Abstract：
:Immunology in recent years has taken a somewhat surprising turn, expressed by a renewed interest in innate immunity. Especially intriguing is the regulatory role exerted by the innate components on the adaptive response, with Toll receptors and complement components being the most investigated. This function has been firmly established for complement protein CR2 (CD21) as part of the BCR co-receptor CD19/CD21/CD81. New findings are now providing a broader picture of complement and its tuning of the immune response; for example, complement proteins have been implicated in the control of T-cell-mediated responses. We will review some of these data here and summarize new discoveries in areas of research on more traditional topics within the complement literature, such as complement and renal diseases, and the therapeutic use of C1-Inhibitor. We cover papers selected from studies presented at the XIX International Complement Workshop, held in Palermo in September 2002, and published within the past six months.
journal_name
Trends Immunoljournal_title
Trends in immunologyauthors
Clemenza L,Dieli F,Cicardi M,Salerno Adoi
10.1016/s1471-4906(03)00118-2keywords:
subject
Has Abstractpub_date
2003-06-01 00:00:00pages
292-6issue
6eissn
1471-4906issn
1471-4981pii
S1471490603001182journal_volume
24pub_type
杂志文章,评审abstract：:Cytokine signaling is dependent on the activation of intracellular molecules, including JAKs (Janus family kinases) and STATs (signal transducers and activators of transcription). Since the discovery of the SOCS (suppressor of cytokine signaling) family molecules in 1997, extensive investigation of these molecules has...
journal_title：Trends in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.it.2003.10.008
更新日期：2003-12-01 00:00:00
abstract：:At two checkpoints, T cell development is controlled by T cell receptor (TCR) signaling, which determines survival and lineage commitment. At the first of these checkpoints, signaling by the pre-TCR, the gammadeltaTCR or the alphabetaTCR has a major but nonexclusive impact on whether cells will become CD4-CD8- gammade...
journal_title：Trends in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.it.2007.01.004
更新日期：2007-03-01 00:00:00
abstract：:Recent advances in genome analysis have provided important insights into the genetic architecture of infectious and inflammatory diseases. The combined analysis of loci detected by genome-wide association studies (GWAS) in 22 inflammatory diseases has revealed a shared genetic core and associated biochemical pathways ...
journal_title：Trends in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.it.2015.12.006
更新日期：2016-02-01 00:00:00
abstract：:House dust mites (HDM; Dermatophagoides sp.) are one of the commonest aeroallergens worldwide and up to 85% of asthmatics are typically HDM allergic. Allergenicity is associated both with the mites themselves and with ligands derived from mite-associated bacterial and fungal products. Murine models of allergic airways...
journal_title：Trends in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.it.2011.06.006
更新日期：2011-09-01 00:00:00
abstract：:Basic immunological research has greatly expanded our understanding of the suspected immunopathology of multiple sclerosis (MS) and, more importantly, spawned a new generation of clinical trials evaluating dozens of immune-based therapies. Adhesion molecules are the furthest into development, although patient acceptan...
journal_title：Trends in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.it.2004.09.012
更新日期：2004-12-01 00:00:00
abstract：:Cell migration is crucial for intrathymic T-cell differentiation. Chemokines and extracellular matrix proteins per se induce thymocyte migration, and recent data suggest a combinatorial role for these molecules in this event. For example, thymocyte migration induced by fibronectin plus CXCL12/SDF1-alpha (stromal cell-...
journal_title：Trends in immunology
pub_type： 杂志文章,评审
doi：10.1016/s1471-4906(02)02224-x
更新日期：2002-06-01 00:00:00
abstract：:Specific immunotherapy (SIT) is a common treatment for allergic diseases. Despite its usage in clinical practice for nearly a century, more-rational and safer allergen preparations are required. Here, the underlying mechanisms and principles of allergen modification for the future use of SIT in the treatment of allerg...
journal_title：Trends in immunology
pub_type： 杂志文章,评审
doi：10.1016/s1471-4906(01)01862-2
更新日期：2001-04-01 00:00:00
abstract：:In addition to exogenous ligands derived from pathogens, natural killer (NK) and other innate cells can recognize endogenous ligands that often act as markers of stress or damage. A recent study reports that one of these receptors, human NKp44, recognizes PDGF-DD, providing a rare example of the recognition of a solub...
