When Clarity Is Crucial: Regulating Ocular Surface Immunity.

Abstract:

:The ocular surface is a unique mucosal immune compartment in which anatomical, physiological, and immunological features act in concert to foster a particularly tolerant microenvironment. These mechanisms are vital to the functional competence of the eye, a fact underscored by the devastating toll of excessive inflammation at the cornea - blindness. Recent data have elucidated the contributions of specific anatomical components, immune cells, and soluble immunoregulatory factors in promoting homeostasis at the ocular surface. We highlight research trends at this distinctive mucosal barrier and identify crucial gaps in our current knowledge.

journal_name

Trends Immunol

journal_title

Trends in immunology

authors

Foulsham W,Coco G,Amouzegar A,Chauhan SK,Dana R

doi

10.1016/j.it.2017.11.007

subject

Has Abstract

pub_date

2018-04-01 00:00:00

pages

288-301

issue

4

eissn

1471-4906

issn

1471-4981

pii

S1471-4906(17)30229-6

journal_volume

39

pub_type

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