Abstract:
:House dust mites (HDM; Dermatophagoides sp.) are one of the commonest aeroallergens worldwide and up to 85% of asthmatics are typically HDM allergic. Allergenicity is associated both with the mites themselves and with ligands derived from mite-associated bacterial and fungal products. Murine models of allergic airways disease for asthma research have recently switched from the use of surrogate allergen ovalbumin together with adjuvant to use of the HDM extract. This has accelerated understanding of how adaptive and innate immunity generate downstream pathology. We review the myriad ways in which HDM allergic responses are orchestrated. Understanding the molecular pathways that elicit HDM-associated pathology is likely to reveal novel targets for therapeutic intervention.
journal_name
Trends Immunoljournal_title
Trends in immunologyauthors
Gregory LG,Lloyd CMdoi
10.1016/j.it.2011.06.006subject
Has Abstractpub_date
2011-09-01 00:00:00pages
402-11issue
9eissn
1471-4906issn
1471-4981pii
S1471-4906(11)00111-6journal_volume
32pub_type
杂志文章,评审abstract::Nitrosation of thiol-containing proteins is a mechanism for cell regulation. Nitric-oxide-releasing nonsteroidal anti-inflammatory drugs (NO-NSAIDs) are chemical entities obtained by adding a nitroxybutyl moiety to a conventional NSAID. NO-NSAIDs inhibit inflammation via cyclo-oxygenase (COX)-dependent and -independen...
journal_title:Trends in immunology
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abstract::T follicular helper (TFH) cells are characteristically defined by their CXCR5 positivity and homing to B cell follicles in secondary lymphoid organs (SLO). An expanded subpopulation of functionally comparable and phenotypically similar PD-1hiCXCR5-CD4+ T cells were recently identified in breast cancer (BC) and rheumat...
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journal_title:Trends in immunology
pub_type: 杂志文章
doi:10.1016/j.it.2006.11.001
更新日期:2007-01-01 00:00:00
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journal_title:Trends in immunology
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journal_title:Trends in immunology
pub_type: 杂志文章,评审
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journal_title:Trends in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.it.2012.11.001
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pub_type: 杂志文章,评审
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journal_title:Trends in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.it.2008.05.002
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journal_title:Trends in immunology
pub_type: 评论,杂志文章
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doi:10.1016/j.it.2020.12.005
更新日期:2021-02-01 00:00:00
abstract::An exemplar outcome of an immunology-based intervention is vaccine development; the current COVID-19 pandemic is a case in point. Can we build an immunology research ecosystem in Africa that nurtures discovery and enables translation? We see African immunologists as key agents of change and discuss obstacles and oppor...
journal_title:Trends in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.it.2020.10.007
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journal_title:Trends in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.it.2014.02.001
更新日期:2014-03-01 00:00:00
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journal_title:Trends in immunology
pub_type: 杂志文章,评审
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journal_title:Trends in immunology
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pub_type: 杂志文章,评审
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journal_title:Trends in immunology
pub_type: 杂志文章,评审
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journal_title:Trends in immunology
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journal_title:Trends in immunology
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journal_title:Trends in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.it.2007.09.001
更新日期:2007-12-01 00:00:00
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journal_title:Trends in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.it.2020.08.006
更新日期:2020-10-01 00:00:00
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journal_title:Trends in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.it.2008.07.004
更新日期:2008-10-01 00:00:00
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journal_title:Trends in immunology
pub_type: 杂志文章,评审
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更新日期:2007-08-01 00:00:00
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journal_title:Trends in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.it.2020.05.002
更新日期:2020-07-01 00:00:00
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journal_title:Trends in immunology
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更新日期:2005-11-01 00:00:00