Abstract:
:Many diseases have an inflammatory component, where neutrophil interactions with the vascular endothelium lead to barrier dysfunction and increased permeability. Neutrophils increase permeability through secreted products such as the chemokines CXCL1, 2, 3, and 8, through adhesion-dependent processes involving beta(2) integrins interacting with endothelial ICAM-1, and through combinations where beta(2) integrin engagement leads to degranulation and secretion of heparin-binding protein. Some neutrophil products, such as arachidonic acid or the leukotriene LTA4, are further processed by endothelial enzymes via transcellular metabolism before the resulting products thromboxane A2 or LTC4 can activate their cognate receptors. Neutrophils also generate reactive oxygen species that induce vascular leakage. This review focuses on the mechanisms of neutrophil-mediated leakage.
journal_name
Trends Immunoljournal_title
Trends in immunologyauthors
DiStasi MR,Ley Kdoi
10.1016/j.it.2009.07.012subject
Has Abstractpub_date
2009-11-01 00:00:00pages
547-56issue
11eissn
1471-4906issn
1471-4981pii
S1471-4906(09)00157-4journal_volume
30pub_type
杂志文章,评审abstract::Plasma cells operate as factories where large quantities of Ig heavy and light chains are made and assembled into functional antibodies. The finished products are shipped out with impressive efficiency. A major component of the machinery necessary for high-rate antibody secretion is an elaborate network of endoplasmic...
journal_title:Trends in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.it.2003.11.004
更新日期:2004-01-01 00:00:00
abstract::Adult neurogenesis plays an important role in brain function and declines with aging. A recent report demonstrates clonal T cell expansion within neurogenic niches of the aged brain, impairing neurogenesis through IFNγ signaling (Dulken et al.,Nature, 2019). These results highlight T cells as important contributors to...
journal_title:Trends in immunology
pub_type: 评论,杂志文章
doi:10.1016/j.it.2019.07.007
更新日期:2019-09-01 00:00:00
abstract::The typical functions of antibodies are based on linking the process of antigen recognition with initiation of innate immune reactions. With the introduction of modern research technologies and the use of sophisticated model systems, recent years have witnessed the discovery of a number of noncanonical functions of an...
journal_title:Trends in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.it.2020.03.006
更新日期:2020-05-01 00:00:00
abstract::Tetramethylpentadecane (TMPD, or commonly known as pristane)-induced lupus is a murine model of systemic lupus erythematosus (SLE). Renal disease and autoantibody production strictly depend on signaling through the interferon (IFN)-I receptor. The major source of IFN-I is immature monocytes bearing high levels of the ...
journal_title:Trends in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.it.2009.06.003
更新日期:2009-09-01 00:00:00
abstract::Two studies show that adding NOTCH ligands to Flt3L cultures increases the yield of cDC1s from mouse and human progenitors. Moreover, these NOTCH-DCs more closely resemble in vivo DCs transcriptionally and functionally. This will be extremely valuable for studying DCs in vitro and for further developing autologous DC-...
journal_title:Trends in immunology
pub_type: 评论,杂志文章
doi:10.1016/j.it.2018.08.002
更新日期:2018-10-01 00:00:00
abstract::When and how adaptive immunity emerged is one of the fundamental questions in immunology. Accumulated evidence suggests that the key components of adaptive immunity, rearranging receptor genes and the MHC, are unique to jawed vertebrates. Recent studies in protochordates, in particular, the draft genome sequence of th...
journal_title:Trends in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.it.2003.11.005
更新日期:2004-02-01 00:00:00
abstract::The signaling lymphocytic activation molecule (SLAM) and SLAM-associated protein (SAP) families have key roles in normal immunity. They have also been implicated in diseases such as immunodeficiencies and auto-immunity. However, recent findings raise issues requiring examination in future investigations of these molec...
journal_title:Trends in immunology
pub_type: 杂志文章
doi:10.1016/j.it.2006.03.003
更新日期:2006-05-01 00:00:00
abstract::Antigen cross-presentation describes the process through which dendritic cells (DCs) acquire exogenous antigens for presentation on MHC class I molecules. The ability to cross-present has been thought of as a feature of specialized DC subsets. Emerging data, however, suggest that the cross-presenting ability of each D...
journal_title:Trends in immunology
pub_type: 杂志文章
doi:10.1016/j.it.2013.02.007
更新日期:2013-08-01 00:00:00
abstract::T follicular helper (TFH) cells are characteristically defined by their CXCR5 positivity and homing to B cell follicles in secondary lymphoid organs (SLO). An expanded subpopulation of functionally comparable and phenotypically similar PD-1hiCXCR5-CD4+ T cells were recently identified in breast cancer (BC) and rheumat...
