evaluate the secular trend for breast cancer mortality in Taiwanese women in the general ...
journal_title：Diabetologia
pub_type： 杂志文章
doi：10.1007/s00125-008-1204-8
更新日期：2009-02-01 00:00:00
abstract：AIMS/HYPOTHESIS:Increased expression and decreased degradation of extracellular matrix (ECM) proteins are key features of chronic diabetic complications. Fibronectin, a predominant ECM protein, has been shown to be overexpressed in all target organs of diabetic complications and in endothelial cells cultured in high le...
journal_title：Diabetologia
pub_type： 杂志文章
doi：10.1007/s00125-005-1939-4
更新日期：2005-11-01 00:00:00
abstract：:The increase in urinary albumin excretion induced by acute exercise in Type 1 (insulin-dependent) diabetic patients is associated with the urinary excretion of cationic proteins. To test whether the renal excretion of glycated albumin (more anionic than non-glycated albumin) is affected by exercise, we submitted seven...
journal_title：Diabetologia
pub_type： 杂志文章
doi：10.1007/BF00408356
更新日期：1991-11-01 00:00:00
abstract：AIMS/HYPOTHESIS:Hyperglycaemia, a key feature of diabetes, is associated with non-enzymatic glycation of plasma proteins. We have shown previously that the reactive alpha-oxoaldehyde, methylglyoxal, non-enzymatically glycates apolipoprotein (Apo)A-I, the main apolipoprotein of HDL, and prevents it from activating lecit...
journal_title：Diabetologia
pub_type： 杂志文章
doi：10.1007/s00125-008-0986-z
更新日期：2008-06-01 00:00:00
abstract：:Hyperinsulinaemia is a reported feature of the inherited multisystem disorder myotonic dystrophy. This phenomenon has been attributed to a compensatory beta cell response to tissue insulin resistance. In this study, circulating concentrations of insulin, proinsulin, and split proinsulin molecules were determined after...
journal_title：Diabetologia
pub_type： 杂志文章
doi：10.1007/BF00401372
更新日期：1992-12-01 00:00:00
abstract：AIMS/HYPOTHESIS:We set out to validate a recently reported type 1 diabetes association from the IFIH1 gene variation in an independent cohort from a population of mixed European descent. METHODS:We genotyped five single-nucleotide polymorphisms in the IFIH1 locus, i.e. rs2111485, rs1990760, rs3747517, rs17783344 and r...
journal_title：Diabetologia
pub_type： 杂志文章
doi：10.1007/s00125-007-0895-6
更新日期：2008-03-01 00:00:00
abstract：:There is ample evidence that environmental factors are involved in the aetiology of type 1 diabetes, but the nature and timing of the interactions are poorly understood. The intrauterine environment is known to play a role in the later development of type 2 diabetes, and this review considers a possible role in type 1...
journal_title：Diabetologia
pub_type： 杂志文章,评审
doi：10.1007/s00125-013-2929-6
更新日期：2013-09-01 00:00:00
abstract：:Non-obese diabetic mice were treated daily with a mixture of gangliosides from day 30 until day 250 of life or until the mice became diabetic. Ganglioside treatment reduced diabetes incidence from 80-90% to 47% and from 20-30% to zero in female and male mice respectively. Gangliosides did not affect the frequency of p...
journal_title：Diabetologia
pub_type： 杂志文章
doi：10.1007/BF00277490
更新日期：1988-11-01 00:00:00
abstract：AIMS/HYPOTHESIS:White cell count has been shown to predict incident type 2 diabetes, but differential white cell count has received scant attention. We examined the risk of developing diabetes associated with differential white cell count and neutrophil:lymphocyte ratio and the effect of insulin sensitivity and subclin...
journal_title：Diabetologia
pub_type： 杂志文章
doi：10.1007/s00125-013-3080-0
更新日期：2014-01-01 00:00:00
abstract：AIMS/HYPOTHESIS:Vitamin D, a molecule with antiproliferative, antiangiogenic, antioxidant and immunosuppressive effects, could play a role in the pathogenesis of severe diabetic retinopathy. We examined whether Taq I polymorphism of the vitamin D receptor is involved in the development of severe diabetic retinopathy. ...
journal_title：Diabetologia
pub_type： 杂志文章
doi：10.1007/s00125-001-0769-2
更新日期：2002-03-01 00:00:00
abstract：AIMS/HYPOTHESIS:We examined the acute postprandial effects of meals containing unsaturated fatty acids on flow-mediated dilation (FMD) of the brachial artery and triacylglycerols in individuals with type 2 diabetes. We hypothesised that consumption of omega-3 fatty acids would enhance vascular function. Saturated fat r...
journal_title：Diabetologia
pub_type： 杂志文章
doi：10.1007/s00125-004-1600-7
更新日期：2005-01-01 00:00:00
abstract：AIMS/HYPOTHESIS:Inflammation is associated with obesity and has been implicated in the development of diabetes and atherosclerosis. During gram-negative bacterial infection, lipopolysaccharide causes an inflammatory reaction via toll-like receptor 4 (TLR4), which has an essential function in the induction of innate and...
