Abstract：
:How allergens trigger the T helper 2 (Th2) response that characterizes allergic lung inflammation is not well understood. Epithelium-derived alarmins released after an allergen encounter activate the innate immune system, including group 2 innate lymphoid cells (ILC2s) which produce the type 2 interleukins IL-5 and IL-13. It has been recently shown that ILC2-derived cytokines are responsible not only for the innate responses underlying allergic inflammation but also for the initiation of the adaptive Th2 response. We review the role of lung ILC2s in the development of allergic inflammation and, in the context of recent findings, propose a common pathway wherein ILC2s, activated by the epithelium-derived cytokine IL-33, link the innate and the adaptive responses after allergen encounter in the lung.
journal_name
Trends Immunoljournal_title
Trends in immunologyauthors
Martinez-Gonzalez I,Steer CA,Takei Fdoi
10.1016/j.it.2015.01.005subject
Has Abstractpub_date
2015-03-01 00:00:00pages
189-95issue
3eissn
1471-4906issn
1471-4981pii
S1471-4906(15)00016-2journal_volume
36pub_type
杂志文章,评审abstract：:Lung capillaries, best known for vital gas exchange, also contribute to neutrophil margination, a phenomenon resulting in large numbers of pulmonary vascular neutrophils. Importantly, the functional relevance of neutrophil margination is unknown. Recent advances in microscopy have altered our understanding of why neut...
journal_title：Trends in immunology
pub_type： 杂志文章,评审
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abstract：:CD8(+) cytotoxic T lymphocyte (CTL) responses are crucial in establishing the control of persistent virus infections. Population studies of HIV-1-infected individuals suggest that CD8(+) CTL responses targeting epitopes that take the greatest toll on virus replication are instrumental in immune control. A major questi...
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journal_title：Trends in immunology
pub_type： 杂志文章,评审
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journal_title：Trends in immunology
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journal_title：Trends in immunology
pub_type： 杂志文章,评审
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journal_title：Trends in immunology
pub_type： 评论,杂志文章
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journal_title：Trends in immunology
pub_type： 杂志文章,评审
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journal_title：Trends in immunology
pub_type： 杂志文章,评审
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journal_title：Trends in immunology
pub_type： 杂志文章
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更新日期：2012-09-01 00:00:00
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journal_title：Trends in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.it.2008.05.002
更新日期：2008-08-01 00:00:00
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journal_title：Trends in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.it.2012.11.001
更新日期：2013-05-01 00:00:00
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journal_title：Trends in immunology
pub_type： 杂志文章
doi：10.1016/j.it.2006.03.004
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journal_title：Trends in immunology
pub_type： 杂志文章,评审
doi：10.1016/s1471-4906(02)02326-8
更新日期：2002-12-01 00:00:00
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journal_title：Trends in immunology
pub_type： 杂志文章,评审
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更新日期：2008-02-01 00:00:00
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journal_title：Trends in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.it.2012.08.004
更新日期：2013-02-01 00:00:00
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journal_title：Trends in immunology
pub_type： 杂志文章,评审
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更新日期：2001-04-01 00:00:00
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journal_title：Trends in immunology
pub_type： 杂志文章
doi：10.1016/s1471-4906(03)00064-4
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journal_title：Trends in immunology
pub_type： 杂志文章,评审
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journal_title：Trends in immunology
pub_type： 传,历史文章,杂志文章,评审
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更新日期：2004-12-01 00:00:00
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journal_title：Trends in immunology
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journal_title：Trends in immunology
pub_type： 杂志文章,评审
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journal_title：Trends in immunology
pub_type： 评论,杂志文章
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更新日期：2016-09-01 00:00:00
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journal_title：Trends in immunology
pub_type： 杂志文章,评审
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journal_title：Trends in immunology
pub_type： 杂志文章,评审
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更新日期：2001-05-01 00:00:00
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journal_title：Trends in immunology
pub_type： 杂志文章,评审
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更新日期：2019-03-01 00:00:00
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journal_title：Trends in immunology
pub_type： 杂志文章,评审
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更新日期：2005-05-01 00:00:00
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journal_title：Trends in immunology
pub_type： 杂志文章,评审
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更新日期：2002-06-01 00:00:00
abstract：:The human immune system comprises cellular and molecular components designed to coordinately prevent infection while avoiding potentially harmful inflammation and autoimmunity. Immunity varies with age, reflecting unique age-dependent challenges including fetal gestation, the neonatal phase, and infancy. Here, we revi...
journal_title：Trends in immunology
pub_type： 杂志文章,评审
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更新日期：2014-07-01 00:00:00
