听力与言语-语言病理学

行为科学

医学伦理学

你正在浏览TRENDS IN IMMUNOLOGY期刊下所有文献
  • Systemic Immunoregulatory Consequences of Gut Commensal Translocation.

    abstract::One major determinant of systemic immunity during homeostasis and in certain complex multifactorial diseases (e.g. cancer and autoimmune conditions), is the gut microbiota. These commensals can shape systemic immune responses via translocation of metabolites, microbial cell wall components, and viable microbes. In the...

    journal_title:Trends in immunology

    pub_type: 杂志文章,评审

    doi:10.1016/j.it.2020.12.005

    authors: McPherson AC,Pandey SP,Bender MJ,Meisel M

    更新日期:2021-02-01 00:00:00

  • Decoding the Heterogeneity of Human Dendritic Cell Subsets.

    abstract::Dendritic cells (DCs) have been classified into distinct subsets based on phenotype and ontogeny. In the past few years, high throughput single-cell approaches have revealed further heterogeneity of human DCs, in particular at the transcriptomic level. Herein examined, are recent studies describing new human DC popula...

    journal_title:Trends in immunology

    pub_type: 杂志文章,评审

    doi:10.1016/j.it.2020.10.002

    authors: Villar J,Segura E

    更新日期:2020-12-01 00:00:00

  • Turning Discoveries into Treatments: Immunology in Africa.

    abstract::An exemplar outcome of an immunology-based intervention is vaccine development; the current COVID-19 pandemic is a case in point. Can we build an immunology research ecosystem in Africa that nurtures discovery and enables translation? We see African immunologists as key agents of change and discuss obstacles and oppor...

    journal_title:Trends in immunology

    pub_type: 杂志文章,评审

    doi:10.1016/j.it.2020.10.007

    authors: Osier FHA,Mwandumba HC,Gray CM

    更新日期:2020-12-01 00:00:00

  • The Paradoxical Roles of Inflammation during PD-1 Blockade in Cancer.

    abstract::Recent studies have reported paradoxical roles of inflammation in tumor immunity triggered by PD-1 checkpoint antibody (Ab) blockade. Here, we elaborate on this controversy and propose a new perspective that might help understand this paradox. Since inflammatory cytokines and PD-1 blockade are known to target differen...

    journal_title:Trends in immunology

    pub_type: 杂志文章,评审

    doi:10.1016/j.it.2020.09.003

    authors: Hill M,Segovia M,Russo S,Girotti MR,Rabinovich GA

    更新日期:2020-11-01 00:00:00

  • Overcoming Immune Checkpoint Blockade Resistance via EZH2 Inhibition.

    abstract::Recent progress in cancer immunotherapy highlights the power of the immune system to control tumors, although a small patient subset responds to current immunotherapies. Additional approaches to mobilize antitumor immunity are required to overcome primary and acquired resistance to immunotherapy such as immune checkpo...

    journal_title:Trends in immunology

    pub_type: 评审

    doi:10.1016/j.it.2020.08.010

    authors: Kim HJ,Cantor H,Cosmopoulos K

    更新日期:2020-10-01 00:00:00

  • Tissue-Specific Features of Innate Lymphoid Cells.

    abstract::Although the function of the circulating immune cell compartment has been studied in detail for decades, limitations in terms of access and cell yields from peripheral tissues have restricted our understanding of tissue-based immunity, particularly in humans. Recent advances in high-throughput protein analyses, transc...

    journal_title:Trends in immunology

    pub_type: 杂志文章,评审

    doi:10.1016/j.it.2020.08.009

    authors: Meininger I,Carrasco A,Rao A,Soini T,Kokkinou E,Mjösberg J

    更新日期:2020-10-01 00:00:00

  • miRNA-Based Therapies in B Cell Non-Hodgkin Lymphoma.

    abstract::Non-Hodgkin lymphoma (NHL) is a diverse class of hematological cancers, many of which arise from germinal center (GC)-experienced B cells. Thus GCs, the sites of antibody affinity maturation triggered during immune responses, also provide an environment that facilitates B cell oncogenic transformation. miRNAs provide ...

