Abstract：
:Amyloid formation contributes to the development of progressive metabolic and neurodegenerative diseases, while also serving functional roles in host defense. Emerging evidence suggests that as amyloidogenic peptides populate distinct aggregation states, they interact with different combinations of pattern recognition receptors (PRRs) to direct the phenotype and function of tissue-resident and infiltrating innate immune cells. We review recent evidence of innate immunomodulation by distinct forms of amyloidogenic peptides produced by mammals (humans, non-human primates), bacteria, and fungi, as well as the corresponding cell-surface and intracellular PRRs in these interactions, in human and mouse models. Our emerging understanding of peptide aggregate-innate immune cell interactions, and the factors regulating the balance between amyloid function and pathogenicity, might aid the development of anti-amyloid and immunomodulating therapies.
journal_name
Trends Immunoljournal_title
Trends in immunologyauthors
Westwell-Roper C,Verchere CBdoi
10.1016/j.it.2019.06.005subject
Has Abstractpub_date
2019-08-01 00:00:00pages
762-780issue
8eissn
1471-4906issn
1471-4981pii
S1471-4906(19)30128-0journal_volume
40pub_type
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