journal_title:Trends in immunology
pub_type: 杂志文章
doi:10.1016/j.it.2017.10.003
更新日期:2017-12-01 00:00:00
abstract::Immunoreceptors are believed to initiate their signaling by association with membrane rafts rich in src-family kinases and other signaling molecules. Although a recent paper casts doubt over this concept, by exposing drawbacks of a commonly used procedure to disturb rafts by cholesterol extraction, several other recen...
journal_title:Trends in immunology
pub_type: 新闻
doi:10.1016/s1471-4906(02)02330-x
更新日期:2002-12-01 00:00:00
abstract::Peptides bound or linked to heat-shock proteins (HSPs) of microbial or mammalian origin have been shown to elicit potent antigen-specific immunity. Some members of the HSP family, such as hsp60, hsp70, hsp90 and gp96, are able also to stimulate cells of the innate immune system directly and thus, act as 'danger'-signa...
journal_title:Trends in immunology
pub_type: 杂志文章
doi:10.1016/s1471-4906(01)02168-8
更新日期:2002-03-01 00:00:00
abstract::The highly polymorphic MHC class Ia molecules have a central role in adaptive immunity. By contrast, the closely related MHC class Ib molecules, which show limited polymorphism, are best known for regulating innate immune responses. Nevertheless, a recent area of interest is the emerging role of class Ib molecules in ...
journal_title:Trends in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.it.2006.07.006
更新日期:2006-09-01 00:00:00
abstract::CD45, the leucocyte common antigen, is a haemopoietic cell-specific tyrosine phosphatase. Many isoforms are generated by alternative splicing, but their function remains obscure. The extracellular domain of CD45 is highly polymorphic in all vertebrates. Importantly, human polymorphic variants that alter CD45 isoform e...
journal_title:Trends in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.it.2006.01.001
更新日期:2006-03-01 00:00:00
abstract::At two checkpoints, T cell development is controlled by T cell receptor (TCR) signaling, which determines survival and lineage commitment. At the first of these checkpoints, signaling by the pre-TCR, the gammadeltaTCR or the alphabetaTCR has a major but nonexclusive impact on whether cells will become CD4-CD8- gammade...
journal_title:Trends in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.it.2007.01.004
更新日期:2007-03-01 00:00:00
abstract::A prominent population of innate CD8+ T cells develops in the thymus of several gene-deficient mouse strains, including Itk, KLF2, CBP and Id3. These cells have the phenotype and function of memory CD8+ T cells, without previous exposure to antigen. Surprisingly, the cytokine IL-4 plays a key role in their development...
journal_title:Trends in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.it.2010.12.004
更新日期:2011-02-01 00:00:00
abstract::The innate immune system is the first line of defense against invading pathogens and is particularly important in warding off bacterial and viral infections presenting at the mucosal cell surface. From this primitive immune response, the more sophisticated adaptive immune system was derived. Despite nearly two decades...
journal_title:Trends in immunology
pub_type: 杂志文章,评审
doi:10.1016/s1471-4906(01)01925-1
更新日期:2001-06-01 00:00:00
abstract::Caspase recruitment domain-containing protein (Card)9 is a nonredundant adapter protein that functions in the innate immune system in the assembly of multifunctional signaling complexes. Together with B cell lymphoma (Bcl)10 and the paracaspase, mucosa-associated lymphoid tissue lymphoma translocation protein (Malt)1,...
journal_title:Trends in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.it.2013.02.006
更新日期:2013-06-01 00:00:00
abstract::In lymphatic tissue, professional antigen-presenting cells (APCs) such as dendritic cells (DCs), mature after sensing microbe-associated molecular patterns (MAMPs) by pattern recognition receptors (PRRs), and subsequently activate T cell immunity. Non-pathogenic MAMPs, derived for example from commensal bacteria, are ...
journal_title:Trends in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.it.2010.06.001
更新日期:2010-08-01 00:00:00
abstract::Autophagy is an evolutionarily conserved homeostatic process by which cells deliver cytoplasmic material for degradation into lysosomes. Autophagy may have evolved as a nutrient-providing homeostatic pathway induced upon starvation, but with the acquisition of cargo receptors, autophagy has become an important cellula...
