CD4+ T-cell responses to self-peptide--MHC.

Abstract:

:Interactions between the T-cell receptor (TCR) and self-peptide-MHC (spMHC) have been hypothesized to modulate T-cell reactivity in the periphery. Recent studies examining CD4+ T-cell responses to spMHC class II describe apparently contradictory findings and arrive at opposite conclusions. One explanation for these seemingly disparate results could be the use of mice that were assumed to be MHC class II null but might express some uncommon MHC class II heterodimers.

journal_name

Trends Immunol

journal_title

Trends in immunology

authors

Ge Q,Bai A,Shen CH,Eisen HN,Chen J

doi

10.1016/s1471-4906(03)00060-7

keywords:

subject

Has Abstract

pub_date

2003-04-01 00:00:00

pages

186-9

issue

4

eissn

1471-4906

issn

1471-4981

pii

S1471490603000607

journal_volume

24

pub_type

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