journal_title：Diabetologia
pub_type： 杂志文章
doi：10.1007/s00125-007-0654-8
更新日期：2007-06-01 00:00:00
abstract：AIMS/HYPOTHESIS:Glucagon-like peptide-1 (GLP-1), a polypeptide hormone secreted by the l-cells in the gastrointestinal tract, has shown promising effects as a new treatment modality for patients with Type II (non-insulin-dependent) diabetes mellitus. However, the pharmacokinetic profile of native GLP-1 with a rapid eli...
journal_title：Diabetologia
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/s00125-001-0719-z
更新日期：2002-02-01 00:00:00
abstract：AIMS/HYPOTHESIS:Depression and glucose intolerance commonly co-occur among non-pregnant individuals; however, the temporal relationship between gestational diabetes (GDM) and depression during pregnancy and the postpartum period is less understood. Our objective was to assess longitudinal associations between depressio...
journal_title：Diabetologia
pub_type： 杂志文章
doi：10.1007/s00125-016-4086-1
更新日期：2016-12-01 00:00:00
abstract：:The spontaneous hypertensive rat is an animal model characterized by a syndrome of hypertension, insulin resistance and hyperinsulinaemia. To elucidate whether in analogy to other insulin resistant animal models an inactivity of the insulin receptor kinase or an alteration of the glucose transporter (GLUT 4) level in ...
journal_title：Diabetologia
pub_type： 杂志文章
doi：10.1007/BF00429089
更新日期：1992-08-01 00:00:00
abstract：:C-peptide was determined in 24-h urine collections and in fasting plasma of 27 Type 1 (insulin-dependent) diabetic children (duration of disease 0-6 years) and in 11 matched normal children. Grouping the patients according to duration of disease from onset to 6 years, it was found that in the first year of disease the...
journal_title：Diabetologia
pub_type： 杂志文章
doi：10.1007/BF00297387
更新日期：1983-02-01 00:00:00
abstract：AIMS/HYPOTHESIS:The AERx insulin Diabetes Management system (AERx iDMS) is a liquid aerosol device that enables insulin to be administered to the peripheral parts of the lung. This study aimed to compare the pharmacokinetic and pharmacodynamic properties of insulin which is inhaled using AERx iDMS with insulin which is...
journal_title：Diabetologia
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/s001250051618
更新日期：2001-03-01 00:00:00
abstract：:The kidney plays a pivotal role in the clearance and degradation of circulating insulin and is also an important site of insulin action. The kidney clears insulin via two distinct routes. The first route entails glomerular filtration and subsequent luminal reabsorption of insulin by proximal tubular cells by means of ...
journal_title：Diabetologia
pub_type： 杂志文章,评审
doi：10.1007/BF00304849
更新日期：1984-09-01 00:00:00
abstract：:We studied the effect of chronic exposure to high glucose on the glucose transport regulation in hamster pancreatic Beta cells in permanent culture (HIT). Cells were exposed to either 5.5 mmol/l or 16.7 mmol/l glucose for 48 h and then glucose transport was studied by measuring the (3H)-2-deoxyglucose uptake for 5 and...
journal_title：Diabetologia
pub_type： 杂志文章
doi：10.1007/BF00405011
更新日期：1991-05-01 00:00:00
abstract：:Endothelium-derived nitric oxide plays a major role in the regulation of vascular tone and in the maintenance of vascular homeostasis. Endothelial dysfunction with impaired nitric oxide biosynthesis and decreased bioavailability has been implicated in insulin resistance syndrome and Type II (non-insulin-dependent) dia...
journal_title：Diabetologia
pub_type： 杂志文章,评审
doi：10.1007/s00125-002-0975-6
更新日期：2002-12-01 00:00:00
abstract：:Four patients with glucagon-producing tumours of the pancreas were investigated. Fasting plasma glucagon concentrations ranged from 209--625 pmol/l. Plasma insulin concentrations were normal except in one patient, where the tumour also produced insulin (558 pmol/l). Intravenous glucose (25 g/m2) depressed the glucagon...
journal_title：Diabetologia
pub_type： 杂志文章
doi：10.1007/BF01219741
更新日期：1979-09-01 00:00:00
abstract：AIMS/HYPOTHESIS:Mesenchymal stem cells (MSCs) can exert an immunosuppressive effect on any component of the immune system, including dendritic cells (DCs), by direct contact, the release of soluble markers and extracellular vesicles (EVs). We evaluated whether MSCs and MSC-derived EVs have an immunomodulatory effect on...
journal_title：Diabetologia
pub_type： 杂志文章
doi：10.1007/s00125-015-3808-0
更新日期：2016-02-01 00:00:00
abstract：:A copy deoxyribonucleic acid (cDNA) clone of the immediate early growth response gene, egr-1 (Krox-24, Zif268, NGFI-1), was isolated through subtractive hybridization screening to identify glucose-induced genes in pancreatic beta cells. Glucose rapidly and transiently induced egr-1 mRNA in the SV40-transformed murine ...
journal_title：Diabetologia
pub_type： 杂志文章
doi：10.1007/s001250051139
更新日期：1999-02-01 00:00:00
abstract：:Previously published Type I (insulin-dependent) diabetes mellitus incidence in 0 to 14-year-old children from 10 countries or areas was compared with the national annual cow milk protein consumption. Countries which were selected for study had appropriate milk protein polymorphism studies, herd breed composition infor...
journal_title：Diabetologia
pub_type： 杂志文章
doi：10.1007/s001250051153
更新日期：1999-03-01 00:00:00