journal_title：Trends in immunology
pub_type： 评论,杂志文章
doi：10.1016/j.it.2018.02.002
更新日期：2018-05-01 00:00:00
abstract：:Nitrosation of thiol-containing proteins is a mechanism for cell regulation. Nitric-oxide-releasing nonsteroidal anti-inflammatory drugs (NO-NSAIDs) are chemical entities obtained by adding a nitroxybutyl moiety to a conventional NSAID. NO-NSAIDs inhibit inflammation via cyclo-oxygenase (COX)-dependent and -independen...
journal_title：Trends in immunology
pub_type： 杂志文章,评审
doi：10.1016/s1471-4906(01)01904-4
更新日期：2001-05-01 00:00:00
abstract：:Senescent cells, albeit not proliferating, are metabolically and transcriptionally active, thereby capable of affecting their microenvironment, notably via the production of inflammatory mediators. These mediators maintain and propagate the senescence process to neighboring cells, and then recruit immune cells for cle...
journal_title：Trends in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.it.2015.02.009
更新日期：2015-04-01 00:00:00
abstract：:Recent progress in cancer immunotherapy highlights the power of the immune system to control tumors, although a small patient subset responds to current immunotherapies. Additional approaches to mobilize antitumor immunity are required to overcome primary and acquired resistance to immunotherapy such as immune checkpo...
journal_title：Trends in immunology
pub_type： 评审
doi：10.1016/j.it.2020.08.010
更新日期：2020-10-01 00:00:00
abstract：:During an immune response, peripheral T-cell populations expand and then contract as the response subsides, thus maintaining a fairly constant number of CD4 and CD8 T cells throughout the life of the individual. The important factors that control this homeostasis are now beginning to be understood. Interleukin-7 (IL-7...
journal_title：Trends in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.it.2005.01.004
更新日期：2005-03-01 00:00:00
abstract：:The 2009 influenza pandemic highlighted the threat that type A influenza poses to human health. Thus, there is an urgency to understand the pathobiology of influenza infection and the contribution of the host immune response to virus elimination and the development of lung injury. This review focuses on the T cell arm...
journal_title：Trends in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.it.2011.02.006
更新日期：2011-05-01 00:00:00
abstract：:Interactions between the T-cell receptor (TCR) and self-peptide-MHC (spMHC) have been hypothesized to modulate T-cell reactivity in the periphery. Recent studies examining CD4+ T-cell responses to spMHC class II describe apparently contradictory findings and arrive at opposite conclusions. One explanation for these se...
journal_title：Trends in immunology
pub_type： 杂志文章
doi：10.1016/s1471-4906(03)00060-7
更新日期：2003-04-01 00:00:00
abstract：:TNF is a master proinflammatory cytokine whose pathogenic role in inflammatory disorders has long been attributed to induction of proinflammatory mediators. TNF also activates cell survival and death pathways, and recent studies demonstrated that TNF also causes inflammation by inducing cell death. The default respons...
journal_title：Trends in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.it.2016.06.002
更新日期：2016-08-01 00:00:00
abstract：:Inducing sustained, robust CD8(+) T cell responses is necessary for therapeutic intervention in chronic infectious diseases and cancer. Unfortunately, most adjuvant formulations fail to induce substantial cellular immunity in humans. Attenuated acute infectious agents induce strong CD8(+) T cell immunity, and are thou...
journal_title：Trends in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.it.2016.01.001
更新日期：2016-03-01 00:00:00
abstract：:Human immunodeficiency virus (HIV) induces a chronic generalized activation of the immune system, which plays an important role in the pathogenesis of AIDS. This ability of the virus might either be an evolved (adaptive) trait or a coincidental side effect of jumping to a new host species. We argue that selection favo...
journal_title：Trends in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.it.2008.04.005
更新日期：2008-07-01 00:00:00
abstract：:Autophagy is a group of cellular pathways that deliver cytoplasmic constituents for lysosomal degradation. The peptides generated from these pathways can be presented by MHC II molecules, making autophagy an important source of antigens for CD4+ T cells. In addition, modules of the molecular machinery of autophagy wer...
journal_title：Trends in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.it.2016.08.017
更新日期：2016-11-01 00:00:00
abstract：:Mammalian group 2 innate lymphoid cells (ILC2s) are responsible for the early production of type 2 cytokines at mucosal barriers upon exposure to allergen. Inflammatory tissue environmental cues can influence ILC2 activity, and this cellular population can be further categorized into subtypes with additional or altern...
