Abstract:
:Activation-Induced cytidine Deaminase (AID) initiates affinity maturation and isotype switching by deaminating deoxycytidines within immunoglobulin genes, leading to somatic hypermutation (SHM) and class switch recombination (CSR). AID thus potentiates the humoral response to clear pathogens. Marking the 20th anniversary of the discovery of AID, we review the current understanding of AID function. We discuss AID biochemistry and how error-free forms of DNA repair are co-opted to prioritize mutagenesis over accuracy during antibody diversification. We discuss the regulation of DNA double-strand break (DSB) repair pathways during CSR. We describe genomic targeting of AID as a multilayered process involving chromatin architecture, cis- and trans-acting factors, and determining mutagenesis - distinct from AID occupancy at loci that are spared from mutation.
journal_name
Trends Immunoljournal_title
Trends in immunologyauthors
Feng Y,Seija N,Di Noia JM,Martin Adoi
10.1016/j.it.2020.04.009subject
Has Abstractpub_date
2020-07-01 00:00:00pages
586-600issue
7eissn
1471-4906issn
1471-4981pii
S1471-4906(20)30089-2journal_volume
41pub_type
杂志文章,评审abstract::The 2009 influenza pandemic highlighted the threat that type A influenza poses to human health. Thus, there is an urgency to understand the pathobiology of influenza infection and the contribution of the host immune response to virus elimination and the development of lung injury. This review focuses on the T cell arm...
journal_title:Trends in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.it.2011.02.006
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abstract::In many flowering plants, intraspecific barriers to self-fertilization ensure outbreeding by interrupting the path of pollen tube growth before egg-sperm interaction. These self-sterility or self-incompatibility (SI) systems are unique among recognition systems, in that they are based on the recognition and rejection ...
journal_title:Trends in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.it.2005.06.005
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abstract::Senescent cells, albeit not proliferating, are metabolically and transcriptionally active, thereby capable of affecting their microenvironment, notably via the production of inflammatory mediators. These mediators maintain and propagate the senescence process to neighboring cells, and then recruit immune cells for cle...
journal_title:Trends in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.it.2015.02.009
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journal_title:Trends in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.it.2018.12.003
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journal_title:Trends in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.it.2005.08.006
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abstract::Non-deletional tolerance resulting in the generation of regulatory T cells within the thymus is a key mechanism for the establishment of immunological self-tolerance. How the high-affinity self-reactive regulatory T cells escape negative selection and what type of antigen-presenting cells positively select them within...
journal_title:Trends in immunology
pub_type: 杂志文章
doi:10.1016/j.it.2006.03.004
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journal_title:Trends in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.it.2005.01.004
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journal_title:Trends in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.it.2020.08.009
更新日期:2020-10-01 00:00:00
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journal_title:Trends in immunology
pub_type: 评论,杂志文章
doi:10.1016/j.it.2016.07.003
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journal_title:Trends in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.it.2017.02.004
更新日期:2017-05-01 00:00:00
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journal_title:Trends in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.it.2005.03.001
更新日期:2005-05-01 00:00:00
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journal_title:Trends in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.it.2012.08.007
更新日期:2012-12-01 00:00:00
abstract::Plasma cells operate as factories where large quantities of Ig heavy and light chains are made and assembled into functional antibodies. The finished products are shipped out with impressive efficiency. A major component of the machinery necessary for high-rate antibody secretion is an elaborate network of endoplasmic...
journal_title:Trends in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.it.2003.11.004
更新日期:2004-01-01 00:00:00
abstract::Protection against pulmonary tuberculosis (TB) by vaccination is often ascribed to the presence of TB-reactive T cells in the lung before infection. Challenging this view, new studies analyzing vaccine-induced T cells in various tissue compartments after parenteral immunization suggest a poor correlation between the p...
journal_title:Trends in immunology
pub_type: 杂志文章
doi:10.1016/j.it.2010.05.002
更新日期:2010-07-01 00:00:00
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journal_title:Trends in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.it.2018.08.007
更新日期:2018-10-01 00:00:00
abstract::Mammalian group 2 innate lymphoid cells (ILC2s) are responsible for the early production of type 2 cytokines at mucosal barriers upon exposure to allergen. Inflammatory tissue environmental cues can influence ILC2 activity, and this cellular population can be further categorized into subtypes with additional or altern...
journal_title:Trends in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.it.2019.10.007
更新日期:2019-12-01 00:00:00
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journal_title:Trends in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.it.2008.07.004
更新日期:2008-10-01 00:00:00
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journal_title:Trends in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.it.2005.12.008
更新日期:2006-02-01 00:00:00
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journal_title:Trends in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.it.2012.11.001
更新日期:2013-05-01 00:00:00
abstract::In vitro-generated mesenchymal stem cells (MSCs) initially attracted interest for their ability to undergo differentiation toward cells of different lineages. More recently, a major breakthrough was the discovery that MSCs exert a profound inhibitory effect on T cell proliferation in vitro and in vivo. Subsequently, M...
journal_title:Trends in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.it.2007.03.001
更新日期:2007-05-01 00:00:00
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journal_title:Trends in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.it.2017.02.003
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journal_title:Trends in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.it.2005.08.013
更新日期:2005-11-01 00:00:00
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journal_title:Trends in immunology
pub_type: 历史文章,杂志文章
doi:10.1016/j.it.2016.04.005
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journal_title:Trends in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.it.2004.11.002
更新日期:2005-01-01 00:00:00
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journal_title:Trends in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.it.2004.09.012
更新日期:2004-12-01 00:00:00
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journal_title:Trends in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.it.2015.02.007
更新日期:2015-04-01 00:00:00
abstract::Inducing sustained, robust CD8(+) T cell responses is necessary for therapeutic intervention in chronic infectious diseases and cancer. Unfortunately, most adjuvant formulations fail to induce substantial cellular immunity in humans. Attenuated acute infectious agents induce strong CD8(+) T cell immunity, and are thou...
journal_title:Trends in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.it.2016.01.001
更新日期:2016-03-01 00:00:00
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journal_title:Trends in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.it.2017.01.001
更新日期:2017-04-01 00:00:00
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journal_title:Trends in immunology
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doi:10.1016/j.it.2010.06.007
更新日期:2010-09-01 00:00:00
abstract::The crucial clinical problem in leprosy is the occurrence of acute inflammatory episodes that lead to nerve damage, even after the infecting organisms have been killed by antibiotics. We suggest that the instability of these inflammatory sites is attributable to a disturbance of the role that nerves play in the regula...
journal_title:Trends in immunology
pub_type: 杂志文章,评审
doi:10.1016/s1471-4906(01)02090-7
更新日期:2002-01-01 00:00:00