    journal_title:Trends in immunology

    pub_type: 杂志文章,评审

    doi:10.1016/j.it.2020.08.006

    authors: Fuertes T,Ramiro AR,de Yebenes VG

    更新日期:2020-10-01 00:00:00

  • Astrocyte Reactivity: Subtypes, States, and Functions in CNS Innate Immunity.

    abstract::Astrocytes are neural parenchymal cells that ubiquitously tile the central nervous system (CNS). In addition to playing essential roles in healthy tissue, astrocytes exhibit an evolutionarily ancient response to all CNS insults, referred to as astrocyte reactivity. Long regarded as passive and homogeneous, astrocyte r...

    journal_title:Trends in immunology

    pub_type: 杂志文章,评审

    doi:10.1016/j.it.2020.07.004

    authors: Sofroniew MV

    更新日期:2020-09-01 00:00:00

  • Rewriting History: Epigenetic Reprogramming of CD8+ T Cell Differentiation to Enhance Immunotherapy.

    abstract::The full potential of T cell-based immunotherapies remains limited by a variety of T cell extrinsic and intrinsic immunosuppressive mechanisms that can become imprinted to stably reduce the antitumor ability of T cells. Here, we discuss recent insights into memory CD8+ T cell differentiation and exhaustion and the ass...

    journal_title:Trends in immunology

    pub_type: 杂志文章,评审

    doi:10.1016/j.it.2020.06.008

    authors: Zebley CC,Gottschalk S,Youngblood B

    更新日期:2020-08-01 00:00:00

  • AID in Antibody Diversification: There and Back Again.

    abstract::Activation-Induced cytidine Deaminase (AID) initiates affinity maturation and isotype switching by deaminating deoxycytidines within immunoglobulin genes, leading to somatic hypermutation (SHM) and class switch recombination (CSR). AID thus potentiates the humoral response to clear pathogens. Marking the 20th annivers...

    journal_title:Trends in immunology

    pub_type: 杂志文章,评审

    doi:10.1016/j.it.2020.04.009

    authors: Feng Y,Seija N,Di Noia JM,Martin A

    更新日期:2020-07-01 00:00:00

  • Origins of the RAG Transposome and the MHC.

    abstract::How innate immunity gave rise to adaptive immunity in vertebrates remains unknown. We propose an evolutionary scenario beginning with pathogen-associated molecular pattern(s) (PAMPs) being presented by molecule(s) on one cell to specific receptor(s) on other cells, much like MHC molecules and T cell receptors (TCRs). ...

    journal_title:Trends in immunology

    pub_type: 杂志文章,评审

    doi:10.1016/j.it.2020.05.002

    authors: Tsakou-Ngouafo L,Paganini J,Kaufman J,Pontarotti P

    更新日期:2020-07-01 00:00:00

  • Inflammation and Skeletal Muscle Regeneration: Leave It to the Macrophages!

    abstract::Inflammation is usually considered as harmful; however, it is also necessary for tissue recovery after injury. Macrophages exert immune and nonimmune functions throughout this process. During skeletal muscle regeneration, they mount an inflammatory response while exerting trophic roles on muscle and mesenchymal stem c...

    journal_title:Trends in immunology

    pub_type: 杂志文章,评审

    doi:10.1016/j.it.2020.04.006

    authors: Chazaud B

    更新日期:2020-06-01 00:00:00

  • ILC3s: Rhythmic Keepers of Gut Integrity at Mealtime.

    abstract::Cyclically, during the day, increased permeability of the intestinal epithelial barrier, allowing nutrient uptake, must be compensated for, to achieve increased protection against potentially harmful components. Seillet et al. demonstrate that, upon food intake, enteric neuron-derived VIP promotes anticipatory mucosal...

    journal_title:Trends in immunology

    pub_type: 评论,杂志文章

    doi:10.1016/j.it.2020.03.011

    authors: Quatrini L,Moretta L,Mingari MC

    更新日期:2020-05-01 00:00:00

  • Noncanonical Functions of Antibodies.

