Abstract:
:Detailed sequence analysis of the companion alpha chains in several T-cell receptor (TCR) beta chain transgenic mice have shown that the mature alpha chain repertoires of CD4+ T cells are biased toward the parental TCR alpha chain sequences. These studies further indicate that it is self-peptide-self-MHC recognition during positive intrathymic selection that biases the structure of the mature TCR alpha chain repertoire. To further establish the causative relationship, it is important to examine whether such a bias can be abolished when positive selection is absent. The human collagen IV-I-A(s) complex-specific KB TCR cannot be positively selected on the self-peptide-self-MHC complexes present in the I-A(s) strain. Therefore, the KB TCR beta chain transgenic mice offer a unique opportunity for addressing this issue.
journal_name
Trends Immunoljournal_title
Trends in immunologyauthors
He X,Viret C,Janeway CA Jrdoi
10.1016/s1471-4906(02)02306-2keywords:
subject
Has Abstractpub_date
2002-10-01 00:00:00pages
467-9issue
10eissn
1471-4906issn
1471-4981pii
S1471490602023062journal_volume
23pub_type
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