Abstract：
:Immunodeficiency due to inborn errors, infections, autoimmune diseases and the toxicity of certain therapies, has become an important clinical challenge. Strategies to enhance immune function could improve the outcome for a considerable number of patients. Although myeloid growth factors have found widespread use in clinical medicine, a 'lymphoid growth factor' has not yet been established in clinical use. Several recent studies have proposed two candidate immunostimulatory cytokines: interleukin-7 (IL-7) and IL-15. In this Review, we discuss recent findings regarding the effects of IL-7 and IL-15 on lymphopoiesis and their potential use for the treatment of immunodeficiency.
journal_name
Trends Immunoljournal_title
Trends in immunologyauthors
Alpdogan O,van den Brink MRdoi
10.1016/j.it.2004.11.002keywords:
subject
Has Abstractpub_date
2005-01-01 00:00:00pages
56-64issue
1eissn
1471-4906issn
1471-4981pii
S1471-4906(04)00339-4journal_volume
26pub_type
杂志文章,评审abstract：:Non-Hodgkin lymphoma (NHL) is a diverse class of hematological cancers, many of which arise from germinal center (GC)-experienced B cells. Thus GCs, the sites of antibody affinity maturation triggered during immune responses, also provide an environment that facilitates B cell oncogenic transformation. miRNAs provide ...
journal_title：Trends in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.it.2020.08.006
更新日期：2020-10-01 00:00:00
abstract：:T-bet was originally described as the key transcription factor defining type 1 T helper (Th) cells. However, it is now clear that it drives the orchestrated generation of effector and memory cells in multiple different lymphocyte lineages. In addition to Th1 cells, CD8 T cells, B cells and some innate lymphocyte popul...
journal_title：Trends in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.it.2017.02.003
更新日期：2017-04-01 00:00:00
abstract：:The mechanisms underlying the failure to control the growth and systemic spread of Leishmania parasites in human visceral leishmaniasis (VL) are not well understood. Although the absence of antigen-specific Th1 responses in the peripheral blood mononuclear cells from VL patients is thought to be causally related to di...
journal_title：Trends in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.it.2007.07.004
更新日期：2007-09-01 00:00:00
abstract：:Recent studies have reported paradoxical roles of inflammation in tumor immunity triggered by PD-1 checkpoint antibody (Ab) blockade. Here, we elaborate on this controversy and propose a new perspective that might help understand this paradox. Since inflammatory cytokines and PD-1 blockade are known to target differen...
journal_title：Trends in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.it.2020.09.003
更新日期：2020-11-01 00:00:00
abstract：:T cells are subject to tight regulatory measures, as uncontrolled responses might be detrimental to the host. Control measures include central or thymic tolerance, and peripheral tolerance mechanisms acting after naive T cells have encountered their cognate antigen, such as anergy induction, the contraction phase (whe...
journal_title：Trends in immunology
pub_type： 杂志文章
doi：10.1016/j.it.2006.09.006
更新日期：2006-11-01 00:00:00
abstract：:Recent studies have uncovered sterile alpha motif and HD domain 1 (SAMHD1) as the restriction factor that blocks HIV-1 replication in myeloid cells. In contrast to previously identified HIV-1 restriction factors, SAMHD1 does not meet a countermeasure developed by HIV-1. However, HIV-2 and certain simian immunodeficien...
journal_title：Trends in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.it.2011.11.002
更新日期：2012-01-01 00:00:00
abstract：:Within the 'success story' of vertebrate evolution, the acquisition and refinement of the adaptive immune system is far from the least impressive example of co-evolution. Members of the tumour necrosis factor superfamily (TNFSF) and TNF receptor superfamily (TNFRSF) have crucial roles in both innate and adaptive immun...
journal_title：Trends in immunology
pub_type： 杂志文章,评审
doi：10.1016/s1471-4906(03)00166-2
更新日期：2003-07-01 00:00:00
abstract：:Nucleotide-binding oligomerization domain protein (NOD)1 and NOD2 participate in signaling pathways that detect pathogen-induced processes, such as the presence of peptidoglycan fragments in the host cell cytosol, as danger signals. Recent work suggests that peptidoglycan fragments activate NOD1 indirectly, through ac...