    abstract::The typical functions of antibodies are based on linking the process of antigen recognition with initiation of innate immune reactions. With the introduction of modern research technologies and the use of sophisticated model systems, recent years have witnessed the discovery of a number of noncanonical functions of an...

    journal_title:Trends in immunology

    pub_type: 杂志文章,评审

    doi:10.1016/j.it.2020.03.006

    authors: Dimitrov JD,Lacroix-Desmazes S

    更新日期:2020-05-01 00:00:00

  • Stem, Effector, and Hybrid States of Memory CD8+ T Cells.

    abstract::CD8+ T cell immunological memory of past antigen exposure can confer long-lived protection against infections or tumors. The fact that CD8+ memory T cells can have features of both naïve and effector cells has forced the field to struggle with several conceptual questions about the developmental origin of the cell and...

    journal_title:Trends in immunology

    pub_type: 杂志文章,评审

    doi:10.1016/j.it.2019.11.004

    authors: Lugli E,Galletti G,Boi SK,Youngblood BA

    更新日期:2020-01-01 00:00:00

  • Exhausted-like Group 2 Innate Lymphoid Cells in Chronic Allergic Inflammation.

    abstract::Mammalian group 2 innate lymphoid cells (ILC2s) are responsible for the early production of type 2 cytokines at mucosal barriers upon exposure to allergen. Inflammatory tissue environmental cues can influence ILC2 activity, and this cellular population can be further categorized into subtypes with additional or altern...

    journal_title:Trends in immunology

    pub_type: 杂志文章,评审

    doi:10.1016/j.it.2019.10.007

    authors: Ebihara T,Taniuchi I

    更新日期:2019-12-01 00:00:00

  • A TCR-Dependent Tissue Repair Potential of MAIT Cells.

    abstract::Three studies published in Cell Reports (Hinks et al., Lamichhane et al., and Leng et al.) describe the transcriptome of human and mouse mucosal-associated invariant T (MAIT) cells after cognate and noncognate stimulation. The results confirm the variability of MAIT cell effector functions and provide evidence of a ne...

    journal_title:Trends in immunology

    pub_type: 评论,杂志文章

    doi:10.1016/j.it.2019.09.001

    authors: Salou M,Lantz O

    更新日期:2019-11-01 00:00:00

  • Platelets in Host Defense: Experimental and Clinical Insights.

    abstract::Platelets are central players in thrombosis and hemostasis but are increasingly recognized as key components of the immune system. They shape ensuing immune responses by recruiting leukocytes, and support the development of adaptive immunity. Recent data shed new light on the complex role of platelets in immunity. Her...

    journal_title:Trends in immunology

    pub_type: 杂志文章,评审

    doi:10.1016/j.it.2019.08.004

    authors: Nicolai L,Gaertner F,Massberg S

    更新日期:2019-10-01 00:00:00

  • Old T Cells Interfer(on) with Neurogenesis.

    abstract::Adult neurogenesis plays an important role in brain function and declines with aging. A recent report demonstrates clonal T cell expansion within neurogenic niches of the aged brain, impairing neurogenesis through IFNγ signaling (Dulken et al.,Nature, 2019). These results highlight T cells as important contributors to...

    journal_title:Trends in immunology

    pub_type: 评论,杂志文章

    doi:10.1016/j.it.2019.07.007

    authors: Rustenhoven J,Herz J,Kipnis J

    更新日期:2019-09-01 00:00:00

  • Transposons to V(D)J Recombination: Evolution of the RAG Reaction.

    abstract::Evolutionarily, how RAG endonucleases in vertebrate immune systems could shed dangerous transposon-like propensities, and instead, support the organized assembly of antigen receptor variable domains, has been unclear. Recent structural work by Schatz and colleagues (Nature, 2019) identifies features of the RAG endonuc...

    journal_title:Trends in immunology

    pub_type: 评论,杂志文章

    doi:10.1016/j.it.2019.06.007

    authors: Lieber MR

    更新日期:2019-08-01 00:00:00

  • Modulation of Innate Immunity by Amyloidogenic Peptides.

