Abstract：
:Epigenetic marks, such as DNA methylation, histone post-translational modifications and miRNAs, are induced in B cells by the same stimuli that drive the antibody response. They play major roles in regulating somatic hypermutation (SHM), class switch DNA recombination (CSR), and differentiation to plasma cells or long-lived memory B cells. Histone modifications target the CSR and, possibly, SHM machinery to the immunoglobulin locus; they together with DNA methylation and miRNAs modulate the expression of critical elements of that machinery, such as activation-induced cytidine deaminase (AID), as well as factors central to plasma cell differentiation, such as B lymphocyte-induced maturation protein-1 (Blimp-1). These inducible B cell-intrinsic epigenetic marks instruct the maturation of antibody responses. Their dysregulation plays an important role in aberrant antibody responses to foreign antigens, such as those of microbial pathogens, and self-antigens, such as those targeted in autoimmunity, and B cell neoplasia.
journal_name
Trends Immunoljournal_title
Trends in immunologyauthors
Li G,Zan H,Xu Z,Casali Pdoi
10.1016/j.it.2013.03.006subject
Has Abstractpub_date
2013-09-01 00:00:00pages
460-70issue
9eissn
1471-4906issn
1471-4981pii
S1471-4906(13)00052-5journal_volume
34pub_type
杂志文章,评审abstract：:Over the years, the role of the eosinophil in asthma and allergic processes has been disputed. Recent human experiments using a humanised monoclonal antibody to interleukin-5 (IL-5), and animal studies involving specific IL-5 gene deletion, indicates that eosinophils might control downstream repair and remodelling pro...
journal_title：Trends in immunology
pub_type： 杂志文章,评审
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更新日期：2004-09-01 00:00:00
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journal_title：Trends in immunology
pub_type： 杂志文章,评审
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更新日期：2017-10-01 00:00:00
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更新日期：2003-02-01 00:00:00
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pub_type： 杂志文章,评审
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更新日期：2001-12-01 00:00:00
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pub_type： 杂志文章,评审
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journal_title：Trends in immunology
pub_type： 杂志文章,评审
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更新日期：2019-03-01 00:00:00
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pub_type： 杂志文章,评审
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更新日期：2020-12-01 00:00:00
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pub_type： 杂志文章,评审
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pub_type： 杂志文章,评审
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journal_title：Trends in immunology
pub_type： 杂志文章,评审
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journal_title：Trends in immunology
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journal_title：Trends in immunology
pub_type： 杂志文章,评审
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更新日期：2003-06-01 00:00:00
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