Abstract:
:The ocular surface is a unique mucosal immune compartment in which anatomical, physiological, and immunological features act in concert to foster a particularly tolerant microenvironment. These mechanisms are vital to the functional competence of the eye, a fact underscored by the devastating toll of excessive inflammation at the cornea - blindness. Recent data have elucidated the contributions of specific anatomical components, immune cells, and soluble immunoregulatory factors in promoting homeostasis at the ocular surface. We highlight research trends at this distinctive mucosal barrier and identify crucial gaps in our current knowledge.
journal_name
Trends Immunoljournal_title
Trends in immunologyauthors
Foulsham W,Coco G,Amouzegar A,Chauhan SK,Dana Rdoi
10.1016/j.it.2017.11.007subject
Has Abstractpub_date
2018-04-01 00:00:00pages
288-301issue
4eissn
1471-4906issn
1471-4981pii
S1471-4906(17)30229-6journal_volume
39pub_type
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journal_title:Trends in immunology
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journal_title:Trends in immunology
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journal_title:Trends in immunology
pub_type: 杂志文章,评审
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doi:10.1016/j.it.2015.12.006
更新日期:2016-02-01 00:00:00
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journal_title:Trends in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.it.2012.06.003
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journal_title:Trends in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.it.2005.08.006
更新日期:2005-10-01 00:00:00
abstract::An exemplar outcome of an immunology-based intervention is vaccine development; the current COVID-19 pandemic is a case in point. Can we build an immunology research ecosystem in Africa that nurtures discovery and enables translation? We see African immunologists as key agents of change and discuss obstacles and oppor...
journal_title:Trends in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.it.2020.10.007
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doi:10.1016/s1471-4906(01)02059-2
更新日期:2001-12-01 00:00:00
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journal_title:Trends in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.it.2008.03.003
更新日期:2008-06-01 00:00:00
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journal_title:Trends in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.it.2013.02.006
更新日期:2013-06-01 00:00:00
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journal_title:Trends in immunology
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journal_title:Trends in immunology
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doi:10.1016/j.it.2003.11.005
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journal_title:Trends in immunology
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journal_title:Trends in immunology
pub_type: 评论,杂志文章
doi:10.1016/j.it.2019.06.007
更新日期:2019-08-01 00:00:00
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journal_title:Trends in immunology
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doi:10.1016/j.it.2003.08.003
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journal_title:Trends in immunology
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doi:10.1016/j.it.2016.11.005
更新日期:2017-02-01 00:00:00
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journal_title:Trends in immunology
pub_type: 杂志文章
doi:10.1016/j.it.2017.10.003
更新日期:2017-12-01 00:00:00