Abstract:
:Astrocytes are neural parenchymal cells that ubiquitously tile the central nervous system (CNS). In addition to playing essential roles in healthy tissue, astrocytes exhibit an evolutionarily ancient response to all CNS insults, referred to as astrocyte reactivity. Long regarded as passive and homogeneous, astrocyte reactivity is being revealed as a heterogeneous and functionally powerful component of mammalian CNS innate immunity. Nevertheless, concepts about what astrocyte reactivity comprises and what it does are incomplete and sometimes controversial. This review discusses the goal of differentiating reactive astrocyte subtypes and states based on composite pictures of molecular expression, cell morphology, cellular interactions, proliferative state, normal functions, and disease-induced dysfunctions. A working model and conceptual framework is presented for characterizing the diversity of astrocyte reactivity.
journal_name
Trends Immunoljournal_title
Trends in immunologyauthors
Sofroniew MVdoi
10.1016/j.it.2020.07.004subject
Has Abstractpub_date
2020-09-01 00:00:00pages
758-770issue
9eissn
1471-4906issn
1471-4981pii
S1471-4906(20)30153-8journal_volume
41pub_type
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journal_title:Trends in immunology
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更新日期:2006-11-01 00:00:00
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更新日期:2020-10-01 00:00:00
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journal_title:Trends in immunology
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doi:10.1016/j.it.2005.08.006
更新日期:2005-10-01 00:00:00
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journal_title:Trends in immunology
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journal_title:Trends in immunology
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