journal_title:Trends in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.it.2012.06.003
更新日期:2012-10-01 00:00:00
abstract::The concept that blood cells arising from hematopoietic stem cells (HSC) can be subdivided into two major lineages, a myelo-erythroid and a lymphoid lineage, has long persisted. Indeed, it has become almost axiomatic that the first branch point from the HSC produces two progenitors, one for myelo-erythroid cells and t...
journal_title:Trends in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.it.2009.03.001
更新日期:2009-05-01 00:00:00
abstract::The vascular endothelium plays a central role in the recruitment and migration of circulating effector cells into sites of inflammation and immune responses. The unique CX(3)C-chemokine, fractalkine, is expressed on activated endothelial cells, and its receptor, CX(3)CR1, is expressed on natural killer cells, monocyte...
journal_title:Trends in immunology
pub_type: 杂志文章
doi:10.1016/s1471-4906(01)02051-8
更新日期:2001-11-01 00:00:00
abstract::Immunodeficiency due to inborn errors, infections, autoimmune diseases and the toxicity of certain therapies, has become an important clinical challenge. Strategies to enhance immune function could improve the outcome for a considerable number of patients. Although myeloid growth factors have found widespread use in c...
journal_title:Trends in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.it.2004.11.002
更新日期:2005-01-01 00:00:00
abstract::CD103(+) dendritic cells (DCs) represent the major migratory DC population in the intestinal lamina propria and are believed to play an essential role in the initiation and regulation of mucosal adaptive immune responses. Small intestine (SI) CD103(+) DCs have an enhanced capacity to generate the vitamin A metabolite,...
journal_title:Trends in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.it.2011.10.001
更新日期:2012-01-01 00:00:00
abstract::Cell migration is crucial for intrathymic T-cell differentiation. Chemokines and extracellular matrix proteins per se induce thymocyte migration, and recent data suggest a combinatorial role for these molecules in this event. For example, thymocyte migration induced by fibronectin plus CXCL12/SDF1-alpha (stromal cell-...
journal_title:Trends in immunology
pub_type: 杂志文章,评审
doi:10.1016/s1471-4906(02)02224-x
更新日期:2002-06-01 00:00:00
abstract::The origin of the Toll-like family of receptors pre-dates the evolutionary split between the plant and animal kingdoms. These receptors are remarkably conserved across the taxonomic kingdoms and have fundamental roles in triggering immune responses. How they trigger such responses, and how these mechanisms arose in ev...
journal_title:Trends in immunology
pub_type: 杂志文章
doi:10.1016/s1471-4906(02)00014-5
更新日期:2003-01-01 00:00:00
abstract::CD8+ T cell immunological memory of past antigen exposure can confer long-lived protection against infections or tumors. The fact that CD8+ memory T cells can have features of both naïve and effector cells has forced the field to struggle with several conceptual questions about the developmental origin of the cell and...
journal_title:Trends in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.it.2019.11.004
更新日期:2020-01-01 00:00:00
abstract::Within the 'success story' of vertebrate evolution, the acquisition and refinement of the adaptive immune system is far from the least impressive example of co-evolution. Members of the tumour necrosis factor superfamily (TNFSF) and TNF receptor superfamily (TNFRSF) have crucial roles in both innate and adaptive immun...
journal_title:Trends in immunology
pub_type: 杂志文章,评审
doi:10.1016/s1471-4906(03)00166-2
更新日期:2003-07-01 00:00:00
abstract::The circadian system ensures the generation and maintenance of self-sustained ~24-h rhythms in physiology that are linked to internal and environmental changes. In mammals, daily variations in light intensity and other cues are integrated by a hypothalamic master clock that conveys circadian information to peripheral ...
journal_title:Trends in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.it.2012.08.007
更新日期:2012-12-01 00:00:00
abstract::Over the years, the role of the eosinophil in asthma and allergic processes has been disputed. Recent human experiments using a humanised monoclonal antibody to interleukin-5 (IL-5), and animal studies involving specific IL-5 gene deletion, indicates that eosinophils might control downstream repair and remodelling pro...
journal_title:Trends in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.it.2004.07.006
更新日期:2004-09-01 00:00:00
abstract::Much attention has focused on the role of co-stimulation in dictating tolerance versus immunity to internalized antigens, with the assumption that the presentation of antigen-derived peptides by MHC molecules occurs constitutively. Here, I highlight our new appreciation for the regulated presentation of phagocytosed a...
journal_title:Trends in immunology
pub_type: 杂志文章
doi:10.1016/j.it.2006.11.001
更新日期:2007-01-01 00:00:00