journal_title：Trends in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.it.2019.10.007
更新日期：2019-12-01 00:00:00
abstract：:Beyond their role in neutralization, antibodies mediate functions such as phagocytosis, cytotoxicity, and maintenance of immune homeostasis. Two modifications to the constant domain control antibody activity: theirreversible genomic selection of isotype/subclass and alterations in glycosylation. Because glycosylation ...
journal_title：Trends in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.it.2017.02.004
更新日期：2017-05-01 00:00:00
abstract：:Non-Hodgkin lymphoma (NHL) is a diverse class of hematological cancers, many of which arise from germinal center (GC)-experienced B cells. Thus GCs, the sites of antibody affinity maturation triggered during immune responses, also provide an environment that facilitates B cell oncogenic transformation. miRNAs provide ...
journal_title：Trends in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.it.2020.08.006
更新日期：2020-10-01 00:00:00
abstract：:Many patients suffer from neuropathic pain as a result of injury to the peripheral nervous system (e.g. post-herpetic neuralgia or diabetic neuropathy) or to the central nervous system (e.g. spinal cord injury or stroke). The most distinctive symptom of neuropathic pain is allodynia, whereby normally non-painful stimu...
journal_title：Trends in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.it.2005.08.001
更新日期：2005-10-01 00:00:00
abstract：:NLRP6, a member of the nucleotide-binding domain, leucine-rich repeat-containing (NLR) innate immune receptor family, regulates inflammation and host defense against microorganisms. Similar to other NLRs, NLRP6 not only participates in inflammasome formation, but is also involved in nuclear factor-κB (NF-κB) and mitog...
journal_title：Trends in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.it.2017.01.001
更新日期：2017-04-01 00:00:00
abstract：:Recent advances in the understanding of medullary thymic epithelial cell biology, and especially of their promiscuous gene expression, have highlighted the indispensable role of thymic medulla in shaping a self-tolerant T-cell repertoire. Additionally, our recent results have shown that cortical thymic epithelial cell...
journal_title：Trends in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.it.2008.03.003
更新日期：2008-06-01 00:00:00
abstract：:Despite extensive, recent research on the development of dendritic cells (DCs), their origin is a controversial issue in immunology, with important implications regarding their use in cancer immunotherapy. Although, under defined experimental conditions, DCs can be generated from myeloid or lymphoid precursors, the di...
journal_title：Trends in immunology
pub_type： 杂志文章,评审
doi：10.1016/s1471-4906(01)02059-2
更新日期：2001-12-01 00:00:00
abstract：:The regulated secretion of cellular proteins is central to the correct function of many cell types, including immune cells. Lymphocyte control of the storage, transport and exocytosis of immunomodulatory molecules is a highly specialised task triggered by T cell receptor engagement. The regulated secretory pathway in ...
journal_title：Trends in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.it.2007.08.008
更新日期：2007-11-01 00:00:00
abstract：:Two recent crystal structures of membrane attack complex/perforin (MACPF) domains found in the complement and perforin families unexpectedly reveal that some proteins of the immune system share a common core fold with their bacterial targets. Although a relationship between MACPF proteins and the previously characteri...
journal_title：Trends in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.it.2007.11.003
更新日期：2008-02-01 00:00:00
abstract：:Recent advances allow aging-associated changes in B-cell function to be approached at a mechanistic level. Reduced expression of genes crucial to lineage commitment and differentiation yield diminished B-cell production. Moreover, intrinsic differences in the repertoire generated by B-cell precursors in aged individua...
journal_title：Trends in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.it.2009.04.005
更新日期：2009-07-01 00:00:00
abstract：:Neurodegenerative diseases are a group of chronic, progressive disorders characterized by the gradual loss of neurons in discrete areas of the central nervous system (CNS). The mechanism(s) underlying their progressive nature remains unknown but a timely and well-controlled inflammatory reaction is essential for the i...
journal_title：Trends in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.it.2008.05.002
更新日期：2008-08-01 00:00:00
abstract：:Chronic viral infections and cancer often lead to the emergence of dysfunctional or 'exhausted' CD8+ T cells, and the restoration of their functions is currently the focus of therapeutic interventions. In this review, we detail recent advances in the annotation of the gene modules and the epigenetic landscape associat...
journal_title：Trends in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.it.2017.05.008
更新日期：2017-08-01 00:00:00