journal_title：Trends in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.it.2013.10.009
更新日期：2014-03-01 00:00:00
abstract：:How innate immunity gave rise to adaptive immunity in vertebrates remains unknown. We propose an evolutionary scenario beginning with pathogen-associated molecular pattern(s) (PAMPs) being presented by molecule(s) on one cell to specific receptor(s) on other cells, much like MHC molecules and T cell receptors (TCRs). ...
journal_title：Trends in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.it.2020.05.002
更新日期：2020-07-01 00:00:00
abstract：:The immune system serves to protect organisms from infectious pathogens. During infection, lymphocytes and cells of the innate immune system, expressing receptors that recognize foreign antigens, proliferate and differentiate to develop effector functions that help to kill the pathogens. Effector functions, such as ce...
journal_title：Trends in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.it.2004.08.012
更新日期：2004-11-01 00:00:00
abstract：:Chronic viral infections and cancer often lead to the emergence of dysfunctional or 'exhausted' CD8+ T cells, and the restoration of their functions is currently the focus of therapeutic interventions. In this review, we detail recent advances in the annotation of the gene modules and the epigenetic landscape associat...
journal_title：Trends in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.it.2017.05.008
更新日期：2017-08-01 00:00:00
abstract：:In lymphatic tissue, professional antigen-presenting cells (APCs) such as dendritic cells (DCs), mature after sensing microbe-associated molecular patterns (MAMPs) by pattern recognition receptors (PRRs), and subsequently activate T cell immunity. Non-pathogenic MAMPs, derived for example from commensal bacteria, are ...
journal_title：Trends in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.it.2010.06.001
更新日期：2010-08-01 00:00:00
abstract：:Neurodegenerative diseases are a group of chronic, progressive disorders characterized by the gradual loss of neurons in discrete areas of the central nervous system (CNS). The mechanism(s) underlying their progressive nature remains unknown but a timely and well-controlled inflammatory reaction is essential for the i...
journal_title：Trends in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.it.2008.05.002
更新日期：2008-08-01 00:00:00
abstract：:Harmless microbes colonizing the gut require the establishment of a well-equilibrated symbiosis between this microbiota and its host. However, the immune system is primed to recognize both conserved microbial patterns and foreign antigens, and therefore developed strong tolerance mechanisms to prevent potential fatal ...
journal_title：Trends in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.it.2016.05.002
更新日期：2016-07-01 00:00:00
abstract：:CD45, the leucocyte common antigen, is a haemopoietic cell-specific tyrosine phosphatase. Many isoforms are generated by alternative splicing, but their function remains obscure. The extracellular domain of CD45 is highly polymorphic in all vertebrates. Importantly, human polymorphic variants that alter CD45 isoform e...
journal_title：Trends in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.it.2006.01.001
更新日期：2006-03-01 00:00:00
abstract：:Over the years, the role of the eosinophil in asthma and allergic processes has been disputed. Recent human experiments using a humanised monoclonal antibody to interleukin-5 (IL-5), and animal studies involving specific IL-5 gene deletion, indicates that eosinophils might control downstream repair and remodelling pro...
journal_title：Trends in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.it.2004.07.006
更新日期：2004-09-01 00:00:00
abstract：:Plasma cells operate as factories where large quantities of Ig heavy and light chains are made and assembled into functional antibodies. The finished products are shipped out with impressive efficiency. A major component of the machinery necessary for high-rate antibody secretion is an elaborate network of endoplasmic...
journal_title：Trends in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.it.2003.11.004
更新日期：2004-01-01 00:00:00
abstract：:The immune system confines neoplasia at various stages of tumor development. Whereas the role of cellular immunity has been investigated widely and utilized in the clinic, the importance of humoral immunity in this process has begun to emerge only in recent years. Circulating antinuclear autoantibodies (ANAs) typicall...
journal_title：Trends in immunology
pub_type： 杂志文章,评审
doi：10.1016/s1471-4906(01)01984-6
更新日期：2001-08-01 00:00:00
abstract：:Increasing age is associated with a decreasing ability to mediate effective immune responses to newly encountered antigens. It is generally believed that this reflects the age-associated decline in the number, repertoire and function of available naive T cells. Here, we propose that naive T cells become increasingly i...
