Abstract：
:The recent Zika virus (ZIKV) epidemic has created an urgent need for a safe and effective vaccine. There is still a dearth of knowledge about ZIKV immunity, but years of investigation into the immunobiology of other flaviviruses has helped to accelerate the development of a ZIKV vaccine. Although the humoral immune response generates the primary correlate of protection from disease, robust T cell responses could enhance ZIKV vaccine efficacy. Additionally, pre-existing immunity to related flaviviruses could generate cross-reactive T cells that may affect immune responses upon vaccination. In this review, we summarize the key discoveries in the area of flavivirus T cell immunity and postulate on how these findings can inform ZIKV vaccine strategies for inducing protective immunity.
journal_name
Trends Immunoljournal_title
Trends in immunologyauthors
Lima NS,Rolland M,Modjarrad K,Trautmann Ldoi
10.1016/j.it.2017.05.004subject
Has Abstractpub_date
2017-08-01 00:00:00pages
594-605issue
8eissn
1471-4906issn
1471-4981pii
S1471-4906(17)30092-3journal_volume
38pub_type
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abstract：:Immunology in recent years has taken a somewhat surprising turn, expressed by a renewed interest in innate immunity. Especially intriguing is the regulatory role exerted by the innate components on the adaptive response, with Toll receptors and complement components being the most investigated. This function has been ...
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journal_title：Trends in immunology
pub_type： 评论,杂志文章
doi：10.1016/j.it.2020.03.011
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journal_title：Trends in immunology
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journal_title：Trends in immunology
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journal_title：Trends in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.it.2016.11.005
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journal_title：Trends in immunology
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doi：10.1016/j.it.2015.11.001
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journal_title：Trends in immunology
pub_type： 杂志文章,评审
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journal_title：Trends in immunology
pub_type： 杂志文章,评审
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journal_title：Trends in immunology
pub_type： 杂志文章,评审
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journal_title：Trends in immunology
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journal_title：Trends in immunology
pub_type： 杂志文章,评审
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journal_title：Trends in immunology
pub_type： 杂志文章,评审
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journal_title：Trends in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.it.2018.08.007
更新日期：2018-10-01 00:00:00
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journal_title：Trends in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.it.2015.12.006
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journal_title：Trends in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.it.2007.07.004
更新日期：2007-09-01 00:00:00
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journal_title：Trends in immunology
pub_type： 杂志文章,评审
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journal_title：Trends in immunology
pub_type： 杂志文章,评审
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journal_title：Trends in immunology
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journal_title：Trends in immunology
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journal_title：Trends in immunology
pub_type： 杂志文章,评审
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journal_title：Trends in immunology
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journal_title：Trends in immunology
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更新日期：2001-07-01 00:00:00
abstract：:Plasma cells operate as factories where large quantities of Ig heavy and light chains are made and assembled into functional antibodies. The finished products are shipped out with impressive efficiency. A major component of the machinery necessary for high-rate antibody secretion is an elaborate network of endoplasmic...
journal_title：Trends in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.it.2003.11.004
更新日期：2004-01-01 00:00:00
abstract：:Immunodeficiency due to inborn errors, infections, autoimmune diseases and the toxicity of certain therapies, has become an important clinical challenge. Strategies to enhance immune function could improve the outcome for a considerable number of patients. Although myeloid growth factors have found widespread use in c...
journal_title：Trends in immunology
pub_type： 杂志文章,评审
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更新日期：2005-01-01 00:00:00