    abstract::Amyloid formation contributes to the development of progressive metabolic and neurodegenerative diseases, while also serving functional roles in host defense. Emerging evidence suggests that as amyloidogenic peptides populate distinct aggregation states, they interact with different combinations of pattern recognition...

    journal_title:Trends in immunology

    pub_type: 杂志文章,评审

    doi:10.1016/j.it.2019.06.005

    authors: Westwell-Roper C,Verchere CB

    更新日期:2019-08-01 00:00:00

  • Mediators of the Resolution of the Inflammatory Response.

    abstract::The termination of inflammation is governed by endogenous molecules collectively referred to as 'mediators of resolution' of inflammation. There is now strong evidence to suggest that failed resolution may underpin autoimmune and inflammatory diseases and could thus be targeted to decrease inflammation. There are many...

    journal_title:Trends in immunology

    pub_type: 杂志文章,评审

    doi:10.1016/j.it.2019.01.007

    authors: Sugimoto MA,Vago JP,Perretti M,Teixeira MM

    更新日期:2019-03-01 00:00:00

  • The Emergence of Natural Killer Cells as a Major Target in Cancer Immunotherapy.

    abstract::Immune 'checkpoint' inhibitors can increase the activity of tumor-resident cytotoxic lymphocytes and have revolutionized cancer treatment. Current therapies block inhibitory pathways in tumor-infiltrating CD8+ T cells and recent studies have shown similar programs in other effector populations such as natural killer (...

    journal_title:Trends in immunology

    pub_type: 杂志文章,评审

    doi:10.1016/j.it.2018.12.003

    authors: Souza-Fonseca-Guimaraes F,Cursons J,Huntington ND

    更新日期:2019-02-01 00:00:00

  • Immunological Functions and Evolutionary Emergence of Heavy-Chain Antibodies.

    abstract::Homodimeric antibodies devoid of light chains have evolved multiple times through convergent evolution, yet their specific immunological functions remain poorly understood. We survey the molecular and structural features of these antibodies, their immunological functions in host defense, and reflect on the long-standi...

    journal_title:Trends in immunology

    pub_type: 杂志文章,评审

    doi:10.1016/j.it.2018.09.008

    authors: Brooks CL,Rossotti MA,Henry KA

    更新日期:2018-12-01 00:00:00

  • The Lung Microvasculature Is a Functional Immune Niche.

    abstract::Lung capillaries, best known for vital gas exchange, also contribute to neutrophil margination, a phenomenon resulting in large numbers of pulmonary vascular neutrophils. Importantly, the functional relevance of neutrophil margination is unknown. Recent advances in microscopy have altered our understanding of why neut...

    journal_title:Trends in immunology

    pub_type: 杂志文章,评审

    doi:10.1016/j.it.2018.09.002

    authors: Granton E,Kim JH,Podstawka J,Yipp BG

    更新日期:2018-11-01 00:00:00

  • Mucosal and Skin Langerhans Cells - Nurture Calls.

    abstract::Langerhans cells (LCs) are classically viewed as unique antigen-presenting cells (APCs) that originate from embryonic precursors and maintain themselves independently in the epidermis. However, recent studies have demonstrated that murine LCs in mucosal epithelia arise and are continuously replenished from circulating...

    journal_title:Trends in immunology

    pub_type: 杂志文章,评审

    doi:10.1016/j.it.2018.08.007

    authors: Hovav AH

    更新日期:2018-10-01 00:00:00

  • 'NOTCHing up' the In Vitro Production of Dendritic Cells.

    abstract::Two studies show that adding NOTCH ligands to Flt3L cultures increases the yield of cDC1s from mouse and human progenitors. Moreover, these NOTCH-DCs more closely resemble in vivo DCs transcriptionally and functionally. This will be extremely valuable for studying DCs in vitro and for further developing autologous DC-...