journal_title：Trends in immunology
pub_type： 杂志文章
doi：10.1016/j.it.2006.05.002
更新日期：2006-07-01 00:00:00
abstract：:Psoriasis is a complex inflammatory process resulting from activation of the well-defined interleukin (IL)-23/T17 cytokine axis. We review the role of key cytokines IL-17 and IL-23 in psoriasis, as well as tumor necrosis factor (TNF)α, focusing on therapeutic cytokine interventions and what they reveal about psoriatic...
journal_title：Trends in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.it.2012.11.005
更新日期：2013-04-01 00:00:00
abstract：:House dust mites (HDM; Dermatophagoides sp.) are one of the commonest aeroallergens worldwide and up to 85% of asthmatics are typically HDM allergic. Allergenicity is associated both with the mites themselves and with ligands derived from mite-associated bacterial and fungal products. Murine models of allergic airways...
journal_title：Trends in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.it.2011.06.006
更新日期：2011-09-01 00:00:00
abstract：:Recent advances in the understanding of medullary thymic epithelial cell biology, and especially of their promiscuous gene expression, have highlighted the indispensable role of thymic medulla in shaping a self-tolerant T-cell repertoire. Additionally, our recent results have shown that cortical thymic epithelial cell...
journal_title：Trends in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.it.2008.03.003
更新日期：2008-06-01 00:00:00
abstract：:Amyloid formation contributes to the development of progressive metabolic and neurodegenerative diseases, while also serving functional roles in host defense. Emerging evidence suggests that as amyloidogenic peptides populate distinct aggregation states, they interact with different combinations of pattern recognition...
journal_title：Trends in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.it.2019.06.005
更新日期：2019-08-01 00:00:00
abstract：:Many diseases have an inflammatory component, where neutrophil interactions with the vascular endothelium lead to barrier dysfunction and increased permeability. Neutrophils increase permeability through secreted products such as the chemokines CXCL1, 2, 3, and 8, through adhesion-dependent processes involving beta(2)...
journal_title：Trends in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.it.2009.07.012
更新日期：2009-11-01 00:00:00
abstract：:To maintain prolonged colonization of the human gastric mucosa, Helicobacter pylori must avoid both innate and adaptive immune responses. During its long coexistence with humans, it has evolved complex strategies to maintain a mild inflammation of the gastric epithelium while limiting the extent of immune effector act...
journal_title：Trends in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.it.2005.01.007
更新日期：2005-04-01 00:00:00
abstract：:Mast cells are currently recognized as effector cells in many settings beyond just allergic reactions, including innate immunity, autoimmunity, chronic inflammatory disorders and atherosclerosis. Signaling pathways of the mast cell response have been widely explored in the past but these are still linked with single a...
journal_title：Trends in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.it.2007.06.007
更新日期：2007-08-01 00:00:00
abstract：:Unlike T cells that recognize digested peptides, B cells recognize their cognate antigen in its native form. The B cell receptor used in recognition can also be secreted to bind to antigens and initiate multiple effector functions such as phagocytosis, complement activation, or neutralization of receptors. While B cel...
journal_title：Trends in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.it.2016.10.003
更新日期：2016-12-01 00:00:00
abstract：:T follicular helper (TFH) cells are characteristically defined by their CXCR5 positivity and homing to B cell follicles in secondary lymphoid organs (SLO). An expanded subpopulation of functionally comparable and phenotypically similar PD-1hiCXCR5-CD4+ T cells were recently identified in breast cancer (BC) and rheumat...
journal_title：Trends in immunology
pub_type： 杂志文章
doi：10.1016/j.it.2017.10.003
更新日期：2017-12-01 00:00:00
abstract：:Protease-activated receptors (PARs) belong to a family of G protein-coupled receptors activated by serine proteases via proteolytic cleavage. PARs are expressed on epithelial cells, endothelial cells, and leukocytes, indicating a role in controlling barrier function against external danger. During inflammation, microo...
journal_title：Trends in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.it.2007.09.001
更新日期：2007-12-01 00:00:00
abstract：:The ocular surface is a unique mucosal immune compartment in which anatomical, physiological, and immunological features act in concert to foster a particularly tolerant microenvironment. These mechanisms are vital to the functional competence of the eye, a fact underscored by the devastating toll of excessive inflamm...
journal_title：Trends in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.it.2017.11.007
更新日期：2018-04-01 00:00:00
