Abstract:
:Complement is not only part of the innate immune system, but has also been implicated in adaptive immunity. The role of complement and its regulatory proteins in modulating T cell activity has been the focus of several recent studies. These, which have included work on the membrane co-factor protein (MCP or CD46), decay accelerating factor (DAF or CD55) and CD59, indicate that complement regulators can influence the proliferative capacity of T cells and their ability to produce cytokines, influencing the outcome of a T cell response to a given antigen. Here we review these studies, which reveal another important link between the innate and the adaptive immune system.
journal_name
Trends Immunoljournal_title
Trends in immunologyauthors
Longhi MP,Harris CL,Morgan BP,Gallimore Adoi
10.1016/j.it.2005.12.008keywords:
subject
Has Abstractpub_date
2006-02-01 00:00:00pages
102-8issue
2eissn
1471-4906issn
1471-4981pii
S1471-4906(05)00314-5journal_volume
27pub_type
杂志文章,评审abstract::Complement is a major defense system of innate immunity and aimed to destroy microbes. One of the central complement regulators is factor H, which belongs to a protein family that includes CFHL1 and five factor H-related (CFHR) proteins. Recent evidence shows that factor H family proteins (factor H and CFHRs) are asso...
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journal_title:Trends in immunology
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doi:10.1016/j.it.2017.02.004
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doi:10.1016/j.it.2011.06.006
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pub_type: 杂志文章,评审
doi:10.1016/s1471-4906(02)00029-7
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journal_title:Trends in immunology
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doi:10.1016/j.it.2004.08.012
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abstract::Basic immunological research has greatly expanded our understanding of the suspected immunopathology of multiple sclerosis (MS) and, more importantly, spawned a new generation of clinical trials evaluating dozens of immune-based therapies. Adhesion molecules are the furthest into development, although patient acceptan...
journal_title:Trends in immunology
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doi:10.1016/j.it.2004.09.012
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pub_type: 评论,杂志文章
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