    journal_title:Trends in immunology

    pub_type: 评论,杂志文章

    doi:10.1016/j.it.2018.08.002

    authors: Guilliams M,Scott CL

    更新日期:2018-10-01 00:00:00

  • Natural Killer Cells Detect a Tumor-Produced Growth Factor: A Vestige of Antiviral Resistance?

    abstract::In addition to exogenous ligands derived from pathogens, natural killer (NK) and other innate cells can recognize endogenous ligands that often act as markers of stress or damage. A recent study reports that one of these receptors, human NKp44, recognizes PDGF-DD, providing a rare example of the recognition of a solub...

    journal_title:Trends in immunology

    pub_type: 评论,杂志文章

    doi:10.1016/j.it.2018.02.002

    authors: Trinchieri G

    更新日期:2018-05-01 00:00:00

  • When Clarity Is Crucial: Regulating Ocular Surface Immunity.

    abstract::The ocular surface is a unique mucosal immune compartment in which anatomical, physiological, and immunological features act in concert to foster a particularly tolerant microenvironment. These mechanisms are vital to the functional competence of the eye, a fact underscored by the devastating toll of excessive inflamm...

    journal_title:Trends in immunology

    pub_type: 杂志文章,评审

    doi:10.1016/j.it.2017.11.007

    authors: Foulsham W,Coco G,Amouzegar A,Chauhan SK,Dana R

    更新日期:2018-04-01 00:00:00

  • PD-1hiCXCR5-CD4+ TFH Cells Play Defense in Cancer and Offense in Arthritis.

    abstract::T follicular helper (TFH) cells are characteristically defined by their CXCR5 positivity and homing to B cell follicles in secondary lymphoid organs (SLO). An expanded subpopulation of functionally comparable and phenotypically similar PD-1hiCXCR5-CD4+ T cells were recently identified in breast cancer (BC) and rheumat...

    journal_title:Trends in immunology

    pub_type: 杂志文章

    doi:10.1016/j.it.2017.10.003

    authors: Gu-Trantien C,Willard-Gallo K

    更新日期:2017-12-01 00:00:00

  • NOD1 and NOD2: Beyond Peptidoglycan Sensing.

    abstract::NOD1 and NOD2 are pattern recognition receptors of the innate immune system with well-established roles in sensing fragments of bacterial peptidoglycan. In addition to their role as microbial sensors, recent evidence indicates that nucleotide-binding oligomerization domains (NODs) can also recognize a broader array of...

    journal_title:Trends in immunology

    pub_type: 杂志文章,评审

    doi:10.1016/j.it.2017.07.004

    authors: Keestra-Gounder AM,Tsolis RM

    更新日期:2017-10-01 00:00:00

  • Positive and Negative Signals in Mast Cell Activation.

    abstract::Mast cells are powerful immune modulators of the tissue microenvironment. Within seconds of activation, these cells release a variety of preformed biologically active products, followed by a wave of mediator synthesis and secretion. Increasing evidence suggests that an intricate network of inhibitory and activating re...

    journal_title:Trends in immunology

    pub_type: 杂志文章,评审

    doi:10.1016/j.it.2017.01.008

    authors: Bulfone-Paus S,Nilsson G,Draber P,Blank U,Levi-Schaffer F

    更新日期:2017-09-01 00:00:00

  • Molecular Dissection of CD8+ T-Cell Dysfunction.

    abstract::Chronic viral infections and cancer often lead to the emergence of dysfunctional or 'exhausted' CD8+ T cells, and the restoration of their functions is currently the focus of therapeutic interventions. In this review, we detail recent advances in the annotation of the gene modules and the epigenetic landscape associat...

    journal_title:Trends in immunology

    pub_type: 杂志文章,评审

    doi:10.1016/j.it.2017.05.008

    authors: Wang C,Singer M,Anderson AC

    更新日期:2017-08-01 00:00:00

  • T Cell Immunity and Zika Virus Vaccine Development.

    abstract::The recent Zika virus (ZIKV) epidemic has created an urgent need for a safe and effective vaccine. There is still a dearth of knowledge about ZIKV immunity, but years of investigation into the immunobiology of other flaviviruses has helped to accelerate the development of a ZIKV vaccine. Although the humoral immune re...

