AID in Antibody Diversification: There and Back Again.

Abstract:

:Activation-Induced cytidine Deaminase (AID) initiates affinity maturation and isotype switching by deaminating deoxycytidines within immunoglobulin genes, leading to somatic hypermutation (SHM) and class switch recombination (CSR). AID thus potentiates the humoral response to clear pathogens. Marking the 20th anniversary of the discovery of AID, we review the current understanding of AID function. We discuss AID biochemistry and how error-free forms of DNA repair are co-opted to prioritize mutagenesis over accuracy during antibody diversification. We discuss the regulation of DNA double-strand break (DSB) repair pathways during CSR. We describe genomic targeting of AID as a multilayered process involving chromatin architecture, cis- and trans-acting factors, and determining mutagenesis - distinct from AID occupancy at loci that are spared from mutation.

journal_name

Trends Immunol

journal_title

Trends in immunology

authors

Feng Y,Seija N,Di Noia JM,Martin A

doi

10.1016/j.it.2020.04.009

subject

Has Abstract

pub_date

2020-07-01 00:00:00

pages

586-600

issue

7

eissn

1471-4906

issn

1471-4981

pii

S1471-4906(20)30089-2

journal_volume

41

pub_type

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