    journal_title:Trends in immunology

    pub_type: 杂志文章,评审

    doi:10.1016/j.it.2017.05.004

    authors: Lima NS,Rolland M,Modjarrad K,Trautmann L

    更新日期:2017-08-01 00:00:00

  • Novel Approaches to Analyze Immunoglobulin Repertoires.

    abstract::Analysis of immunoglobulin (Ig) repertoires aims to comprehend Ig diversity with the goal of predicting humoral immune responses in the context of infection, vaccination, autoimmunity, and malignancies. The first next-generation sequencing (NGS) analyses of bulk B cell populations dramatically advanced sampling depth ...

    journal_title:Trends in immunology

    pub_type: 杂志文章,评审

    doi:10.1016/j.it.2017.05.003

    authors: Wardemann H,Busse CE

    更新日期:2017-07-01 00:00:00

  • The Immunoregulatory Roles of Antibody Glycosylation.

    abstract::Beyond their role in neutralization, antibodies mediate functions such as phagocytosis, cytotoxicity, and maintenance of immune homeostasis. Two modifications to the constant domain control antibody activity: theirreversible genomic selection of isotype/subclass and alterations in glycosylation. Because glycosylation ...

    journal_title:Trends in immunology

    pub_type: 杂志文章,评审

    doi:10.1016/j.it.2017.02.004

    authors: Jennewein MF,Alter G

    更新日期:2017-05-01 00:00:00

  • Transcription Factor T-bet Orchestrates Lineage Development and Function in the Immune System.

    abstract::T-bet was originally described as the key transcription factor defining type 1 T helper (Th) cells. However, it is now clear that it drives the orchestrated generation of effector and memory cells in multiple different lymphocyte lineages. In addition to Th1 cells, CD8 T cells, B cells and some innate lymphocyte popul...

    journal_title:Trends in immunology

    pub_type: 杂志文章,评审

    doi:10.1016/j.it.2017.02.003

    authors: Kallies A,Good-Jacobson KL

    更新日期:2017-04-01 00:00:00

  • NLRP6: A Multifaceted Innate Immune Sensor.

    abstract::NLRP6, a member of the nucleotide-binding domain, leucine-rich repeat-containing (NLR) innate immune receptor family, regulates inflammation and host defense against microorganisms. Similar to other NLRs, NLRP6 not only participates in inflammasome formation, but is also involved in nuclear factor-κB (NF-κB) and mitog...

    journal_title:Trends in immunology

    pub_type: 杂志文章,评审

    doi:10.1016/j.it.2017.01.001

    authors: Levy M,Shapiro H,Thaiss CA,Elinav E

    更新日期:2017-04-01 00:00:00

  • Microbial Dysbiosis in Common Variable Immune Deficiencies: Evidence, Causes, and Consequences.

    abstract::Common variable immunodeficiency (CVID) is an immune disorder that not only causes increased susceptibility to infection, but also to inflammatory complications such as autoimmunity, lymphoid proliferation, malignancy, and granulomatous disease. Recent findings implicate the microbiome as a driver of this systemic imm...

    journal_title:Trends in immunology

    pub_type: 杂志文章,评审

    doi:10.1016/j.it.2016.11.008

    authors: Berbers RM,Nierkens S,van Laar JM,Bogaert D,Leavis HL

    更新日期:2017-03-01 00:00:00

  • T Cell Exhaustion in Glioblastoma: Intricacies of Immune Checkpoints.

    abstract::Glioblastoma is an aggressive and incurable primary brain tumor. While the blockade of immune checkpoints leads to reversal of T cell exhaustion in many cancers, the efficacy of this therapy in glioblastoma requires further consideration of the brain microenvironment beyond T cell activity. Neural cells are crucially ...

    journal_title:Trends in immunology

    pub_type: 杂志文章,评审

    doi:10.1016/j.it.2016.11.005

    authors: Mirzaei R,Sarkar S,Yong VW

    更新日期:2017-02-01 00:00:00

167 条记录 1/5 页 « 12345 »